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PubMed2006

Carbon dioxide laser vaporization of condyloma acuminata.

UNLABELLED: Carbon dioxide laser vaporization of condyloma acuminata continues to be the treatment with a greater rate of success and with excellent cosmetic results. OBJECTIVE: To evaluate the clinical outcome of carbon dioxide laser vaporization of condyloma acuminata at a referral center in Mexico. MATERIALS AND METHODS: Carbon dioxide laser vaporization was performed for condyloma acuminata in 46 women and 35 men, measured from 3 to 60 months with colposcopy or peneoscopy every 6 months. It was a clinical prospective study. RESULTS: The average length of follow-up in women was 21 months, and the average length of follow-up in men was 16 months. The women's study follow-up showed an initial success rate of 93%, and the recurrence rate after 6 months of treatment was 7%. The follow-up of men showed an initial success rate of 69%, and the recurrence rate after 6 months was 25%. The success rate in women after the second treatment was 100% without recurrence. In men, the second treatment success rate was 88%, and the recurrence rate after 6 months was 33%. CONCLUSIONS: Carbon dioxide laser vaporization condyloma acuminata provides an excellent rate of success and patient satisfaction.

Colposcopy↗
PubMed1997

Antibodies against human papillomavirus type 6 capsids are elevated in men with previous condylomas.

Serum samples from 47 men with current condylomas, 32 men with a history of condylomas and from 205 men with no history of genital wart disease, who were attending sexually transmitted disease (STD) clinics at two different hospitals in Stockholm, were analyzed for the presence of immunoglobulin G (IgG) and A (IgA) antibodies to capsids of human papillomavirus types 6 and 11. IgG to HPV type 6 was found among 35% of patients with a history of condylomas compared to 10% of controls (p = 0.0003), but only among 27% of patients with current condylomas. Antibodies to HPV 6 and to HPV 11 showed a very limited correlation, suggesting that the antibodies are HPV-type restricted. The results strengthen conclusions from a previous serological study indicating that IgG antibodies against HPV 6 develop late during condylomatous disease and mostly reflect previous exposure to the virus.

Antibodies, Viral↗
PubMed1965

GIANT CONDYLOMA ACUMINATA: INCIDENCE AMONG CASES DIAGNOSED AS CARCINOMA OF THE PENIS.

Twenty-four cases of giant condyloma acuminata were found among 100 cases diagnosed as carcinoma of the penis. One of the 24 tumours showed early malignant change. The characteristic histological pattern of giant condyloma consists of broad processes composed of prickle cells associated with little keratinization. The malignant condylomas show, in comparison, a loss of prickle cell preponderance, increased basal cell activity and frequent keratinization, or may present as a solid papillary epithelioma forming broad sheets of uniform cells with many mitoses. The incidence of malignant change in the giant condyloma and the relationship between the benign and malignant tumours are discussed.

Adenocarcinoma↗
PubMed1996

Randomised double-blind trial of recombinant interferon-beta for condyloma acuminatum.

OBJECTIVE: To evaluate the safety and efficacy of two intralesional doses of recombinant human interferon-beta (r-hIFN-beta: Rebif, Ares Serono), given 3 times a week for 3 weeks, in the treatment of condyloma acuminatum. DESIGN: A randomised, double-blind, within-patient, placebo-controlled study. SUBJECTS: 25 patients (24 males, 1 female) with a history of condyloma acuminatum. Twenty had failed previous treatment for condyloma acuminatum. In each patient, 3 distinct lesions were selected for treatment. Each selected lesion was randomly assigned to receive intralesionally one of the following: r-hIFN-beta 33,000 IU/day, r-hIFN-beta 1 x 10(6) IU/day, or matching placebo. SETTING: Institut Alfred Fournier, Paris, France. OUTCOME MEASURES: Response was evaluated colposcopically at the end of treatment (day 22) and 5 weeks later (month 2). Complete response (CR) was defined as disappearance of the treated lesion. Partial response (PR) was defined as at least a 50% reduction in size, but not disappearance of the treated lesion. RESULTS: The higher dose of 1 x 10(6) IU achieved significantly more complete and partial remissions than placebo, both by the end of treatment, and 5 weeks later. CONCLUSIONS: r-hIFN-beta appears to be safe and effective when administered intralesionally to patients with condyloma acuminatum. Most of the treated patients had failed previous treatments and were therefore a resistant population.

Adolescent↗
PubMed1998

Tissue specific HPV expression and downregulation of local immune responses in condylomas from HIV seropositive individuals.

