Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “MONILIASIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 883 records · Page 49Linked to original sources
PubMed1962

Production in mice of tolerance to the toxic manifestations of Candida albicans.

Hasenclever, H. F. (National Institutes of Health, Bethesda, Md.) and William O. Mitchell. Production in mice of tolerance to the toxic manifestations of Candida albicans. J. Bacteriol. 84:402-409. 1962. - Lethal toxic manifestations of Candida albicans in mice were demonstrated by the intravenous injection of 10(7) viable yeast cells. Untreated control animals had an average survival time of 4.5 to 10 hr after challenge. No multiplication of C. albicans could be demonstrated in the tissues of untreated infected controls 12 hr after challenge. Mice infected ip with C. albicans 6 days before iv challenge survived for periods three to four times longer than controls. Mice previously infected with other fungi also demonstrated tolerance to the toxicity of C. albicans. Coccidioides immitis and C. stellatoidea were especially effective. High-titer rabbit antiserum to viable C. albicans yeast cells was not protective. Studies of total and differential peripheral leukocytes indicated that mice in the tolerant state demonstrated a slight granulocytosis. Direct evidence of the protective effect of the granulocytic response was not shown

Animals↗
PubMed1962

Production of tolerance to the toxicity of Candida albicans by nonfungal materials.

Hasenclever, H. F. (National Institute of Allergy and Infectious Diseases, Bethesda, Md.) and W. O. Mitchell. Production of tolerance to the toxicity of Candida albicans by nonfungal materials. J. Bacteriol. 84:1325-1329. 1962.-Tolerance in mice to the toxic manifestations of viable Candida albicans cells was elicited by injections of Salmonella enteritidis or S. typhosa lipopolysaccharides, or complete Freund's adjuvant. The greatest host stimulation occurred when the lipopolysaccharides were given 1 or 6 days before intravenous challenge. The highest level of tolerance produced by intraperitoneal preinfection with C. albicans was found when the yeast cells were injected 6 days before challenge. Older mice appeared to require larger amounts of endotoxin to demonstrate toxicity tolerance. Protection in mice that received both lipopolysaccharide injections and C. albicans intraperitoneal preinfection was slightly higher than in those mice given only the individual components.

Animals↗