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At least 883 records · Page 49Linked to original sources
PubMed1990

Pharmacological activities of delta-aminolaevulinic acid, protoporphyrin IX and haemin in isolated preparations of rabbit gastric fundus and jejunum.

1. Pharmacological effects of delta-aminolaevulinic acid (ALA), protoporphyrin IX and haemin were examined in isolated preparations of rabbit jejunum and gastric fundus suspended in oxygenated Ringer-Locke solution at pH 7.0. 2. In jejunal preparations, delta-aminolaevulinic acid (3.0-4.5 mM), protoporphyrin IX (1.1-2.2 mM) and haemin (3.0-4.5 mM) dose-dependently reduced the amplitude of contractions and increased resting length. Pretreatment with prazosin (10(-7) M) inhibited effects produced by delta-aminolaevulinic acid (3 mM) and protoporphyrin IX (1.1 mM) but not those of haemin (3 mM). 3. In fundic preparations, dose-dependent contracture occurred in response to delta-aminolaevulinic acid (0.1-3.0 mM) protoporphyrin IX (0.1-2.2 mM) and haemin (0.6-6.3 mM). Effects qualitatively resembled those of noradrenaline (0.1-0.4 microM). Prazosin (10(-7) M) attenuated these effects, depressing the maximum response and causing a rightward shift of the concentration-response curves. 4. It is concluded that actions of delta-aminolaevulinic acid at alpha 1-adrenoceptor sites are unlikely to be related to the autonomic neuropathy of acute porphyria. Its in vitro effects occurred only at comparatively high concentrations and were mimicked by protoporphyrin IX and haemin. It is suggested that ALA is more likely to modify autonomic functions by an indirect action, since it is known at low dose levels to influence GABA-ergic functioning.

Aminolevulinic Acid↗
PubMed1972

Environmental lead pollution in an urban soft-water area.

An investigation has been reported on the clinical and metabolic effects of lead acquired by soft domestic water from lead plumbing systems in 23 Glasgow households. The lead content of water from cold taps was up to 18 times the upper acceptable limit and was proportional to the amount of lead in the plumbing system. The blood lead of 71 inhabitants of these houses showed a significant positive correlation with water lead content. Delta-aminolaevulic acid dehydrase activity, an extremely sensitive indicator of lead exposure, showed a significant negative correlation with water-lead content. Atmospheric lead was within acceptable limits in all but one house and no significant correlation could be found with biochemical measurements. A small number of clinical abnormalities were found but could not be directly attributed to lead toxicity. The results of the study underline the possible danger to health of lead plumbing systems in soft-water regions.

Adolescent↗
PubMed1971

Porphyrin biosynthesis in the erythrocytes of patients with sideropenic anaemias.

The ability of erythrocytes to synthesize porphyrins from delta-aminolaevulic acid was compared in healthy people, patients with true iron-deficiency anaemia, and anaemic patients with rheumatoid arthritis. Porphyrin synthesis was found to be impaired in true iron deficiency but not in rheumatoid arthritis cases showing a similar degree of anaemia. The delta-aminolaevulic acid dehydratase activity and the rate of porphobilinogen synthesis did not differ in the three groups studied. The most probable mechanism of impairment of porphyrin synthesis in the anaemia of true iron deficiency seems to be a partial block in the conversion of porphobilinogen into porphyrins. High endogenous and exogenous protoporphyrin concentration did not affect the synthesis of porphyrins.

Amino Acids↗
PubMed1975

[Excretion of delta-aminolevulinic acid during combined radiotherapy of patients with cervix carcinoma. 2. Medical check-ups for lead in the Vienna area among various occupational and personal groups].

A report is given of an increase in urinary delta-aminolaevulinic acid (ALA) excretion in patients with cervical carcinoma treated by extracorporeal radiotherapy as well as with radium and telecobalt. It was found, that 16 out of 17 patients showed an increase of 125% (on average) in the elimination of ALA on the seventh day after irradiation. A return to noraml ALA-values was found in nine patients 42 days after radiotherapy whilst in six patients a further increase in ALA elimination occurred in comparison with the values recorded on the seventh post-irradiation day. The possible causes of the lead elimination, indicated by the ALA test, as well as the possibility of lead as an aetiological factor in tumour genesis are discussed.

Aminolevulinic Acid↗
PubMed1987

[Determination of delta aminolevulinic acid in the urine of cows in acute mass lead poisoning].

The concentration of delta aminolevulinic acid (ALA) in the urine of dead heifers (n = 3), diseased cows (n = 13) and clinically healthy cows (n = 29) was determined in the course of acute mass intoxication with lead. At the same time, the content of lead was determined in kidney, liver, in rumen contents of dead heifers and in the beet pulp fed to the animals. The ALA concentrations were converted to values per uniform specific weight of urine and per gram of creatinine secreted with urine. As found, the determination of ALA concentration per gram of creatinine is diagnostically insignificant in the case of lead poisoning. The average ALA values in the urine of the dead and clinically diseased cows (221.0, 119.9 and 72.3 mumol per litre) markedly differed from the average values of ALA concentrations in the urine of the clinically healthy animals (41.2, 32.8 and 25.6 mumol per litre). Owing to the wide variability of the determined ALA concentration in urine it appeared useful in cases of suspicion of lead poisoning of cattle to determine ALA concentration in the urine of the group of clinically diseased animals and in the group of clinically healthy animals in order to compare ALA secretion with urine in the two groups. A 2.9-fold average increase of ALA in the urine of clinically diseased animals, compared with the ALA values in the urine of clinically healthy animals, already testifies to lead intoxication.

Acute Disease↗
PubMed1978

Experimental lead intoxication in dogs: a comparison of blood lead and urinary delta-aminolevulinic acid following intoxication and chelation therapy.

Intravenous lead administration to dogs produced an acute syndrome of lead intoxication charcterized by depression, vomiting, anorexia and weight loss. The effect of chelation therapy with calcium disodium ethylene diamine tetraacetate, penicillamine or both was determined by serially monitoring changes in blood lead and urine delta-aminolevulinic acid. Following therapy, blood lead values were significantly lower in chelated dogs than non-treated lead exposed dogs on days 7 and 10. Urine delta-aminolevulinic acid at day 7 was significantly higher in untreated lead exposed dogs than in other groups. There was no significant difference in blood lead or urine delta-aminolevulinic acid between lead intoxicated dogs which underwent the indicated chelation therapy protocols. There was, however, a trend for higher urinary delta-aminolevulinic acid excretion in those intoxicated dogs undergoing calcium disodium ethylene diamine tetraacetate therapy as opposed to those undergoing penicilamine therapy. There was no significant correlation between blood lead and urinary delta-aminolevulinic acid previous to lead exposure. However, after lead exposure significant correlation was present at days 4, 7, 10 and 14. Certain lead exposed dogs following chelation therapy were noted to have normal blood lead levels but elevated urinary delta-aminolevulinic acid suggesting that blood lead does not always correlate with metabolic effects of lead in the body. Urinary delta-aminolevulinic acid was therefore recommended as an additional laboratory parameter which improved assessment of lead exposure in dogs, particularly in determining adequacy of chelation therapy.

Aminolevulinic Acid↗