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At least 883 records · Page 49Linked to original sources
PubMed1998

The GAIA software framework for genome annotation.

We describe a software framework, GAIA, that supports semi-automated annotation of uncharacterized sequence data. The annotation framework incorporates annotation by data source integration, data analysis, and manual data entry. Components of the system include a configurable, open data analysis pipeline, a relational information storage manager, and Java-based graphical user interfaces. We discuss design decisions and tradeoffs in building such a system, and policies and strategies for producing consistent, uniform, high quality annotation.

Base Sequence↗
PubMed1998

At risk of first or recurring heart disease.

OBJECTIVES: The self-reported prevalence of risk factors for heart disease among Canadians with and without heart disease is estimated. The characteristics associated with these risk factors are examined in order to identify groups to be targeted for primary and secondary prevention. DATA SOURCE: The data are from the household component of the 1994/95 National Population Health Survey (NPHS). ANALYTICAL TECHNIQUES: For the population aged 20 and older with and without heart disease, bivariate and multiple regression analyses were used to determine associations between four risk factors (smoking, high blood pressure, diabetes, and inactivity) and demographic characteristics and socioeconomic status. MAIN RESULTS: According to the NPHS, 4.4% of people aged 20 and older reported that they heart disease. However, many more adults had risk factors for this disease. As well, about one-quarter of those without heart disease and half of those with heart disease had two or more risk factors. To some extent, many of these risks are modifiable. The groups particularly at risk were people older than 35, those with less than high school graduation, those in households with inadequate income, people who consumed three or more drinks a day, and residents of the Atlantic provinces, Quebec and Ontario.

Adult↗
PubMed1998

Age of smoking initiation: implications for quitting.

OBJECTIVES: The effect of an early age of smoking initiation on cigarette consumption and on the probability of quitting is analyzed for people aged 21 to 39. DATA SOURCE: The data are from Statistics Canada's 1994/95 National Population Health Survey. The findings in this article are based on 3,449 randomly selected respondents aged 21 to 39 who were or had ever been daily smokers. ANALYTICAL TECHNIQUES: Logistic regression was used to analyze the association between age of smoking initiation and heavy cigarette consumption (more than 20 a day). Survival analysis techniques were used to study the relationship between age of smoking initiation and smoking cessation for men and women. Cox proportional hazard models were used to control for potential confounding factors such as education, household income, depression, chronic stress, self-esteem, and amount smoked. MAIN RESULTS: Among 21- to 39-year-olds, smoking initiation during early adolescence was associated with greater daily cigarette consumption and a lower cumulative probability of quitting.

Adolescent↗
PubMed1998

The health of northern residents.

OBJECTIVES: This article examines differences in health status and health determinants between residents of the North (Yukon and Northwest Territories) and of the provinces, and between Aboriginal and non-Aboriginal territorial residents. The use of health services and medications is also analyzed. DATA SOURCE: The data are from the 1994/95 National Population Health Survey (NPHS), both the territorial and provincial components. The population analyzed consists of household residents aged 12 and older. MAIN RESULTS: Compared with non-Aboriginal Northerners, Aboriginal people in the territories more frequently rated their health poorly. However, they reported fewer injuries and diagnosed chronic conditions. The prevalence of alcohol consumption was lower among Aboriginal people, while the proportion of smokers was substantially higher. A lower proportion of Aboriginal territorial residents had consulted a general practitioner in the previous year, and a higher proportion had consulted a nurse. Aboriginal people also had a low rate of medication use.

Adolescent↗
PubMed1998

Pregnancy-related hospital use.

OBJECTIVES: This article describes provincial variations in women's hospital use during pregnancy, childbirth and the postnatal period. DATA SOURCE: The data were extracted from the Person-Oriented Information Data Base, maintained by Health Statistics Division at Statistics Canada. This data base is comprised of hospital admission data submitted by general and allied hospitals to provincial and territorial governments and is considered complete for each jurisdiction. Data were not available for the Yukon Territory. ANALYTICAL TECHNIQUES: A group of 57,627 women who gave birth during October and November 1993 was identified from hospital admission records using selected ICD-9 and CCP codes. These records were then linked to other hospital admissions that occurred in the six months before and the four months after childbirth. MAIN RESULTS: Approximately 15% of women who gave birth in October and November 1993 were admitted to hospital at least once during the six months before childbirth. Only 4% were re-admitted during the four months after the birth.

Canada↗
PubMed1998

Home care in Canada.