OBJECTIVE: To study the effect of tissue specific human papillomavirus (HPV) expression and its effect on local immunity in condylomas from HIV positive individuals. METHODS: Biopsy specimens of eight penile and eight perianal condylomas from HIV seropositive individuals were analysed. Expression of viral genes (HIV-tat and HPV E7 and L1) was determined by RT-PCR. The status of local immunity also was determined by RT-PCR by measuring CD4, CD8, CD16, CD1a, HLA-DR, and HLA-B7 mRNA levels in the tissues. Differentiation was determined by measuring involucrin, keratinocyte transglutaminase, as well as cytokeratins 10, 16, and 17. Proliferation markers such as PCNA and c-myc were also determined. RESULTS: The transcription pattern of HPV in perianal condylomas, which preferentially expressed the early (E7) gene, was different from that of penile condylomas, which primarily expressed the late (L1) gene. This transcription pattern is in good correlation with the keratinisation and differentiation patterns of the two epithelia: perianal biopsies preferentially expressed K16 and K17 while penile warts mainly expressed K10, markers of parakeratotic and orthokeratotic epithelia, respectively. Perianal biopsies also showed a higher degree of proliferation (PCNA and c-myc). Interestingly, transcription of HIV-tat was also higher in perianal than in penile biopsies. A high degree of local immunodeficiency was observed in perianal biopsies--that is, levels of CD4, CD16, and CD1a mRNAs were significantly lower. A negative correlation between CD1a (Langerhans cells) levels and HPV E7 levels was established. HPV E7 levels positively correlated with HIV-tat levels. Perianal tissues demonstrated more CD1a depression and tat associated HPV upregulation. CONCLUSION: HIV influences the expression of HPV genes resulting in local immunosuppression that might lead to an inappropriate immune surveillance of viral infection. Also, tissue type is an important factor in controlling viral transcription in a differentiation dependent manner. These findings may explain the higher rate of dysplasia and neoplasia in the perianal area.

Antibody Formation↗
PubMed2000

Telomerase activity in giant condyloma acuminatum.

A 46-year-old male came to our hospital 1 month after noticing a 2-cm penile tumor. Since malignant findings such as atypical cells and mitosis were not observed in the frozen sections obtained at operation, the pathological diagnosis of this tumor was giant condyloma acuminatum. This tumor was analyzed by a telomeric repeat amplification protocol method, and telomerase activity was revealed. For comparison, a case of squamous cell carcinoma and a case of condyloma acuminatum were examined. Telomerase activity was observed in our case and in the case of squamous cell carcinoma. To our knowledge, this is the first case of telomerase activity in giant condyloma acuminatum ever reported. In addition to the histological examination, measurement of telomerase activity may provide valuable objective diagnostic information on evaluating the degree of malignancy of giant condyloma acuminatum and in obtaining a differential diagnosis between the benign and malignant.

Biomarkers, Tumor↗
PubMed1995

Condyloma and cervical intraepithelial neoplasia of the endometrium.

Many studies have shown the presence of squamous metaplasia, dysplasia, carcinoma in situ and squamous cell carcinoma of the endometrium, whether they arose de novo or from direct extension from the cervix. Condyloma associated with squamous metaplasia or dysplasia of the endometrium is rare. We report a case of cervical intraepithelial neoplasia (CIN I) and condyloma of the endometrium. A 58-year-old woman presented with high-grade dysplasia on two successive pap smears. A total vaginal hysterectomy showed extensive CIN I and condyloma involving the entire endometrium. DNA in situ hybridization and polymerase chain reaction documented the presence of condyloma.

Base Sequence↗
PubMed2000

[Buschke-Loewenstein giant condyloma in the perianal region with inguinal invasion: a case report].

The giant condyloma acuminatum of the perianal region is a tumor characterised by its large size with the propensity to infiltrate into deeper tissues, contrasting with a microscopically benign pattern. The evolution after malignant transformation of condyloma and lymph node invasion is rare. However it is exceptionally observed a lymph node invasion of microscopically benign condyloma acuminatum. The authors report a case of microscopically benign giant condyloma acuminatum of the perianal region associated with inguinal invasion, discovered in a 47 year-old man. Treatment consists in extensive surgery of the tumor and inguinal nodes, followed by a radiation therapy.

Anus Neoplasms↗
PubMed2001

[Evaluation the pathological diagnostic values of koilocyte in condyloma acuminatum].

