[Innervation and development of collagen fibers].
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Collagen↗
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Results for “Musculoskeletal Development”
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[Results of observations on the stimulation of the longitudinal bone growth].
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Bone Development↗
[Development defects of the skeleton].
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Bone Diseases↗
[Muscle insertion and bone growth; its significance in functional orthodontics].
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Bone Development↗
[Scintigraphy in preparation for revision alloplasty of the hip joint].
The author presents an account of the development of scintigraphic methods in the detection of inflammatory processes of the musculoskeletal system. The original method used in vitro 111In labelled separated leucocytes. It was improved by the possibility to label leucocytes by means of HMPAO 99mTc. In vivo leucocytes can be labelled by means of monoclonal antibodies. Nanocolloid offers similar possibilities as regards use and gives a good yield. Its use is simple and the preparation is available. Scintigraphy with nanocolloid must be considered nowadays the first scintigraphic method used when an inflammatory process is suspected, in particular of the extremities. Scintigraphy with nanocolloid can differentiate in planned revision alloplasty septic and aseptic loosening. The mentioned finding can be used for planning, implementation and ensuring the operation. The author was able, in collaboration with the department of nuclear medicine, to test scintigraphy with nanocolloid in five patients with complains after alloplasty of obscure origin. Patients' data are listed in table a and two cases are discussed in more details.
Aged↗
Future directions in magnetic resonance contrast media.
In June 1988 Gd DTPA became the first MR contrast agent to be approved for clinical use in adult patients in the United States. Initial approval was given for its use in imaging of the head. One year later approval was extended to include spine studies. This was soon followed by approval for use in children aged 2 years and older. Research is continuing to expand the applications of Gd DTPA in MR imaging of the musculoskeletal system, abdomen, and in MR angiography. Research is ongoing in the development of new agents, attempting to reduce toxicity, permit increased doses, or target specific organs. Gd DOTA has been in clinical use in Europe for approximately 1 year. Two neutral (nonionic) agents, Gd HP-DO3A and Gd DTPA-BMA, have just completed phase III clinical trials. Mn DPDP and AMI-25 are two targeted compounds that have entered clinical trials. Formulations intended for opacification of the gastrointestinal tract, with both Gd DTPA and magnetic particles, have been evaluated in Europe and in the United States.
Contrast Media↗
[Water-electrolyte balance and functional state of the kidneys in cosmonauts after a 185-day space flight].
Fluid-electrolyte metabolism and renal function of the crewmembers of the 185-day space flight were examined. Various changes in fluid-electrolyte metabolism and its regulation were seen in the Commander and Flight-Engineer. As most other crewmembers who performed similar flights, Cr showed fluid and sodium retention, whereas FE displayed higher than preflight sodium excretion in the urine. These differences were associated with individual variations of regional hemodynamics which modified the renin-angiotensin-aldosterone system in a different manner. Postflight both crewmembers showed a higher excretion of bivalent ions. The higher excretion of calcium was accompanied by a lower concentration of total and ionized calcium in the serum as well as by a lower concentration of PTH and calcitonin. The loading KC1 test made it possible to assess variations in potassium metabolism that occurred during flight. They included the inability of tissues to retain potassium due to atrophic processes which developed in the weightless state and due to the unloading of the musculoskeletal system.
Adaptation, Physiological↗
Promoting normalcy in chronically ill children.
Chronic orthopaedic conditions or orthopaedic conditions associated with other chronic conditions affect an estimated 150,000 children in the United States. The ultimate cost in human and financial resources depends upon the success of habilitation efforts throughout childhood. This article identifies major areas of concern to the continuing care of the child and family who must cope with chronic problems and proposes nursing approaches to resolve them.
Activities of Daily Living↗
Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine.
