Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Goiter”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 883 records · Page 49Linked to original sources
PubMedDate not supplied

[The effect of factors in the accident at the Chernobyl, Atomic Electric Power Station on the development of nodular goiter in the immediate postirradiation period].

With the purpose of studying effects of a complex of factors of Chernobyl Atomic Power Plant breakdown on evolution of nodular goiter, an analysis was carried out of clinical and laboratory evaluation of 6572 individuals (3549 men and 3023 women) who had taken part in the elimination of aftermath of Chernobyl accident, with regard to sex, dose and length of time during which the above individuals were exposed to radiation. Duration of exposure did not appear to affect nodular goiter rates either in men (7.92% in liquidators of "iodine" period and 8.19% among those of "noniodine" period of irradiation, or women (17.31% and 24.66% respectively). Results of studies made 5-7 years after the Chernobyl accident did not show relationship between incidence rate of nodular goiter and dose of radioactive irradiation received.

Acute Disease↗
PubMed1997

[About changes in the structure of surgically treated goiter].

On the base of our own goiter material treated surgically between 1974-1996, we compared incidence of various types of goiter and thyroid carcinoma in years 1974-1985 and 1986-1996. We stated statistically significant decrease of operated Basedow goiter and significant incidence increase of thyroid cancer. In given years frequency of incidence of differentiated and anaplastic thyroid carcinoma have been changed.

Adolescent↗
PubMedDate not supplied

[The structural-functional status of the thyroid in patients with nodular goiter evacuated from the 30-kilometer zone of the Chernobyl Atomic Electric Power Station].

An analysis was performed of results of ultrasonic and hormonal investigations in 239 patients with nodular goiter revealed in a screening-type clinical and laboratory examination of the 3371 persons evacuated from the 30-km zone of ChNPP, at their ages randing between 18 to 68 years. In 84.20% of patients in the group who took part in the elimination of effects of the Chernobyl accident (PEEA)--"PEEA + the evacuated"--the diameter of the nodules did not exceed 1 cm, in 6.1% it ranged from 1 to 2 cm, and in 13.41% it exceeded 2 cm. Distribution of nodules in the group "the evacuated" did not differ much from that in the above group. In 20% of patients with nodular goiter, there were functional disturbances concurrent with the autoimmune processes. No effects were detected of small doses of extra irradiation on the pattern of structural-and-functional indices in patients with nodular goiter evacuated from the 30-km zone of ChNPP who took part in EEA.

Adolescent↗
PubMed1998

[Two new cases of autonomous ectopic goiter].

We observed two cases of autonomous intrathoracic goiter in patients with no past history of thyroidectomy. After resection, the surgical specimens confirmed the non-malignant nature of the goiter. We discuss the literature on management of autonomous intrathoracic goiter.

Goiter, Substernal↗
PubMedDate not supplied

Total versus subtotal thyroidectomy in the management of multinodular goiter.

BACKGROUND: The choice between subtotal and total thyroidectomy for multinodular goiter is controversial. MATERIAL AND METHODS: Subtotal and total thyroidectomy have been respectively performed in 108 and 451 euthyroid patients with multinodular goiter. RESULTS: After subtotal and total thyroidectomy, transient recurrent laryngeal nerve (RLN) palsy occurred in 1 patient (0.9%) and 3 (0.6%), transient asymptomatic hypoparathyroidism in 27 (25%) and 131 (29%), and transient symptomatic hypoparathyroidism in 2 (1.8%) and 13 (2.9%), respectively (P = NS). After subtotal thyroidectomy, recurrence occurred in 27 patients (26%) Re-operation in 14 patients resulted in transient RLN palsy in 2 patients (14%), transient asymptomatic hypoparathyroidism in 6 (43 %) and transient symptomatic hypoparathyroidism in 2 (14%). CONCLUSIONS: The failure to demonstrate any 'hormonal advantage' in preserving thyroid tissue by subtotal thyroidectomy, and the low morbidity rate and no need for re-operation after primary total thyroidectomy, make the latter the procedure of choice for the management of non-toxic multinodular goiter.

Adult↗
PubMedDate not supplied

[Surgical treatment of goiter in residents of the Kiev district].

