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Ionically self-assembled carboxymethyl cellulose/surfactant complexes for antistatic paper coatings.

We show that ionically self-assembled polyelectrolyte/surfactant complexes allow a facile route to tailor the electrical surface resistance of paper sheets for antistatic dissipative regime. We use anionic polyelectrolyte carboxymethyl cellulose (CMC) where cationic alkyltrimethylammonium chloride surfactants (C(n)TAC) with the alkyl chain lengths n=12, 14 or 16 methyl units are ionically complexed by precipitation from aqueous solutions. Such alkyl chains are sufficiently long to allow self-assembly in solid films after solvent evaporation. Short chain lengths, e.g., n=8, did not lead to precipitation. Small angle X-ray scattering indicates cylindrical self-assembly in bulk samples. Upon exposing bulk samples under humidity of 50% RH for 18 h, conductivity of ca. 10(-5) S/cm at room temperature is achieved based on AC-impedance analysis. Flexographic printing and spray coating were selected to conceptually test the feasibility as paper coatings and surface sheet resistances of ca. 10(9) Omega are reached. The results indicate that self-assembled polyelectrolyte/surfactant complexes can allow sufficient conductivity levels for antistatic paper coatings potentially due to protonic conductivity and suggest to develop processes and materials for realistic applications.

Journal Article↗

Effects of ozonation process on lignin-derived compounds in pulp and paper mill effluents.

The effect of ozonation process on pulp and paper mill effluents was investigated. The objectives were to: (1) identify various compounds in wastewater from a pulp and paper mill, (2) evaluate decolorization and organic removal efficiency by conventional bubble reactor and (3) evaluate the biodegradability at various progressive stages of ozonation. The qualitative GC/MS analyses were performed before and after the biological treatment and ozonation process. Two groups of compounds were observed in this wastewater: lignin-derived compounds and aliphatic compounds used in the pulp and paper production process (i.e. n-alkanes, fatty alcohols, fatty acid and ester). Treatment efficiency was measured by decolorization and TOC removal rates. Additionally, the utilization coefficient (k) and BOD/COD ratio were determined to observe the biodegradability of ozonized effluents. The results indicated that after 45 min, the ozonation of effluents yielded almost colorless effluent with over 90% decolorization efficiency and with corresponding ozone capacity rate of 20.0 mg O(3)L(-1). This decolorization was not always accompanied by the mineralization of the organic matters therefore ozonation was not related to TOC removal rates. The BOD/COD ratio increased from 0.10 to a maximum value of 0.32 with ozone flow rate (O/F) of 4.0 L min(-1). It was confirmed by the utilization coefficient as first order BOD equation, the magnitude k value increased from 0.21 day(-1) to maximum value of 0.47 day(-1) as the ozonation time was raised to 60 min with O/F 4.0 L min(-1).

Color↗

Commentary: the National Workshop to Develop the Chiropractic Research Agenda: 10 years on, a new set of white papers.

This commentary reports on the advances that have occurred over the 10-year period since the first National Workshop to Develop the Chiropractic Research Agenda was held and introduces the second set of white papers that were produced as a result of the 10th annual Research Agenda Conference. Four working groups were convened to update the original 5 white papers that represented the most significant results from the first workshop in 1996. Each group was to review the first report, examine the action steps and recommendations that were published in each report to see how much had been completed in the past decade, and develop new action steps and recommendations for the future. Four new articles were developed, each updating and adding significant amounts of new research to the original versions. New action steps and recommendations will help move the profession forward into the future. Chiropractic scientists have worked diligently over the past decade to address the recommendations noted in the first set of white papers. Despite significant advances in knowledge and scientific capacity, the chiropractic profession is still confronted with a large number of research challenges.

Chiropractic↗

Monitoring degradation in paper: non-invasive analysis by unilateral NMR. Part II.

High quality paper samples have been oxidized with a specific oxidant to reproduce one of the possible causes of the aging of paper. All samples have been characterized by 13C CP-MAS NMR spectroscopy. The artificial aging of paper has been monitored using a standard NMR relaxometer and the results have been compared with the corresponding data obtained using an unilateral NMR relaxometer. Experimental values obtained with both techniques are in agreement, demonstrating that unilateral NMR relaxometric measurements constitute a suitable non-invasive method for assessing the degradation process of cellulose-based materials. The sensitivity of the non-invasive NMR method allows the detection of degradation even at a very early stage. Effects due to the sample volume and to the penetration depth have been investigated.

