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PubMedDate not supplied

Lesions of rat infralimbic cortex enhance recovery and reinstatement of an appetitive Pavlovian response.

The prefrontal cortex (PFC) has a well-established role in the inhibition of inappropriate responding, and evidence suggests that the infralimbic (IL) region of the rat medial PFC (MPFC) may be involved in some aspects of extinction of conditioned fear. MPFC lesions including, but not those sparing the IL cortex increase spontaneous recovery of extinguished conditioned fear when tested 24 h after an initial extinction session. The current experiment extended these findings by use of appetitive rather than aversive conditioning. Ten IL-lesioned and 11 sham-operated rats were trained on a Pavlovian task in which a conditioned stimulus (CS) was followed by food pellets (the unconditioned stimulus or US). IL lesions had no effect on extinction of the conditioned response (CR, magazine entries) during the first extinction session. However, the level of spontaneous recovery between the first extinction session and a second, 24 h later, was increased in IL-lesioned rats relative to sham animals. In contrast, evidence of savings measured between the extinction sessions did not differ between groups. Furthermore, reinstatement of the CR following unsignaled delivery of the US was also increased in IL-lesioned rats.

Animals↗
PubMedDate not supplied

Explanatory and illustrative visualization of special and general relativity.

This paper describes methods for explanatory and illustrative visualizations used to communicate aspects of Einstein's theories of special and general relativity, their geometric structure, and of the related fields of cosmology and astrophysics. Our illustrations target a general audience of laypersons interested in relativity. We discuss visualization strategies, motivated by physics education and the didactics of mathematics, and describe what kind of visualization methods have proven to be useful for different types of media, such as still images in popular science magazines, film contributions to TV shows, oral presentations, or interactive museum installations. Our primary approach is to adopt an egocentric point of view: The recipients of a visualization participate in a visually enriched thought experiment that allows them to experience or explore a relativistic scenario. In addition, we often combine egocentric visualizations with more abstract illustrations based on an outside view in order to provide several presentations of the same phenomenon. Although our visualization tools often build upon existing methods and implementations, the underlying techniques have been improved by several novel technical contributions like image-based special relativistic rendering on GPUs, special relativistic 4D ray tracing for accelerating scene objects, an extension of general relativistic ray tracing to manifolds described by multiple charts, GPU-based interactive visualization of gravitational light deflection, as well as planetary terrain rendering. The usefulness and effectiveness of our visualizations are demonstrated by reporting on experiences with, and feedback from, recipients of visualizations and collaborators.

Computer Graphics↗
PubMed2003

Popular media and 'excessive daytime sleepiness': a study of rhetorical authority in medical sociology.

Problem sleepiness is emerging as a medical problem in the US and Britain. Though an increasingly salient complaint, clinical medicine is only peripherally involved in the diagnosis and treatment of sleep troubles. Paramount in shaping public perceptions and experiences of sleep are the popular media. The apparent chasm between self-reported sleep troubles and the routine medical gaze is the point of departure for this inquiry. Aided by the idea of rhetorical authority, a case is made for the conspicuous influence of newspapers, magazines and the Internet in shaping a persuasive cultural directive to become conscious of soporific states and their possible deleterious consequences. Attending to this cultural directive, a growing number of people are self-diagnosing with a novel sleep disorder, excessive daytime sleepiness. The increasing significance of popular culture in the creation of medical troubles summons an alternative version of medical sociology. A limited case for this claim is made by revisiting two key ideas in this field: naming diseases and the classic distinction between illness and disease.

Attitude to Health↗
PubMed2004

CAPPS II: the foundation of aviation security?

A new computer system is being developed to classify U.S. air travelers by the degree of terrorist threat they might pose. Reports indicate that the system--called CAPPS II--would use large amounts of information about each passenger, perhaps including such personal details as his or her magazine-subscription behavior. We argue that what is publicly known about CAPPS II raises questions about how substantially the system would improve aviation security. We discuss conditions under which CAPPS II could yield safety benefits, but suggest that it might be more prudent to view the system as one component of future security arrangements rather than the centerpiece of these arrangements.

Accidents, Aviation↗
PubMed2004

Travel risks in a time of terror: judgments and choices.