The article characterizes the mortality rates of nodular and mixed euthyroid goiter in the Ukraine Republic and discusses the results of surgical treatment of 681 patients with various forms of goiter. In view of the double increase of the number of cases of thyroid carcinoma in the last 4 years, the authors suggest resecting the thyroid gland more extensively than in the previously conducted economical resections. Radioimmunological study of the thyroid hormones and thyrotropin in dynamics showed activation of hypophyseal +thyrotropic function after the operation. The authors, therefore, recommend using thyroidin without fail. Postoperative recurrences-1.5%, stable hypothyroidism-1.8%.

Adult↗
PubMed1983

[Surgical tactics in recurrent goiter].

On the basis of an experience with 109 operations for different kinds of recurrent goiter certain indications and contraindications for operation are recommended. For the prevention of recurrencies and conservative treatment of a recurrent goiter the administration of thyroid hormones is indicated. Original details of the method and operative technique are described.

Goiter↗
PubMed2001

Thyroid status and leptin in Basedow-Graves and multinodular goiter patients.

In this study it was of interest to investigate the relationship between plasma leptin levels and thyroid function in recently diagnosed 27 Basedow-Graves patients and 22 multinodular goiter patients brought to euthyroid state with 1 mo of propylthiouracil (PTU) treatment. A group of 15 control subjects matched for age, gender, and body mass index were also studied. In Basedow-Graves patients there were significantly higher T4 and T3 levels accompanied by a marked fall in plasma thyroid-stimulating hormone (TSH). In multinodular goiter patients with PTU, the plasma T3 and T4 levels were significantly lower than in Basedow-Graves and TSH was markedly higher. However, TSH values in multinodular goiter patients were signifcantly lower than the control Plasma leptin levels were unchanged in all groups. These data suggest that leptin levels are not affected by thyroid dysfunction.

Adult↗
PubMed1994

Antithyroid effects in vivo and in vitro of babassu and mandioca: a staple food in goiter areas of Brazil.

Babassu (Orbignya phalerata), a palm-tree coconut fruit, mixed with mandioca (Manihot utilissima) is the staple food of people living in the endemic goiter area of Maranhao in Brazil, where goiter prevalence among schoolchildren was still 38% in 1986 despite an adequate iodine intake in most of the population. Therefore, the question arose as to whether or not the ingestion of babassu alone or mixed with mandioca contributed to the persistence of endemic goiter in this area of Brazil. In this investigation we examined the potential antithyroid effects of babassu and mandioca by means of in vivo studies in Sprague-Dawley rats, in vitro studies in porcine thyroid slices and using a purified porcine thyroid peroxidase (TPO) system. Samples of various edible parts of babassu and mandioca flour were homogenized and extracted in goitrogen-free water (GFW) for in vivo experiments, and in methanol (100 g/l), GFW or 0.06 mol/l phosphate buffer (pH 7.0) for in vitro experiments. The edible parts of babassu produced significant in vivo antithyroid effects (p < 0.05- < 0.001) in rats on a high iodine intake (14 micrograms I- day-1.rat-1), as well as distinct and reproducible antithyroid and anti-TPO activities in both in vitro systems, their action being similar to that of the thionamide-like antithyroid drugs propylthiouracil and methimazole.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Acute suppurative thyroiditis in a primary intrathoracic goiter.

OBJECTIVE: To describe a case of acute suppurative thyroiditis and focal abscess formation in a patient with a primary intrathoracic goiter. METHODS: We summarize the initial clinical manifestations, the pathologic findings, and the surgical treatment of a woman with an enlarging mediastinal mass. RESULTS: A 41-year-old woman had a fever and a sudden increase in severity of compressive symptoms after a remote urinary tract infection. Smears from an intraoperative fine-needle aspiration biopsy showed necrotic debris, polymorphonuclear leukocytes, hemosiderin-laden macrophages, and degenerated follicular epithelial cells. Urine and tissue cultures grew Escherichia coli. The patient underwent resection of an 800-g primary intrathoracic goiter with associated degeneration, necrosis, hemorrhage, and abscess formation. CONCLUSION: To our knowledge, this is the first reported case of acute suppurative thyroiditis and abscess formation occurring within a primary intrathoracic goiter.

