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At least 883 records · Page 49Linked to original sources
PubMed2001

Detoxification effect of iron-encaging zeolite-processed water in tributyltin-intoxicated Euglena gracilis Z.

In our previous paper, we reported the restoration promoting effects of mineral-encaging zeolite-processed water, especially of a Fe-encaging one, on tributyltin chloride (TBTCl)-intoxicated Euglena gracilis. This present study extends the investigation on the behavior of TBTCl and a xenobiotic enzyme, cytochrome P-450, in Euglena cells incubated with or without Fe-encaging zeolite-processed water (FeZW). Subcellular fractionation of TBTCl-intoxicated Euglena cells, atomic absorption spectrophotometry, and GC analyses showed that TBTCl was rapidly incorporated into the cells to halt cell motility. GC-MS showed that FeZW promoted conversion of TBTCl to dibutyltin (DBT) as the major metabolite in the microsomal fraction of the cells. An in vitro incubation system with heat-treated microsomes did not convert TBTCl to DBT. The contribution of cytochrome P-450 in the microsomal fraction was suggested by an immunochemical method. The results suggest that the improvement of detoxification by FeZW in the TBT-intoxicated Euglena cells should be due to activation of biotransformation system of the Euglena cells by FeZW.

Animals↗
PubMed1991

Significance of reduced food and water consumption in rats intoxicated with vanadium.

1. Male Wistar rats were given, for four weeks, a limited amount of food, or the amount of food and water equal to that consumed by rats drinking solely an aqueous solution of ammonium metavanadate instead of water (AMV) of 0.3 mg V/cm3 concentration. 2. In rats with limited access to food but free access to water, a significant decrease of body weight increment was observed, together with an increase of the haemoglobin level and a decrease in the percentage of reticulocytes and polychromatophilic erythrocytes in the peripheral blood. 3. In the rats which did not receive food and water ad libitum a significant decrease of the body weight increment and an increase of the haemoglobin level were noted. 4. In animals drinking the aqueous AMV solution instead of water the body weight increment diminished significantly, and so did the erythrocyte count and haemoglobin level, whereas the percentage of reticulocytes and polychromatophilic erythrocytes increased in the peripheral blood.

Animals↗
PubMed1985

Water deprivation-sodium chloride intoxication in a group of feeder lambs.

Six of a group of 100 feeder lambs that had been deprived of sodium chloride, then more recently deprived of water, developed water deprivation-sodium chloride intoxication soon after water and a mineral supplement containing sodium chloride were reintroduced. The clinical signs included somnolence, intense thirst, and generalized muscle fasciculations. Serum chemical analyses revealed profound hypernatremia and hyperchloremia. Two mildly affected lambs recovered with partial water restriction and 2 severely affected lambs died despite medication to reduce cerebral edema. Postmortem examination of the 2 treated lambs and the 2 lambs found dead revealed microscopic evidence of cerebral edema and cerebrocorticonecrosis.

Animals↗
PubMed1986

Effect of acute alcoholic intoxication on myocardial electrolyte and water distributions.

Myocardial electrolyte distributions and sarcolemmal permeability in vivo were compared among control, acutely alcoholic, and recovery groups of rats. Rats in the alcoholic group received an intraperitoneal dose of 56 ml 12.5% ethanol per kg rat over a 5-h period. One hour after receiving the last injection of ethanol, blood was withdrawn from the right atrium and the heart excised. Rats in the recovery group had one day to recover from the alcohol treatment. Control rats were injected with n-saline instead of ethanol. Myocardial extracellular space was assessed by morphometric and tracer techniques. Results indicate that myocardial water content increases during acute alcoholic intoxication and this increase is restricted to the extracellular space. The nominal cellular concentration of potassium increased nearly 10% while that of sodium fell by nearly one-third. Plasma concentration of magnesium increased markedly (36%) and that of calcium fell slightly (5%). The results suggest that the myocardial sarcolemma is not rendered leaky by acute ethanol intoxication even several days after binge drinking, when the skeletal muscle cell sarcolemma appears to become slightly more permeable.

Alcoholic Intoxication↗
PubMedDate not supplied

[The effect of the preliminary intake of mineral waters in acute alcoholic intoxication (an experimental study)].

101 male Wistar rats (body mass 180-200 g) received a single dose of ethanol in two concentrations--96% and 30%. High ethanol concentrations produced a direct damage to gastric and duodenal mucosa. 30% ethanol inhibited secretion of glucagon, insulin and aldosterone. This inhibition rapidly changes for the hormones rise in the blood. Hydrocortisone was high over the experiment. Previous intake of mineral water prevents damage to the gastroduodenal mucosa induced by 96% ethanol and modifies the hormonal response provoked by 30% ethanol as evident from reduced expression of the two phases.

Alcoholic Intoxication↗
PubMed1964

HYPONATREMIA.

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Acute Kidney Injury↗