OBJECTIVE: To examine bone development in children and adolescents who have uncomplicated idiopathic epilepsy and had received monotherapy with carbamazepine or valproic acid for at least 1 year. METHODS: Thirty-nine patients from 6 to 19 years of age (18 girls) were studied. Total bone mineral content (BMC) and trabecular volumetric bone mineral density were measured at the distal radius using peripheral quantitative computed tomography. Maximum isometric grip force was determined with a standard dynamometer. Alkaline phosphatase activity and deoxypyridinoline (a marker of bone resorption) were assessed in serum and urine, respectively. RESULTS: Trabecular volumetric bone mineral density was significantly decreased in the entire group (z score mean +/- standard deviation: -0.62 +/- 1.04) and in the subgroup using valproic acid (-0.75 +/- 1.18). In the carbamazepine subgroup, there was a similar but nonsignificant trend (-0.50 +/- 0.90). Total BMC and isometric maximum grip force were normal in the entire study population (0.10 +/- 1.22) and in the 2 subgroups. The relationship between BMC and grip force was similar between patients and healthy participants. Urinary levels of deoxypyridinoline were significantly elevated above normal in the whole study population (1.35 +/- 2.00) and in both the valproic acid and the carbamazepine subgroups. CONCLUSIONS: Bone turnover can be increased, but bone mass is adequate in children and adolescents who have uncomplicated idiopathic epilepsy and who receive monotherapy with carbamazepine or valproic acid.
Adolescent↗
The role of ultrasound in the diagnosis and management of psoriatic arthritis.
Psoriatic arthritis (PsA) presents many diagnostic, management and research challenges for rheumatologists who wish to obtain early diagnosis, differentiate synovitis and enthesitis, monitor disease activity accurately and objectively, prevent the development of structural damage, deliver local therapy accurately, and obtain PsA tissue for research purposes. Musculoskeletal ultrasound (MSUS) is widely used by European rheumatologists in their clinical practice to meet these challenges and has the potential to become the rheumatologist's stethoscope in Europe and North America. This paper examines the evidence that MSUS can improve clinical evaluation of patients with PsA for synovitis and enthesitis, that MSUS is more sensitive than plain radiography in detecting structural damage in joints, that MSUS can improve the success of joint aspiration and guide biopsy of PsA tissues. Recent exciting developments in the management of PsA are detailed including the role of power Doppler in the diagnosis of enthesitis in PsA, the role of MSUS in objective monitoring of disease activity, the evaluation of MSUS in the diagnosis of sacroiliitis, and the use of MSUS to guide therapeutic injection of the sacroiliac joints.
Arthritis↗
The use of participatory action research and ergonomics in the prevention of work-related musculoskeletal disorders in the newspaper industry.
The newspaper industry is one of many in which employees are reported to be at risk for work-related musculoskeletal disorders of the upper extremities and low back. The purpose of this 18-month demonstration project was to assess the usefulness of a participatory ergonomics process as a strategy to reduce the risk factors associated with musculoskeletal disorders at a metropolitan newspaper company. The company involved had 455 employees and a daily circulation of 75,200. Employees from both office and production areas participated. The participatory action research approach utilized required investigators to work collaboratively with the study population. Using a five-step continuous improvement process, the ergonomics committee identified and evaluated jobs having ergonomic risk factors. This was followed by the development, implementation, and evaluations of interventions aimed at reducing risk factor exposure. The committee's productivity and participant feedback were used as measures of the committee's effectiveness. During the project period, interventions were implemented in 11 of 12 targeted departments. Participant ratings of effectiveness for different aspects of the ergonomics process were generally favorable. The mean and median cost for ergonomic interventions were $376 and $25, respectively. This project demonstrated that participatory action research could be used to develop and implement ergonomic solutions that reduce the risk factors associated with work-related musculoskeletal disorders.
Adult↗
Twenty-five years of clinical experience with bone banking in Israel.
BACKGROUND: Bone banking and the clinical use of banked tissue are the most common forms of allopreservation and transplantation in modern medicine. OBJECTIVES: This article reviews 25 years (1973-98) of experience in bone banking in Israel. METHODS: A nationwide survey on the clinical application of the banked musculoskeletal tissues during 1996 was conducted by means of a written questionnaire sent to all orthopedic departments in Israel. RESULTS: The response rate to the questionnaire was 84%. A total of 257 cases were allocated bone allografts: the majority comprised 225 spongy bones, 26 were massive bone allografts and 6 were soft tissue allografts. CONCLUSION: Improvement of quality control and quality assurance of the banked tissues, together with development of skills in the use of osteoinductive and osteoconductive materials, cast the future of musculoskeletal tissue banking.
