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[Is rigid rectoscopy obsolete?].

Flexible fiberoptic sigmoidoscopy more and more replaces sigmoidoscopy with a rigid tube. In a retrospective series of 152 rigid sigmoidoscopies we analysed depth of endoscopy and findings. In 36% of patients without anaesthesia endoscopy had to be stopped at 15 cm and in further 31% at 20 cm leading to a highly significant difference to the anesthetized patients (p less than 0.0005). A good history of the present illness allows separating of bleeding carcinoma and polyps proximal to the sigmoid colon which have to be examined by colonoscopy. In routine screening for blood loss per anum it is desirable to achieve in all patients a maximal security not to overlook a finding, because of the medical costs. We have enlarged the list of indications for the rigid sigmoidoscopy by Marks et al. as a practical compromise: delineation of rectal lesions, side localization and critical rectal measurements, surveillance of disease states or anastomoses within its reach, for performing rectal biopsy and rectal polypectomy, in patients with possible contamination of the instrument, endoscopy in the anesthetized patient before a proctological operation if case history excludes a higher sited lesion. In all other cases there is an indication for colonoscopy or barium contrast enema. It is stressed that in patients with blood loss per anum the search for the source always is done by flexible fiberoptic sigmoidoscopy.

Adult↗

Effects of rigid lens flexure on vision.

Rigid lenses may flex on the eye, particularly when the center thickness is less than 0.12 mm. Rigid oxygen permeable materials are less rigid than PMMA and can be expected to flex more easily.

Adolescent↗

Detection of an abnormal plasma clot structure by a simple rigidity assay.

We report here on a patient whose abnormal fibrin clot was detected via the measurement of clot rigidity with a simple buoyant inner cylinder elastometer. The patient's clinical coagulation studies were all within normal limits except for prolonged thrombin and reptilase clotting times and high level of fibrin split products. The measured rigidity of the patient's clot was approximately ten times lower than that of a clot formed from normal pooled plasma. Light scattering studies indicated that this modified structure was not caused by a gross change in gel fiber morphology. Antithrombin activity was eliminated as a possible cause of the altered clot structure; this suggests the possibility of a modified fibrinogen. Abnormalities in the reptilase time and fibrinogen levels in two siblings support the hypothesis that the modification is an inherited defect. We suggest that the simple measurement of rigidity can be used rountinely to detect abnormalities in plasma clot structure. The screening for such disorders should be of importance to clinician, patient, and biochemical researcher.

Aged↗

[Rigid and flexible links in the neurophysiological correlates of immunological processes].

The regulation of immune reactions is maintained by a brain system consiting of rigid and versatile ("flexible") links. The main rigid link of this system is the posterior hypothalamic area. This area has a minimal latency and obvious reactions of single neuron activity, excitability, DC potential level. A correlation between the rigid and versatile links during separate phases of immune reaction, is shown. The discovered reaction depends on immune reactivity.

Amygdala↗

Structural changes in intact tubular bone after application of rigid plates with and without compression.

The influence of a rigid plate on the structure of intact tubular bone was studied in forty adult rabbits using a four-hole commercial-steel DCP-ASIF plate attached to each tibiofibular bone, with and without compression. The morphological changes in the bone underlying the plate were examined and were assessed quantitatively at one day to thirty-six weeks after operation. The rigid plate induced porotic changes in the cortical bone, which were evident three weeks after the operation and increased rapidly between twelve and eighteen weeks. At thirty-six weeks, resorption cavities occupied 40.6 per cent of the cortical wall of the bones plated with compression and 41.2 per cent of the wall of those plated without compression. The changes were visible slightly earlier in the presence of compression. A rigid plate brought about a statistically significant increase both in the outer diameter of the bone and in the diameter of the medullary space as a result of subperiosteal new-bone formation and concomitant subendosteal bone resorption.

Animals↗

Rigid membranes of Malayan ovalocytes: a likely genetic barrier against malaria.

