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A blind man (E.A.) was asked to draw pictures suggesting wheels in various kinds of motion. Six pictures were drawn by E.A. The pictures were shown to sighted subjects, who were asked to assign labels to the pictures, in a multiple-choice format. The labels were assigned at a rate above chance. We argue that the pictures are metaphoric and that pictorial metaphor relies on common properties of the static picture and the kinetic referent.
Eight groups of learning disabled children (N = 100), categorized by the clinical Lexical Paradigm as good readers or poor readers, were individually administered the Gilmore Oral Reading Test, Form D, by one of four input/retrieval methods: (1) the standardized method of administration in which the child reads each paragraph aloud and then answers five questions relating to the paragraph [read/recall method]; (2) the child reads each paragraph aloud and then for each question selects the correct answer from among three choices read by the examiner [read/choice method]; (3) the examiner reads each paragraph aloud and reads each of the five questions to the child to answer [listen/recall method]; and (4) the examiner reads each paragraph aloud and then for each question reads three multiple-choice answers from which the child selects the correct answer [listen/choice method]. The major difference in scores was between the groups tested by the recall versus the orally read multiple-choice methods. This study indicated that poor readers who listened to the material and were tested by orally read multiple-choice format could perform as well as good readers. The performance of good readers was not affected by listening or by the method of testing. The multiple-choice testing improved the performance of poor readers independent of the input method. This supports the arguments made previously that a "bypass approach" to education of poor readers in which testing is accomplished using an orally read multiple-choice format can enhance the child's school performance on reading-related tasks. Using a listening while reading input method may further enhance performance.
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This study investigated the relationship between the development of formal operations and the formation of ego identity in adolescence. Two Piagetian formal tasks, the combinatorial and equilibrium in the balance, and two measures of ego identity, a semistructured interview and an incomplete sentences test, were administered to 20 males and 20 females each at age levels 10-12, 13-15, and 16-18 years. Significant positive correlations were obtained between combinatorial ability and degree of identity, suggesting that high identity may facilitate the application of combinatorial operations. Males exhibited superior performance on the balance task; thus they may utilize more effective cognitive strategies, or be more inherently motivated to solve mechanical problems than females. On the identity interview, females showed a greater degree of commitment to future goals than males in middle adolescence; this may reflect the earlier maturation of females.
Article covers methodic approaches to evaluation of occupational risk for workers exposed to occupational hazards, suggests a concept concerning formation and evaluation of occupational risk, defines risk zones according to the length of exposure. All results can serve as a base for application of information technology to industrial medicine and determine tactics of hygienic and clinical monitoring. Occupational risk was suggested to be evaluated approximately and rapidly by means of length of exposure as an integral parameter. Topical problems were defined within the whole concept.
When parents label novel parts of familiar objects, they typically provide familiar whole-object terms before offering novel part terms (e.g., "See this cup? This is the rim."). Such whole-part juxtaposition might help children to accurately interpret the meaning of novel part terms, but it can do so only if they recognize the conjunction as a potential cue to part meaning. Two studies examined (a) whether 3- to 4-year-olds use whole-part juxtaposition to accurately interpret novel part terms and (b) how they might do so. Study 1 confirmed that children indeed use juxtaposition to guide learning of novel part terms. Furthermore, 2 control conditions clarified that children's use of juxtaposition was not simply due to memory effects, such as the facilitation of lexical access, nor to recognition of the grammatical frame that typically accompanies juxtaposition. Study 2 revealed that children readily use juxtaposition in a novel, gestural format. Such flexibility in recognizing and utilizing novel variants of juxtaposition strongly suggests that pragmatic understanding lies at the heart of children's sensitivity to whole-part juxtaposition.
We studied aspects of clock cognition that might underlie the sensitivity of the CDT in screening for dementia of the Alzheimer type (DAT). Two groups, 15 patients with mild-moderate DAT and 15 controls, were assessed with the CDT and specially designed tests of clock-related cognition. Patients were impaired on the CDT, but they did not differ from controls in copying a clock face or selecting the correct representation of a given time. Patients were worse than controls at distinguishing between clock and nonclock objects, detecting anomalies in clocks, and in setting time irrespective of response format. These findings suggest that semantic-conceptual aspects of clock-related cognition are important in discriminating between patients with DAT and controls.
The salience of various precursory requirements for the formation of symbols is discussed. The conclusion is drawn that several necessary precursors could be assumed, and two experiments are described that were designed to test for the presence of these precursors in autistic children compared to matched retarded children. First, there was a study of the children's ability to imitate and form internal images, and then there was a study of their development of a concept of object permanence and ability to anticipate. These studies led to the conclusion that the autistic children could form internal images but seemed to lack the ability to manipulate them in a purposeful and meaningful manner, as reflected in their inability to show symbolic imitations and their lack of tendency to use elements of their perceptions that might allow prediction of future events. The findings are discussed in terms of cognitive and social development.