OBJECTIVE: To evaluate the histological diagnostic values of koilocyte in histopathologic diagnosis of condyloma acuminatum. METHODS: Koilocyte was served as diagnostic criteria to scan 2 063 biopsies and compared the results with "goldan standard" of histopathologic diagnosis of condyloma acuminatum. RESULTS: Using koilocyte as diagnostic standard to diagnose condyloma acuminatum, the sensitivity and specificity were 77.93% and 95.26%, with positive predictive value 97.25%, negative predictive value 66.70%, positive likelihood rate 81.81, negative likelihood rate 23.17, under diagnostic rate 22.07%, misdiagnostic rate 4.74%. CONCLUSION: The koilocyte was proved to be one of classical histopathological morphologic features of human papillomavirus infection and other virus infection which served one of the most important histopathological markers for diagnosis of condyloma acuminatum, but not the only one.

Biopsy↗
PubMed2002

P27 expression in normal epithelium and condylomas of the vulva in HIV positive and negative women.

PURPOSE: The objective of the present study was to evaluate the expression of the p27 protein in the normal epithelium and vulvar condylomas in human immunodeficiency (HIV) positive and negative patients. METHODS: Eight samples of normal vulvar epithelium were evaluated (Group A), ten of the HIV negative vulvar condyloma patients (Group B) and another eight of the vulvar condyloma HIV positive patients (Group C). The DNA of human papillomavirus (HPV) was identified by means of polymerase chain reaction (PCR). Immunohistochemistry was the method used to evaluate the expression of p27 using monoclonal mouse antibody (Monoclonal Mouse, anti-human p27, Clone Sx 53 G8). The immunoexpression was evaluated at a magnification of 400x, counting a minimum of 1,000 cells per slide. RESULTS: The results obtained were the following: a) comparing groups A and B and groups A and C there was a significant difference in relation to the expression of the p27 protein which was 63.32% in group A and only 13.35% and 18.89% in groups B and C, respectively; b) comparing groups B and C among them, there was no significant difference. CONCLUSION: We concluded that in normal vulvar tissue the p27 protein is present in a large number of cells and that in vulval condylomas its expression is very much lowered both in HIV positive and negative cases.

Capsid↗
PubMedDate not supplied

Condyloma acuminatum and human papilloma virus infection in the oral mucosa of children.

PURPOSE: The purpose of this study was to investigate the clinicopathological features of oral condylomas in children and condylomatous lesions of their mothers. Moreover, the authors sought to determine the mode of transmission of this disease and to find the genotype of human papilloma virus (HPV) in the children's oral condyloma. METHODS: Nine instances of oral condyloma acuminatum in children and lesions in their mothers were reviewed. Their HPV genotypes were evaluated by in situ hybridization (ISH). RESULTS: This study revealed that the lesions appeared during 3 years of age and the most common location was the hard and soft palate. Seven of the 9 mothers had experienced vulva and/or oral cavity condylomata during pregnancy. Social evaluation confirmed sexual abuse in 1 girl, and probable sexual abuse in another girl. The results of ISH demonstrated HPV 16/18 DNA being positive in 5 of the 9 cases, and HPV 6 and HPV 11, HPV 6 and HPV 16/18, HPV 6, and HPV 11 DNA being positive, respectively, in 1 case. HPV DNA types in mother-child pairs were not concordant. CONCLUSIONS: Oral condyloma acuminatum in children is probably induced by HPV 16/18. The mode of transmission by sexual abuse is the most likely route. Prenatal transmission of HPV to children is rare. This study provides further confirmation of possible different genotype and transmission in oral CA of children and adults.

Adult↗
PubMed2004

[Surgical treatment for laryngeal condyloma acuminata in children].

OBJECTIVE: To investigate the therapeutic methods of laryngeal condyloma acuminata in children. METHOD: Operative treatment was performed in 43 cases of laryngeal condyloma acuminata in children. Direct laryngoscopy with removal of laryngeal tumor under surface anesthesia was performed in 26 cases, and trachea cannula, retaining laryngoscopy with removal of laryngeal tumor under general anesthesia were performed in 17 cases, hypodermic implantation of the removal condyloma acuminata at medial upper arm and submucous injection of interferon at vocal fold were performed in 13 cases at the same time. RESULT: Cases were followed-up, 26 cases were cured, 7 cases were improved, 2 cases were dead, 7 cases needed tracheotomy, 3 cases had difficulty of decannulation. CONCLUSION: Wide affected part and high recurrence rate are characters of this disease, the tumor can be removed more accurately and the recurrence rate can be decreased when performing self-retaining laryngoscopy with removal of laryngeal tumor combined with hypodermic implantation of the removal condyloma acuminata at medial upper arm and submucous injection of interferon at vocal fold. Difficulty of decannulation can also be avoided after tracheotomy.

Child, Preschool↗
PubMed1991

[The male factor in the incidence and persistence of condyloma of the cervix and intraepithelial cervical neoplasms].

