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PubMed1983

The Berkeley Orthokeratology Study, Part II: Efficacy and duration.

Relative efficacy of orthokeratology (OK) was evaluated by assessing changes in refractive error, visual acuity, and corneal curvature in 31 treated and 28 randomized control subjects who wore conventional rigid contact lenses. The duration of changes was studied by monitoring subjects after lens wear was discontinued. After an average of 444 days of contact lens wear the treatment group showed an overall mean reduction in spherical equivalent refractive error of 1.01 D compared with 0.54 D in the control group (p = 0.02). Both groups had considerable variation in refractive error change. Corresponding mean improvements in unaided visual acuity were -0.27 and -0.20 log of the minimum angle of resolution [log (MAR)]. Corneal curvature decreased in both comparison groups, but the actual diopter value was about one-half that of the refractive change. The changes in these characteristics tended to occur during the first 132 days of wear, and additional aggressive lens therapy during the remaining 241 days of treatment produced little additional change. The refractive error fluctuated considerably during the period of follow-up and these fluctuations tended to be larger in those subjects who had shown greater changes in refractive error. When the lenses were removed, ocular characteristics returned steadily toward baseline levels. Ninety-five days after discontinuing lens wear, the refractive error had returned 75 and 69% of the way to baseline levels for the treatment and control groups, respectively. Visual acuity and corneal curvature showed similar rebound after 95 days. We conclude that it is possible to reduce myopia about 1D; however, the change is not permanent. Results indicate that the level of vision during periods of nonlens wear would be unstable, making it difficult to predict what the quality of vision would be under a retainer lens wear program.

Clinical Trials as Topic↗
PubMed1983

The Berkeley Orthokeratology Study, part III: safety.

The safety of orthokeratological (OK) procedures was assessed by monitoring several ocular characteristics including corneal thickness, refractive astigmatism, corneal astigmatism, correctable spectacle-acuity, corneal edema, corneal staining, and endothelial cell density. Safety was also assessed by reviewing the number and causes of extra clinical visits that occurred because of ocular complications and by determining whether safety factors were related to patients lost to follow-up. Over the 1.2-year period from the baseline examination to the end of the lens-wearing phase of the study, the Treatment (T) and Control (C) groups had, respectively, only small changes in their mean levels of corneal thickness (0.2 vs. 3.2 microns), refractive astigmatism (0.07 vs 0.01 D), and corrected spectacle acuity (0.02 vs 0.018 logarithm of the minimum angle of resolution). Analysis of time trend data obtained from scheduled monthly examinations also showed that changes in mean corneal thickness and mean corneal astigmatism were small and not clinically important in either comparison group during the course of the treatment. As a result of complications from lens wear, the T group required 1.25 times as many extra visits as the C group (p = 0.14). However, none of these visits provided sufficient clinical indication for the discontinuance of lens wear. Loss to follow-up typically occurred because of either poor compliance with the study protocol or loss of motivation caused by minor contact lens-related symptoms such as blurred vision, slight discomfort, or frequently lost lenses. These reasons were similar in both comparison groups. It appears that OK treatment is safe for the types of patients who participated in this study, but it may require more patient monitoring than would be needed to achieve and maintain a physiologically acceptable fit with conventional hard contact lens prescriptions.

Astigmatism↗
PubMed2001

The role of myocilin/TIGR in glaucoma: results of the Glaucoma Research Foundation catalyst meeting in Berkeley, California, March 2000.

Approximately 3 years ago, the first major (biochemical, molecular biologic, and biologic) insight into primary open-angle glaucoma was the finding that mutations in the myocilin (MYOC/TIGR) gene were related to certain forms of juvenile onset of this disease. Since then, a great deal of work has been done to determine the possible mechanisms by which MYOC/TIGR might cause not only juvenile but also adult-onset primary open-angle glaucoma. To assess the current knowledge and those areas in which more research is necessary, a meeting of scientists was held by the Glaucoma Research Foundation of San Francisco, California in the spring of 2000. This meeting attempted to concentrate on the MYOC/TIGR protein rather than the genetics of this gene. Possible functions and roles of this protein intracellularly and extracellularly were critically examined and discussed. Normal transcriptional and translational events and the effect of mutations on these events were explored. The discussions yielded insight not only in those areas in which important information is known but also in vital areas in which little is currently understood. This review attempts to summarize the current knowledge regarding MYOC/TIGR and to elucidate the points that the people attending the meeting thought needed further study.

Cytoskeletal Proteins↗
PubMed1988

The California Child Health and Development Studies of the School of Public Health, University of California at Berkeley.

The Child Health and Development Studies are prospective longitudinal studies on medical and social aspects of pregnancies and on the health and development of children. Data have been assembled on about 20,000 pregnancies occurring in one hospital between 1959 and 1967, and on follow-up of the children through adolescence. A currently ongoing project updates certain vital statistics of the entire study population. The data assembled in this longitudinal study supported a wide range of research projects, several of which proved to be important for the health of mothers and children. Notwithstanding, subsets of the assembled data, with potential value for public health, have not yet been explored. The data archive has been made accessible to the research community at large so that other significant research topics can be investigated. In the following article, brief descriptions are given of the history and design of the Child Health and Development Studies, of the contents of the data archive, and of the major areas of research that have been explored. Procedures to obtain access to the data and to the user's manual are explained, and a bibliography is included.

Adolescent↗