Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “CRIPPLES”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 91 records · Page 5Linked to original sources
PubMed1995

Opioids for chronic pain of non-malignant origin--caring or crippling.

Pain management has improved in the past few decades. Opioid analgesics have become the mainstay in the treatment of cancer pain whilst inter-disciplinary pain management programmes are the generally accepted approach to chronic pain of non-malignant origin. Recently some pain specialists have advocated the use of opioids in the long-term management of non-cancer pain. This has raised some fundamental questions about the purpose of pain management. Is it best to opt for maximum pain relief and comfort, or should one emphasise function and activity as higher priorities? Will the use of opioids create more autonomy for pain sufferers or will this add handicaps to lives which are already limited? Until more clinical outcome data are available we advocate caution in the use of opioid analgesia. Such caution can, and does, raise questions about the rights of the patient and the rights of the prescriber in a context where the facts do not point to a clear course of action.

Analgesics, Opioid↗
PubMed1976

Crippling lung disease after measles and adenovirus infection.

Four children who developed severe lung disease after measles are described. One child died and three have been left with severe impairment of lung function. It is suggested that secondary infection with an adenovirus was responsible for causing the lung disease in these patients. The immune response to measles was abnormal. Measles virus may have rendered the children more susceptible to serious complications from infection with the adenovirus. The many deaths from 'measles pneumonia' in developing countries and the occasional occurence of post-measles bronchiectasis in this country may be due to secondary adenovirus infections. Further viral and serological studies are required to confirm this hypothesis.

Adenoviridae Infections↗
PubMed1986

Reconstruction of the urethra for hypospadiac cripples by microvascular free flap transfers.

A proximal hypospadias, despite multiple procedures, may remain uncorrected either totally or because of multiple fistulae. In such circumstances there is often a severe shortage of skin on the ventral surface of the penis and scrotal skin may already have been used. The microvascular transfer of a radial forearm flap may then be used and, because of the thinness of the flap, a tube may be developed from it as well as covering skin. The long vascular pedicle ensures a good vascular input at the recipient site by anastomosis of the radial vessels to the femoral vessels. Two cases are presented which would have proved difficult to reconstruct by any other means.

Adolescent↗
PubMed1997

The crippling consequences of fractures and their impact on quality of life.

Around 40% of white women and 13% of white men in the United States have at least one fragility fracture after the age of 50 years. The risk of fracture increases with advancing age and progressive loss of bone mass, and varies with the population being considered. The age-adjusted incidence of fragility fractures in both sexes is 25% lower in Britain and many areas of Europe than in the United States. Mortality 5 years after hip or vertebral fracture is about 20% in excess of that expected; mortality rate is highest in men > 75 years suffering from a variety of chronic diseases. Most excess deaths occur in the first 6 months after hip fracture. One year after hip fracture, 40% of patients are still unable to walk independently, 60% have difficulty with at least one essential activity of daily living, and 80% are restricted in other activities, such as driving and grocery shopping. Moreover, 27% of these patients enter a nursing home for the first time. Less is known of the epidemiology of vertebral fractures and of the associated mortality and morbidity. Although an estimated 30% of postmenopausal U.S. white women have osteoporosis, and 1 in 4 has at least one vertebral deformity, two thirds of vertebral fractures remain undiagnosed. After a clinically diagnosed vertebral fracture, survival rate decreases gradually from that expected without fracture. Women with severe vertebral deformities have a consistently higher risk of back pain and height loss. An accurate assessment of the risk of fractures associated with osteoporosis and of their impact on quality of life is essential if appropriate and cost-effective interventions are to be designed for different populations.

Persons with Disabilities↗
PubMed1999

Crippling of CD3-zeta ITAMs does not impair T cell receptor signaling.

We evaluated the importance of CD3-zeta ITAMs in T cell responses by breeding the P14 transgenic TCR into mice in which CD3-zeta chains lacking all or part of their ITAMs were genetically substituted for wild-type CD3-zeta chains. In contrast to the H-Y TCR, the P14 TCR permitted the development of peripheral CD8+ T cells harboring signaling-defective CD3-zeta subunits. The absence of functional CD3-zeta ITAMs did not reduce the spectrum of activation events and effector functions that constitute the normal attributes of mature CD8+ T cells. The only detectable differences were quantitative and noted only when T cells were challenged with suboptimal peptide concentrations. Therefore, the ITAMs present in the CD3-gammadeltaepsilon module are sufficient for qualitatively normal TCR signaling and those present in CD3-zeta have no exclusive role during T cell activation.

Animals↗