Journal Article↗

Most cited papers in Toxicon.

Citation of a published work is one of the parameters considered in the analysis of relevance and importance of scientific contributions. In 2002, for the first time the Impact Factor of Toxicon has risen above 2.0, placing it at the 17th position among 76 journals in the 'toxicology' field. The aim of this article was to identify the most cited articles in Toxicon, that have contributed to the steady increase of its Impact Factor. The number of citations, complete reference and type of all documents appearing in Toxicon in the period 1963-2003 were retrieved from the ISI Web-of-Science homepage. The documents retrieved were sorted by the number of citations received. A 'citation index', defined as the number of citations divided by the number of years since publication, was calculated for each document. It was clearly seen that reviews in Toxicon received 4.4-fold more citations than articles. Unexpectedly, it was found that recent papers were proportionally more cited than old ones. A decrease in the proportion of papers dealing on 'snake*' through out the period and the broadened range of subjects of the most cited papers recently published in Toxicon reflects an increased 'visibility' in other fields of toxinology. Research on plant toxins gained its own space in Toxicon with newer publications showing high citation indexes. It can be postulated that these facts helped to increase Toxicon's Impact Factor from 1.248 in 1999 to 2.003 in 2002. With the increased number of issues in Toxicon as well as publications of subject-dedicated volumes containing mostly reviews, the Impact Factor of Toxicon is expected to keep rising in the near future.

Bibliometrics↗

Litmus paper helps detect potential pancreatoenterostomy leakage.

BACKGROUND: Leakage of pancreatoenterostomy remains as a serious and fatal complication after pancreatectomy. Several risk factors have been reported, ie, normal pancreatic parenchyma, small pancreatic duct, a large amount of intraoperative blood loss, management of the cut surface of the pancreas, and the presence of preoperative jaundice. Transected pancreatic ductules on the cut surface of the pancreas that are not drained into the main pancreatic duct after pancreatectomy are one of the risks. The pancreatic juice is alkaline and turns red litmus to blue. METHODS: In order to detect the transected pancreatic ductules on the cut surface of the pancreas, red litmus paper is applied to the cutting surface of the pancreas after stimulation of secretin. RESULTS: Nondrained, transected pancreatic ductules on the cut surface of the pancreas can be detected as blue spots on the red litmus paper. The corresponding areas to the blue spots can be transfixed with sutures to close the nondrained and transected pancreatic ductules. CONCLUSION: Litmus paper can be expected to detect pancreatoenterostomy leakage after pancreatectomy.

Humans↗

Home monitoring of 17 hydroxyprogesterone levels in congenitx127drenal hyperplasia with filter paper blood samples.

OBJECTIVE: The purpose of this study was to evaluate the usefulness of 17 hydroxyprogesterone (17OHP) determination in dried filter paper blood samples from patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency. It was hypothesized that these home samples would enhance patient treatment. STUDY DESIGN: Results of 17OHP determination in simultaneously collected venous and dried filter paper blood samples were compared to establish assay reliability. Thereafter, parents mailed dried filter paper blood samples collected before each hydrocortisone dose. RESULTS: The 17OHP levels in wet and dried blood samples correlated well (r = 0.98). Results did not change when stored for 2 weeks under various conditions. Blood sampling at different times of the day provided insights into the patterns of 17OHP secretion and identified times of inadequate adrenal suppression. Dose adjustments were then made considering the time of day when adrenal suppression was inadequate. CONCLUSION: Home monitoring of 17OHP is a reliable and practical approach for assessing adrenal steroid activity in patients with congenital adrenal hyperplasia. Considering the time of day of 17OHP elevations also facilitates hydrocortisone dosing adjustment.

17-alpha-Hydroxyprogesterone↗

The use of a non-lethal tool for evaluating toxicological hazard of organochlorine contaminants in Mediterranean cetaceans: new data 10 years after the first paper published in MPB.