Journal Article↗
PubMedDate not supplied

[Study of mechanical work of the heart in patients with toxic goiter by means of electrokymography].

A study was made of the electrokymogram (EKG) of the left and the right ventricle of the heart in 54 patients suffering from toxic goiter chiefly with a marked clinical picture of the disease. Electrokymography permitted to detect enlargement of the ventricles. Excited pulsation of the ventricles with a rapid rise in systole and a sharp fall in diastole pointed to myocardial hyperfunction. Rapid and energetic contractions of the heart led to intensification of the oscillatory movements of the heart in the chest cavity, and to its rotation. A low-wave pulsation with small frequent waves of low amplitude pointed to a reduction of the contractile function of the myocardium; this was also indicated by the increase of the latent EKG time and the paradoxical movements at the beginning of systole. After the effective treatment the EKG of the ventricles showed almost no difference from the curves of healthy individuals. Changes in the character of the ventricular pulsation in toxic goiter were observed already at the early phase of the disease when some of the patients still displayed no changes in the ECG, and no X-ray data pointing to the affection of the heart were as yet evident. In the presence of phenomena of cardiac insufficiency the EKG objectively proved the presence of changes in the myocardium. The EKG data corresponded to the severity of the clinical picture of the disease. Electrokymography serves as a valuable method for analysis of the function of myocardium of the ventricles in toxic goiter.

Adolescent↗
PubMed1998

[The analysis of exercise efficiency and autonomic function in children with nontoxic nodular goiter during suppressive L-thyroxine therapy].

UNLABELLED: The aim of the study was the analysis of exercise efficiency and the function of the autonomic system in children with a nontoxic nodular goiter (NNG) subjected to TSH suppression. The study comprised 17 children, aged 11-18 years, with NNG treated with suppressive L-thyroxine doses for 6-36 months (mean 24 months). Exercise efficiency was examined on a moving track according to the protocol of Bruce. Analysis of the autonomic function was based on functional tests of the circulatory system and monitoring of the QTc interval. A group of healthy children with a negative heart and thyroid history served as control. Statistically significant acceleration of the heart rate (p<0.01) was found in NNG patients subjected to TSH suppression, compared with controls. The remaining results included a fall in exercise efficiency parameters:work load (p<0.001) and duration (p<0.003), metabolic equivalent (p<0.005), and the maximal oxygen consumption index Vo2 (p<0.005) at normal values of double product. A significant decrease was revealed in the ejection fraction during exercise (61+/-1.9 vs 67+/-5.9 p<0.001) in the group of children with nontoxic nodular goiter. CONCLUSIONS: 1. In the subclinical state of hyperthyroidism no functional disorders were observed in the autonomic system, which controls the circulatory system. 2. Exercise tolerance was reduced in patients with nontoxic nodular goiter subjected to TSH suppression. 3. A relationship was found between the level of thyroid hormones (TSH, FT4) indicating the subclinical state of hyperthyroidism and the acceleration of heart rate, reduction in the ejection fraction of the left ventricle of the heart after exercise and shortening of load test duration. 4. Higher rest values of heart rate were observed in children treated with suppressive doses of L-thyroxine, compared with controls.

English Abstract↗
PubMed1992

[The significance of the lymphocyte adherence inhibition test in patients with diffuse toxic goiter].

Patients with diffuse toxic goiter reveal an increased adhesive capacity of lymphocytes evidencing a reduction of lymphokine production by lymphocytes which would suppress adhesiveness. The degree of increase of adhesive properties of lymphocytes depended on the severity of the clinical picture of diffuse toxic goiter, being higher in those with a severe course. Results of the test of lymphocyte adhesion suppression reflect the state of cellular immunity, severity of the clinical course of diffuse toxic goiter and efficacy of treatment.

Adult↗
PubMed2006

[Stimulation with 0,3 mg recombinant human thyrotropin (rhTSH) increases the effect of 131I therapy in patients with nontoxic nodular goiter. A prospective, randomized, double-blind trial--secondary publication].

