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At least 883 records · Page 49Linked to original sources
PubMed2003

Cataract formation after initial trabeculectomy in young patients.

OBJECTIVE: To evaluate the risk of cataract formation in young patients after initial trabeculectomy. DESIGN: Retrospective, noncomparative case series. PARTICIPANTS: Thirty-four eyes from 27 patients undergoing initial trabeculectomy at the Glaucoma Consultation Service, Massachusetts Eye and Ear Infirmary (mean age, 43.7 years; range, 12-54 years). INTERVENTION: Follow-up averaged 42.6 months (range, 11-90 months). METHODS: Lens status was observed before surgery and at 3 months; 6 months; and 1, 2, 3, 4, 5, and 6 years after initial trabeculectomy. MAIN OUTCOME MEASURE: The main outcome measure was defined as cataract extraction for visually significant lenticular opacifications that developed after trabeculectomy. RESULTS: The rate of cataract extraction after initial trabeculectomy was 24% (n = 8). The average time from trabeculectomy to cataract extraction was 26 months (range, 5-58 months). Progression of lenticular opacities occurred throughout the follow-up period. There was no increased rate of cataract formation in subjects with uveitic and steroid-induced glaucoma when compared with all other types of glaucoma. In the patients with both eyes in the study, the first eye was a predictor of cataract progression in the fellow eye. CONCLUSIONS: Cataract is a common complication after trabeculectomy in young patients. The 24% rate of cataract extraction after trabeculectomy reported in this study is a significant risk of which young patients contemplating surgery should be aware.

Adolescent↗
PubMed1994

The relation of socioeconomic factors to age-related cataract, maculopathy, and impaired vision. The Beaver Dam Eye Study.

PURPOSE: To investigate the relations between socioeconomic factors and the prevalence of age-related cataract, maculopathy, and visual impairment. METHODS: A population-based sample of 4926 people 43 to 86 years of age was examined from 1988 to 1990. Education, income, employment status, marital status, nuclear sclerosis, cortical, and posterior subcapsular cataract, age-related maculopathy, and impaired vision were all ascertained using standard protocols. RESULTS: While controlling for age, sex, diabetes status, multivitamin use, alcohol consumption, and cigarette smoking, less education was significantly associated with nuclear and cortical cataract, and lower income was significantly associated with cortical and posterior subcapsular cataract and impaired vision. There was a "U-shaped" relation between income and cataract surgery. Neither income nor education was related to age-related maculopathy. There was no relation of marital status to cataract status or age-related maculopathy. CONCLUSION: These data suggest that education and income are associated with cataract, cataract surgery, and impaired vision. These relations were not explained by other risk factors measured in the study.

Adult↗
PubMed1994

National study of cataract surgery outcomes. Variation in 4-month postoperative outcomes as reflected in multiple outcome measures.

BACKGROUND: Although ophthalmologists have long recognized that visual acuity alone is an inadequate measure of visual impairment, the need for and outcomes of cataract surgery historically have been assessed in terms of visual acuity. PURPOSE: To examine the relation among different cataract surgery outcome measures, including a 14-item instrument designed to measure functional impairment caused by cataract (the VF-14), at 4 months after cataract surgery. METHODS: The authors performed a longitudinal study of 552 patients undergoing first eye cataract surgery by 1 of 75 ophthalmologists practicing in Columbus, Ohio, St. Louis, Missouri, or Houston, Texas. Patients were interviewed, and clinical data were obtained preoperatively (July 15, 1991-March 14, 1992) and 4 months postoperatively. RESULTS: The percentage of patients judged to be improved at 4 months after cataract surgery varied by the outcome measure used: Snellen visual acuity (96%); VF-14 score (89%); satisfaction with vision (85%); self-reported trouble with vision (80%); and Sickness Impact Profile score (67%). The change in patients' ratings of their trouble with vision and their satisfaction with vision were correlated more strongly with the change in VF-14 score than with the change in visual acuity (operated eye or better eye). The average change in VF-14 score was unrelated to the preoperative visual acuity in the eye undergoing surgery. CONCLUSION: Estimates of the proportion of patients benefiting from cataract surgery vary with the outcome measure used to measure benefit. Change in VF-14 score, a measure of functional impairment related to vision, may be a better measure of the benefit of cataract surgery than change in visual acuity.

Aged↗
PubMed1995

Distribution of cataract types in the Italian-American case-control study and at surgery in the Parma area.