OBJECTIVES: This article describes the social, socioeconomic and other health-related characteristics of people receiving formal, publicly funded home care services. DATA SOURCE: The data are from the household component of the 1994/95 National Population Health Survey. The analysis covers 16,291 respondents aged 18 or older. ANALYTICAL TECHNIQUES: Recipients of publicly funded home care services were profiled using weighted univariate frequencies and multivariate logistic regression. MAIN RESULTS: Recipients of publicly funded home care services in 1994/95 numbered over half a million. People who were elderly, female, had two or more chronic conditions or were living with others accounted for large proportions of these recipients. Characteristics significantly associated with receiving home care included old age, poor or fair general health, abstinence from alcohol (compared with regular use), low income, living alone, needing help with some activity of daily living, and having cancer or the effects of a stroke.

Activities of Daily Living↗
PubMed1998

Falling short of Pap test guidelines.

OBJECTIVES: This article examines the associations between women's characteristics and getting or not getting a Pap test. DATA SOURCE: The data are from the 1994/95 National Population Health Survey (NPHS) conducted by Statistics Canada. ANALYTICAL TECHNIQUES: Multivariate logistic regressions were used to determine the odds of women not complying with Pap test guidelines, that is, of never having had a Pap test, and among women who had had one, of not having done so in the last three years. MAIN RESULTS: One in four women aged 18 to 69 had either never had a Pap test or had not had one in the three years before the NPHS. Notably, older women--who are at the greatest risk for cervical cancer--are less compliant with screening guidelines than younger women. Other characteristics of women with high odds of never having had a Pap test are: being single, being a resident of Quebec, having immigrated to Canada, having less than a secondary school education, not being in the highest income group and having had no sex partners in the previous year.

Adult↗
PubMed1998

Multiple-risk behaviour in adolescents and young adults.

OBJECTIVES: This article examines the prevalence of four risk behaviours among teenagers and young adults: smoking, binge drinking, sex with multiple partners, and sex without a condom. DATA SOURCE: The data are from a Health Canada-sponsored supplement to the 1994/95 National Population Health Survey. The analysis is based on 905 respondents aged 15 to 19 and 1,055 respondents aged 20 to 24. ANALYTICAL TECHNIQUES: Prevalence estimates of the four risk behaviours were calculated for males and females in each age group. An index of multiple-risk behaviour was derived by summing the four risk behaviours. Hierarchical multiple regression was used to examine how sets of variables are related to multiple-risk behaviour. MAIN RESULTS: Multiple-risk behaviour was higher among young people who had never married, who were not students, and who did not live with a parent. Feeling distressed was positively linked with multiple-risk behaviour, while regular attendance at religious services was negatively linked with such conduct.

Adolescent↗
PubMed1998

Maternal education and risk factors for small-for-gestational-age births.

OBJECTIVES: This article examines the association between maternal education, smoking and other risk factors and small-for-gestational-age (SGA) births. DATA SOURCE: The data are from the 1994/95 National Longitudinal Survey of Children and Youth. The analysis was restricted to a subsample of 4,181 children younger than age 2 and was based on information provided by their biological mothers. ANALYTICAL TECHNIQUES: Logistic regression was used to estimate the odds ratios for SGA by maternal education, controlling for maternal smoking during pregnancy, household income, family status, maternal age at birth of child, and use of prenatal care. MAIN RESULTS: Maternal education and smoking during pregnancy appear to have independent effects on SGA, after controlling for other risk factors. The effects of maternal education, smoking and other risk factors are likely underestimated, as the analysis pertains only to children who had survived at the time of the interview.

Adolescent↗
PubMed1998

Maternal education and fetal and infant mortality in Quebec. Fetal and Infant Mortality Study Group of the Canadian Perinatal Surveillance System.

OBJECTIVES: This article examines differences in fetal and infant mortality by maternal education in the province of Quebec, where the rates are among the lowest in Canada. DATA SOURCE: The data are from linked birth and infant death records (including stillbirths) for the 1990-1991 birth cohorts in Quebec. MAIN RESULTS: Fetal and infant mortality rates were greater for the offspring of mothers with less than 12 years of education, compared with mothers with at least 14 years, even after adjusting for maternal age, parity, marital status and infant's sex. When intermediate factors such as birthweight or both gestational age and fetal growth were taken into account, the differentials in mortality by education diminished. If all education groups had experienced the low rates attained by the higher education group, the number of fetal and infant deaths would have been reduced by approximately 20%.

Adolescent↗
PubMed1998

Single women and the dynamics of Medicaid.

