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Photoelectric plethysmography in monitoring skin circulation.

Photoelectric plethysmography is not new, but is a simple noninvasive technique to determine erythrocyte volume and oxygen saturation. The data are immediately available, accurate, repeatable, and recordable. Methods currently used for estimating microcirculation and oxygen saturation include clinical tests such as observation of skin color, temperature changes, capillary refill, and bleeding; chemical tests such as fluorscein injection; radioactive isotopes (24Na, 131I, 99mTc, and 133Xe); and instrumental methods (both invasive and noninvasive) such as temperature and infrared thermometry, thermocouples, oxygen probes, and/or the plethysmometer. None of these methods is entirely satisfactory.

Amplifiers, Electronic↗

Physicians' perceptions regarding body temperature in health and disease.

Although body temperature has been monitored for more than a century as a means of distinguishing health from disease, physicians' perceptions of concepts of clinical thermometry are largely unknown. To characterize such perceptions, we did a descriptive analysis of responses to a survey questionnaire dealing with body temperature. Seventy-five percent of the 268 physicians and physicians-in-training surveyed offered 37 degrees C (98.6 degrees F) as their definition of "normal body temperature." Only 10 (4%) specified a particular body site (eg, oral or rectal) of temperature measurements in their definition. Although 98% believed that body temperature normally varies during the day, there was not a consensus as to the magnitude of such variability. There was also considerable disagreement as to the specific temperatures defining the lower and upper limits of the febrile range. Subjects exhibited a clear preference for the Fahrenheit scale in their responses. Medical students differed significantly from graduate physicians in several of the areas examined.

Body Temperature↗

Bayesian analysis of noninvasive versus oral temperature measurements to determine hypothermia in postoperative patients.

Measurement of body temperature in the postanesthesia care unit (PACU) is an important parameter in patient management. Failure to reach minimal acceptable body temperature standards has been associated with physiologic derangements, the application of additional therapy, and prolonged PACU stays. Newer methods to monitor temperature introduced into the PACU have been touted to be adequate for detecting clinically significant changes in temperature. In this study, skin core-temperature-corrected liquid crystal thermography (LCT), axillary (AT) electronic, and infrared tympanic membrane (ITT) temperatures were compared with oral thermistor thermometry (OT) in 205 PACU patients. Regression analysis suggests that when compared with the oral method, ITT tends to overestimate and AT and LCT tend to underestimate oral temperatures. Mean temperatures obtained by LCT (35.5 +/- 1.0 degrees C), AT (35.1 +/- 0.9 degrees C), and ITT (36.3 +/- 0.8 degrees C) differed significantly from OT (36.0 +/- 0.7 degrees C) mean temperatures. We applied Bayesian analysis to assess the sensitivity and specificity of each method, using a hypothermia reference of < 36 degrees C. Results suggest that the definition of hypothermia may depend on the modality used to assess body temperature in the PACU.

Adult↗

Unreliability of the infrared tympanic thermometer in clinical practice: a comparative study with oral mercury and oral electronic thermometers.

BACKGROUND: This study was designed to determine the magnitude and frequency of measurement errors with infrared tympanic thermometers in the clinical setting. METHODS: In a convenience sample of 137 adult inpatients, we compared body temperatures measured by a Diatek 9000 Infrared Aural Thermometer and an IVAC 2090 CoreCheck Tympanic Thermometer between themselves, in right versus left ears, and against concurrently measured oral temperatures using both an electronic thermoprobe and conventional glass mercury thermometer. RESULTS: There was a significant between-brand difference of 0.6 degrees C (IVAC <Diatek) for both ears; right-versus-left ear temperature group differences were not statistically significant with either thermometer, but ear-to-ear temperature variation was large, with individual right-left differences as great as 2.5 degrees C; significant differences were found between oral and ear temperatures with the IVAC thermometer (0.5 degrees C, ear <oral) but not with the Diatek thermometer; no significant difference was found between oral electronic and mercury temperature measurements; and cerumen had no significant effect on ear temperature measurements. CONCLUSIONS: The variability and inaccuracy of temperatures measured by the infrared tympanic thermometers were sufficiently large to suggest that the use of these devices for routine thermometry may be potentially hazardous.

Adolescent↗

A vascular stent as an active component for locally enhanced magnetic resonance imaging: initial in vivo imaging results after catheter-guided placement in rabbits.