A high frequency of nonhemolytic hereditary ovalocytosis in Malayan aborigines is thought to result from reduced susceptibility of affected individuals to malaria. Indeed, Kidson et al. recently showed that ovalocytes from Melanesians in Papua New Guinea are resistant to infection in culture by the malarial parasite Plasmodium falciparum. In order to determine if protection against parasitic invasion in these ovalocytes might be the result of some altered membrane material property in these unusual cells, we measured their membrane and cellular deformability characteristics using an ektacytometer . Ovalocytic red cells were found to be much less deformable in comparison to normal discoid red cells. Similar measurements on isolated membrane preparations revealed a marked reduction in ovalocytic membrane deformability. To produce equal deformation of ovalocytic and normal membranes, ovalocytes required an 8-10-fold increase in applied shear stress, indicating that their membrane was capable of deforming under sufficient stress. To test the possibility that this increased membrane rigidity might confer resistance to parasitic invasion, we performed an in vitro invasion assay using Plasmodium falciparum merozoites and Malayan ovalocytes of varying deformability from seven different donors. The level of infection of the ovalocytes ranged from 1% to 35% of that in control cells, and the extent of inhibition appeared to be closely related to the reduction in membrane deformability. Moreover, we were able to induce similar resistance to parasitic invasion in nonovalocytic normal red cells by increasing their membrane rigidity with graded exposure to a protein crosslinking agent. Our findings suggest that resistance to parasite invasion of Malayan ovalocytes is the result of a genetic mutation that causes increased membrane rigidity.

Blood Viscosity↗

Corneal response to rigid and hydrogel lenses during eye closure.

Corneal changes were monitored in 14 subjects following 3 hr of eye closure while wearing selected oxygen permeable rigid and hydrogel lenses. The mean increase in corneal thickness ranged from 82.5 to 29.5 microns for rigid lenses with oxygen transmissibilities (Dk/L) between 0.2 X 10(-9) and 57.0 X 10(-9) (cm/sec) (ml O2/ml X mmHg), respectively, and ranged from 82.5 to 23.5 microns for hydrogel lenses with Dk/L between 2.5 X 10(-9) and 70.0 X 10(-9) (cm/sec) (ml O2/ml X mmHg), respectively. No differences in the amount of swelling between rigid and hydrogel lenses of the same oxygen transmissibility were observed (t-test, P greater than 0.20). Combining the swelling data for both types of lenses shows that a minimum lens oxygen transmissibility of approximately 75 X 10(-9) (cm/sec) (ml O2/ml X mmHg) is necessary during eye closure to prevent contact lens induced edema. The estimated oxygen tension under a lens with this Dk/L value is 40 mmHg. Recovery of the cornea to baseline thickness follows a nonlinear time course, with the rate of dehydration decreasing as the cornea thins. For initial swelling of 40-54 microns, 55-69 microns, and 70 microns and above, the time to reach baseline thickness was 1.5, 2.0, and 2.5 hr, respectively. Effects on vision, corneal curvature, distortion, and epithelial integrity were not clinically significant during this short period of eye closure.

Adult↗

[Congestive cardiomyopathy associated with a stiff spinal column. "Rigid spine syndrome"].

The "rigid spine syndrome" is a rare form of myopathy characterised by rigidity of the dorso-lumbar spine, hyperextension of the neck and muscular retraction limiting mobility, especially of the upper limbs with elbows fixed in semi-flexion. This condition, which was first described relatively recently, has been little studied: only 8 cases have been published to this day. We report the case of a 20 year old man with this syndrome, associated with a severe diffuse non-obstructive hypertrophic cardiomyopathy. Electronic microscopy and histoenzymological studies were performed on the skeletal muscle. They confirmed myopathic changes, demonstrating a great variation in diameter of the fibres, but there was no evidence of a predominating histoenzymological form (type I muscular atrophy) as previously reported. Although there have been no other reports of cardiac involvement in the "rigid spine syndrome", a link between the two conditions would seem to be likely.

Adult↗

The digitus quintus, rigid stoma, 4-5 position gastroplasty.

In 55 patients a rigid stoma gastroplasty was performed. The operative technique is described. It includes the construction of a rigid stoma and a double line of staples across the stomach to give a pouch volume of 40 to 60 ml. The diameter of the stoma is established by a nasogastric tube and the digitus quintus of the assistant's hand at the level of the cuticle. A 1- to 2-year follow-up indicates that these stomas do not dilate but tend to decrease in diameter. Stomal stenosis occurred in 2 of the 55 patients studied. Weight loss was satisfactory, although incomplete in most patients. It is likely that the weight loss will not be as great as with intestinal bypass. There were no serious late postoperative complications. However, an appreciable number of patients had emesis early in the postoperative period, intolerance of red meat and constipation. It is apparent that a rigid stoma of constant diameter is at least as important as a small gastric pouch in achieving adequate and lasting weight loss. A longer follow-up is necessary to assess this procedure completely.

