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[Preparation and anti-HIV activity study of baicalien and its benzylated derivatives].

Baicalein (1) was prepared from baicalin by acid hydrolysis with yield of 24%. 5, 6-Dibenzyl-7-hydroxyl-flanone (4) and 6-benzyl-5, 7-dihydroxyl-flanone (5) were obtained by using different benzylating agents, and then hydrolyzing those benzylated compounds. The total yield of (4) and (5) were 5.9% and 5%, respectively. Both 4 and 5 were less effective than baicalien on inhibition of HIV-1 RT in vitro.

Anti-HIV Agents↗

[Effect of thiol-oxidizing agents on several enzymes in rat liver mitochondria].

The sulphydryl groups of nonprotein thiols and proteins of mitochondria, activity of enzymes, oxidative phosphorylation and swelling of these organellas were studied as affected by the thiol-oxidizing agents. Diamide and azoester are shown to oxidize SH-groups of mitochondria, inhibit isocytrate dehydrogenase and succinate: cytochrome oxidation and inhibits energy-dependent swelling of mitochondria. Under the effect of azoester the rate of oxygen consumption by mitochondria increases and there occurs their sharp swelling.

Animals↗

[Activity of quaternary ammonium derivatives against 145 strains of rapidly-growing atypical mycobacteria].

A survey about 145 atypical mycobacteria strains belonging to the M. fortuitum y M. chelonae complex sensitivity in response to three quaternary ammonium derivates has been performed by means of the dilutional and agar spreading methods. High strain sensitivity has been detected, having the three investigated antiseptics a very similar behaviour. The correlation rates and the regression lines equations have been obtained. And as a result of the high values we have obtained, it's possible to get the strain CMI directly from the corresponding inhibition halo.

Anti-Infective Agents, Local↗