In the Mediterranean Sea, top predators, and particularly cetacean odontocetes, accumulate high concentrations of organochlorine contaminants and toxic metals, incurring high toxicological risk. In this paper we investigate the use of the skin biopsies as a non-lethal tool for evaluating toxicological hazard of organochlorines in Mediterranean cetaceans, presenting new data 10 years after the paper published by Fossi and co-workers [Mar. Poll. Bull. 24 (9) (1992) 459] in which this new methodology was first presented. Some organochlorine compounds, now with worldwide distribution, are known as endocrine disrupting chemicals (EDCs). Here the unexplored hypothesis that Mediterranean cetaceans are potentially at risk due to organochlorines with endocrine disrupting capacity is investigated. High concentrations of DDT metabolites and PCB congeners (known as EDCs) were found in the different Mediterranean species (Stenella coeruleoalba, Delphinus delphis, Tursiops truncatus and Balaenoptera physalus). In this paper we also propose benzo(a)pyrene monooxygenase (BPMO) activity in marine mammal skin biopsies (non-lethal biomarker) as a potential indicator of exposure to organochlorines, with special reference to the compounds with endocrine disrupting capacity. A statistically significant correlation was found between BPMO activity and organochlorine levels (DDTs, pp(')DDT, op(')DDT, PCBs and PCB99) in skin biopsies of males of B. physalus. Moreover a statistical correlation was also found between BPMO activity and DDT levels in skin biopsies of the endangered Mediterranean population of D. delphis. These results suggest that BPMO induction may be an early sign of exposure to organochlorine EDCs and can be used for periodic monitoring of Mediterranean marine mammal toxicological status.

Animals↗

Non-identical neural mechanisms for two types of mental transformation: event-related potentials during mental rotation and mental paper folding.

Reaction times, accuracy and 128-channel event-related potentials (ERPs) were measured from 14 normal, right-handed subjects while they performed two different parity-judgment tasks that require transformations of mental images: a relatively simple task requiring a single transformation (mental letter rotation), and a more complex task involving a coordinated sequence of transformations (mental paper folding). Reaction times increased monotonically with larger angular displacements from the upright (for mental rotation) and with number of squares carried (for mental paper folding). Both the tasks resulted in amplitude modulation of an approximately 420-700 ms latency ERP component at parietal electrodes. Scalp topographies indicated that right parietal cortex was activated during mental rotation, but bilateral parietal regions were activated during mental paper folding. Our results support the notion of a right hemispheric superiority for tasks involving simple, single mental rotations, but indicate greater involvement of the left hemisphere when a more complex sequence of transformations are required. This task-dependent lability of hemispheric function may account for some of the inconsistent results reported by previous neuroimaging and electrophysiological studies.

Adult↗

Quantification of cough-related urine loss using the paper towel test.

OBJECTIVE: To develop and test a simple and rapid method for quantifying the urine loss resulting from three deep coughs using an ordinary brown paper towel. METHODS: A brown paper towel is held lightly against the perineum during three single coughs performed in the upright stance. The resulting wetted area was calculated using simple geometry; if desired, leakage volume can be interpolated from a calibration curve, which demonstrates the relationship between wetted area (cm2) and volume (mL) of leakage. Four bench tests of the method were performed. In addition, the test-retest reliability of the method was evaluated in eight elderly women with mild stress urinary incontinence, a sample size adequate to detect a 1-mL difference with 80% power. RESULTS: The smallest measurable quantity of fluid resulted in a wetted area of 0.04 cm2 (equivalent to 0.2 microl). For leakage volumes up to 6 mL, the regression showed that each 1 mL of fluid volume resulted in an average 25.4 cm2 increase in wetted area (coefficient of determination: 0.97). In eight women with stress incontinence 95% of within- and across-visit comparisons of urine loss were within 1 mL. CONCLUSION: The paper towel test is a simple and reliable measure providing immediate visual and quantitative feedback of cough-related urine loss typical of mild-to-moderate stress urinary incontinence.

Aged↗

Storage of viruses on filter paper for genetic analysis.