Adolescent↗

[Effects of 4'ethyl-2-methyl-3-piperidinopropiophenone on experimental rigidity and spinal cord activities (author's transl)].

Effects of 4'ethyl-2-methyl-3-piperidonopropiophenone hydrochloride (EMPP) on experimental rigidities in rats and spinal cord activities in cats were studied. EMPP in a dose range of 1.25 approximately 10 mg/kg i.v. reduced EMG spikes of the intercollicular decerebrate rigidity and anemic decerebrate rigidity in rats. In alpha-chloralose anesthetized cats, EMPP in a dose range of 2.5 approximately 10 mg/kg i.v. caused a dose-related inhibition of the flexor reflex without any effect on the patellar reflex. In spinal cats, 2.5 approximately 10 mg/kg of EMPP caused a dose-related inhibition of the flexor reflex but the potency was less than that in anesthetized cats. Oral administration of EMPP 100 approximately 200 mg/kg produced a selective inhibition of the flexor reflex and the effect was twice as potent as tolperisone and chlormezanone. On the other hand, EMPP at 2.5 approximately 10 mg/kg i.v. which had little effect on the patellar reflex inhibited both monosynaptic and polysynaptic reflex potentials recorded from the ventral root to the same extent and also depressed dorsal root reflex potential recorded from the dorsal root in spinal cats. EMPP reduced the frequency of spontaneous gamma-motoneurone discharges in spinal cats, but had no appreciable effect on GIa discharges from muscle spindle of the triceps surae muscle. These results indicate that EMPP reduces alpha- and gamma-efferent activities and that EMPP exerts a marked inhibitory effect on spinal cord activities acting on the spinal cord and supraspinal structures.

Action Potentials↗

A comparison of biopsy results using rigid and fibreoptic bronchoscopes.

A comparison of the results of bronchial biopsy in the histological diagnosis of lung cancer obtained via the fibreoptic bronchoscope and the rigid bronchoscope has been made. Positive biopsy rates of 72% with the fibreoptic bronchoscope and 51% with the rigid bronchoscope were obtained (P less than 0.001). Evidence is presented to show that this difference was not due to selection of patients. The negative biopsy rates in the presence of proven visible tumour were 9% with the fibreoptic bronchoscope and 16% with the rigid bronchoscope.

Bronchi↗

Principles of less rigid internal fixation with plates.

The paradox of internal fixation for treating fractures is that fixation is required to achieve union, while flexibility is necessary to restore normal mechanical properties of bone after union. Three series of experiments were performed to investigate the role of plate rigidity on fracture repair and changes in bone mass. Using plates with tenfold differences in axial and bending rigidities, the authors were able to show some advantages in fracture healing and bone remodelling with less rigid plates.

Animals↗

[Influence of ionic strength on the thermodynamic rigidity of the native DNA molecule in aqueous and aqueous-organic solvents].

The analysis of experimental and theoretical data for the dependence of the thermodynamic rigidity of the native DNA molecule on the ionic strength of solution has been fulfilled. It has been shown that in aqueous-salt solutions of DNA the statistical segment length (A) of the DNA molecule remains constant over the range of intermediate ionic strengths (mu > 0.002) and considerably increases over the range of small mu < 0.002. On the basis of viscosimetry and flowbirefringence measurements of aqueous-organic solutions of native DNA it has been hypothesized that the macromolecule's thermodynamic rigidity does not depend on the dielectric properties of the medium. In this connection it has been concluded that nonshielded Coulomb interactions between the nearest phosphate groups exert a stronger influence on the thermodynamic rigidity of the macromolecule as compared with Debye--Hückel interactions. The consideration of the hydrodynamical and optical data for aqueous organic DNA solutions of difinite ionic strength shows that the value of [n]/[eta] for DNA and consequently the optical anisotropy of the macromolecule remains constant irrespective of the presence of nonelectrolyte. On this basis it has been concluded that no appreciable alteration of the microform anisotropy occurs in all the systems under consideration.

DNA↗

Nocturnal penile tumescence and rigidity monitor--use in a family practice.

We describe our experience using the nocturnal penile tumescence and rigidity monitor (NPTR) in 181 impotent patients referred to the specialized evaluation service in our Family Medicine Center, and review the literature. The 181 patients were referred to the center during 18 months. Their mean age was 53.5 +/- 9.45 years (range 26-76) and 92% were married; about a quarter (26.8%) suffered from impotence for 4-10 years. They were referred by urologists (54.7%), psychiatrists (24.3%), and general practitioners (13.8%). About a third had a normal rigidity, more than half had a normal base tumescence, but only a quarter had normal tip tumescence. Abnormal rigidity and tumescence was significantly associated with diabetes but not with hypertension. We conclude that family physicians have to be actively involved in and responsible for the diagnosis and treatment of impotent patients. Reading and interpreting NPTR is a simple as reading an electrocardiogram and can easily be performed in a primary care setting.