RATIONALE AND OBJECTIVE: A vascular stent constructed as a high frequency resonator improves the local signal-to-noise ratio at magnetic resonance (MR) imaging. After catheter placement and intravascular expansion, the stent can be used as an inductively coupled coil for MRI. The imaging properties of this balloon-expandable active MRI stent (AMRIS) were evaluated after x-ray fluoroscopy guided placement in the abdominal aorta of five rabbits using MR angiography (MRA) and flow measurements. METHODS: The AMRIS was implanted in the abdominal aorta of five rabbits using a balloon catheter inserted through the common carotid artery. The rabbits were examined by MRA (3D fast low-angle shot) at 1.5 tesla before and after intravenous injection of an iron-oxide-based blood pool contrast medium (dose 50 micro mol Fe/kg) and flow measurements (ECG-triggered phase contrast cine gradient-echo sequence). Signal-to-noise ratios (SNR) were calculated and flow volume curves were generated. The in-stent increase in temperature was measured in vitro using a fiberoptic thermometry system. RESULTS: The SNR was 5.0 +/- 0.6 outside the stent and 23.2 +/- 14.1 within the stent ( < 0.0 5) in plain MRA, 19.5 +/- 5.0 outside and 30.7 +/- 8.2 within the stent ( < 0.05) in contrast enhanced MRA, and 5.8 +/- 1.6 and 13.9 +/- 5.9, respectively ( < 0.05) in the magnitude images of the flow measurements. Flow volume curves within and distal to the stent were comparable. CONCLUSIONS: The expandable active MRI stent produces local signal enhancement in MRA and MR flow measurements after catheter placement and thus may improve assessment of the stented vessel segment by MR imaging.

Animals↗

Comment on "Critique of q-entropy for thermal statistics".

It was recently argued [M. Nauenberg, Phys. Rev. E 67, 036114 (2003)] that the theory sometimes referred to as nonextensive statistical mechanics has no physical basis, for a considerable variety of reasons, including the impossibility of measuring the temperature out of the Boltzmann-Gibbs (BG) theory. We comment here on virtually all the physically and mathematically relevant issues, and point out what we consider to be severe inadvertences contained in that paper. In particular, we factually argue, through computer simulations, the validity of the zeroth principle of thermodynamics, and of the basic rules of thermometry for nonextensive systems. This fact further supports the possible connection with the thermodynamics of nonextensive statistical mechanics, which is already known to be consistent with the first, second, and third principles. All the foundational steps (e.g., the uniqueness of the entropy and the stationary state distribution) have already been established for nonextensive thermostatistics on similar grounds than those long known for BG statistics, the former corresponding to power laws (expected for long-range interactions when size N diverges before time t), and the latter correspond to the BG exponential law (expected for long-range interactions when N diverges after t, as well as for short-range interactions in any diverging order for N and t). We conclude that the invalidating arguments made by Nauenberg by no means apply.

Comment↗

Photon-assisted tunneling in electron pumps

We measure photon-assisted tunneling in 4- and 6-junction electron pumps at photon frequencies up to 60 GHz. We determine the microwave voltage at the pumps using noise thermometry. The standard theory of leakage in the electron pump, modified to include photon-assisted tunneling, describes our experiments well. From this test of theory we argue that, in the absence of external microwaves, photon-assisted tunneling driven by 1/f noise is an important error mechanism in electron pumps.

Journal Article↗

Phase-fluctuating 3D Bose-Einstein condensates in elongated traps.

We find that in very elongated 3D trapped Bose gases, even at temperatures far below the BEC transition temperature T(c), the equilibrium state will be a 3D condensate with fluctuating phase (quasicondensate). At sufficiently low temperatures the phase fluctuations are suppressed and the quasicondensate turns into a true condensate. The presence of the phase fluctuations allows for extending thermometry of Bose-condensed gases well below those established in current experiments.

Journal Article↗

Cooling dynamics of ultracold two-species Fermi-Bose mixtures.

We compare strategies for evaporative and sympathetic cooling of two-species Fermi-Bose mixtures in single-color and two-color optical dipole traps. We show that in the latter case a large heat capacity of the bosonic species can be maintained during the entire cooling process. This could allow one to efficiently achieve a deep Fermi degeneracy regime having at the same time a significant thermal fraction for the Bose gas, crucial for a precise thermometry of the mixture. Two possible signatures of a superfluid phase transition for the Fermi species are discussed.

Journal Article↗

Feedback cooling of a one-electron oscillator.

A one-electron oscillator is cooled from 5.2 K to 850 mK using electronic feedback. Novel quantum jump thermometry reveals a Boltzmann distribution of oscillator energies and directly measures the corresponding temperature. The ratio of electron temperature and damping rate (also directly measured) is observed to be a fluctuation-dissipation invariant, independent of feedback gain, as predicted for noiseless feedback. The sharply reduced linewidth that results from feedback cooling illustrates the likely importance for improved fundamental measurements and symmetry tests.

Journal Article↗

Critical temperature of a trapped, weakly interacting Bose gas.

We report on measurements of the critical temperature of a harmonically trapped, weakly interacting Bose gas as a function of atom number. Our results exclude ideal-gas behavior by more than two standard deviations, and agree quantitatively with mean-field theory. At our level of sensitivity, we find no additional shift due to critical fluctuations. In the course of this measurement, the onset of hydrodynamic expansion in the thermal component has been observed. Our thermometry method takes this feature into account.

Journal Article↗

Virial theorem and universality in a unitary fermi gas.