The purpose of this study was to develop a method to store viruses on filter paper without the need for special conditions for future use of the genetic material. Two non-enveloped viruses were used as models. Infectious bursal disease virus (IBDV), a double-stranded RNA virus that infects chickens, belongs to the Birnaviridae family. Hemorrhagic enteritis virus (HEV), with double-stranded DNA, belongs to the Adenoviridae family. Three different solutions were found suitable for loading the virus. The viruses were stored at room temperature or at 37 degrees C for periods of 5-30 days. Direct reverse transcription-polymerase chain reaction (RT-PCR) (without previous extraction of the RNA) was carried out on filter paper loaded with IBDV, and fragments of the expected size were detected. HEV DNA was extracted from filter paper loaded with purified virus or crude tissue. PCR fragments were found to be of similar intensity to those of control virus that was kept in a tube at -20 degrees C. This method permits the storage and transport of viruses from the field or from clinics to a regional laboratory or any laboratory elsewhere, without the need for prior treatment or special environmental conditions.

Animals↗

Hypoxic hazards of traditional paper bag rebreathing in hyperventilating patients.

It is traditional practice to treat acute hyperventilation (thought to be due to anxiety) by having patients rebreathe into a brown paper bag. The author reports three cases in which this treatment, erroneously applied to patients who were hypoxemic or had myocardial ischemia, resulted in death. This clinical experience motivated a study of the effects of paper bag rebreathing in normal volunteers. Subjects deliberately hyperventilated to an average end-tidal CO2 concentration of 21.6 (SD, 3.2) mm Hg and then continued to hyperventilate into a no. 4 Kraft brown paper bag containing the calibrated sensors for a Hewlett-Packard 47210A capnograph and a Teledyne TED 60J digital oxygen monitor. Fourteen men and six women with an average age of 36 years (SD, 6.1) were tested. Results are reported as mm Hg. After 30 seconds of rebreathing, mean change in O2 from room air was -15.9 (SD, 4.6) and mean CO2 was 38.7 (SD, 6.2); at 60 seconds, -20.5 (6.0) and 40.2 (6.4); at 90 seconds -22 (6.8) and 40.5 (6.4); at 120 seconds -23.6 (6.8) and 40.7 (6.5); at 150 seconds -25.1 (1.2) and 41 (7.3); and at 180 seconds -26.6 (8.4) and 41.3 (7.5). A few subjects achieved CO2 levels as high as 50, but many never reached 40. The mean maximal drop in O2 was 26 (8.8); seven subjects had drops in oxygen of 26 mm Hg at three minutes, four had drops of 34 mm Hg, and one had a drop of 42 mm Hg.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Analysis of filter-paper-absorbed, finger-stick blood samples for chloroquine and its major metabolite using high-performance liquid chromatography with fluorescence detection.

Methodology has been developed to facilitate the collection, transport, and analysis of blood samples in studies of chloroquine absorption and metabolism. The method utilizes high-performance liquid chromatography (HPLC) with fluorescence detection to quantify chloroquine and its major metabolite, desethylchloroquine, in 100-microliters quantities of blood collected on filter paper. Detection limits are 5 ng/ml for both analytes. No loss of either analyte occurred from filter-paper-collected blood spots stored over a twelve-weeks' period at room temperature. Filter-paper-collected, finger-stick blood spots give values for each analyte comparable to corresponding determinations on venous, whole-blood samples. The HPLC mobile phase selected has general applicability to the separation of antimalarial drugs. The methodology permits effective assessment of chloroquine prophylaxis compliance and parasite drug resistance in remote, malaria-endemic regions.

Blood Specimen Collection↗

Guidelines for authors of books and papers on complementary medicine.

Writing about complementary medicine, whether intended for book or journal publication, has often suffered from three flaws: inadequate attention to the origin and nature of knowledge claims; careless use of problematic concepts such as 'holistic' or 'natural' and poor application of basic principles of good scholarship. In this paper I present guidelines to promote better writing. With respect to knowledge claims, authors need to be explicit about the origin of the claim; that is, the reasons why they believe it to be true. Many books and papers on complementary medicine are flawed because their authors avoided explaining why they have made particular claims. Claims can be justified by using personal experience or by quoting scientific research. When using personal experience, authors need to: describe the practitioners concerned; use generalities about practitioners with care and be wary when referring to 'classical' or 'traditional' practitioners. When quoting scientific research, authors should: cite references and use these sparingly and specifically; avoid 'secondary sourcing', reliance on abstracts and the referencing of authorities; use 'weasel words' ('may' or 'can') with extreme care; think carefully about causal inferences and take care with laboratory-based research. Many of the concepts found in books and papers on complementary medicine are used rather carelessly. Concepts such as holism or 'natural' medicine, or even the concept of 'complementary' and 'conventional' medicine, are often taken to have simple and obvious meanings. Yet these concepts are extremely slippery and open to differing interpretations, especially if they are used with insufficient care. Authors should apply basic principles of good scholarship by displaying thoroughness and attention to detail; reflecting on the validity of each point made; reflecting on the limitations of their arguments and maintaining a level of disinterestedness. However, authors should avoid trying to sound academic for the sake of it: the use of long words, obscure jargon and dense and lengthy prose does not make a work scholarly.

