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[Effect of antibiotics on the indices on nonspecific immunity].

Multiple (for 14 and 20 days) administrations of antibiotics, such as tetraolean, tetracycline and penicillin from the beginning of the animal immunization (rabbits and albino rats) with typhoid fever and candidosis vaccines inhibited activity of both the non-specific and the specific immunity.

Animals↗

[Gram-negative eubacteria isolated from the water, molluscs and algae of the Black Sea].

Microorganisms strains (384) have been isolated from water, algae and molluscs collected in the Karadag reserve and the village of Katsiveli (Black Sea shore of the Crimea); 81 of the above strains are gram-negative oxidase-positive rods which require sodium ions for their growth. A group of nonfermenting mobile bacteria deprived of arginine dihydrolase have been distinguished among the latter; as to their physiological and biochemical properties and sensitivity to some antibiotics these bacteria were referred to Alteromonas, Marinomonas, Pseudoalteromonas genera.

Animals↗

[Epidemiological mechanism for the formation of drug-resistant bacterial populations].

The concept on the epidemiological mechanism of formation of drug-resistant bacterial populations was substantiated. Investigations showed the epidemiological mechanism of formation of the drug-resistant populations of staphylococci in the purulent-inflammatory foci to be represented in 81.4 per cent of the patients by superinfection with resistant microbes. The latter group of the patients could be divided into two subgroups: in one of the subgroups (34.9 per cent) a reduction of sensitivity in the initial staphylococci was seen in the presence of donor bacteria which later either remained in the focus or were eliminated. In this case it could be supposed that there occurred a preliminary infection with the resistant staphylococci or with the transducing bacteriophages.

Anti-Bacterial Agents↗

[Complications from antibiotic therapy].

Analysis of 302 side effects of antibiotic theraphy is presented. The side effects were studied comparatively as dependent on the antibiotic group. Dependence of the toxic and toxicoallergic reactions to the antibiotics on the antibiotic blood levels were noted. Previous sensitization resulted in more frequent and earlier side effects. The analysis and clinical observations showed that antibiotic therapy should take into account the results of the laboratory tests, i.e. examination of the kidney functional state, antibiotic levels in the blood and urine, tolerance of the drug by the patient.

Acute Disease↗

[Change in the plasmocytic reaction of immunized animals during the use of antibiotics].

The effect of tetracycline and tetraolean on the shifts in the plasma-cell elements was studied experimentally on male albino rats of Wister line and rabbits immunized with foreign erythrocytes and typhoid fever vaccine respectively. It was noted that prolonged use of the antibiotics for 10 to 12 days inhibited proliferation of the plasmic cells, the inhibitory effect of tetracycline being more pronounced. At the same time an inhibitory effect of the antibiotics on the antibody formation in the animals was found in the experiments.

Animals↗

[Pseudomonas aeruginosa--the causative agent of infection in birds].

Pseudomonas aeruginosa was isolated from the viscera of diseased and dead birds (young and adult chickens) as well as from 9 poultry houses on seven farms. Its typing was performed on the basis of the blue-green coloration of the cultures, their hemolytic activity, the pleasant odour of lime-tree, the growth in culturing at 42 degrees C, the presence of the pyocianin pigment, and the positive results of the cytochromoxidase test after Gaby and Hadley and the biochemical test after Kovacs. The pathogenicity of the agent was demonstrated through the experimental parenteral infection of chicks, albino mice, and guinea pigs. Pseudomonas aeruginosa cultures showed weak sensitivity and good resistance to the various drugs tested. Most active proved streptomycin, kanamycin, and spectam.

Ampicillin↗