Adult↗

[Torsion rigidity of the outer sheaths of flexible medical endoscopes].

The torsion rigidity of the outer sheaths of flexible medical endoscopes was theoretically and experimentally studied. It has been shown that the bulk of the torsion rigidity of the sheaths is provided by the outer plastic sheath plus a procedure for its fastening to the braiding, as well as the braiding. A way of fastening the outer sheath to the braiding has a great impact on torsion rigidity.

Endoscopes↗

Peyronie's disease: surgical treatment based on penile rigidity.

Operative treatment of Peyronie's disease has the risk of penile shortening and/or loss of erection. To avoid these complications, we used plaque incision together with polytetrafluoroethylene (Gore-Tex) graft insertion in men with preserved penile rigidity and only implanted a penile prosthesis in men with erectile failure. Between August 1986 and July 1992, 24 men 36 to 72 years old (mean age 53 years) underwent surgery. Of the men 16 with adequate penile rigidity by history and/or RigiScan study, and severe curvature underwent plaque incision and polytetrafluoroethylene graft insertion. Eight men had erectile failure, including 4 with distal flaccidity as demonstrated by RigiScan study. These 8 men received a penile prosthesis (semirigid in 6 and inflatable in 2). In addition, 2 of these men also required plaque incision because of persistent curvature. With a mean followup of 47 months (range 20 to 92), all 16 men with incision and a polytetrafluoroethylene graft had excellent erections with satisfactory intercourse. Minimal curvature away from the plaque incision site, not causing any difficulty with sexual performance, occurred in 7 patients. The men with a penile prosthesis engage in normal intercourse without residual or recurrent curvature. Incision of Peyronie's plaque and polytetrafluoroethylene graft insertion is associated with an excellent functional result in men with normal preoperative penile rigidity. A penile prosthesis should be reserved for men with erectile failure.

Adult↗

[Extraction of foreign bodies with rigid oesophagoscopy: personal experience].

The Authors report their personal experience with regard to extraction of foreign bodies with a rigid oesophagoscope carried out in the last 16 years. All the patients studied live in Northern Italy, in Brianza Est, in area of about 100,000 inhabitants. One hundred and sixty-two cases were treated from 1977 to 1992. In order to better evaluate pathological evolution, we divided this period into two parts: 1977-1984 and 1985-1992. The data revealed are as follows: 1) Women always prevailed over men (73% in the first period and 67% in the second); 2) Foreign body extraction increased by 57% in the second period; 3) Patients most frequently treated were between the ages of sixty and eighty; 4) Foreign bodies most frequently extracted were bones (at all ages), coins (in the children) and large meat bolus (in older subjects). The Authors affirm that they were able to extract all foreign bodies employing the rigid oesophagoscope. Occasional difficulties which emerged during extraction were overcome successfully thanks to the vast experience of the medical staff. As a matter of fact, their experiences leads them to reject abandoning the rigid oesophagoscope for the flexible optical fibres also because even those ENT Departments with vast experience in the use of fibres are not always able to remove all kind of foreign bodies.

Adolescent↗

Criteria for examiner-independent nocturnal penile tumescence and rigidity monitoring (NPTR): correlations to invasive diagnostic methods.

78 patients (pts.) with erectile dysfunction (ED) underwent conventional diagnostic evaluation including NPTR monitoring with the Rigiscan, intracavernous drug testing, dynamic cavernosometry, doppler evaluation, pharmaco-angiography and neurologic tests. Only erections of the best rigidity recorded over three nights served for classification into three classes of rigidity. Patients with neurogenic impotence showed significantly poorer and fewer erectile events per hour than vasculogenic impotent men. Patients with arteriogenic ED had better erections than patients with venogenic or mixed arterio-venogenic ED. Severity of organic ED during conventional diagnostic work-up correlated to loss of rigidity during NPTR recordings, but no differential diagnosis between arteriogenic, venogenic or neurogenic impotence could be made with NPTR data alone. The presented criteria for NPTR evaluation permit a time-saving, examiner-independent analysis.

Adult↗