Shortly after the 2002 terrorist attacks in Bali, readers of Conde Nast Traveler magazine were surveyed regarding their views on the risks of travel to various destinations. Their risk estimates were highest for Israel, and lowest for Canada. Estimates for the different destinations correlated positively with (1) one another, (2) concern over aspects of travel that can make one feel at risk (e.g., sticking out as an American), (3) worries about other travel problems (e.g., contracting an infectious disease), and (4) attitudes toward risk. Respondents' willingness to travel to a destination was predicted well by whether their estimate of its risk was above or below their general threshold for the acceptability of travel risks. Overall, the responses suggest orderly choices, based on highly uncertain judgments of risks. Worry played a significant role in these choices, even after controlling for cognitive considerations, thereby supporting the recently proposed "risk as feelings" hypothesis. Thus, even among people who have generally consistent and defensible beliefs, emotions may affect choices. These results emerged with people selected for their interest in and experience with the decision domain (travel), but challenged to incorporate a new concern (terror).

Journal Article↗
PubMed2005

Five-year trends in patterns of drug use among people who use stimulants in dance contexts in the United Kingdom.

AIMS: To describe and evaluate trends in the use of stimulant drugs over a 5-year period using an under-studied data collection method. DESIGN: Repeated-measures cross-sectional survey. SETTING AND PARTICIPANTS: Annual magazine-based survey targeting people who use stimulant drugs in dance contexts. MEASUREMENTS: Life-time use prevalence (ever used), age of first use, current use prevalence (any use within the last month) and extent of use within the last month (number of days used) for a range of stimulant drugs. Additional measures of quantity of ecstasy used were also collected. FINDINGS: Trends in life-time and current prevalence over time have been detected and comparisons made between different stimulant drugs. Evidence is obtained of broad stability in patterns of stimulant use in respect of age of first use and frequency of use among ongoing users. Despite an apparent reduction in the current prevalence of ecstasy use, the proportion of heavy users (usually >4 pills per session) has more than doubled between 1999 and 2003. CONCLUSIONS: This purposively sampled population study has yielded time trend data broadly consistent with other indicators, where they exist, and also has demonstrable potential to identify new drug trends. Further comparisons of purposive samples and randomly formed samples are needed.

Adolescent↗
PubMed2006

The prevalence of psychotic symptoms among methamphetamine users.

AIMS: To examine the prevalence of psychotic symptoms among regular methamphetamine users. DESIGN: Cross-sectional survey. SETTING: Participants were recruited from Sydney, Australia, through advertisements in free-press magazines, flyers and through word-of-mouth. PARTICIPANTS: Methamphetamine users (n = 309) who were aged 16 years or over and took the drug at least monthly during the past year. MEASUREMENTS: A structured face-to-face interview was used to assess drug use, demographics and symptoms of psychosis in the past year. Measures of psychosis included: (a) a psychosis screening instrument derived from the Composite International Diagnostic Interview; and (b) the Brief Psychiatric Rating Scale subscales of suspiciousness, unusual thought content, and hallucinations. Dependence on methamphetamine was measured using the Severity of Dependence Scale. FINDINGS: Thirteen per cent of participants screened positive for psychosis, and 23% had experienced a clinically significant symptom of suspiciousness, unusual thought content or hallucinations in the past year. Dependent methamphetamine users were three times more likely to have experienced psychotic symptoms than their non-dependent counterparts, even after adjusting for history of schizophrenia and other psychotic disorders. CONCLUSION: The prevalence of psychosis among the current sample of methamphetamine users was 11 times higher than among the general population in Australia. Dependent methamphetamine users are a particularly high-risk group for psychosis.

Adolescent↗
PubMed1989

Dietary manipulation in childhood atopic dermatitis.

The dietary habits of 73 children seen consecutively in a dermatology out-patient department were studied to ascertain the nature and frequency of dietary manipulation and to assess any potential hazards. Although most children had only mild flexural dermatitis, 71% had had significant alterations made to their diet before attendance at hospital. Almost all diets were unsupervised and only six children had seen a dietitian. Over half had been started on diets before any professional advice had been sought. Information on diet had come from media, books or magazines (51%), friends (32%), general practitioners (27%) and district nurses or health visitors (18%). The major dietary alterations included the exclusion of eggs, dairy products and food additives, and the use of soya and goat's milk. Under 10% of patients claimed benefit from these largely unsupervised diets. Harmful practices included the frequent use of unboiled, unpasteurized goat's milk, unmodified goat's milk in a baby of 4 months and the use of severely restricted diets. Three children (6%) in the diet group had been on diets which were considered by a hospital dietitian to be particularly dangerous. However, there was no evidence of growth retardation, failure to thrive or specific deficiency syndromes in the group we studied. Uncontrolled, unsupervised and often prolonged dietary alterations are commonplace in children with atopic dermatitis. This is a potentially serious health problem.

Adolescent↗
PubMed1992

Preferred sources of information on AIDS among high school students from selected schools in Zimbabwe.