In a randomized, double-blind, placebo-controlled trial, 57 patients with nontoxic nodular goiter were stimulated with either 0.3 mg recombinant human thyrotropin (rhTSH) or placebo before radioactive iodine 131I therapy. After one year the goiter reduction had improved by 35% compared to conventional 131I therapy. The difference was most pronounced in patients with a large goiter. Adverse effects, including development of permanent hypothyroidism, were significantly more frequent in the rhTSH group. Patient satisfaction was high and uninfluenced by the use of rhTSH.

English Abstract↗
PubMed1990

[The so-called goiter of the accessory thyroid glands].

In the period of 1954-1966, 74 patients were operated on for goiter of the accessory thyroid glands (GATG). Of them, in 45 in histologic investigation, papillary adenoma or microfollicular, less often parenchymatous, goiter were revealed, in 29--papillary cancer or papillary adenoma at the state of malignization. The long-term follow-up (up to 30 years) of the patients with reoperations for GATG recurrences, or subsequent development of a "goiter" has shown that GATG presented a metastasis of papillary thyroid cancer into the lateral lymph nodes of a neck. At operation, the revision of a thyroid gland with intervention on it is mandatory. The term GATG we haven't used from 1966.

Adolescent↗
PubMed1990

[The determination of natural killer cells in the peripheral blood of patients with diffuse toxic goiter].

Natural killer cells were evaluated in patients with diffuse toxic goiter by determining large granule-containing lymphocytes in the peripheral blood that was found to be reduced depending on the course of diffuse toxic goiter. The values were lower in severe course of the disease. Results of the quantitative determination of large granule-containing lymphocytes in the complex with other clinico-laboratory findings reflect the severity of the course of chronic diffuse goiter, state of unspecific immunity and treatment efficacy.

Adult↗
PubMedDate not supplied

[Concentration of anti-brain antibodies in the blood of patients with diffuse toxic goiter and thyrotoxic encephalopathy].

The content of anticerebral antibodies was studied in the peripheral blood of 10 healthy persons, 42 patients with diffuse toxic goiter and 25 patients with thyrotoxic encephalopathy. It was determined by a method of passive hemagglutination using a human brain protein extract as an antigen. In the healthy persons antibodies to cerebral antigens were undetectable whereas in 24 of 42 patients with diffuse toxic goiter without signs of the nervous system involvement they were detected (log2 titer--2.3 +/- 0.36). Most of them had polyvalent allergy, thyrotoxicosis recurrence or neuroinfection. Anticerebral antibodies were detected in 88% of the patients with thyrotoxic encephalopathy and their titer (5.6 +/- 0.66) significantly exceeded that in the patients with diffuse toxic goiter without encephalopathy. A possible reason for the appearance of anticerebral antibodies in patients was discussed. The autoimmune nature of thyrotoxic encephalopathy was assumed.

Adolescent↗
PubMed1985

[Autoimmune thrombocytopenia and diffuse-toxic goiter].

The authors describe 10 patients with associated diffuse toxic goiter and thrombocytopenic purpura and a female patient with associated goiter and a three-shoot autoimmune peripheral cytopenia. In 8 patients thyrotoxicosis preceded the appearance of thrombocytopenia, in 3 patients, both the conditions were diagnosed at a time. In 4 patients, the measurements were taken of the IgG content on the surface of platelets according to Dixon et al. In 3 patients, the IgG content turned out to be appreciably elevated, in one patient, the content of IgG was within normal, however the latter patient was examined after prednisolone intake that had given rise to an increase in the platelet count. Two patients who received radioactive iodine and three patients treated by thyrostatic drugs were later on subjected to splenectomy. In 4 patients, thrombocytopenic purpura remitted after subtotal strumectomy. One female patient was subjected to sectoral resection of the thyroid. Two years after surgery the patient, who was in an euthyroid state, developed thrombocytopenia which required splenectomy. It is possible that in the latter case there was no direct relation between the two diseases. The relationship between the two autoimmune diseases, diffuse toxic goiter and thrombocytopenic purpura, remained unclear in other 10 cases. The relationship between the diseases under consideration and approaches to specifying the character of such a relationship are under discussion.

Adolescent↗