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PubMed1991

Two-stage resuscitation of the cat brain after prolonged cardiac arrest.

Following prolonged cardiac arrest, reperfusion of the brain is endangered by the low blood perfusion pressure during the early resuscitation phase. In order to avoid low perfusion brain injury, a two-stage resuscitation protocol was applied to cats submitted to 30 min potassium chloride induced cardiac arrest: first, the heart was resuscitated, followed--after stabilisation of blood pressure--by recirculation of the brain. During cardiac resuscitation the brain was disconnected from the general circulation by inflating a pneumatic cuff around the neck. The results were compared with the outcome of conventional one-stage resuscitation following 15 min cardiac arrest. Cardiac resuscitation was successful in 5 out of 8 animals with 15 min and in 6 out of 13 animals with 30 min cardiac arrest. In successfully resuscitated animals of both groups, brain energy metabolism recovered to normal within 3 h although two-stage resuscitation increased brain ischemia time to 37-61 min. Two-stage resuscitation, in consequence, is a promising approach for revival of the brain after prolonged cardiac arrest.

Adenosine Triphosphate↗
PubMed2002

Unexpected cardiac arrest among children during surgery, a North American registry to elucidate the incidence and causes of anesthesia related cardiac arrest.

Relatively rare adverse events, such as unexpected cardiac arrest, are difficult to study in the clinical setting. These events are often unpredictable in their occurrence (prompting interest in their investigation) and do not occur with sufficient frequency in any single institution to provide an adequate sample for analysis. A disease-specific registry is an epidemiological technique that can be used to collect data on a set of relatively rare unpredictable events. This approach was adopted for investigation of cardiac arrest in children when it became apparent from analysis of malpractice claims that a significant clinical problem existed. This report provides a brief historical account of the development of the Pediatric Peri-Operative Cardiac Arrest (POCA) Registry and elaborates on the methodology including strengths, weaknesses, and practical implementation issues.

Adolescent↗
PubMed2006

Epidemiology, trends, and outcome of out-of-hospital cardiac arrest of non-cardiac origin.

INTRODUCTION: The majority of victims who experience out-of-hospital cardiac arrest (OHCA) have ventricular fibrillation (VF) as the presenting rhythm and are thought to have a cardiac etiology for their arrest. Over the past decade, the incidence of VF OHCA has declined. The aims of this study were to describe the epidemiology of OHCA of non-cardiac origin in Olmsted County MN and to determine the trends that have occurred over time. METHODS: All residents with a traumatic OHCA from 1995 to 2005 were included for analysis. OHCA data were collected prospectively according to the Utstein method. Cardiac arrests were classified as cardiac or non-cardiac in origin and the etiology determined based on autopsy reports, electronic medical records, and/or emergency medical services reports. RESULTS: During the study period, 414 OHCAs were identified, 90 (21.7%) of which were classified as non-cardiac. Mean age was 61.5+/-19.7 years. Response time was 7.73+/-2.9 min, and 40 (44.4%) were bystander-witnessed. Sixty-eight (75.6%) arrests occurred at home, 13 (14.4%) in a public place, and 9 (10%) in other locations. Bystander CPR was performed in 17 (18.9%) cases. The presenting rhythm was VF in 2 (2.2%) cases, PEA in 54 (60%), and asystole in 34 (37.8%). Eight (8.9%) patients survived to hospital discharge. Respiratory failure (35.6%), unknown (15.6%), and pulmonary embolism (13.3%) were the most common etiologies. The mean percentage of arrests due to a non-cardiac cause in three sequential time-periods (1995-1999, 2000-2002, 2003-2005) was 9.4%, 20.1% and 37.7%, respectively. CONCLUSIONS: Over the study period, 21.7% of OHCAs were non-cardiac in origin. PEA was the most common presenting rhythm and respiratory failure the most common etiology. 8.9% of patients survived. The decreasing number of VF arrests may be a contributing factor to the increasing proportion of OHCAs of non-cardiac etiology observed in the out-of-hospital setting.

Algorithms↗
PubMed2001

Long-term mortality among patients discharged alive after out-of-hospital cardiac arrest does not differ markedly compared with that of myocardial infarct patients without out-of-hospital cardiac arrest.

