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At least 91 records · Page 5Linked to original sources
PubMed2001

Development of non-ABO RBC alloantibodies in patients undergoing allogeneic HPC transplantation. Is ABO incompatibility a predisposing factor?

BACKGROUND: Data from the appearance of RBC antibodies other than ABO in patients undergoing HPC transplantation are limited. STUDY DESIGN AND METHODS: The incidence and specificity of non-ABO RBC alloantibodies are described in a series of 217 patients undergoing allogeneic HPC transplantation because of various hematologic malignancies. RESULTS: Eight patients (3.7%) developed 10 antibodies after transplant. None of these patients had previously been immunized. Seven patients had one RBC antibody and one patient had three RBC antibodies. Antibody specificity were anti-Jk(b) (2 patients), -Kell (2), -M (2), -Le(b) (1), and -D (1). Finally, two patients had a panagglutinin. The mean time between transplant and antibody detection was 23 days (range, 16-672). The source of the HPCs, the conditioning regimen administered, and the type of GVHD prophylaxis administered did not influence the rate of antibody formation. On multivariate analysis, ABO blood group incompatibility (p = 0.005) and patient's age (p = 0.02) were the only two variables significantly associated with the development of RBC alloantibodies. CONCLUSION: Patients undergoing allogeneic HPC transplantation are at risk of developing RBC-specific antibodies despite the immunosuppressive therapy administered. Antibody formation was more frequently observed in ABO-mismatched cases, which suggests a potential role of this incompatibility in facilitating antibody production.

ABO Blood-Group System↗
PubMed1987

Distribution of the ABO system and Rh factor in Sardinia.

The authors examine the genetic structure of the Sardinian population based on the gene frequencies of the ABO blood group system and the Rh factor. The sample, composed of 13,972 individuals, is subdivided on the basis of altitude zones (mountain, internal hills, coastal hills and plains) and by historical-geographic zones. Also examined are the frequencies of a group of communities of different altitude and historical-geographic zones. The results point to genetic heterogeneity within both altitude and historical-geographic zones as well as within the single communities. A distribution gradient is seen for the IA and I0 alleles of the ABO system, namely: mountains, internal hills, coastal hills, plains.

ABO Blood-Group System↗
PubMed1972

ABO blood groups, rhesus factor and intestinal metaplasia of the stomach.

The presence or absence of intestinal metaplasia of the stomach was determined in 272 patients by direct vision biopsy of standardized intragastric sites using fiberoptic gastroscopy. Analysis of ABO blood groupings and Rhesus factor failed to reveal an association with metaplasia.

ABO Blood-Group System↗
PubMed2005

Correlation between ABO blood groups, major risk factors, and coronary artery disease.

To investigate a possible association of ABO blood groups with coronary artery disease in well-documented patients, we designed a cross-sectional study of 2026 patients, known case of coronary artery disease in angiography, who underwent coronary artery bypass graft at Tehran Heart Center, with regard to coronary artery disease major risk factors as well as ABO blood groups. Analysis did not show any significant difference between the frequency of ABO blood groups in coronary artery disease patients compared to the Iranian general population. In addition, frequency of cardiac risk factors was similar in coronary artery disease patients with different blood groups. Therefore, these finding suggest that there is no correlation between various ABO blood groups and development of coronary artery disease. Moreover, the prevalence of major risk factors was equal in patients with different blood groups, and blood groups had no impact on development of premature coronary artery disease in individual subjects.

ABO Blood-Group System↗
PubMed1993

Human plasma alpha 2-macroglobulin and von Willebrand factor possess covalently linked ABO(H) blood group antigens in subjects with corresponding ABO phenotype.

