The conformational space of nascent peptide-accepting 3'-aminoacyl ribonucleos(t)ides: 1H NMR data and ab initio calculations of puromycin and some synthetic analogs.
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The cytostatic effects of puromycm, [(6)N]O(2')-dibutyryl 3',5'-adenosine monophosphate, and adenosine on asynchronous and synchronous cultures of the murine mastocytoma, P815Y, have been studied. Cell growth was arrested after a minimum of one further division. A model is proposed for the inhibition of cell division in which the periods of inhibition and growth arrest are separated in time by one cell cycle.
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