PURPOSE: To compare the distribution of cataract types at surgery with the distribution detected in an ophthalmology clinic-based case-control study in the same geographic area (Parma, Italy). METHODS: The distribution of cataract type assessed according to the Lens Opacities Classification System I in 284 consecutive patients 45 years of age or older, who were admitted for cataract surgery to the Institute of Ophthalmology in Parma during 1994, was compared with the distribution assessed in 1008 participants in the Italian-American case-control study of age-related cataract in the Parma metropolitan area from 1987 to 1989. RESULTS: Analysis of cataract distribution indicates in the surgical group, compared with the case-control population, a significant increase of nuclear (N) and posterior subcapsular (PSC) opacities (any), a reduction of pure forms of cortical and N cataracts, and a marked increase of mixed types of opacities with a simultaneous N and PSC component. CONCLUSION: Although cortical opacities are probably the most prevalent type of age-related lens change in the general population of Parma metropolitan area, the type of cataract most frequently responsible for the decision of patients to undergo cataract surgery is a mixed type of opacity with an N-PSC component.

Aged↗
PubMed1995

Cataract surgery in one eye or both. A billion dollar per year issue.

PURPOSE: To measure the relative effect of cataract surgery in the second eye compared with the first eye on functional impairment, satisfaction, and vision problems. METHODS: Seventy-five randomly selected ophthalmologists in three cities in the United States were enrolled in a National Study of Cataract Outcomes. They, in turn, referred eligible, sequential patients scheduled for first-eye cataract surgery. Interviews were conducted at enrollment, 4 months after first-eye surgery, and 12 months after first-eye surgery. An attempt was made to conduct a special, preoperative interview of those patients scheduled to undergo second-eye surgery before the 4-month interview. Each interview included administration of the VF-14 (a 14-item questionnaire that assessed visual function), as well as questions about symptoms possibly related to cataract, "trouble with vision," and satisfaction with vision. RESULTS: Seven hundred seventy-two patients were enrolled in the study, and interview data to 12 months were obtained from 669 (86%) patients. Of these patients, 243 (36%) underwent cataract extraction in the second eye during the 12-month period of observation. Overall, subjects who underwent cataract surgery in both eyes during the 12-month period had 61% greater improvement in VF-14 score (P < 0.001), 27% more decline in trouble with vision (P < 0.001), and 24% greater improvement in satisfaction with vision (P < 0.001) compared with those who underwent surgery in only one eye. CONCLUSIONS: Cataract surgery in the second eye of patients with bilateral cataract is associated with clinical and statistically significant improvement in functional impairment, trouble with vision, and satisfaction with vision.

Aged↗
PubMed1997

Incident cataract surgery: the Beaver Dam eye study.

PURPOSE: The authors describe the incidence of cataract surgery in participants of the Beaver Dam Eye Study. METHODS: Objective evidence of cataract extraction as obtained at follow-up examinations of participants of a population-based cohort is given. Participants included all adults 43 to 84 years of age who lived in the city or township of Beaver Dam, Wisconsin. RESULTS: Age-adjusted incidence is significantly greater for women, for those with lower diastolic blood pressure, for those with hypertension, widows/widowers, and for those who report that their vision is worse than it had been. Multivariate analyses disclose that the following characteristics (with their respective odds ratios) are significantly associated with incident cataract surgery: age (odds ratio [OR] for 10 years 1.40; 95% confidence interval [CI] 1.02, 1.91); cigarette smoking (> or = 35 pack years; OR 1.91; 95% CI 1.16, 3.17); nuclear cataract (OR 35.58; 95% CI 10.12, 125.17 at age 50 years); cortical cataract (OR 3.75; 95% CI 2.40, 5.88); posterior subcapsular cataract (OR 15.51; 95% CI 8.27, 29.09); impaired vision (OR 3.76; 95% CI 2.33, 6.05); intraocular pressure (> or = 14 mmHg; OR 2.56; 95% CI 1.50, 4.38); visual sensitivity to light (OR 1.94; 95% CI 1.19, 3.17); refractive error (myopic) (OR 1.99; 95% CI 1.22, 3.24); yellow color (OR 1.69; 95% CI 1.02, 2.81); and being examined by an ophthalmologist within 2 years (OR 1.54; 95% CI 1.03, 2.30). CONCLUSIONS: Many factors are associated with cataract surgery, but the prior presence of posterior subcapsular cataract is the most important lens opacity. In addition, visual function changes, which may be relatively mild, are associated with subsequent incident surgery.