Parkinson's disease (PD) is a movement disorder that also affects central cognitive processing; however, the extent to which high-order cognitive processes disrupted by PD affect complex motor function is incompletely explicated. The present analysis provides an examination of the relative contributions of simple motor versus complex cognitive functions involving sequencing, problem solving, and overall cognitive status to complex motor movements involving sequencing and temporal ordering in PD. Motor sequencing performance was videotaped for quantitative scoring. Compared with an age-matched control group, the PD group was impaired on motor agility and motor sequencing tasks in addition to cognitive sequencing and set shifting tasks. Neither current cognitive functioning, age, disease duration, nor overall intellectual abilities accounted for the relationships between motor sequencing and cognitive sequencing abilities in PD. By contrast, both sequencing and nonsequencing executive functions predicted motor sequencing performance as well as or better than motor rigidity or overall cognitive status. These relationships were strongest for the most challenging motor sequencing task, fist-edge-palm, and did not apply to the least challenging task, which required simple alternations of hand movements. Unlike PD, controls showed correlations between motor sequencing tests and executive functioning only tapping nonsequencing abilities. Thus, despite the predominant motor feature of PD, executive functions, as assessed by sequencing and set formation, predicted motor sequencing performance as well as or better than simple motor performance. The results further suggest that the more complex the motor sequencing task, the more susceptible it is to influence from generalized cognitive sequencing ability.
The purpose of this qualitative study was to extend our understanding of how adolescents view nicotine addiction. This secondary analysis included 80 open-ended interviews with adolescents with a variety of smoking histories. The transcribed interviews were systematically analyzed to identify salient explanations of nicotine addiction. These explanations presuppose causal pathways of nicotine exposure leading to addiction and include repeated use, the brain and body "getting used to" nicotine, personal weakness, and family influences. A further explanation is that some youths pretend to be addicted to project a "cool" image. These explanations illustrate that some youths see themselves as passive players in the formation of nicotine addiction. The findings can be used in the development of programs to raise youth awareness about nicotine addiction.
In order to encode an event or a thought into language, the speaker has to access words from the mental lexicon and order them according to the rules of syntax. The present study taps into these components of language production as they proceed in time. The utterances investigated were Dutch noun phrases with a prenominal adjective (e.g., het groene huis--the green house). The results of two picture--word interference experiments showed interference effects from semantically related noun distractors, extending findings from production of single words to the production of phrases. In addition, the syntactic format of the noun phrase had an influence on the size and the time course of the semantic interference effect. On the basis of the results of these two experiments, a working model of the processes involved in the production of noun phrases is proposed.
The present work investigated the role of children's and adults' metacognitive monitoring and control processes for unbiased event recall tasks and for suggestibility. Three studies were conducted in which children and adults indicated their degree of confidence that their answers were correct after (Study 1) and before (Study 2) answering either unbiased or misleading questions or (Study 3) forced-choice recognition questions. There was a strong tendency for overestimation of confidence regardless of age and question format. However, children did not lack the principal metacognitive competencies when these questions were asked in a neutral interview. Under misleading questioning, in contrast, children's monitoring skills were seriously impaired. Within each age group, better metacognitive differentiation was positively associated with recall accuracy in the suggestive interview.
Previous research has demonstrated how children develop the ability to use notational representations to indicate simple quantities. These studies have shown a developmental shift from the use of idiosyncratic, to analogical, to conventional, numerical notations. The present paper extends these findings by reporting the results from a study in which children from 3 to 7 years old were asked to write a representation to indicate a quantity presented in a game-like scenario. Three kinds of quantities were included: whole numbers, zeros, and fractions. The children's notations were shown to them shortly after they were produced and then again two weeks later to see if children could interpret them. The results showed the familiar developmental pattern towards increased use of conventional notations for all quantities. The ability to read the notations was greatest for conventional numbers where performance was at ceiling, lower for analogue representations, and very poor for idiosyncratic global recordings. Children's choice of a notational format was influenced almost entirely by their age and not by the quantity being represented. Children were able to solve the zero problems almost as well as they could the whole numbers, but their understanding and use of representations for fractions was very limited.
Radiofrequency (RF) is an alternating electric field with an oscillating frequency of 500,000 Hz. If the resulting current flows through a percutaneously introduced electrode, heat will be produced around the electrode because the body tissue acts as a resistor. RF can, therefore, be used to ablate nervous tissue in the treatment of chronic pain. This method has gained acceptance for percutaneous cordotomy and for the treatment of trigeminal neuralgia. For spinal pain, the method had little success initially, but since the introduction of small diameter instrumentation, the results have markedly improved. he mechanism of action of RF has not been challenged until recently even though there was awareness that some observations were not consistent with the heat concept. The formation of heat is not the only occurrence during RF treatment, however. The tissue surrounding the electrode is also exposed to the RF electric field. This exposure has a biological effect as has been demonstrated both in cells in a cell culture and in the exposure to RF of dorsal root ganglia, resulting in transsynaptal induction of early gene expression in the dorsal horn. The mode of action of RF is, therefore, uncertain at the moment. The method of pulsed RF is based on the concept that the production of heat has been a by-product of RF treatment and that the clinical effect is due to exposure to the electric field. In pulsed RF, the generator output is interrupted to allow for the elimination of heat in the silent period. The early results have been encouraging, but the results of controlled, prospective studies are not yet available. Since there are now 2 almost diametrically opposed views on the mode of action of RF, it is difficult to give recommendations for treatment. The decision is easy for indications for which heat RF has traditionally been contraindicated such as the treatment of peripheral nerves and trigger points. When the application of heat carries a potential risk, for instance if the dorsal root ganglion is the target structure, the use of pulsed RF is also recommended. As for the medial branch the situation is controversial. Since there are controlled studies available showing the effect of heat lesions, it is recommended that the technique should not be changed until further studies have been completed. Finally, the equipment for RF treatment is described and safety issues are discussed.
