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Spinal cord compression due to pseudomonas in a heroin addict. Case report.

Involvement of the spinal cord has not been reported in osteomyelitis of the spinal column caused by Pseudomonas aeruginosa. Cerebrospinal fluid findings have been reported only once in osteomyelitis of the spine by this agent. Our patient had persistently increased cerebrospinal fluid protein during an acute episode of cervical spine osteomyelitis, characterized by fever and neck pain. Roentgenograms of the cervical spine and neurologic examination did not show any definite abnormality. He became paraplegic 18 months later, after having symptoms of numbness of the feet and progressive weakness of the legs for 1 month. A surgical procedure and antibiotic treatment resulted in remarkable recovery. A bone specimen grew P. aeruginosa.

Cervical Vertebrae↗

[Granulocytic sarcoma (so-called chloroma) as a possible cause of spinal cord compression. Case report and differential diagnosis].

Granulocytic sarcomas (so-called chloromas) are rare extramedullary tumorlike proliferates of myelogenous precursor cells that may de novo precede acute leukemia or coincide with the first manifestation or relapse of acute myeloid leukemia. Rarely, such tumors represent the initial manifestation of a blast crisis in the course of a chronic myeloproliferative disease, such as chronic myeloid leukemia. If they occur in aleukemic patients incorrect diagnoses may result. Differential diagnostic considerations are being discussed by presenting the case of a 58-year-old man who experienced spinal cord compression by an isolated epidural mass lesion.

Biopsy↗

Unusual presentation of spinal cord compression related to misplaced pedicle screws in thoracic scoliosis.

Utilization of thoracic pedicle screws is controversial, especially in the treatment of scoliosis. We present a case of a 15-year-old girl seen 6 months after her initial surgery for scoliosis done elsewhere. She complained of persistent epigastric pain, tremor of the right foot at rest, and abnormal feelings in her legs. Clinical examination revealed mild weakness in the right lower extremity, a loss of thermoalgic discrimination, and a forward imbalance. A CT scan revealed at T8 and T10 that the right pedicle screws were misplaced by 4 mm in the spinal canal. At the time of the revision surgery the somatosensory evoked potentials (SSEP) returned to normal after screw removal. The clinical symptoms resolved 1 month after the revision. The authors conclude that after pedicle instrumentation at the thoracic level a spinal cord compression should be looked for in case of subtle neurologic findings such as persistent abdominal pain, mild lower extremity weakness, tremor at rest, thermoalgic discrimination loss, or unexplained imbalance.

Abdominal Pain↗

Agnogenic myeloid metaplasia and spinal cord compression.

A 55-year-old White male with agnogenic myeloid metaplasia, proved on bone marrow trephine biopsy, underwent splenectomy for abdominal discomfort. Six months later he developed paraparesis and on myelography multiple extradural obstructions were seen. In the absence of other obvious diagnostic possibilities, these were attributed to areas of extramedullary haematopoiesis, and he was treated with local radiotherapy. However, the neurological deficit progressed and emergency laminectomy and decompression were undertaken. Tissue obtained at this time confirmed the diagnosis of agnogenic myeloid metaplasia. A repeat myelogram showed complete relief of the obstruction, but the patient developed fulminating septicaemia and died. These findings are reported in view of the great rarity of spinal cord compression due to multiple areas of extramedullary haematopoiesis.

Humans↗

Asymptomatic advanced hepatocellular carcinoma presenting with spinal cord compression.

HCC is the most frequent primary malignancy of the liver and one of the most common cancers in the world. HCC is substantially a complication of liver cirrhosis, and because HBV and HCV are the predominant causes of chronic liver disease and cirrhosis worldwide, they have a propensity to lead to HCC. Common sites of HCC metastases include the lung, lymph nodes, and portal vein. Bony metastases are rare, and when they do occur the disease is usually far advanced and is associated with clinical manifestations of abdominal pain, weight loss, jaundice, hepato-splenomegaly, ascities, deranged LFTs, and elevated AFP. We report here a patient with asymptomatic advanced HCC, normal LFTs, and normal AFP values presenting with spinal cord compression.

Biopsy, Fine-Needle↗

Spinal cord compression as a result of Rosai-Dorfman disease of the upper cervical spine in a child.

BACKGROUND: Rosai-Dorfman disease is characterized by massive painless cervical lymphadenopathy, but can also include nasal obstruction, tonsillar enlargement, or hearing abnormalities. The disease occurs most often in the third and fourth decades. Most authors have suggested that it represents either an autoimmune disease or a reaction to an infectious agent that has yet to be discovered. Less than 50 cases of central nervous system involvement have been reported. CASE ILLUSTRATION: We report a child with cervical spinal cord compression due to Rosai-Dorfman disease of the cervical spine. PROGNOSIS: This disease has variable outcomes from relatively benign to insidious over decades. Our case is unusual in that the patient was a child and had involvement of the spine with resultant cord compression, a combination that has been reported rarely.

Adolescent↗

MR examination for spinal cord compression: impact of a multicoil system on length of study.

Twenty spinal studies to rule out cord compression using a multicoil array system were compared with the 20 consecutive previous studies in which a 5 x 11 inch flat plate coil (5 x 11 FPC) was used on the same 1.5 T MR scanner. The multicoil studies averaged 53 min shorter overall (105 min with the 5 x 11 FPC versus 52 min with multicoil). The reduction in scan time was maximal in studies when Gd-DTPA was administered (76 min reduction) or when the results showed noncompressive epidural disease or intramedullary disease (78 min). Scan quality was diagnostic in all examinations, and lesion localization was superior with the multicoil. The multicoil system substantially reduces scan times when whole spine studies are performed.

Adult↗

Acute changes in somatosensory evoked potentials following graded experimental spinal cord compression.

Amplitude and latency of cortical somatosensory potentials evoked in cats by peripheral nerve stimulation were measured before, during, and for 5 hours after injury of spinal cord segment L-7 by a predetermined degree and duration of compression. An amplitude decrease, slight and transitory, was first observed after compression reduced the segmental cross section by 60%. After an 80% compression, amplitude reduction was initially larger and lasted longer, but recovered 2.5 hours after injury to a level that did not differ statistically from control values. After total (100%) compression, evoked responses disappeared abruptly and did not recover significantly. Latency was unaltered at all degrees of compression. Structural damage increased with the degree of compression. In this model, evoked potential changes neither reflect nor predict the magnitude of acute incomplete spinal cord injury.

Animals↗

Spinal-cord compression due to extradural amyloidosis of the cervico-occipital hinge, in a hemodialysed patient. A case report.

Long-term dialysed patients can develop an arthropathy, called dialysis arthropathy, due to the deposition and transformation of the beta2 microglobulin into amyloid. The involvement of the spine, called destructive spondyloarthropathy (DSA), occurs between 10 and 25 percent; of these patients, and sometimes causes neurological damage. The disc space narrowing, vertebral body erosion and pseudocystis, in presence of polyarthropathy, chronic renal failure, and carpal tunnel syndrome, allows to make a diagnosis of DSA, which is proved by histological finding of beta2 microglobulin-amyloid. We report a rare case of spinal cord compression due to beta2 microglobulin-amyloid deposit in extradural space of cervico-occipital hinge.

Adult↗