Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Gravidity”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 883 records · Page 49Linked to original sources
PubMed1978

Intermittent exposure of gravid rats to 1% nitrous oxide and the effect on the postnatal growth of their offspring.

Three groups of pregnant rats were exposed to 1% nitrous oxide 6 hours a day, 5 days per week for the first, first and second, and all 3 weeks of gestation. The offspring were weighed and measured at weekly intervals. The following variables were evaluated in control and experimental groups: litter size, body weight, tail length and body length. Litter sizes in animals exposed for the first and second weeks of gestation were significantly smaller than the controls. A two-way nested statistical analysis of the data revealed that over an 8-week period the experimental rats were significantly smaller than the control rats of the same age. Analysis of the 95% confidence intervals revealed no particular pattern related to the timing of the exposure to nitrous oxide.

Animals↗
PubMed1984

Distribution of norethisterone and ethinylestradiol in the gravid rat and in the feto-placental unit of rhesus monkeys following intragastric administration of norethisterone acetate in combination with ethinylestradiol. I. Direct determinations.

The time course of the concentration of the 14C- and 3H-labelled substances and of unchanged norethisterone was determined in maternal plasma and selected tissues of the feto-placental unit after intragastric administration of a combination of 14C-norethisterone acetate (NET-Ac) and 3H-ethinylestradiol (EE2), respective commercial formulation: Ostro - Primolut , to pregnant rats. When given intragastrically in doses of 1 mg NET-Ac/kg and 0.002 mg EE2/kg both synthetic steroids were rapidly and completely absorbed. Highest concentrations of 14C-labelled substances were measured 0.5 h p. admin . in maternal and fetal tissues. Only approximately 1% of total radioactivity in maternal plasma (= 30 ng NET/ml) corresponded to unchanged norethisterone. Less than 1% of the dose administered passed the placental barrier. The maximum NET-levels in the fetuses amounted to 4 ng NET/g tissue. The highest levels of EE2-metabolites in the fetuses were found 2-5 h after administration with 34 pg EE2-equiv./g corresponding to only 0.15% of the dose administered in total fetuses. 14C- and 3H-radioactivity was eliminated from the fetuses with a similar or only a slightly lower rate than from the maternal organism. When administered intragastrically the twofold dose (2 mg NET-Ac/kg plus 0.004 mg EE2/kg) to pregnant rhesus monkeys maximum NET plasma levels of 40 ng/ml were observed after 2 h. Thereafter the NET plasma levels decreased with a half-life of 1.4 hours. The time course of NET concentrations in ovary and pituitary mirrored plasma levels whereas that in placenta and amniotic fluid paralleled plasma levels at a 30-50% and 3-15% niveau , respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1984

Distribution of norethisterone and ethinylestradiol in the gravid rat and in the feto-placental unit of rhesus monkeys following intragastric administration of norethisterone acetate in combination with ethinylestradiol. II. Autoradiography.

The tissue distribution of 14C- and 3H-radioactivity was studied in pregnant rats and in fetuses of rhesus monkeys after intragastric administration of a combination of 14C-norethisterone acetate (14C-NET-Ac; 1 mg/kg rat, 2 mg/kg rhesus monkey) and of 3H-ethinyl-estradiol (3H-EE2; 2 micrograms/kg rat, 10 micrograms/kg rhesus monkey), respective commercial formulation: Ostro-Primolut, by means of autoradiographic methodology. The results of these present investigations confirm quantitative studies of a low, transitory passage of 14C-NET-Ac and 3H-EE2 into the fetuses. Within the fetuses the highest concentrations of 14C-radioactivity were found in the liver, in the vertebra, in heart and brain. No 3H-radioactivity could be observed within the fetuses. The autoradiographic studies do not indicate any specific enrichment of NET-Ac or EE2 and their metabolites in fetal organs and tissues.

Animals↗
PubMed1983

Post-gravidic Budd-Chiari syndrome treated by mesocaval H-graft shunt.

A new case of Budd-Chiari syndrome following pregnancy is reported. The patient, shortly after her second normal delivery, showed clinical evidence of hepatic venous outflow impairment. The diagnosis of Budd-Chiari syndrome was supported by angiographic studies, computed tomography, liver scanning and histology. Because of the poor results reported in the literature following medical treatment, portosystemic shunting was considered. At laparotomy, due to the huge caudate lobe hypertrophy, a mesocaval H-graft shunt was performed, using a 10 mm woven Impraflex graft. The patient is well, with normal liver function tests, 24 months following the procedure.

Adult↗
PubMed1983

Pathophysiology of gravidity.

Regulating processes during embryonal and fetal growth are discussed (genes, hormones). Due to viral infections there can be disorder of fetal life (resorption, mumification, abortion and malformations). Mucosal Disease is hold up as an example to describe that it depends on the moment of infection, on the development of immunologic competence and on the qualities of the virus, what happens after infection. The development of immunologic competence is considered carefully. An infection with Mucosal Disease-virus can find expression in disorders of intrauterine development, malformations, manifest nerval symptoms and death because of viral reproduction in the fetus. Pathogenesis of the disturbance of the development of the central nervous system and of the skin are discussed in detail. Infection with Mucosal Disease-virus and infection with Blue Tongue-virus are compared. Different to the development of these viruses is the IBR-virus, with propagates mainly in trophoblasts. This virus causes fetal death because of anoxia or brings about necrosis in the fetus. Similar to this virus is the virus of Aujeszky's Disease, different to this virus is the Hog Cholera-virus. Except of abortion and still-birth, after infection with this virus suckling pigs can be born, which show hypoplasia of the cerebellum or dysmyelogenesis. Furthermore they can be immunologically tolerant. In conclusion there is a comment on the Parvovirus infection, which results in the SMEDI-Syndrome (stillbirth, mumification, embryonic-death, infertility): effect of infection of gametes via sperm is infertility, because there is no decomposition of corpus luteum graviditatis, the sow acts as if she is pregnant. The economical loss is extremely high.

Animals↗