Authorship↗

Removal of 125I from radioactive experimental waste with an anion exchange paper membrane.

The behavior of radioactive iodide and chloride ions through an anion exchange paper membrane to remove 125I from radioactive experimental waste has been studied with nonequilibrium thermodynamic analyses. Anion exchange paper membrane was found to be electroconductively more permeable to iodide ion than to chloride ion. The iodide ion bound more strongly to the anion exchange site within a membrane phase than the chloride ion by more than twice. The results suggested that an anion exchange paper membrane was appropriate for the filtration removal system.

Filtration↗

Degradation of historical paper: nondestructive analysis by the NMR-MOUSE.

The NMR-MOUSE is a mobile sensor for single-sided NMR inspection of organic materials which takes advantage of the principles of magnetic resonance and inside-out-NMR. Historical books dating from the 17th century were measured at different points by positioning the NMR-MOUSE on the paper. Different degrees of paper degradation can be discriminated from the regularized inverse Laplace transform of the envelope of the acquired echo signals. For the first time the degradation of historical paper was characterized entirely nondestructively by NMR. As a contribution to current preservation efforts, NMR shows great promise for future use in damage assessment of historical documents.

Journal Article↗

Measuring IGF-I, IGFBP-2 and IGFBP-3 from dried blood spots on filter paper is not only practical but also reliable.

OBJECTIVE: The aim of this study is to adapt measurements of IGF-I, IGFBP-2 and IGFBP-3 to dried blood filter disk assays. METHODS: Measurements of the three analytes in serum samples and in the corresponding blood spotted onto filter paper were compared by applying standard radioimmunoassays. RESULTS: In paired experiments, the quantity of all antigens measured on dried filter spots showed an excellent correlation to that in serum (R>0.88) and in addition this correlation was independent of the whole blood hematocrit value. Recovery of IGF-I, IGFBP-2 and IGFBP-3 in experiments using recombinant standards mixed with whole blood was well correlated with the recovery of the plasma fraction on the filter paper. All of the blood spot assays showed a inter- and intra-assay variation of less than 10% and the blood spots were stable over a period of more than 5 months stored at -20 degrees C. CONCLUSIONS: Taken together, these data clearly demonstrate that such a filter paper assay is a reliable procedure to monitor changes of IGF-I, IGFBP-2 and IGFBP-3 content in blood. The obvious advantages of this methods concerning storage, handling and shipping of blood probes helps to solve the logistics of centralised measurements of these three analytes.

Adult↗

Identification of chlorinated dimethoxystilbene isomers and homologues in bleached paper products

We report here the identification of a novel class of compounds, the chlorinated dimethoxystilbenes (pinosylvins), in bleached paper products. Pinosylvins are naturally occurring compounds in wood that deter infections and predators. These compounds are being chlorinated during the pulp bleaching process. Two dichlorinated pinosylvins have previously been identified in bleached paper pulp, but we have identified other isomers and more highly chlorinated homologues in various bleached paper products. These compounds are present at concentrations on the order of hundreds of ppb. On the basis of the mass spectra of synthesized standards, we can distinguish the isomers in which the chlorines are located on the ethylene moiety from those in which the chlorines are located on the aromatic ring with the methoxy groups. In addition, we can predict the chlorine substitution patterns on both rings for these compounds using linear relationships between retention indexes and calculated dipole moments. The toxicity of these compounds is not known; however, isomers related to the pesticide methoxychlor are proestrogenic.

Journal Article↗