OBJECTIVE: To investigate transitions in and out of Medicaid for a cohort of single adult women of childbearing age in order to address questions that arise as policymakers try to encourage transitions from welfare to work. DATA SOURCES: Longitudinal data from Waves 2 through 8 of the 1990 panel of the Survey of Income and Program Participation, a nationally representative survey of American adults covering May 1990-1992. STUDY DESIGN: We estimate a series of discrete-time logit models with duration dependence to obtain transition probabilities among Medicaid, privately insured, and uninsured spells. Explanatory variables in the models include prior insurance history, income limits on Medicaid by state, and important socioeconomic and demographic characteristics. We use these models to characterize insurance spells for a cohort of single women. PRINCIPAL FINDINGS: Most Medicaid spells are relatively short. Over half end in a year or less; only one spell out of seven lasts longer than five years. Two-thirds of Medicaid disenrollees become uninsured. Former welfare recipients are prone to frequent changes in insurance status. In states with more generous income limits for AFDC, women stay on Medicaid longer, but they do not move into the program at a faster rate. CONCLUSIONS: Imposing time limits on Medicaid eligibility would affect only a small proportion of Medicaid spells but would eliminate a significant proportion of the caseload at a point in time. In considering changes in Medicaid that would encourage transitions from welfare to work and would alter the dynamics of Medicaid, policymakers need to consider how transitions both in and out of private insurance and Medicaid would be affected.

Adult↗
PubMed1998

Medical outcomes study short form 36: testing and cross-validating a second-order factorial structure for health system employees.

OBJECTIVE: To test the factorial validity of the SF-36. DATA SOURCE: Sample data collected in 1995 and 1996 using telephone interviews with health system employees as part of a study of health status. METHODS OF ANALYSIS: Confirmatory factor analysis and structural equation modeling techniques were used to evaluate the data. PRINCIPAL FINDINGS: The results of this study suggest that (1) Mental Health and Physical Health are not independent; (b) Mental Health cross-loads onto Physical Health; (c) general health loads onto Mental Health instead of Physical Health; (d) many of the error terms are correlated; (e) the physical function subscale is not reliable across the samples or the "age" or "education" subgroups; and (f) the mental health subscale path from Mental Health is not reliable across some subgroups. This hierarchical factor pattern was replicated across both samples. CONCLUSIONS: This study supports the second-order factorial structure of the SF-36. Adding the covariance path between the variables Physical Health and Mental Health improved model fit. Two paths from the second-order latent variables to the first-order latent variables differ from the original hypothesized structure of the SF-36. Health perception was influenced by Mental Health rather than Physical Health, and mental health was influenced by both Mental Health and Physical Health. This cross-loading suggests that the perception of Physical Health greatly affects mental health. Scale instabilities in the SF-36 across subgroups suggest that a comparison of mean scores or summary scores is inappropriate. Data interpretation can be improved if multigroups structural equation modeling is used.

Activities of Daily Living↗
PubMed1998

Attitudes toward smoking.

OBJECTIVES: This article examines socio-demographic variations in attitudes about the health effects of smoking, second-hand smoke, and the importance of smoke-free environments. DATA SOURCE: The data are from the Health file of the 1996/97 cross-sectional provincial household component of the National Population Health Survey, conducted by Statistics Canada. The sample consists of 60,260 respondents aged 12 or older. ANALYTICAL TECHNIQUES: Three smoking attitudes scores were derived. Multivariate analyses were used to study how age, sex, educational attainment, province and smoking status were associated with attitude scores. MAIN RESULTS: Smokers placed less emphasis than non-smokers on the health risks associated with smoking. Older Canadians, particularly smokers aged 65 and older, tended to have more lenient attitudes toward smoking, compared with younger age groups. Respondents with high school education or less held more lenient attitudes, compared with those with a university degree. Quebec residents were more tolerant of tobacco use than were residents of other provinces.

Adolescent↗
PubMed1998

Work stress and health.

OBJECTIVES: This article describes work stress experienced by the employed population. It examines associations between job strain, job insecurity, physical demands, low co-worker support and low supervisor support, and four health outcomes: migraine, work injury, high blood pressure and psychological distress. DATA SOURCE: The data are from the household component of the 1994/95 National Population Health Survey conducted by Statistics Canada. Results are based on a sample of 9,023 employed Canadians aged 18 to 64. ANALYTICAL TECHNIQUES: Multivariate analyses were used to estimate associations between work stress and health problems, while controlling for other potential stressors. MAIN RESULTS: Among men, job strain was associated with migraine and psychological distress, and among women, with work injury. Job insecurity was associated with migraine among women. High physical demands were related to work injury in both sexes. Low co-worker support was related to migraine among men, and to work injury and psychological distress among women.

Adolescent↗
PubMed1998

Variations in angioplasty and bypass surgery.

