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PubMedDate not supplied

Clinical chronopharmacology of ACTH 1-17. I. Effects on plasma cortisol and urinary 17-hydroxycorticosteroids.

The aim of the investigation was to study the effects of ACTH 1-17 on both plasma cortisol and urinary 17-OHCS in health adult young males with regard to the time (clock hours) at which this polypeptide was injected. Eight healthy adults (males from 18-30 years) volunteered for the study. They were synchronized with a diurnal activity from 0700 to 0000 and a nocturnal rest. Each week, during 6 consecutive weeks (January 19 to February 25, 1980), a 3-day test was performed on Saturday, Sunday and Monday. On Sundays 3 control-tests and 3 ACTH-tests were programmed during which either saline or 100 micrograms ACTH 1-17 were injected i.m. at respectively 0700, 1400 and 2100. During each 3 day-test (72 h) the urinary excretion of 17-OHCS was determined every 4 h at fixed clock hours. In addition, on Sundays, venous blood was sampled prior to control or ACTH injections at respectively 0700, 1400, and 2100 and 20, 40, 60, 90, 120, 150 and 180 min thereafter. Plasma cortisol (radioimmunoassay) was determined in samples thus collected. Both conventional and cosinor methods were used for statistical analyses. A strong and statistically significant rise of plasma cortisol was observed after all of the ACTH 1-17 injections. The obtained mean response curves were observed after all of the ACTH 1-17 injections. The obtained mean response curves were similar in form and parallel. The highest plasma cortisol curve corresponded to ACTH injected at 0700, the lowest to ACTH injected at 2100. The curve corresponding to ACTH injected at 1400 went in-between. The 24-h urinary excretion of 17-OHCS after ACTH 1-17 was approximately 4 times greater than the control value when injected at 0700, approximately 3 times greater than control when injected at 1400 and only twice greater than control when injected at 2100. In terms of changes in plasma cortisol and 17-OHCS the greatest best benefit of ACTH 1-17 is achieved when this polypeptide is injected at 0700, rather than at 1400 or 2100 in diurnally active subjects.

17-Hydroxycorticosteroids↗
PubMedDate not supplied

[Seasonal dynamics of adrenal 11-hydroxycorticosteroid secretion in Citellus erythrogenus susliks].

It has been demonstrated that during different periods of life cycle of the ground squirrels their adrenals produce various amounts of glucocorticoids. Maximum secretion of 11-oxycorticosteroids by the adrenals was noted in active period of animals (May), decreasing to the period of preparation to hibernation (August). During hibernation of the animals, 11-oxycorticosteroid secretion exhibits intrinsic endogenous rhythm. Whereas the first half of hibernation is characterized by a constant secretion (October, November, December), during the second one (from January till March) the secretion of 11-oxycorticosteroids by the adrenals increases.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[Study of the relationship between the function of the lymphocytes and monocytes and the level of various lipids and 11-hydroxycorticosteroids in diabetes mellitus].

On the example of diabetes mellitus there was shown a close interrelationship between the blood lymphocytes and monocytes function, on the one hand, and the disturbances of carbohydrate and lipid metabolism--on the other hand. Patients were examined both during the decompensated stage of diabetes and during the compensated one as a result of treatment. A reduction of lipid and 11-oxycorticosteroid level, a rise in T-lymphocyte percentage, an increase of the lymphocyte blasttransformation reaction, and of lysosomal and phagocytic activity of monocytes followed the treatment.

11-Hydroxycorticosteroids↗