Third-year medical students participated in a program using a meal conference approach to teach ambulatory nutrition concepts called "Building Better Health Through Nutrition." The series of three interactive presentations was given during the required family medicine clerkship. A pretest and posttest were used to measure acquisition of nutrition knowledge. There was a statistically significant (P less than 0.05) average increase in posttest compared to pretest scores. Seventy percent of students rated the meal conference approach as "effective" or "very effective" and 76% stated that the series expanded their knowledge of nutrition's role in clinical medicine. We conclude that the meal conference format is an effective way to teach nutrition during the clinical years in medical school.
According to traditional concepts, ascites formation and portal hypertension in cirrhosis lead to a deficit in the 'effective' extracellular fluid (ECF) and blood volumes respectively. The renin-angiotensin-aldosterone (RAA) system is thus stimulated and the kidneys retain fluid as a homeostatic mechanism to restore the ECF and blood volumes. Recent studies, however, show that approximately two-thirds of patients with ascites do not have a stimulated RAA system and in those without clinical evidence of fluid retention the RAA system is actually suppressed. These findings are incompatible with the concepts of reduced effective ECF and blood volumes. Despite the fact that most patients retaining sodim and accumulating ascites have a normal plasma aldosterone concentration, other evidence strongly suggests a dominant role for aldosterone in the regulation of renal sodium excretion. There might therefore be an increased renal tubular sensitivity to aldosterone in cirrhosis. For the one-third of patients with ascites who do have a stimulated RAA system this may well be a response to reduced effective ECF and/or blood volumes in accord with traditional concepts.
Whether and when children can apply their developing understanding of belief to persuasion was examined using interactive puppet tasks. Children selected 1 of 2 arguments to persuade a puppet to do something (e.g., pet a dog) after hearing the puppet's belief (e.g., "I think puppies bite"). Across 2 studies, 132 children (ages 3-7 years) engaged in these persuasion tasks and in false-belief reasoning tasks, presented in puppet and story formats. Belief-relevant argument selection increased with age, as did appropriate reasoning about false beliefs, and occurred more in puppet than story tasks. Results suggest that improvements in belief reasoning in early childhood may be reflected in social interactions such as persuasion.
Protein-glutathione mixed disulfide (protein-S-SG) formation was investigated in developing rat conceptuses during early organogenesis (gestational day 10, GD 10) using the whole embryo culture system. Low levels of protein-S-SG (25.0 +/- 6.6 pmoles resolved GSH/conceptus) were found in conceptuses under normal culture conditions. Incubation of the conceptuses with 75-500 microM diamide (a thiol oxidant) resulted in rapid increases in protein-S-SG (to 2- to 16-fold that of control values) in a dose-dependent manner during 30 min of the culture period. Approximately 20% of the observed cytosolic glutathione (GSH) depletion following diamide (500 microM) could be accounted for as mixed disulfides of protein sulfhydryls, when determined in whole conceptual tissues after 15 min. The most extensive S-thiolation of protein sulfhydryls by GSH was observed in visceral yolk sac (VYS) when compared to embryo proper and ectoplacental cone. This result indicates that the most abundant, sensitive, or accessible protein sulfhydryls were found in the VYS. Inhibition of glutathione disulfide reductase activity by pretreatment of the conceptuses with 25 microM BCNU for 2 hr potentiated protein-S-SG formation elicited by 75 microM diamide. Reincubation of the conceptuses in fresh media, following the 15-min treatment with 500 microM diamide, reversed both the GSH depletion and the protein-S-SG formation in conceptal tissues. The reduction of the protein-S-SG was dependent on adequate intracellular GSH levels and was inhibited when GSH was rapidly depleted by subsequent addition of N-ethylmaleimide (NEM, 100 microM). Under the same experimental conditions, addition of 1 mM dithiothreitol (DTT) did not significantly enhance the GSH restoration rate nor the protein-S-SG reduction rate. The results also indicated that low levels of intracellular cysteine do not play an important role in the reduction of protein-S-SG. Protein-S-SG formation may be important for cellular regulation and in mediating the embryotoxicity elicited by diamide or other oxidative stresses.