OBJECTIVES: This article describes rates of and times to revascularization procedures for heart attack patients. DATA SOURCE: The data are from Statistics Canada's Person-Oriented Information Data Base. Hospital discharge records for heart attack patients were linked for fiscal years 1992/93 and 1993/94. ANALYTICAL TECHNIQUES: Hospital patients admitted between April 1 and September 30, 1993 with a primary diagnosis of acute myocardial infarction (AMI) were followed for six months to determine what percentage underwent percutaneous transluminal coronary angioplasty and/or coronary artery bypass graft surgery. Analyses of time-to-procedure were performed for those patients who had not been hospitalized for AMI in the previous 12 months. MAIN RESULTS: Approximately 24,000 Canadians were discharged from hospital during the first half of fiscal year 1993/94 with a diagnosis of AMI. Within six months, 8.7% had an angioplasty and 6.7% had a bypass; overall, 14.9% were revascularized. Women were less likely than men to have a bypass, but angioplasty rates did not differ significantly. The rate of revascularization declined with age. After adjusting for age and sex, rates were higher in the western provinces.

Adult↗
PubMed1998

Factors influencing accuracy of screw displacement axis detection with a D.C.-based electromagnetic tracking system.

Recent technical improvements and cost reductions in electromagnetic motion tracking systems invite their application to motion axis determination in the surgical setting. After evaluation of the accuracy of a state-of-the-art D.C. electromagnetic tracking system, which generates complete three-dimensional kinematic outputs from just a single receiver, we calculated screw displacement axes (SDA's) from its source data. The accuracy of SDA determination from such source data was evaluated for various rotational increment sizes around a revolute joint. A novel smoothing procedure, customized for this type of source data, was developed, enabling SDA detection from incremental rotations of less than 1 deg, at an accuracy appropriate for intra-operative measurement of human joint motion. Examples of SDA determination are given for motion tracking of a ball joint and of the elbow articulation.

Electromagnetic Phenomena↗
PubMed1998

The Danish Medical Birth Registry.

BACKGROUND: The Danish Medical Birth Registry (MBR) was established in 1968 and has been computerized since 1973. The primary purpose of the registration is to monitor the health of the newborns and of the quality of the antenatal and delivery care services, but the registry is increasingly being used in research. Major changes in registration have taken place in 1978 and 1991. The paper describes the content and usage of the MBR over time and suggests research topics for the future. RESULTS: A broad scope of studies illustrates how the MBR has been used, either as single data source, linked with data from other registries or with data from interviews or self-completed questionnaires. Validations have shown variations in the quality of data, depending on source, and have underlined the need for constant quality control. Any access to data at the individual level is subjected to special provisions laid down by the Data Surveillance Authority and also requires a permission from the National Board of Health. CONCLUSIONS: The time from conception to early childhood is an important period concerning future health for the individual. The Danish Medical Birth Registry is a valuable tool in this respect, which has not yet been used to its full potential in research or monitoring. Experience indicates that the quality of the registry depends upon having a close link to the staff responsible for delivery services and thus having the necessary specialised skills and interest.

Data Interpretation, Statistical↗
PubMed1995

Insulin dependent diabetes in children under 5: incidence and ascertainment validation for 1992.

OBJECTIVE: To establish the incidence of insulin dependent diabetes diagnosed in children under 5 years of age in the British Isles during 1992, comparing the national and regional results with those of our 1988 national study, and estimating the 1992 study's level of case ascertainment. DESIGN: Active monthly reporting of cases by consultant paediatricians through the framework of the British Paediatric Surveillance Unit, with additional reports from specialist diabetes nurses and regional health authorities. SUBJECTS: All children diagnosed under the age of 5 years with primary insulin dependent diabetes from 1 January to 31 December 1992 (inclusive) and resident in the British Isles at diagnosis. RESULTS: 387 children (208 boys and 179 girls) were confirmed to have insulin dependent diabetes, giving a national incidence of 9.3/100,000/year. This is similar to the 9.9/100,000/year found in 1988. Three sample capture-recapture analysis, which could only be applied across the 12 (out of 18) regions supplying regional information to the study, suggested ascertainment rates of 78% for the British Paediatric Surveillance Unit, 67% for specialist nurses, 69% for regional health authorities, and 99% for the aggregated registry. CONCLUSIONS: The national incidence of diabetes in the under 5s in the British Isles did not differ between 1988 and 1992. Nearly complete (99%) ascertainment of cases was possible only for regions for which three data sources were available. Capture-recapture analysis highlighted both the need for more than one data source and for each data source to be complete for the whole study area.

Age Factors↗