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PubMed1987

Eicosanoids as immunomodulators of penetration by Schistosome cercariae.

To infect a definitive host, schistosome cercorioe must identify and penetrate intact skin. This involves complex biochemical and morphological changes over a fairly brief time (48 hours), and possibly offers a potential point of intervention against infection. Attempts to define a vaccine against the invading organisms have so far been unsuccessful, but unravelling the complex biochemical interactions of schistosome penetration and transformation seems to suggest possible pharmacological or immunopharmacological interventions against these initial stages of infection.

Journal Article↗
PubMed2002

Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata, Schistosoma mansoni cercariae, Artemia salina and Tilapia nilotica.

The toxicity of soluble derivatives (potassium salt) of lapachol and isolapachol in different stages of the life cycle of Schistosoma mansoni is evaluated. The potassium salts of isolapachol and lapachol showed significant molluscicidal activity against the adult snail (LC90<7 ppm) and snail egg masses (LC90<3 ppm). Cercaricidal assays revealed strong activities for both compounds. Lethality assays against brine shrimp eggs (Artemia salina Leach) indicated very high toxicity for the potassium salt of isolapachol (LC90=1.54 ppm), differently from the potassium salt of lapachol that can be considered non toxic (LC90=176.3 ppm). The same tendency is observed with piscicidal activity, for which the isolapachol salt has showed higher toxicity. The obtained selectivity ratios concerning LC50 and LC90 for lapachol, in relation to Tilapia nilotica lethality assay are 2.33 and 1.26, respectively. Despite the piscicidal toxicity, the use of the salt of lapachol can be recommended for field tests in Schistosomiasis, with caution.

Animals↗