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At least 883 records · Page 49Linked to original sources
PubMedDate not supplied

[Effect of hormonal preparations on lysosome enzyme activity in rat tissues].

Experiments on white male rats were made to study and compare the action of hormonal drugs (testosterone propionate, retabolil and chorionic gonadotropin) on lysosomal enzymes of different tissues. There were differences in the changes in the activity of acid phosphatase, ribonuclease, cathepsins and beta-galactosidase after a single administration of testosterone and after a course of drug treatment. Retabolil and chorionic gonadotropin acted on lysosomal enzymes of spermatic vesicles similarly to testosterone given in a single dose. As far as the activity of liver cathepsins and beta-galactosidase is concerned retabolil was found to produce an opposite effect as compared to that of testosterone.

Anabolic Agents↗
PubMed1981

Biochemical modulation of the submandibular salivary gland of castrated male mice treated with anabolic steroids.

The possibility that 19-nortestosterone decanoate, an anabolic steroid which has no androgenic effect in mice, may promote the recovery of certain biochemical parameters of the submandibular gland of castrated mice had been studied. It was demonstrated that protein, RNA and sialic acid concentrations, as well as, protease, acid phosphatase and succinate dehydrogenase activities were found to be similar to control values in the castrated mice treated with 19-nortestosterone decanoate (anabolic steroid) or testosterone propionale. The effects on seminal vesicle and levator ani muscle were also considered. The interaction between 19-nortestosterone decanoale and androgen-binding receptors in the submandibular gland is discussed.

Animals↗
PubMedDate not supplied

[Cytochemical study of peroxidase activity and the peroxidase-endogenous hydrogen peroxide system in the peripheral blood neutrophils of mice exposed to prodigiozan and retabolil].

The paper concerns changes in the activity of some enzymes of azurophil granules of mouse neutrophils under a single administration of the bacterial polysaccharide prodigiosan and the synthetic anabolic hormone retabolil. Prodigiosan increases 1.4-fold the activity of the peroxidase-hydrogen peroxide system in azurophil granules of intact mice. In mice with leukopenia, prodigiosan normalizes the leukocyte count after 24 hours. At the same time there is an increase in the activity of peroxidase. It is assumed that under the effect of the same drug the cells of the animals in different physiological conditions may show an activation of the different components of antimicrobial defence. Retabolil raises the activity of peroxidase 96 hours after the first administration. Following 192 hours the activity reduces to normal and remains unchanged after the second drug administration.

Anabolic Agents↗