The aim of our research was to study the long-term prognosis among patients discharged alive after an out-of-hospital cardiac arrest (OHCA) in comparison with patients discharged alive after acute myocardial infarction (AMI) without OHCA, and also to study the long-term influence of AMI in connection with OHCA. Our research was conducted in the municipality of Göteborg. We retrospectively studied patients discharged from hospital 1990-91 after an OHCA of cardiac aetiology and patients discharged after an AMI without prehospital cardiac arrest. During 1980-98, we studied all patients discharged alive after OHCA of cardiac aetiology, divided into groups of precipitating AMI and no AMI. The study includes 48 patients discharged alive after an OHCA 1990-91, 30 (62%) of whom had a simultaneous AMI and 1425 patients with an AMI without OHCA. Compared with AMI survivors, survivors of an OHCA of cardiac origin were younger but had more frequently a history of congestive heart failure. Their mortality rate during the subsequent 5 years was 46%, compared with 40% among survivors of an AMI (NS). The 5-year mortality rate among patients with an OHCA precipitated by an AMI was 40%. When correcting for differences at baseline, the adjusted risk ratio for death among patients with an OHCA of cardiac origin was 1.2 (95% CI 0.8-1.8) compared with patients with an uncomplicated AMI. During 1980-98, 215 patients were judged as having an OHCA precipitated by an AMI and 115 patients had an OHCA of cardiac aetiology but no simultaneous AMI. Five-year mortality was 54% and 50% respectively (NS). It is concluded that survivors of an OHCA of cardiac origin differed from survivors of an uncomplicated AMI in that they were younger and more frequently had a history of cardiovascular disease. Their 5-year mortality after discharge was similar to that of survivors of an AMI without a prehospital cardiac arrest, even after adjusting for differences at baseline.

Adult↗
PubMed1987

Cerebrospinal fluid changes in experimental cardiac arrest (maximal stress).

Cardiac arrest produces a prompt and maximal increase of plasma catecholamines, with associated elevations of the hormones involved in the endocrine response to stress. To investigate the participation of the central nervous system (CNS) in the generation of the endocrine response, the catecholamines epinephrine and norepinephrine in cerebrospinal fluid (CSF) were measured before, during, and after cardiac arrest accompanied by cardiopulmonary resuscitation (CPR) in adrenalectomized (ADX) and sham-operated (SHAM) dogs. We also determined the activity of acetylcholine esterase (AChE), an intracellular enzyme released into the CSF after hypothalamic or caudate stimulation. During CPR, plasma epinephrine increased significantly in SHAM but not ADX dogs, increasing from (mean +/- SE) 480 +/- 171 to 29,800 +/- 14,200 pg/ml (P less than 0.05). Prearrest CSF norepinephrine was higher in ADX than SHAM dogs and increased in both groups with cardiac arrest, but the increase was significant only in SHAM animals; CSF epinephrine remained unchanged during or after cardiac arrest. CSF AChE activity increased during and after defibrillation; the difference with basal levels became significant when the peak postarrest values were considered (P less than 0.05). These results document biochemical changes occurring in the CNS during maximal stress represented by cardiac arrest. It is suggested that CSF norepinephrine and AChE activity elevations are markers for hypothalamic activation from the stress of cardiac arrest.

Acetylcholinesterase↗
PubMed2000

Management of malignant ventricular arrhythmias and cardiac arrest.

Sudden cardiac death continues to be a major health problem in the United States, accounting for approximately 400,000 deaths per year. The last 10 yrs have seen major advances in the primary and secondary prevention of this problem. In patients who have survived an episode of cardiac arrest, the AVID study conclusively established the superiority of the implantable cardioverter defibrillator over empiric amiodarone. For patients with recurrent hemodynamically destabilizing ventricular tachycardia and ventricular fibrillation, intravenous amiodarone has emerged as a potent therapeutic agent, especially when other agents such as lidocaine and procainamide have not been effective. Finally, recent work has focused on the risk stratification of patients for sudden cardiac death. Both the MADIT and MUSTT studies suggest that patients with coronary artery disease, reduced ejection fraction, and nonsustained ventricular tachycardia who are inducible to a sustained ventricular arrhythmia at electrophysiology testing have improved survival with an implantable cardioverter defibrillator.

Amiodarone↗
PubMed1993

Out-of-hospital transcutaneous pacing by emergency medical technicians in patients with asystolic cardiac arrest.