From 1988 to 1990, prospectively, were studied 113 masculine couples (males), and 113 women, treated for intraepithelial cervical neoplasia, alone, or associated to viral infection by human papilloma virus-80 males were asymptomatic (70.7%). Colposcopy and local application of acetic acid, were needed for the diagnosis of 69.9% of lesions, which presented with a gray color to a brilliant white color. Papulous lesion, (56.70%) was most frequent; and the classical lesions as condyloma acuminatum, were 15.52%; urethral cytology was positive for condyloma (one condyloma in 30%), and biopsies in 91.66%. There were persistence and recidiva, nonsignificant, when the man had received treatment suggesting that the treatment does not alter the appearance of condyloma, nor cervical intraepithelial, neoplasia.

Age Factors↗
PubMed1990

[Possibilities of cytologic and histologic methods of diagnosing flat condyloma of the cervix uteri].

A comprehensive study in 165 women has employed cytologic, colposcopic and histologic evaluation. Flat cervical condylomas were identified in 27 women (mean age, 29 years). Over 50% of these condylomas coexisted with dysplasia of various severity and 2 condylomas with squamous cell carcinoma in situ. The most reliable diagnostic techniques for flat condylomas are cytologic and histologic tests of selectively excised tissue samples.

Adolescent↗
PubMed1991

[Malignant transformation of perianal condyloma acuminatum].

A case of squamous cell carcinoma developing in a perianal condyloma acuminatum in a 38-year-old man treated for over 5 years with podophyllin is presented. Although there are many reports of malignant transformation of condyloma acuminatum in the skin and mucosal surfaces of the male and female genitalia, it is quite rare in the perianal region. In this case there were foci of carcinoma in-situ and of frank invasion, as well as areas of squamous cell carcinoma in the large perianal condyloma. The lesion was widely excised, and completely removed, and the site covered with a split-thickness graft from the thigh. Later, repeated dilatations of the anus were required. Repeated histologic examinations of condyloma acuminatum are needed to diagnose possible malignant transformation.

Adult↗
PubMed1989

Detection and localization of human papillomavirus in penile condylomas and squamous cell carcinomas using in situ hybridization with biotinylated DNA viral probes.

Human papillomavirus (HPV) has been previously demonstrated in male genital neoplasms using Southern blot hybridization (SBH) and in situ hybridization with radiolabeled probes (ISH-R). In this study we used in situ hybridization with biotinylated DNA viral probes (ISH-B), a technique that can be applied to routinely collected and processed tissue. Thirty cases of exophytic penile condyloma acuminatum and nine cases of invasive squamous cell carcinoma of the penis were examined for the presence of HPV using ISH-B for HPV types 6, 11, 16, 18, 31, and 33. HPV DNA was found in 25 of 30 (83%) penile condylomas; HPV type 6 in 13 (43%); and HPV type 11 in 12 (40%). Slight cross-reactivity between HPV types 6 and 11 was noted. None of the condyloma cases was positive for HPV types 16, 18, 31, or 33. One of the nine patients with squamous cell carcinoma of the penis was positive for HPV 16. In situ hybridization with biotinylated DNA viral probes is a highly sensitive method for detecting and localizing HPV in penile condylomas. This method, however, may not be as sensitive as SBH for detecting HPV in invasive penile squamous cell carcinomas.

Adolescent↗
PubMed1987

The use of topical 5-fluorouracil in the treatment of genital condylomas.

Topical 5-FU is indicated for therapy-resistant condylomas and for extensive untreated vulvar condylomas. It may be the treatment of choice for vaginal condylomas. Applications of 5-FU once weekly to the vagina and twice weekly to the vulva for 10 weeks appear to be as effective as continued regimens but are better tolerated. Perhaps the greatest value of 5-FU lies in the periodic application for prevention of recurrences of condylomas removed by surgical methods.

Administration, Topical↗
PubMedDate not supplied

Immunosuppression as a high-risk factor in the development of condyloma acuminatum and squamous neoplasia of the cervix.

The iatrogenic immunosuppression in renal transplant recipients has been associated with an increased incidence of malignancy in these patients. Among 132 female transplant recipients at risk for the development of squamous lesions of the cervix, 11 (8.5%) developed cervical condylomas. Six (4.5%) of the 11 patients developed cervical neoplasia. The average age of the patients at the time of initial diagnosis was 32.2 years. The lag time from transplantation to the diagnosis of the condyloma was 22.4 months, and the lag time from transplantation to the diagnosis of cervical neoplasia was 38.0 months. The increased incidence of condylomas as well as of intraepithelial neoplasia of the cervix in this group of patients with an established higher risk of malignancy supports the hypothesis that condylomas may represent a precursor lesion of cervical cancer. Immunosuppression should be included among the high-risk factors in the development of cervical neoplasia.

Adult↗