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At least 883 records · Page 49Linked to original sources
PubMed1977

[Experiences with a new percutaneously effective antirheumatic preparation].

The new substance Etofenamat (Rheumon Gel) is effective percutaneously in the treatment of rheumatic diseases. The gel is shown to be an effective antiphlogistic and analgetic, especially in vertebragenic diseases. The results of treatment of 81 patients are summarized. In a total of 56 patients, use of Etofenamat led to an evident improvement, for example, freedom from pain. Treatment for up to 9 days, eliminated pain in 73 of the 81 patients. In 28 patients out of 38, the mobility of joints was favourably effected. No side effects were observed.

Administration, Topical↗
PubMed1977

[Experience with a locally applicable antirheumatic (author's transl)].

Clinical trials with 2-(2-hydroxyethoxy)-ethyl-N-(a,a,a-trifluoro-m-tolyl)-anthranilate (etofenamate, active principle of Rheumon Gel) were carried out on a total of 69 patients suffering from extra-articular rheumatic complaints and painful spinal syndromes as well as from post-operative and post-accident complaints. Criteria for assessment included spontaneous pain, pressure pain and pain on movement and also limitation in joint mobility. The new gel formulation proved to have a good analgesic efficacy both in a double blind trial against placebo gel and the open study. Those patients treated with Rheumon Gel showed improvement in the symptoms spontaneous pain and pain on movement, in a large number of which patients showing improvement, in a large number of which patients showing improvement the spontaneous pain was completely eliminated. The differences in therapeutic effect compared to the placebo group as well as those of the final clinical assessment were statistically significant. Particularly good therapeutic results were observed in extra-articular rheumatic complaints and in activated arthroses. The skin tolerance of Rheumon Gel was found to be excellent. The gel form permits good and rapid penetration through the skin. The nursing staff also willingly administered the product because of its pleasant protective properties for skin and clothing.

Administration, Topical↗
PubMed1988

UV-induced erythema model: a tool in dermatopharmacology for testing the topical activity of non-steroidal anti-inflammatory agents in man.

UV-induced erythema is a well known inflammatory model applied both in animal and human skin to test the activity of topical non-steroidal anti-inflammatory compounds in a great variety of pharmaceutical formulations. The aim of this study was to evaluate the inhibitory efficacy of piroxicam in two different topical formulations (cream 0.5, 1 and 1.5% and gel 1%) as compared to three non-steroidal compounds, benzydamine, etofenamate and indomethacin (cream 5%), on erythema induced after UV-injury on the back of 5 healthy subjects. The results showed that piroxicam in cream formulation, indomethacin cream and etofenamate gel have a similar effect, decreasing the erythema size 7 h after irradiation. However, benzydamine cream and piroxicam gel showed no effect with this method. We may conclude that this model is adequate and precise for selecting the most appropriate galenic dosage form for an active compound in terms of its clinical efficacy when topically administered.

Administration, Topical↗
PubMed1987

[Topical use of Rheumon-Gel in the combined treatment of patients with rheumatoid arthritis].

Rheumon-Gel was used for therapy of 51 patients with rheumatoid arthritis. It has been shown that the drug has a marked antiinflammatory and analgesic action, a positive effect on a number of subjective (pain in the joints and constrained movements in the morning), objective (body temperature, edema and joint function), and laboratory (leucocyte count, ESR, C-reactive protein, titer of antistreptolysin-O and antistreptohyaluronidase) indices and therefore it can be recommended for multimodality therapy of rheumatic patients, particularly of those with rheumatoid arthritis combined with G. I. tract diseases when the use of most of the antirheumatic drugs is counterindicated.

Administration, Topical↗