BACKGROUND: Transcutaneous cardiac pacemakers generate electrical stimuli that pace the heart through external electrodes that adhere to the chest wall. Transcutaneous pacing has been useful in some patients with bradycardia, but its efficacy in patients with asystole and full cardiac arrest has been limited, possibly because of delays in the initiation of pacing. We studied the efficacy of early transcutaneous pacing in patients with out-of-hospital asystolic cardiac arrest. METHODS: For three years we provided transcutaneous pacemakers to about half the fire districts in a large emergency-medical-services system (the intervention group). In these districts, we authorized emergency medical technicians (EMTs) to begin transcutaneous pacing in patients with cardiac arrest and primary asystole or post-defibrillation asystole. Pacing was done as early as possible, before endotracheal intubation or intravenous medication. EMTs in the other fire districts (the control group) treated similar patients with basic cardiopulmonary resuscitation but without transcutaneous pacing. RESULTS: The EMTs in the intervention group initiated transcutaneous pacing in 112 of the 278 patients with primary asystole. Of these patients, 22 (8 percent) were admitted to the hospital, and 11 (4 percent) were discharged. Among the 259 patients treated by the EMTs in the control group, 21 (8 percent) were admitted to the hospital, and 5 (2 percent) were discharged. The two groups did not differ significantly with respect to the rate of hospital admission or survival. Survival after early pacing for post-defibrillation asystole was no better than survival after pacing for primary asystole. CONCLUSIONS: Transcutaneous pacing appears to offer no benefit in patients with asystolic cardiac arrest, even when it is performed as early as possible by EMTs in the field. Our data suggest that the widespread implementation of early transcutaneous pacing for out-of-hospital asystolic cardiac arrest would be ineffective.

Cardiac Pacing, Artificial↗
PubMed2003

Mechanisms and alternative methods of achieving cardiac arrest.

Elective cardiac arrest during surgery can be achieved by inducing depolarization, polarization, or influencing calcium mechanisms. Depolarized arrest, induced by elevating the extracellular potassium concentration, is currently the most commonly used technique. However, injury associated with ionic imbalance involving sodium and calcium overload, together with maintained metabolic processes aimed at correcting these imbalances, have lead to alternatives being sought. "Polarized" arrest, induced by sodium-channel blockers or by agents that activate potassium channels, has been shown to exert equal or superior protection. Similarly, agents that induce calcium desensitization may also prove to enhance protection. These alternative techniques, however, require extensive characterization before introduction into routine clinical use can be recommended.

Adenosine↗
PubMed1985

Emergency department use of transcutaneous pacing for cardiac arrests.

Transcutaneous cardiac pacing is a rapid technique for pacing the heart using skin electrodes to pass repetitive electrical impulses through the thorax. This paper reports the results of transcutaneous pacing in a series of 52 emergency department patients. Patients were selected for pacing if they were unconscious and in asystole (30 patients) or unconscious with a pulseless or hemodynamically ineffective bradycardia (22 patients). In all cases, transcutaneous pacing was attempted after initial resuscitative drug therapy failed. Of the 26 patients with successful ECG capture, 14 were initially in asystole, 11 were initially in a pulseless bradycardia, and one had a hemodynamically ineffective bradycardia. Of the eight patients developing a pulse, four developed a measurable BP. The four patients who developed a measurable BP were young (ages 22 to 39 yr) and only one had an underlying cardiac etiology for his cardiac arrest. No patient survived to be discharged from the hospital. Twenty-five of the 52 patients also had a transvenous pacemaker inserted, with successful electrical capture in five of the patients. Only one of the transvenously paced asystolic patients subsequently developed a BP. There were no patients successfully paced transvenously who were not successfully paced transcutaneously.

Adult↗
PubMed2005

The fully automatic external cardioverter defibrillator: reality of a new meaningful scenario for in-hospital cardiac arrests.

Sudden cardiac death is an unresolved problem which causes significant mortality and morbidity in both the community and in-hospital setting. Cardiac arrest is often caused by ventricular tachyarrhythmias which may be mostly interrupted by cardioversion or defibrillation. The single most critical factor for survival is the response time. Over the last 30 years, there have been virtually no procedural changes in the way hospitals address in-hospital resuscitation. A unique device has been developed that eliminates human intervention and assures defibrillation therapy is administered in seconds. This is accomplished with a fully automatic, external bedside monitor defibrillator designed to be prophylactically attached to hospitalized patients at risk of ventricular tachyarrhythmia. The safety and efficacy of the device has been demonstrated in multicenter US and European trials. Thus, this device allows a new scenario which may increase survival and enables meaningful redistribution of health resources.