Unitary Fermi gases, where the scattering length is large compared to the interparticle spacing, can have universal properties, which are independent of the details of the interparticle interactions when the range of the scattering potential is negligible. We prepare an optically trapped, unitary Fermi gas of 6Li, tuned just above the center of a broad Feshbach resonance. In agreement with the universal hypothesis, we observe that this strongly interacting many-body system obeys the virial theorem for an ideal gas over a wide range of temperatures. Based on this result, we suggest a simple volume thermometry method for unitary gases. We also show that the observed breathing mode frequency, which is close to the unitary hydrodynamic value over a wide range of temperature, is consistent with a universal hydrodynamic gas with nearly isentropic dynamics.

Journal Article↗

Ballistic phonon thermal transport in multiwalled carbon nanotubes.

We report electrical transport experiments, using the phenomenon of electrical breakdown to perform thermometry, that probe the thermal properties of individual multiwalled carbon nanotubes. Our results show that nanotubes can readily conduct heat by ballistic phonon propagation. We determine the thermal conductance quantum, the ultimate limit to thermal conductance for a single phonon channel, and find good agreement with theoretical calculations. Moreover, our results suggest a breakdown mechanism of thermally activated C-C bond breaking coupled with the electrical stress of carrying approximately 10(12) A/m2. We also demonstrate a current-driven self-heating technique to improve the conductance of nanotube devices dramatically.

Journal Article↗

Thermodynamics of interacting fermions in atomic traps.

We calculate the entropy in a trapped, resonantly interacting Fermi gas as a function of temperature for a wide range of magnetic fields between the BCS and Bose-Einstein condensation end points. This provides a basis for the important technique of adiabatic sweep thermometry and serves to characterize quantitatively the evolution and nature of the excitations of the gas. The results are then used to calibrate the temperature in several ground breaking experiments on (6)Li and (40)K.

Journal Article↗

Molecules of fermionic atoms in an optical lattice.

We create molecules from fermionic atoms in a three-dimensional optical lattice using a Feshbach resonance. In the limit of low tunneling, the individual wells can be regarded as independent three-dimensional harmonic oscillators. The measured binding energies for varying scattering length agree excellently with the theoretical prediction for two interacting atoms in a harmonic oscillator. We demonstrate that the formation of molecules can be used to measure the occupancy of the lattice and perform thermometry.

Journal Article↗

Critical temperature and thermodynamics of attractive fermions at unitarity.

The unitarity regime of the BCS-BEC crossover can be realized by diluting a system of two-component lattice fermions with an on-site attractive interaction. We perform a systematic-error-free finite-temperature simulation of this system by diagrammatic determinant Monte Carlo method. The critical temperature in units of Fermi energy is found to be T(C)/epsilonF=0.152(7). We also report the behavior of the thermodynamic functions, and discuss the issues of thermometry of ultracold Fermi gases.

Journal Article↗

Optimization of electromagnetic phased-arrays for hyperthermia via magnetic resonance temperature estimation.

A technique for the optimization of electromagnetic annular phased arrays (APAs) for therapeutic hyperthermia has been developed and implemented. The controllable inputs are the amplitudes and phases of the driving signals of each element of the array. Magnetic resonance imaging (MRI) is used to estimate noninvasively the temperature distribution based on the temperature dependence of the proton resonance frequency (PRF). A parametric model of the dynamics that couple the control inputs to the resultant temperature elevations is developed based on physical considerations. The unknown parameters of this model are estimated during a pretreatment identification phase and can be continuously updated as new measurement data become available. Based on the parametric model, a controller automatically chooses optimal phases and amplitudes of the driving signals of the APA. An advantage of this approach to optimizing the APA is that no a priori information is required, eliminating the need for patient-specific computational modeling and optimization. Additionally, this approach represents a first step toward employing temperature feedback to make the optimization of the APA robust with respect to modeling errors and physiological changes. The ability of the controller to choose therapeutically beneficial driving amplitudes and phases is demonstrated via simulation. Experimental results are presented which demonstrate the ability of the controller to choose optimal phases for the APA using only information from magnetic resonance thermometry (MRT).

Computer Simulation↗

Nonparametric 1-D temperature restoration in lossy media using Tikhonov regularization on sparse radiometry data.

Microwave thermometry has the potential to characterize thermal gradients in lossy materials down to a few centimeters depth. The problem of retrieving temperature profiles from sets of brightness temperatures is studied using Galerkin expansion of one-dimensional (1-D) temperature profiles combined with Tikhonov regularization and predefined boundary conditions. From a priori knowledge of the temperature field shape, smooth Chebyshev polynomials are used as basis functions in the series expansion. The proposed estimator does not require iterative calculations that are normally performed using conventional numerical methods for signal parameter estimation and is, thus, very fast. Noise effects versus bandwidth limitations (smoothness of solutions) are studied in terms of four performance indexes defined in the text. In general, statistical spread of the temperature estimator increases with increasing number of Chebyshev polynomials. Systematic deviation from true values (bias) decreases as the number of Chebyshev polynomials increases. Results show that smooth temperature profiles can be reproduced using 6-7 Chebyshev polynomials. With additional constraints such as boundary conditions and maxima localization, a three-frequency-band radiometric scan is sufficient to produce acceptable results in regions with low thermal gradients. As the spatial variability of the 1-D temperature profile increases, more radiometric bands (5-6) are required to provide nonbiased estimates.

Algorithms↗