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PubMed1977

[The pattern of distribution of free amino acids in human amniotic fluid related to the duration of pregnancy. Part II: Changes in concentration in pathological pregnancy (author's transl)].

18 free amino acids from 196 specimens of amniotic fluid of pathological pregnancies between the 28th and 41st week of pregnancy were measured by gaschromatography. The concentrations of the amino acids in amniotic fluid in normal and pathological pregnancies were analysed by statistical methods. There were only minor differencies of concentration of free amino acids in the amniotic fluid between normal and pathological pregnancies with the exception of hydroxyproline. This was found in a significantly higher concentration in the amniotic fluid of the pathological group. Supposing that the materno-fetal as well as the feto-maternal amino acid exchange may be reduced by the placenta insufficiency, the significantly higher concentration of hydroxyproline in the amniotic fluid during pathological pregnancies may be caused higher fetal urine excretion of hydroxyproline into the amniotic fluid. The increase of hydroxyproline in the amniotic fluid of pathological pregnancies is probably an early diagnostic parameter of an impaired transplacental exchange -- placenta insufficiency.

Amino Acid Metabolism, Inborn Errors↗
PubMed1977

Amniotic fluid cortisol in high-risk human pregnancies.

Amniotic fluid cortisol (AFC) levels were measured in 76 normal and 67 high-risk human pregnancies. When compared to normal gestations, diabetic pregnancies were found to be associated with lower AFC levels, while toxemic, early Rh-sensitized, and other stressed pregnancies had higher mean cortisol values. Serially followed normal and high-risk pregnancies showed a progressive rise in AFC with increasing gestational age. Significant correlation between AFC concentrations and lecithin/sphingomyelin (L/S) ratios was noted in normal, diabetic, and toxemic gestations. These results are concordant with the hypothesis that cortisol may be involved in fetal lung development.

Amniotic Fluid↗
PubMed1979

[Comparative examinations of high-molecular maternal serum protein bodies during pregnancy--a contribution to biochemical pregnancy control (author's transl)].

The maternal Serum concentrations of beta 1 SP 1, IgM and alpha 2-macroglobulin were determined in relation to the gestation age, using the simple radial immunodiffusion method in 102 non-pathologic pregnancies and 35 pregnancies involving risk factors. To assess the clinical relevance of these determinations, we examined to what extent the changes in concentration of beta 1 SP 1 IgM and alpha 2-macroglobulin would permit a prognostically useful conclusion on the placenta function and foetal condition. All patients with lowered beta 1 SP 1-serum concentrations were examined for their antepartua CTG-evaluation, as well as the type of termination of parturition. The normal distribution for beta 1 SP 1 showed a continuous rise in serum concentration up to the 37th pregnancy week. During the last 3 weeks, beta 1 SP 1 remained almost constant. For the cases with EPH-gestosis and placenta insufficiency, a beta 1 SP 1-concentration below the normal distribution level was found in the large majority of all cases. In diabetes mellitus during gravidity, twin gravidity and MHN, the determination of beta 1 SP 1 is not of any decisive prognostic significance. The maternal serum levels of IgM showed no significant differences when comparing normal pregnancy and risk pregnancy. The serum concentration of alpha 2-macroglobulin increased in both groups of patients with increasing gestation age. Of the three examined protein bodies, we consider beta 1 SP 1 to be a good, additional parameter for the assessment of the trophoblast function.

Female↗