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PubMedDate not supplied

Using film dressings.

Film dressings were one of the first modern wound-dressing products. They are extremely flexible, transparent and adhesive. They have no capacity to absorb fluid but are able to 'breathe off' small amounts of fluid by a process known as moisture vapour transpiration (MVT). The rate of MVT varies between brands but is, at best, minimal. This means that such dressings are not suitable for wounds that produce anything more than a minimal amount of exudate. Film dressings should not be used interchangeably with film products designed for intravenous cannula retention. Intravenous cannula dressings are designed to keep the cannula site dry and have a much higher MVT rate, whereas film dressings are designed to keep the wound moist.

Humans↗
PubMed1990

Comparison of a hydrocolloid dressing and silver sulfadiazine cream in the outpatient management of second-degree burns.

The purpose of this prospective randomized study was to evaluate the use of an occlusive hydrocolloid dressing (Duoderm hydroactive, Squibb) and silver sulfadiazine (Silvadene, Marion) cream in the outpatient management of second-degree burns. The inclusion criteria consisted of burns less than 15% total body surface area that were evaluated within 24 hours of injury and did not require hospital admission. Fifty patients were randomly assigned after having been screened through a list of seven exclusion criteria. On initial evaluation the burns were photographed and screened for causative agent, location, size, depth, tetanus status, and presence of associated burns and injuries. Patients were seen in followup at least biweekly and evaluated for wound bed healing, wound margin healing, pain, number of dressing changes between visits, and ease of dressing application and removal. On final evaluation the burns were photographed and inspected for appearance of the healed burn, repigmentation, wound contraction, approximate time for dressing change, patient compliance, limitation of activity, overall impression of the treatment, and number of days for complete healing. Results were compared using a two-tailed t-test with p less than 0.01. Both groups were statistically similar in age, sex, and size. Duoderm-treated burns had statistically significantly better wound healing, repigmentation, less pain, fewer dressing changes, less time for dressing changes, and less cost. Duoderm-treated patients had statistically significantly less limitation of activity, better patient compliance, greater patient comfort, better overall acceptance, and felt the treatment was more aesthetically pleasing. The results reveal that the Duoderm Hydroactive dressings are superior to Silvadene cream in the outpatient management of second-degree burns.

Adolescent↗
PubMed1988

[Temporary skin replacement with lyophilized swine skin and foam substances--comparative experimental studies].

Using the skin replacement materials Corethium 2, Coldex, Epigard and SYSpur-derm, both fresh wound and wounds up to 6 days old were covered in rats. The histological work-up 1-7 days later showed material-dependent differences in the wound reaction. Under Corethium 2, a heavy layer of wound exudate formed on the first day both on fresh and granulating wound surfaces. Beneath this layer granulation tissue formed that was of regular thickness and well vascularized, filling the defect. Reepithelialization of the wound surface was not hindered by the material. In contrast, a strong connection was established between the wound base and the covering material when using the three foam substances Coldex, Epigard and SYSpur-derm, through the formation of granulation tissue. This process was dependent on the age of the wound. Thickening of the granulation tissue under the covering material was suppressed by the foam substances. Reepithelialization of the surface of the wound was disturbed by the growth of granulation tissue. The netlike structure of Epigard and the properties of the cover layer (fluid-resistant and protective against bacteria) make it possible for the granulation tissue to infiltrate evenly in the whole area of the wound covering and permit growth within the material right up to the surface. In addition to granulation tissue, epithelium also grows into the foam and spreads evenly. Epigard is suitable for long-term covering of large wounds. SYSpur-derm has a different fine structure than Epigard, which hinders the growth of granulation tissue, so that there are only cone-shaped connections between the wound base and the covering material. Rapid desiccation of the wound exudate cannot be prevented. Leukocytes and granulation tissue cannot spread in the foam. With SYSpur-derm an intermediate layer of wound exudate was observed more frequently than with Epigard. SYSpur-derm should be changed regularly in order to remove the detritus and exsudate from the wound. In comparison with polyurethane foam material the polyvinyl-alcohol foam (Coldex) was more complicated to handle, did not adapt as well to the wound, and dried up within a few hours. Between the base of the wound and Coldex, an intermediate layer often formed and, because of the rapid drying-out process, there was appreciably less infiltration with leukocytes and granulation tissue than with SYSpur-derm. With Coldex, as a rule the granulation tissue was more generously vascularized than in the other three materials.

Animals↗
PubMed1990

Cultured epidermal grafts in the treatment of leg ulcers.

Cultured epidermal grafts offer a major advance in the treatment of burns and other disabling skin wounds in which there are few other available treatments. Cultured allografts offer immediate availability, obviating skin biopsies. Theoretically, they could be grown in advance, cryopreserved, and stored in skin banks. They provide rapid coverage of wounds and produce prompt relief of pain and healing that continues for many weeks after the graft has been applied. Their mechanism of action has not been elucidated, but it seems likely that the allografted cells do not survive permanently and are gradually replaced by host epithelial cells. Release of growth factors by cultured allografts may contribute significantly to their wound healing properties. Whatever their mechanism of action, they promote rapid epithelialization at least in small chronic wounds. Especially for the elderly patient with nonhealing ulcers, they offer an alternative treatment option that is simple, painless, and noninvasive.

Biological Dressings↗
PubMed1977

[Effect of the external use of triamcinolone acetonide under foil occlussive dressings on the plasma cortisol level and on the diurnal rhythm of plasma cortisol].

Plasma cortisole concentration was measured in 44 patients with chronic dermatitis before, during, and after occlusive treatment with corticosteroid-containing ointment (triamcinolone-acetonide). In all patients plasma cortisole concentration decreased (p less than 0.001) and the day-night-rhythm disappeared. Five patients in whom less than 20% of the body-surface was treated, showed the same but less significant changes in the plasma cortisole concentration. In some patients the plasma coritsole concentrations increased three days after therapy, and their day-night-rhythm returned. This "systemic effect" of topical treatment with triamcinolone-acetonide is not the reason for the therpeutic efficacy, but rather the local concentration of steroids in the skin.

Administration, Topical↗