Adult↗
PubMed1998

Cataracts after total body irradiation and bone marrow transplantation in patients with acute leukemia in complete remission: a study of the European Group for Blood and Marrow Transplantation.

PURPOSE: Advances in bone marrow transplantation (BMT) have consistently improved long-term survival. Therefore, evaluation of late complications such as cataracts is of paramount importance. METHODS AND MATERIALS: We analyzed data of 2149 patients from the EBMT registry. A cohort of 1063 patients were evaluable for survival and ophthalmologic status after transplant for acute leukemia (AL) in first or second complete remission. Conditioning therapy included either single-dose total body irradiation (STBI) or fractionated TBI (FTBI) grouped in different dose rates (low: LDR < or = 0.04 Gy/min; high: HDR > 0.04 Gy/min). RESULTS: The overall 10-year estimated cataract incidence (ECI) was 50%. It was 60% in the STBI group, 43% in the FTBI group < or = 6 fractions, and 7% in the FTBI group > 6 fractions (p < 10(-4)). It was significantly lower (30%) in the LDR than in the HDR groups (59%;p < 10(-4)). Patients receiving heparin for veno-occlusive disease prophylaxis had fewer cataracts than those who did not (10-year ECI: 33% vs. 53%, respectively;p = 0.04). The 10-year ECI was 65% in the allogeneic vs. 46% in the autologous BMT patients (p = 0.0018). Factors independently associated with an increased risk of cataract were an older age (> 23 years), higher dose rate (> 0.04 Gy/min), allogeneic BMT, and steroid administration (> 100 days). The use of FTBI was associated with a decreased risk of cataract. Heparin administration was a protective factor in patients receiving STBI. In terms of cataract surgery, the unfavorable factors for requiring surgery were: age > 23 yr, STBI, dose rate > 0.04 Gy/min, chronic graft-vs.-host disease (cGvHD), and absence of heparin administration. Among the patients who required cataract surgery (111 out of 257), secondary posterior capsular opacification was observed in 15.7%. CONCLUSION: High dose rate and STBI are the main risk factors for cataract development and the need for surgery, and the administration of heparin has a protective role in cataractogenesis.

Adolescent↗
PubMed1991

Assessment of contrast sensitivity. Part II: The relationship between objective lens opacity and laser interferometric contrast sensitivity in the cataract patient.

The laser interferometer can effectively bypass the optics of the eye and measure retinal function in patients with immature cataracts. However, it is not known how much laser interferometric measurements are impaired by cataract density. In this study we compared objective lens opacity using the IntraOptics opacity lensmeter with contrast sensitivity (CS) measured by a Randwal He-Ne laser interferometer. Comparison of lens opacity with CS in the cataract population revealed an inverse linear relationship between objective lens opacity and retinal contrast sensitivity. Separation by cataract type showed correlation coefficients as high as -0.91 for nuclear sclerotic predominant cataracts and as low as no significant correlation for posterior subcapsular predominant cataracts. Comparisons of before and after implantation surgery contrast sensitivities (as measured by the laser interferometer) with preoperative lens opacities (as measured by the IntraOptics opacity lensmeter) quantified the extent to which laser interferometric measurements underestimated potential retinal function. We found that for all cataracts, other than posterior subcapsular predominant cataracts, potential contrast sensitivity (in decibels) was underestimated by about 0.2 to 0.3 times the opacity measured by this technique.

Adult↗
PubMed1996

Improved stereoacuity: an indication for unilateral cataract surgery.

PURPOSE: To determine whether stereoacuity is an objective indicator of functional improvement following unilateral cataract surgery. SETTING: Department of Opthalmology, Loyola University Chicago, Maywood, Illinois. METHODS: Seventeen consecutive patients with unilateral cataracts (8 pseudophakic, 9 phakic in contralateral eye) were studied prospectively. Best corrected distance visual acuity in the eye with cataract ranged from 20/40 to 20/400. Distance acuity in the eye without cataract was 20/20 or 20/25. All patients had cataract surgery with posterior chamber intraocular lens implantation. Stereoacuity was measured preoperatively and postoperatively; at near by Titmus test (TT) and at distance by B-VAT BVS random dot E (BVRDE) and contour circles (BVC). Nonparametric Spearman rank correlation and Wilcoxon rank tests were used for analysis. RESULTS: Preoperatively, reduced near visual acuity in the cataractous eye correlated with reduced near stereo (TT), r = .6, P = .01. Postoperatively, near stereoacuity improved in all but one patient, from a median of 200 seconds of arc (sec arc) to 40 sec arc (P = .004); distance stereoacuity improved in all but two patients from a median of unrecordable to 120 sec arc (BVC) (P = .006). Preoperatively none of the patients could see the largest distance BVRDE target, whereas postoperatively 4 of 17 had BVRDE stereoacuity of 120 to 240 sec arc (P = .06). CONCLUSIONS: Patients with unilateral cataracts have reduced stereoacuity, correlating with their reduced monocular visual acuity. In this study, distance and near stereoacuity improved postoperatively. Decreased stereoacuity may provide an indication for unilateral cataract surgery.