Following various national HIV and AIDS awareness campaign activities under the auspices of the Ministries of Health and Education, Zimbabwe, an AIDS KABP survey was undertaken. The study sample comprised 478 high school students randomly selected and stratified to represent sex and Forms 1 through to 6. The study instrument was a 31-item questionnaire designed to assess the students' knowledge, attitudes, practices and sources of information in relation to HIV syndrome. This report reviews only that part of the study dealing with sources of information. Newspapers, television, radio and magazine were the most frequently cited sources of first information. Classmates were cited by 20% to over 30% of respondents as first sources of information. Authority figures like health workers, parents, teachers, the Church did not emerge as significant sources of first information. Doctors were identified as the most preferred source of information in future. Sources of first information were related to age, form level, sex and location of school attended. There were notable differences between boarding school respondents and day scholars. No regional differences were noted.

Acquired Immunodeficiency Syndrome↗
PubMed1992

A preliminary description of the United Kingdom community psychiatric nursing literature, 1960-1990.

Five hundred and two items about community psychiatric nursing have been located and classified. The data indicate a continuing rising trend in the number of publications on this subject. The majority of the literature is about the clinical role of the community psychiatric nurse (CPN) and is descriptive/analytical in nature. The second largest proportion is research, the third largest topic is management and administration and the fourth largest is CPN education. The amount of 'clinical' literature as a proportion of the whole has been in decline since the mid-1970s. The majority of papers cannot be classified by the specialism of community psychiatric nursing to which they relate, but a small and significant number have been written about the care of the elderly mentally ill. Overall, the practising CPNs have been the most prolific writers, followed by academic nurses and then nurse managers. Contributions from other professions are miniscule. Over recent years the contribution of nurse managers has declined, and that of academic nurses has risen. The contribution of practising CPNs remains robust. Research publications also continue to rise, the majority being produced by academics, but large contributions are also being made by nurse managers and practising CPNs. In the early years nearly all publications of articles were in populist nursing magazines. In recent years the spread of journals in which items about community psychiatric nursing appear has widened considerably.

Bibliographies as Topic↗
PubMed1996

Information needs and sources of information for women with breast cancer: a follow-up study.

This paper reports a study which examined the specific information needs and sources of information for 105 women with breast cancer at two time points, the time of diagnosis and a mean of 21 months from diagnosis. At diagnosis the priority information needs concerned survival issues. Further from diagnosis survival issues were still a concern, but information about the risk to family members of getting breast cancer showed a significant increase in importance. Information about sexual attractiveness was ranked last at both the newly diagnosed and follow-up stages. Information sources at the time of diagnosis centred around the specialist breast care service, while further from diagnosis few professional or voluntary sector sources were utilized, with women receiving most of their information from media sources such as women's magazines. The relevance of these findings for nurses and other health care professionals is discussed.

Adult↗
PubMed2005

Gluten-free diet survey: are Americans with coeliac disease consuming recommended amounts of fibre, iron, calcium and grain foods?

OBJECTIVE: This survey was conducted to assess nutrient intakes and food consumption patterns of adults with coeliac disease who adhere to a strict gluten-free diet. DESIGN: Three-day estimated self-reported food records were used to assess daily intakes of calories, percent daily calories from carbohydrates, dietary fibre, iron, calcium and grain food servings. SUBJECTS: Volunteers for this survey were recruited through notices placed in coeliac disease support group newsletters, as well as a national magazine for persons with coeliac disease. Forty-seven volunteers met all criteria for participation and returned useable food records. RESULTS: Group mean daily intake of nutrients by gender: Males (n = 8): 2882 calories; 55% carbohydrate; 24.3 g dietary fibre; 14.7 mg iron; 1288.8 mg calcium; 6.6 grain food servings. Females (n = 39): 1900 calories; 52% carbohydrate; 20.2 g dietary fibre; 11.0 mg iron; 884.7 mg calcium; 4.6 grain food servings. Recommended amounts of fibre, iron and calcium were consumed by 46, 44 and 31% of women and 88, 100 and 63% of men, respectively. CONCLUSIONS: Nutrition therapy for coeliac disease has centred around food allowed/not allowed on a gluten-free diet. Emphasis also should be placed on the nutritional quality of the gluten-free diet, particularly as it concerns the iron, calcium and fibre consumption of women. The use of the estimated food record as the dietary survey method may have resulted in the under-reporting of energy intake. Due to the small sample size and possible bias of survey participants, the findings of this survey may not be representative of the larger coeliac community.

Adult↗
PubMed2005

Etiology of atopy in infancy: the KOALA Birth Cohort Study.