Bone Banks↗
ICF Core Set for patients with musculoskeletal conditions in early post-acute rehabilitation facilities.
PURPOSE: The aim of this consensus process was to decide on a first version of the ICF Core Set for patients with musculoskeletal conditions in early post-acute rehabilitation facilities. METHODS: The ICF Core Set development involved a formal decision-making and consensus process integrating evidence gathered from preliminary studies including focus groups of health professionals, a systematic review of the literature and empiric data collection from patients. RESULTS: Fifteen experts selected a total of 70 second-level categories. The largest number of categories was selected from the ICF component Body Functions (23 categories or 33%). Seven (10%) of the categories were selected from the component Body Structures, 22 (31%) from the component Activities and Participation, and 18 (26%) from the component Environmental Factors. CONCLUSION: The Post-acute ICF Core Set for patients with musculoskeletal conditions is a clinical framework to comprehensively assess patients in early post-acute rehabilitation facilities, particularly in an interdisciplinary setting. This first ICF Core Set will be further tested through empiric studies in German-speaking countries and internationally.
Activities of Daily Living↗
The effects of external beam irradiation on the growth of flat bones in children: modeling a dose-volume effect.
PURPOSE: To model the effects of external beam irradiation on the developing flat bones of pediatric patients undergoing radiation therapy (RT) for tumors involving the musculoskeletal system. METHODS AND MATERIALS: Patients with image-guided RT plans including areas adjacent to facial or pelvic flat bones underwent retrospective contouring of nontumor involved flat bones ipsilateral and contralateral to the treatment side. Radiation dose-volume information and bone volume data (initial and the most recent follow-up) were analyzed in 15 paired flat bones from 10 patients (ages 1.0-17.0 years). The models to predict bone growth after completion of RT (v(post)) were based on initial bone volume (v(pre)), the patient's age, time to follow-up (t), and the dose-volume parameter (v(Int35+)). RESULTS: We developed a dose effects model as follows: Log (v(post) / v(pre)) = beta(time)t + beta(age group)t + beta(dose)t v(Int35). The dose-volume parameter v(Int35) predicted significantly for alterations in growth in younger patients, but not for older patients. The predictability of the fitted model for relative change in bone growth improved in the younger age group with the addition of the dose-volume term v(Int35) (correlation coefficient of r = 0.5510 to r = 0.6760 with the addition v(Int35)). CONCLUSIONS: Our model accurately predicted flat bone growth and is notable for the inclusion of radiation dose-volume information, which is now available in the image-guided RT era. Further refinement of this model in a prospective patient population is underway.
Adolescent↗
The alchemy of tendon repair: a primer for the (S)mad scientist.
During vertebrate development, mesenchymal progenitors capable of forming bone, cartilage, muscle, fat, or tendon arise from either neural crest or somitic mesoderm. Transcriptional programs that specify mesenchymal cell fates are initiated and modified by paracrine cues provided by TGF-beta superfamily members and mediated in part via the regulated assembly of Smad-containing multiprotein transcription factor complexes. In this issue of the JCI, Hoffmann and colleagues have identified that Smad8 activation drives tendon formation from C3H10T1/2 cells, a murine cell line that recapitulates many features of normal multipotent mesenchymal cells (see the related article beginning on page 940). Cells programmed to the tenocyte cell fate in vitro formed tenogenic grafts in vivo. These results add to the accumulating evidence that proliferating, multipotent mesenchymal progenitor cells can be programmed to yield multiple cell types--e.g., osteoblasts, myocytes, chondrocytes, and tenocytes--that may be useful in cell-based therapeutic approaches to musculoskeletal diseases.
Bone Development↗
Development and evaluation of a method for evaluating pediatric residents' knowledge and skill in performing physical examinations of the ankle and knee.
