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[Streptococcal toxins & their relations to rheumatic fever].
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The epidemiology of rheumatic fever.
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[Present concept of the epidemiology of rheumatic fever].
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[On the diagnostic significance of the Finalgon test in acute rheumatic fever].
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[Experimental pathology of rheumatic fever].
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CONFERENCE report; rheumatic fever management.
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Treatment of rheumatic fever.
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PREVENTION of rheumatic fever.
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[Treatment of rheumatic fever].
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[A contribution to the autoimmune theory of rheumatic fever].
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PROPHYLAXIS of rheumatic fever.
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[Modern treatment of rheumatic fever].
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Guideline maintenance and revision. 50 years of the Jones criteria for diagnosis of rheumatic fever.
OBJECTIVE: To understand better the factors that led to revisions of the Jones criteria, a widely used diagnostic guideline for diagnosis of rheumatic fever. DESIGN: The original publication of the Jones criteria and the four revisions were examined to identify changes. A computer software maintenance paradigm was applied, and modifications were categorized as corrective (error correction), perfective (enhancements in response to user needs), or adaptive (responses to new knowledge). RESULTS: Modifications of the Jones criteria were primarily corrective and perfective. Disease characteristics, originally characterized as major manifestations, were subsequently categorized as minor manifestations and vice versa. Twenty years after the initial publication, a requirement was added to enhance specificity (evidence for antecedent streptococcal infection). Descriptions of rheumatic manifestations became more detailed over time to eliminate ambiguous definitions and provide information to help clinicians decide about borderline cases. This emphasis on corrective and perfective maintenance contrasts with an expectation that adaptive changes would predominate, as with most knowledge-based systems. In fact, despite 50 years of technologic and methodologic advances in medicine, only echocardiography and new antibody testing contributed new knowledge that bears on the diagnosis of rheumatic fever. CONCLUSIONS: Corrective and perfective maintenance can be avoided by making effective use of knowledge that exists at the time a guideline is published. Despite the apparent durability of the Jones criteria, carefully structured, evidence-based guidelines should require less corrective and perfective maintenance. Adaptive maintenance can be anticipated if the quality of evidence or the level of consensus that supports each recommendation is explicitly recorded.
[Rheumatic fever and post-streptococcal arthritis. Clinical review].
We report 11 patients diagnosed of Acute Rheumatic Fever (ARF), and 7 of Poststreptococcal Reactive Arthritis (PSRA): patients with group A beta hemolytic streptococcal infection and articular disease who do not fulfill the modified Jones criteria. All patients with ARF were treated with monthly prophylaxis (with penicillin G benzathine). Carditis was seen in five patients, but only one of them has developed a mitral valve insufficiency. The prophylaxis in patients with PSRA was individualized. None of these patients had clinical evidence of carditis during the acute disease, but one of them developed a mitral and aortic stenosis two years after the initial episode. The possible indication of penicillin prophylaxis in these patients with PSRA in suggested.
[Rheumatic fever. The clinical profile of a persistent disease].
Clinical and social aspects of patients with rheumatic fever that were studied in the Internal Medicine Department of the "Instituto Nacional de Pediatría" during the last decade were analyzed. Variations observed in the clinical profile all around the world and the sudden and unexpected outbreak of the disease in the United States made this revision necessary so that the pediatrician remains actualized and aware. Damage to the heart is as always a major concern. Laboratory and radiological tests necessary to sustain the clinical diagnosis and those needed for further evaluation are discussed. To mention some social aspects regarding this group is essential because of the great difference between our patients and those recently seen in the United States.
Clinical profile of acute rheumatic fever in children.
A prospective study was done to determine the clinical profile of acute rheumatic fever in the first attacks and in recurrences separately. The data were compared with those from other countries. Eighty children were in their first attack while 46 had recurrences. Arthritis, the most common manifestations, was seen in 61 per cent of patients with first attack followed by carditis in 41 per cent, chorea in 28 per cent and subcutaneous nodules in 3 per cent. However, in the recurrences, arthritis was present in 52 per cent, carditis in 81 per cent, chorea in 11 per cent, and nodules in 4 per cent of cases. In both the groups, no case with erythema marginatum was seen. The results show that in the first attack the clinical picture broadly resembles that in European and North American countries. The presenting symptoms and signs are different during recurrence.