We recently identified ABO(H) blood group structures in Asn-linked sugar chains of human von Willebrand factor (vWF) purified from factor VIII concentrates (J Biol Chem 267:8723, 1992). We surveyed plasma glycoproteins carrying ABO(H) blood group antigens by Western blotting analysis and sandwich enzyme-linked immunosorbent assay using blood group-specific monoclonal antibodies (MoAbs) and a lectin. Two major plasma proteins showing apparent molecular weight of about 180 Kd and 270 Kd by sodium dodecyl sulfate polyacrylamide gel electrophoresis reacted with blood group-specific MoAbs and Ulex europaeus lectin I in accordance with donor blood group. Direct sequence analysis of the protein bands showed their identity with the N-terminal sequences of alpha 2-macroglobulin (alpha 2M) and vWF, respectively. The two bands also reacted with anti-alpha 2M and anti-vWF antibodies. The alpha 2M and vWF prepared from plasma by immunoprecipitation showed the appropriate blood group antigenicity. After incubation with endoglycosidase F, both alpha 2M and vWF lost almost all reactivity with anti-blood group reagents. About 90% of plasma vWF, but only approximately 10% of alpha 2M, was immunoprecipitated with anti-blood group antibody. These results indicate that at least two plasma glycoproteins, vWF and alpha 2M, possess Asn-linked ABO(H) blood group antigens in normal individuals with corresponding ABO phenotype. Therefore, ABO(H) blood group antigens in plasma glycoproteins should be considered during preparation of plasma materials for therapeutic use.

ABO Blood-Group System↗
PubMed1996

Angiotensin I-converting enzyme (ACE) polymorphism and ABO blood groups as factors codetermining plasma ACE activity.

The activity of serum angiotensin I-converting enzyme (ACE) was measured in 197 unrelated healthy Caucasian subjects. Plasma ACE activity was correlated with sex, ABO blood groups, and ACE insertion/deletion (I/D) polymorphism. Marked differences in plasma ACE activity levels were observed both among the blood groups and among ACE phenotypes. The corresponding ACE activities were as follows: blood group A, 19.45+/-0.96 (mean+/-SE); O, 20.74+/-1.58; B, 26.17+/-1.40; AB, 24.77+/-1.93 (U/mL: F=4.173; p=0.006983). With ACE genotypes: II, 16.96+/-1.33; ID, 24.25+/-1.05; DD, 27.14+/-1.20 (U/mL; F=6.359; p=0.002165). No difference was observed between men and women. The I/D polymorphism and the ABO system turned out to be two independent (additive) factors influencing plasma ACE activity. Together, they are responsible for 9.56% of the phenotypic variability of ACE. We discuss the role of the ABO system in the known effects of glycosylation of proteins.

ABO Blood-Group System↗
PubMed1975

Factor V (proaccelerin) concentration in 1016 blood donors. The effects of age, sex, and ABO blood groups.

Factor V (proaccelerin) concentration was measured in the plasma of 1016 regular and controlled blood donors. Age had a highly significant effect on factor V concentration. The median rose from 99 per cent at the age of 20 to 123 at the age of 60 years. Minor effects of sex and ABO blood groups were suggested. Interactions between these factors were found negligible. Accuracy and precision of the assay method and the use of percentiles in the laboratory reports are discussed. The results may support the hypothesis of relation between high concentration of coagulation factor V and predisposition to thrombosis.

ABO Blood-Group System↗
PubMed1976

Factor VIII (AHG) levels in 1016 regular blood donors. The effects of age, sex, and ABO blood groups.

Factor VIII (AHG) activity was assayed in the plasma specimens from 1016 regular and controlled blood donors. Age and ABO blood groups had highly significant effects on factor VIII concentrations, whereas the effect of sex was not significant. The median in the donors of blood group O rose from 87% at the age of 20 to 119% at the age of 60 years, and the median in blood groups A and B+AB of corresponding ages rose from 108 to 147%. An interaction effect of age and blood groups was present only at the 5% level of significance. The present data and the previous findings of others suggest the existence of an association between high factor VIII levels and thrombotic states.

ABO Blood-Group System↗