Aged↗
PubMed1997

Incidence of posterior capsular plaque in cataract surgery.

OBJECTIVE: To determine the incidence of posterior capsular plaque detected during cataract surgery, its association with age and type of cataract, and its impact on vision. SETTING: Raghudeep Eye Clinic and Iladevi Cataract & IOL Research Centre, Ahmedabad, India. METHODS: This prospective study comprised 256 consecutive eyes having extracapsular cataract extraction with posterior chamber intraocular lens implantation. The presence of plaque on the posterior capsule was noted and charted. Plaque peeling or posterior capsulorhexis was not done at the time of surgery. Mean patient age was 59 years (range 24 to 83 years). Follow-up was up to 1 year. RESULTS: The overall incidence of plaque was 10.16%. The incidence by type of cataract was 5.13%, nuclear sclerotic; 12.50%, posterior subcapsular; 9.68%, mixed; 27.27%, mature (P < .05). The difference in incidence according to cataract type was highly significant between patients older than 50 years and those younger than 50 years (P < .001). At the end of 1 year, 61.54% of patients with plaque maintained a visual acuity of 20/20 to 20/30; 30.77%, 20/40; 7.69%, 20/60 or worse. CONCLUSION: The incidence of plaque was higher in eyes with mature cataract at any age and in eyes with posterior subcapsular cataract in younger patients. Its presence was compatible with reasonable vision at the end of 1 year.

Adult↗
PubMed1997

Catquest questionnaire for use in cataract surgery care: description, validity, and reliability.

PURPOSE: To describe and evaluate the Catquest self-assessment questionnaire for cataract patients. SETTING: Thirty-five Swedish departments of ophthalmology. METHODS: The Catquest is designed to be used by cataract surgeons for continuous quality control regarding appropriateness and outcome of surgery. It is administered before and after cataract surgery. The questionnaire focuses on visual disabilities in daily life, activity level, cataract symptoms, and degree of independence. The results are interpreted using a benefit matrix that credits not only a decrease in visual disabilities and cataract symptoms but also an improvement or a maintenance of a preoperative activity level. The questionnaire was used by consecutive patients having surgery during March 1995 at the participating surgical units. RESULTS: A full range of responses was given to all questions. A strong relationship was found between patients' responses to questions about visual disabilities in daily life and their general opinion about vision (P < .001). The answers showed a high stability when test-retest reliability was evaluated and a high internal consistency when different questions about visual disabilities were compared (P < .001). The answers from cataract patients before surgery were significantly different from those of a control group that did not have cataract (P < .0001). CONCLUSION: The Catquest had high validity and reliability when used as a disease-specific instrument testing visual disabilities in patients having cataract extraction.

Aged↗
PubMed1999

Complications after early surgery for congenital cataracts.

PURPOSE: To study the type and frequency of complications requiring additional surgery in infants operated on for congenital cataract before 12 months of age. METHODS: The medical records of 57 infants who underwent surgery for unilateral and bilateral congenital cataracts during a five-year-period were reviewed retrospectively. The follow-up period ranged from 9 to 70 months with a mean of 37 months. Cataract extraction was performed on 83 eyes. RESULTS: Thirty-eight operations for after-cataracts were performed on 32 out of 83 eyes. Fourteen vitrectomies were made on 11 eyes because of pupillary block glaucoma. Glaucoma requiring trabeculectomy developed in eight eyes 2 to 14 months after cataract extraction. This type of glaucoma occurred almost exclusively in eyes operated on during the first two months of life. CONCLUSION: Complications requiring additional surgery are very common in infants operated on for congenital cataracts during the first year of life. Glaucoma requiring trabeculectomy developed particularly in infants who had their cataract extraction very early. Glaucoma development was not more common in infants operated on for after-cataract.