BACKGROUND: Pediatric residents need the knowledge and physical examination skills to evaluate common musculoskeletal injuries. The ankle and the knee are the 2 most common sites of musculoskeletal injury in young athletes. Methods for evaluating pediatric residents' knowledge and skills in examining the ankle and knee are needed. OBJECTIVES: 1) To describe the development of a method for evaluating pediatric residents' knowledge and skill in performing physical examinations of the ankle and knee, and 2) to report the reliability of this method. METHODS: A written test and a Clinical Skills Assessment Examination (CSAE) with a rating index were developed by the investigators to evaluate pediatric residents' knowledge and skills in examining the ankle and knee. Fifty-eight pediatric residents completed the written test and examined the ankle and knee of one standardized patient at the beginning of a required 1-month adolescent medicine rotation. Forty-eight residents repeated the evaluation at the end of the month. The investigators rated the residents' performance of the CSAE and then assessed interrater reliability using Cronbach's alpha. Test-retest correlation was calculated to assess the reliability of the written test. RESULTS: Test-retest correlation for the written test was 0.72, establishing its reliability. Interrater reliability for rating the CSAE of the ankle and knee was 0.98 and 0.90, respectively. CONCLUSION: Pediatric residents' knowledge and skills in examining the ankle and knee can be reliably evaluated using the written test and CSAE described in this article. These could be used to assess the effectiveness of current curricula in improving pediatric residents' knowledge and skill in evaluating ankle and knee complaints and to assist in the design of future curricula. musculoskeletal, evaluation methods, resident curriculum.
Adolescent Medicine↗
[Generalized tendomyopathy. I: Clinical aspects, follow-up and differential diagnosis].
Generalized tendomyopathy (GTM), or fibromyalgia, is a disorder characterized by diffuse pain in the musculoskeletal apparatus which usually begins at a single site, e.g., as low-back pain or cervical syndrome, and develops into generalized pain over months or years. It is accompanied by increased tenderness at characteristic tender points, although the pain threshold on the whole is reduced. In addition to the main symptoms (pain in the musculoskeletal system, tenderness at the tender points), autonomic and functional symptoms are almost invariably present and are often accompanied by pathological psychological findings such as neuroses and depression. To date, no reliable laboratory parameters or pathognomonic histological findings have been identified. The disorder affects primarily women, beginning around the age of 35 and reaching its peak during or after the menopause. It also affects young people and those over age 60, although it is much less common in these cases. Secondary forms are observed particularly in rheumatoid arthritis. The differential diagnosis must first distinguish primary GTM from the secondary forms. There must also be further differentiation between internal and psychiatric disorders and primary GTM. This can be achieved in many cases by careful clinical diagnosis, although a more complete examination is sometimes required.
Diagnosis, Differential↗
Musculoskeletal tissue banking in Singapore: 15 years of experience (1988-2003).
PURPOSE: To report 15 years' experience of musculoskeletal tissue banking by the National University Hospital Tissue Bank. METHODS: This study describes the development of Singapore's national bone bank since its establishment in 1988. The bone bank's protocol follows guidelines recommended by the American Association of Tissue Banks and the European Association of Tissue Banks using strict donor selection criteria. Informed consent is obtained from all potential donors for tissue procurement and laboratory tests. Detailed medical history, thorough clinical examination, and chart review is performed for consenting donors. Suitable donors are subjected to tests for hepatitis B, hepatitis C, syphilis, and culture/sensitivity test of tissue for aerobic and anaerobic organisms. For living donors, repeat testing for AIDS and hepatitis C is performed at least 180 days after procurement. Tissue procurement is performed under sterile conditions. Small tissues are procured using the 'sterile double jar technique' and long bones using the 'sterile triple wrap technique', both developed by the author. Deep-frozen bones are gamma irradiated at 25 kilograys. Morsellised bones are lyophilised and gamma irradiated. Meticulous preparation for grafts is performed during transplantation. Antibiotic prophylaxis is used for 2 weeks. RESULTS: The bank maintains a good quality control. In January 2003, it was accredited ISO 9001 status. Up to June 2003, it has procured 440 bones from 440 living donors and 1055 allografts from 63 deceased donors. 854 musculoskeletal transplantations have been performed using tissues processed by the bank. Complication rate encountered was only 2.2%. CONCLUSION: The tissue bank provides high-quality allografts for safe tissue transplantations.
Bone Transplantation↗