Clinical Trials as Topic↗
PubMedDate not supplied

Symmetrical columnar necrosis of the basal ganglia and brain stem in an adult following cardiac arrest.

Prolonged cardiac arrest resulting from a methadone overdose in an adult produced an unusual pattern of symmetrical columnar necrosis of the diencephalon and the brain stem tegmentum. This pattern of anoxic encephalopathy has previously been described in neonates, infants and in one adult case. Our description of a further case underlines the fact that under exceptional circumstances it may also occur in adults.

Adult↗
PubMed1982

Office and operating room management of cardiac arrest.

Management of cardiac arrest depends on a four-minute period of potential reversibility. Success depends on immediate diagnosis, documentation of the onset of cardiac arrest, and establishment of treatment priorities. Pupillary dilation, complete in two minutes, serves to verify the onset and duration of cardiac arrest. Treatment involves two phases--the emergency phase of oxygenation and perfusion and the definitive phase of restoring the spontaneous effective heartbeat. The two mechanisms of cardiac arrest, ventricular fibrillation and asystole, are characterized, and the conditions necessary for each to occur are listed. The treatment of ventricular fibrillation is defibrillation, whereas ventricular asystole responds to cardiac stimuli--a precordial blow, epinephrine, or calcium. The mnemonic "SALT CAN ADD GOOD TIME" is suggested as a guide for drug dosage, and a treatment flowchart is outlined.

Emergencies↗
PubMed1989

Aeromedical transport of patients with post-traumatic cardiac arrest.

Patients experiencing cardiac arrest secondary to trauma make up 8% to 15% of air ambulance scene flights in reported series. Our study examined the role of aggressive physician intervention at the accident scene in conjunction with rapid air transport to a trauma center in reducing the mortality after post-traumatic cardiac arrest. We retrospectively studied 67 patients who experienced cardiac arrest before the arrival of the flight team. Fifty-eight patients were victims of blunt trauma, and nine sustained penetrating trauma. Forty-seven patients were transported to the base hospital; 20 were pronounced dead at the scene after resuscitation attempts were made. Six patients developed a pulse and blood pressure and were hospitalized; none survived to hospital discharge. Review of autopsy data revealed that the majority of patients had head or thoracoabdominal injuries or both that were incompatible with life. We conclude that physician intervention at the scene and rapid aeromedical transport are not likely to improve mortality after traumatic cardiac arrest.

Adolescent↗
PubMed2005

In-hospital cardiac arrest and resuscitation outcomes: rationale for sudden cardiac death approach.

AIM: To assess the frequency of cardiac arrest and outcomes and predictors of survival after cardiopulmonary resuscitation in hospitalized patients. METHODS: We prospectively analyzed the data on all patients who experienced cardiac arrest while hospitalized at the Split University Hospital between January and December 2003. Data were collected on patients' demographic characteristics, etiology and presentation of cardiac arrest, time, site, methods, and outcomes of cardiopulmonary resuscitation. RESULTS: Out of 120 cases of cardiac arrest among 32,861 hospitalized patients, 76.7% were witnessed. Ninety-six (80.0%) patients with cardiac arrest underwent resuscitation, and 22.5% of them were discharged alive. The survival rate was 20.0% at the Department of Internal Medicine, 29.2% in the Coronary Care Unit, and only 7.1% in other departments (P=0.058, chi2 test). Out of 92 patients with witnessed cardiac arrest, 28.3% survived to discharge, whereas only one of 28 patient with unwitnessed cardiac arrest survived to discharge (P=0.004, Fisher's exact test). More patients with cardiac arrest due to ventricular fibrillation or pulseless ventricular tachycardia survived than patients with asystole and pulseless electrical activity (47.6% vs 10.7%, respectively, P<0.001, Fisher's exact test). None of the patients with unclassified cardiac arrest survived until discharge. Cardiac arrest survivors were significantly younger (60.8+/-12.9 vs 71.1+/-11.7 years, P<0.001, Student t-test). Sex had no influence on survival. There were no significant circadian or hospital shift differences in the frequency rate of cardiac arrest, but the rate of successful resuscitation was lower during the night shift. CONCLUSION: The rate of successful resuscitation was higher in the coronary care unit, during the day and in younger witnessed cardiac arrest patients with ventricular fibrillation or pulseless ventricular tachycardia.

