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At least 883 records · Page 49Linked to original sources
PubMed1978

Proximal enterectomy stimulates distal hyperplasia more than bypass or pancreaticobiliary diversion.

To determine the contribution of intraluminal factors to postresectional intestinal hyperplasia, cell proliferation in the distal intestine of male rats was studied after 50% proximal enterectomy or 50% proximal bypass and also after transposition of the duodenal papilla to the mid small bowel. Within 48 hr all three operations increased RNA and DNA content s in the ileal mucosa 16 to 50% over control values. At 48 hr and 1 week the response distal to resection exceeded that of bypass or pancreaticobiliary diversion; nucleic acid contents, DNA specific activity, villous height, crypt depth, and luminal circumference were greatest 1 week after resection. By 1 month, however, chemical and histological values after resection were equalled or surpassed by those in the other two groups. In excluded jejunum itself, mucosal atrophy lowered RNA and DNA contents to 60% of control levels 1 month postoperatively. Neither pancreaticobiliary diversion nor proximal enteric bypass produces the same rate of distal hyperplasia as proximal resection. Modest colonic hyperplasia may contribute to intestinal adaptation after proximal enterectomy. Adaptive postrescetional cell proliferation appears not to be mediated simply by intraluminal nutrition or enteric secretions; hormonal factors may also be important.

Animals↗
PubMed1984

[Generalized peritonitis of non-traumatic colonic origin. Reflexions on 62 cases].

The authors analyze sixty-two cases of acute generalized peritonitis with a non-traumatic colonic etiology. They point out that the prognosis depends on three main factors: the age of the patient, the time spent in diagnosis and the therapeutic difficulties. They recommend a gastrographin colonic enema to obtain earlier diagnosis, in the absence of radiological evidence of pneumoperitoneum, in elderly patients presenting with abdominal signs. They also recommend multistage surgical management combining effective drainage of the abdominal cavity with resection of the perforated segment of the colon, whenever there is extensive damage to the colon, or in the presence of a tumor. In their view, conservative surgery should be confined to strictly selected cases not involving tissue resection. These indications are essential if a satisfactory result is to be achieved.

Adult↗
PubMed1984

Reducing the risk of wound infection in operations upon the colon.

One hundred and forty-seven patients undergoing elective colonic operations during a 30 month period were studied. The over-all wound infection rate was 6.8 per cent. Thirty-seven patients had subcutaneous drains used and, in none, did a wound infection develop. The incidence of wound sepsis in the remaining patients was 9.1 per cent. Wicks appear to be of benefit in reducing the incidence of wound infections in elective colonic operations.

Adenocarcinoma↗