The aim of the KOALA Birth Cohort Study in the Netherlands is to identify factors that influence the clinical expression of atopic disease with a main focus on lifestyle (e.g., anthroposophy, vaccinations, antibiotics, dietary habits, breastfeeding and breast milk composition, intestinal microflora composition, infections during the first year of life, and gene-environment interaction). The recruitment of pregnant women started in October 2000. First, participants with 'conventional lifestyles' (n = 2343) were retrieved from an ongoing prospective cohort study (n = 7020) on pregnancy-related pelvic girdle pain. In addition, pregnant women (n = 491) with 'alternative lifestyles' with regard to child rearing practices, dietary habits (organic, vegetarian), vaccination schemes and/or use of antibiotics, were recruited through organic food shops, anthroposophic doctors and midwives, Steiner schools, and dedicated magazines. All participants were enrolled between 14 and 18 wk of gestation and completed an intake questionnaire on family history of atopy and infant care intentions. Documentation of other relevant variables started in the pregnant mother and covered the first and third trimester as well as early childhood by repeated questionnaires at 14-18, 30, and 34 wk of gestation and 3, 7, 12, and 24 months post-partum. A subgroup of participants, including both conventional and alternative lifestyles, was asked to consent to maternal blood sampling, breast milk and a faecal sample of the infant at 1 month post-partum, capillary blood at age 1 yr, venous blood and observation of manifestation of atopic dermatitis during home visits at the age of 2 yr (using the UK working party criteria and the severity scoring of atopic dermatitis index), and buccal swabs for DNA isolation from child-parent trios. From the start, ethical approval and informed consent procedures included gene-environment interaction studies. Follow-up at 3 and 7 months post-partum was completed with high response rates (respectively 90% and 88% in the conventional group, and 97% and 97% in the alternative group). The home visits at 2 yr of age will be completed in 2005. Preliminary results show that we have succeeded in recruiting a large population with various lifestyle choices with a fairly large contrast with regard to dietary habits (including organic foods, vegetarian diet), vaccination schemes and/or use of antibiotics. We have also been able to collect a large number of faecal samples (n = 1176) and capillary blood samples at age 1 yr (n = 956). Furthermore, a large proportion of the participants have consented with genetic studies. Mid 2006 we expect to report our first results on the relationship between the various exposures in early life and childhood atopy. An outline of the focus and design of the KOALA Birth Cohort Study is presented.

Anthroposophy↗
PubMedDate not supplied

Rejuvenation in the early 20th century.

The first theoretical reflections concerning the relation of hormone production with the ageing process stemmed from Charles Edouard Brown-Séquard (1817 1894). At the age of 72 years he experimented on himself with an injection of animal testicular extract. The Viennese physiologist Eugen Steinach (1861 1944) gained world-wide acknowledgement for his theory of 'autoplastic' treatment of ageing. He deduced that after vasoligation, an increased incretory hormonal production would ensue following the cessation of the secretory output of the gonads. The first operation was performed in 1918 and resulted in a vasectomy boom over the next two decades. The Russian Serge Voronoff (1866 1951), working in Paris, was one of the first to transplant testicular tissue from a monkey into a human reproductive gland in 1920. Five years later he had already performed this procedure on 300 patients and attracted patients from all over the world. In America early efforts of human testicular transplantation were performed by Frank Lydston and V.D. Lespinasse. Steinach's vasoligation was taken over by many American doctors, e.g., Harry Benjamin and Charles H. Chetwood. Among the patients who underwent a rejuvenation operation according to Steinach's method were Sigmund Freud (1856 1939) and the Irish poet and Nobel Prize winner William Butler Yeats (1865-1939). Two caricatures from the German magazine Simplicissimus published in 1927, confirm that the rejuvenation operations were constantly in the limelight of the printed media. From 1935 onwards rejuvenation operations gradually lost their appeal due to the introduction of artificial androgens.

Europe↗
PubMedDate not supplied

Investigations in pet birds (Agapornis spp.) fed different vitamin K contents in the diet.