Cataract↗
PubMed2000

[Changes in the lens epithelium of diabetic and non-diabetic patients with various forms of opacities in senile cataract].

BACKGROUND: The crucial role of the lens epithelium with respect to cataractogenesis has to be further evaluated. In this prospective clinical study, morphological characteristics of human lens epithelium in type-II diabetics and nondiabetics were examined and compared. MATERIALS AND METHODS: 30 (16 female, 14 male, mean age 73.0 years) of the overall 59 patients with age-related cataract suffering from type-II diabetes were assigned to group I and 29 nondiabetics (16 female, 13 male, mean age 68.2 years) to group II. Age, gender, type of cataract and the blood parameters fasting blood sugar and glycolized hemoglobin were further parameters. The different types of opacities (LOCS II) were summarized into 4 groups. After surgery the collected hematoxylin-eosin stained anterior central lens capsules with attached lens epithelial cells were analyzed by light microscope for the cell parameters cell density (morphometry), nucleus area (A0), nucleus volume (V), cell area (A) and nucleus-plasma-ratio. RESULTS: The mean cell density in type-II diabetics (group I) is 3691 +/- 346 cells/mm2 and in nondiabetics (group II) 4162 +/- 504 cells/mm2, respectively (p = 0.001). The total female mean cell density (4036 +/- 525 cells/mm2) was not significantly higher than the male (3788 +/- 412 cells/mm2). A decrease of the mean cell density could be attributed to age only in the nondiabetic group. With regard to the type of cataract the posterior subcapsular cataract shows the lowest mean cell density (3620 +/- 333 cells/mm2) and the nuclear cataract (4250 +/- 513 cells/mm2) the highest, respectively. The medium nucleus area and -volume and cell area are in the type-II diabetic group significantly larger than in nondiabetics. With regard to the type of cataract the posterior subcapsular opacity has the significantly largest values. The medium nucleus-plasma-ratio in type-II diabetics is lower than in nondiabetics and decreased with age. CONCLUSIONS: The significantly lower mean cell density in type-II diabetics compared with nondiabetic eyes and in posterior subcapsular cataracts in comparison with nuclear and cortical cataracts seem together with the other morphological cell characteristics to be due to the cataractogenic influence of diabetic metabolic disorder on the lens epithelium, especially in cases of posterior subcapsular opacity. These may be some clues for the primary cataractogenic importance of the lens epithelium in type-II diabetes.

Age Factors↗
PubMed1981

[30 years of cataract operation (author's transl)].

A survey is given of 26443 cataract operations at the University Eye Hospital of Graz in the years 1950-1980. Different phases are evident: 1. Extraction with a forceps. 2. A phase of expression. 3. Extraction by means of an erysiphake. 4. Extraction with a cryo-extractor. Enzymatic zonulolysis is of particular importance and performed with trypsin only. Almost all cataract operations are performed by enzymatic zonulolysis with trypsin. Details of the operation technique are pointed out. The connections between cataract surgery and increased intraocular pressure, vitreous body complications and retina and mentioned. Complications during and after operation and problems of anesthesia are discussed. Different special questions like cataract diabetes, cataract and myopia, cataracta complicata, cataracta congenita, cataracta traumatica and cataracta secundaria are pointed out. Our opinion is also given on combined operations like cataract and glaucoma, cataract and keratoplasty or binocular cataract operation. The correction of aphakia by means of intraocular lenses or refractive keratoplasty is discussed.

Anesthesia, General↗
PubMed2003

Cataract blindness in Paraguay--results of a national survey.

PURPOSE: To estimate the burden of visual loss and blindness due to cataract in people aged 50 years and over in Paraguay. METHODS: Forty clusters of 60 persons each who were 50 years and older (2400 eligible persons) were selected by systematic random sampling from the entire population of Paraguay. A total of 2136 persons were examined (89% coverage). RESULTS: For the population 50 years and over, the age- and gender-adjusted prevalence of bilateral blindness (VA < 3/60 with available correction) was 3.14% (95% CI: 2.2-4.4). The adjusted prevalence of bilateral cataract blindness (VA < 3/60) was 2.01% (95% CI: 1.3-3.0), making cataract the major cause of bilateral blindness in this age group (64%). The adjusted prevalence of bilateral severe visual impairment (VA < 6/60 with available correction) was 5.17% (95% CI: 3.9-6.7) and the adjusted prevalence of severe visual impairment due to bilateral cataract (VA < 6/60) was 3.09% (95% CI: 2.2-4.3). The cataract surgical coverage (persons) was 44% for bilaterally blind persons with VA < 3/60; 36% for persons with bilateral VA < 6/60; and 28% for any eye with VA < 6/60 due to cataract. With IOL implantation, 77% of the operated eyes could see 6/18, against 46% of the non-IOLs (p < 0.005), a significant better outcome. CONCLUSION: There is a need to increase the cataract surgical coverage in Paraguay. The number of eye surgeons is adequate but the accessibility of cataract surgical services in rural areas and the affordability of surgery to large sections of society are major constraints.