Aged↗
PubMed1998

Management of cardiac arrest in operation theatre.

Cardiac arrest is better prevented than treated. Cardiac arrest in operation theatre is reversible in 90% cases. So as soon as cardiac arrest occurs immediate treatment should be started. Time is very important factor. Cardiac arrest in patient with cardiac diseases, other medical diseases, electrolyte disturbances are difficult to reverse. The time interval between cardiac arrest and the death of tissue in the central nervous system is approximately three and half minutes and there is ample clinical justification for accepting this period, though patients have survived intact for longer intervals. It can, however, only be completely acceptable on the basis that the patient is adequately oxygenated up to the moment of cardiac arrest. If hypoxia is present before this occurs, then severe neurological damage may result from even shorter periods of ischaemia than three and a half minutes. Resuscitation will often be ineffective if the precipitating cause is not recognised and treated. It requires a calm and logical mind with a good understanding of medicine to sort out and treat the underlying condition while at the same time performing emergency resuscitation. A review of management of cardiac arrest in operation theatre is presented.

Cardiopulmonary Resuscitation↗
PubMed2001

Outcome in cardiac arrest patients found to have cardiac standstill on the bedside emergency department echocardiogram.

UNLABELLED: Patients presenting in cardiac arrest frequently have poor outcomes despite heroic resuscitative measures in the field. Many emergency medical systems have protocols in place to stop resuscitative measures in the field; however, further predictors need to be developed for cardiac arrest patients brought to the emergency department (ED). OBJECTIVE: To examine the predictive value of cardiac standstill visualized on bedside ED echocardiograms during the initial presentations of patients receiving cardiopulmonary resuscitation (CPR). METHODS: The study took place in a large urban community hospital with an emergency medicine residency program and a high volume of cardiac arrest patients. As part of routine care, all patients arriving with CPR in progress were subject to immediate and brief subxiphoid or parasternal cardiac ultrasound examination. This was followed by brief repeat ultrasound examination during the resuscitation when pulses were checked. A 2.5-MHz phased-array probe was used for imaging. Investigators filled out standardized data sheets. Examinations were taped for review. Statistical analysis included descriptive statistics, positive and negative predictive values, and likelihood ratios. RESULTS: One hundred sixty-nine patients were enrolled in the study. One hundred thirty-six patients had cardiac standstill on the initial echocardiogram. Of these, 71 patients had an identifiable rhythm on monitor. No patient with sonographically identified cardiac standstill survived to leave the ED regardless of his or her initial electrical rhythm. Cardiac standstill on echocardiogram resulted in a positive predictive value of 100% for death in the ED, with a negative predictive value of 58%. CONCLUSIONS: Patients presenting with cardiac standstill on bedside echocardiogram do not survive to leave the ED regardless of their electrical rhythms. This finding was uniform regardless of downtime. Although larger studies are needed, this may be an additional marker for cessation of resuscitative efforts.

Adult↗
PubMed1981

Prolonged safe ischemic cardiac arrest using hypothermic Bretschneider cardioplegia combined with topical cardiac cooling. Clinical experience with cardiac arrest of up to 180 minutes in a few borderline cases.

Out of 494 patients operated upon using Bretschneider cardioplegia, 8 complicated surgical procedures (3 cases of single or double valve replacement combined with coronary bypass grafting, 2 cases of double valve replacement, 2 cases of multiple coronary bypass procedures and one case of aortic valve replacement with replacement of the ascending aorta) required a mean aortic cross-clamp time of 164 minutes. Four patients had a single infusion, and 4 other patients 2 or more infusions, of cold cardioplegic solution. With the aid of topical cooling, the myocardial temperature was reduced to a mean value of 12.8 degrees C. Postoperatively the heart in all patients resumed a good contractile activity. None sustained myocardial infarction during the perioperative or postoperative period. One patient died on the 19 postoperative day because of subdural hemorrhage not related to the cardioplegic procedure. All other patients have survived from 10 to 63 months (mean 23 months).

Coronary Artery Bypass↗