In the past many discussions about possible toxic effects of vitamin K(3) fed to pet birds arose frequently, and were published also in magazines for pet bird fanciers, in the internet as well as in veterinary journals. Therefore, the aim of this study was an evaluation of effects of different dosages of vitamin K(3) on birds' health when given orally for a longer period. These investigations were carried out with adult lovebirds (Agapornis spp.) fed a pelleted diet with different levels of vitamin K(3) (menadione-sodium-bisulphite): control group 0 mg, group V1 20 mg and group V2 200 mg/kg diet dry matter. General condition and well being of the lovebirds were checked daily. Body weight gains as well as feed and water intakes were examined once a week. Every 2-month blood samples of each lovebird were collected and analysed. After a period of 6 and 10 months, respectively, four birds of each group were necropsied in order to carry out a pathological and histological examination. In general, the behaviour, feed and water intakes as well as quality of excreta were not influenced by ingestion of diets with different levels of vitamin K(3). All variations were in physiological ranges. Individuals of all groups showed positive body weight gains and an active reproduction status. However, the best body mass (BM) development and egg laying activity could be observed in lovebirds of group V2 with the highest vitamin K(3) supplementation. In the haemotogram some time-depending variations could be observed; however, a systematic influence of vitamin K(3) could not be determined in any group or at any time. All analysed biochemical values in plasma and the activities of enzymes were within normal ranges. Only few birds of every group showed aberrant histological findings, but none of these could be related to the vitamin K(3) intake. Moreover, no forced accumulation of vitamin K(3) in the liver depending on vitamin K(3) intake was found. This result suggests a rapid metabolism of the absorbed vitamin K(3). All in all, the application of pelleted diets with addition of 20 or 200 mg vitamin K(3)/kg diet over a period of several months did not affect pet birds' health. Given these results, any doubts about the compatibility of usual doses of vitamin K(3) in diets for lovebirds must be considered as absolutely groundless.

Administration, Oral↗
PubMed1998

Rural youth: HIV/STD knowledge levels and sources of information.

Though it is recognised that a sound knowledge of HIV/STD transmission is insufficient on its own to ensure that young people practise safer sex, knowledge of this sort is a necessary prerequisite to safe sex behaviours. Research on the HIV/STD knowledge levels of young people has shown that, while they have high levels of HIV knowledge, they generally have little idea about the transmission of other STDs. Moreover, most of this research has been conducted with more accessible youth in large urban centres. The research reported in this paper focused on HIV/STD knowledge levels, awareness of safe and unsafe sexual practices, and the information sources accessed by 1168 young people living in small rural towns in Queensland, Tasmania and Victoria. As with mainstream youth, the participants in this study had high levels of HIV knowledge and very low levels of knowledge about the transmission of other STDs, their names and symptoms. Practical knowledge of the safety of sexual practices was good, although a number of students confused high risk practices with high risk groups. Students mainly accessed informal information sources such as parents, peers and magazines and took little advantage of more formal sources even when they were available in their towns. There were few gender differences in levels of knowledge; however, girls accessed more information sources and knew more names of STDs. The implications of these findings are discussed in relation to young people developing critical attitudes towards more informal sources, and the better use of more formal sources.

Adolescent↗
PubMed1996

Gender differences in food-related concerns, beliefs and behaviours of north Queensland adolescents.

OBJECTIVE: To describe the beliefs, attitudes, behaviours and knowledge of North Queensland adolescents about food and nutrition. METHODOLOGY: A questionnaire surveyed 791 Year 8 students from private schools. RESULTS: More girls than boys felt guilt about food, sometimes ate from boredom, reported trying to select foods that were good for them and were concerned about the fat content of food; 30% of boys and 17% of girls thought they should be concerned about their food intake only when overweight. Low daily dietary intakes were reported for bread, fruit, vegetables and dairy products with only 24% eating at least one fruit, one vegetable, one dairy product and one core cereal food daily. Fat and sugar intake was high: 41% students ate high fat savoury foods and 53% ate high sugar foods at least seven times during the week. Parents, television and school provided information about food and nutrition to 70-80% of these students, followed by friends and magazines with doctors and teachers providing information on weight and weight loss to 10% of students. CONCLUSIONS: Doctors should be aware of the low intake of recommended foods as well as the high intakes of fat and sugar among adolescents and the gender differences in food related beliefs and behaviours when treating nutrition related diseases and providing guidance for their prevention.

Adolescent↗
PubMed2004

Ask your doctor: the construction of smoking in advertising posters produced in 1946 and 2004.

This paper examines two full-page A3 poster advertisements in mass magazines produced at two time points over a 60-year period depicting smoking and its effects, with particular relation to lung cancer. Each poster represents the social and cultural milieu of its time. The writings of Foucault are used to explore the disciplinary technologies of sign systems as depicted in the two posters. The relationships between government, tobacco companies and drug companies and the technologies of production are examined with regard to the development of smoking cessation strategies. The technologies of power are associated with the constructions of risk and lifestyles. The technologies of the self locate smokers as culpable subjects responsible for their individual health. Finally, the meshing of these technologies places the doctor in the frame as "authoritative knower" and representative of expert systems.

Advertising↗