Aged↗
PubMed2002

A simplified cataract grading system.

A simplified method for grading the presence and severity of different cataract types is needed for field use in assessment of the magnitude of the cataract problem. A cataract grading system was developed by a panel of experts with the objective of making available a simple system for use with a slit lamp to allow for the reliable grading of the most common forms of cataract by relatively inexperienced observers. Three levels, reflecting progressive severity, for grading of nuclear, cortical and posterior subcapsular (PSC) cataract were included in the classification; three standard photos were used for grading nuclear cataract. Field evaluation from four different sites indicated very good to fair interobserver agreement with the use of this system following minimal training of residents in ophthalmology at each site. Further testing of this system is warranted. The WHO simplified cataract grading system should allow for the obtaining of comparable data across countries based on field assessment of the most common forms of cataract.

Cataract↗
PubMed2005

Clinical research, comparison of the subjective visual function in patients with epiphora and patients with second-eye cataract.

PURPOSE: To assess the subjective visual disability of patients with epiphora and to compare the results with that of patients waiting for second eye cataract surgery. DESIGN: A prospective, randomised, questionnaire-based study. METHODS: Forty-six patients with epiphora listed for dacryocystorhinostomy and 50 patients having second eye cataract extraction were enrolled. A questionnaire focusing on functional visual disability in daily life and based on VF-14 was completed for each participant. RESULTS: Eighty-six percent of patients with epiphora and 41% of second-eye cataracts had difficulty reading small print (P < 0.05). The extent of such difficulty was moderate to great in 48% of epiphora and only 26% of cataract patients .A substantial percentage of epiphora patients and second eye cataract also reported difficulty with other tasks, such as doing fine work (78.9% vs. 42%) (P < 0.05), watching television (63.1% vs. 19%) (P < 0.05), seeing steps or stairs (43.4% vs. 10%) (P < 0.05), or reading signs (39.1% vs. 4%) (P < 0.05), respectively. CONCLUSIONS: There is widespread recognition of the effect of cataract on visual function. This has resulted in substantial government funding to improve access to cataract surgery. In comparison, epiphora is rarely considered as a significant cause of visual disability. This study suggests that patients with epiphora suffer the same if not more of a visual handicap than patients awaiting second eye cataract surgery.

Activities of Daily Living↗
PubMed2004

Five-year incidence of cataract in older persons with diabetes and pre-diabetes.

PURPOSE: To investigate longitudinal associations between diabetes and the 5-year incidence of cataract and cataract surgery. (A population-based, cohort study of 2335 persons with baseline ages 49 years or older resident in the Blue Mountains region, west of Sydney, Australia). METHODS: Baseline information on diabetes history was collected during an interviewer-administered questionnaire. Impaired Fasting Glucose (IFG) was defined as venous plasma glucose between 6.0 and 7.0 mmol/L and newly diagnosed diabetes as plasma glucose >7.0 mmol/L, using fasting blood glucose measurements taken at baseline. Retroillumination lens photographs from the baseline and 5-year follow-up examinations were graded for presence of cortical, posterior subcapsular (PSC) and nuclear cataract. RESULTS: We found a 2-fold higher 5-year incidence of cortical cataract in participants with IFG, multivariate adjusted odds ratio (OR) 2.2, 95% confidence interval (CI) 1.1-4.1. Incident PSC cataract was more frequent among persons with diabetes, but this association was statistically significant only for those with newly diagnosed diabetes, multivariate adjusted OR 4.5 (CI 1.5-13.0). There were no statistically significant associations found between incident nuclear cataract or cataract surgery and either diabetes or IFG. CONCLUSIONS: These epidemiological data suggest that IFG, a pre-diabetic condition, may be a risk factor for the development of cortical cataract.

Aged↗