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Jugular thrombophlebitis complicating bacterial pharyngitis (Lemierre's syndrome).

Lemierre s syndrome is a rare syndrome caused by Fusobacterium necrophorum, a gram-negative anaerobic organism that normally inhabits the oropharynx. The syndrome follows primary oropharyngeal infection and affects previously healthy adolescents in a characteristic manner with fatal results if left untreated. The authors present two cases seen at their institution and discuss the clinical and radiologic features of the syndrome, along with considerations for patient management.

Adolescent↗

Experimental infusion thrombophlebitis. Importance of the infusion rate.

The importance of the method of administration of acid glucose infusions for the venous inflammatory response has been investigated in two series of experimental trials. 60 ml of 5% glucose solution was administered into rabbit-ear veins in three ways: 1) continuously over 5 hours (slow infusion), 2) continuously over 1 hour (rapid infusion), 3) discontinuously during 2 X 30 minutes with an interval of 4 hours (discontinuous infusion). Microscopical examination of the veins revealed that the inflammatory changes were less pronounced after rapid and discontinuous infusions than after slow infusions.

Animals↗

Fatal septic thrombophlebitis due to Salmonella enteritidis.

The case is reported of a patient with gastric adenocarcinoma with metastases who developed a septic focus in a saphenous vein. Salmonella enteritidis was cultured from blood, sputum and stool specimens, and from a thrombus removed from a varicosity of the saphenous vein. Extraintestinal infections caused by non-typhoid salmonella usually afflict debilitated and immunocompromised patients. Metastatic septic foci may appear anywhere in the organism, including the vascular system, but involvement of the venous system has not previously been reported.

Adenocarcinoma↗