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Performance of a brain PET camera based on anger-logic gadolinium oxyorthosilicate detectors.

UNLABELLED: A high-sensitivity, high-resolution brain PET scanner ("G-PET") has been developed. This scanner is similar in geometry to a previous brain scanner developed at the University of Pennsylvania, the HEAD Penn-PET, but the detector technology and electronics have been improved to achieve enhanced performance. METHODS: This scanner has a detector ring diameter of 42.0 cm with a patient aperture of 30.0 cm and an axial field of view of 25.6 cm. It comprises a continuous light-guide that couples 18,560 (320 x 58 array) 4 x 4 x 10 mm(3) gadolinium oxyorthosilicate (GSO) crystals to 288 (36 x 8 array) 39-mm photomultiplier tubes in a hexagonal arrangement. The scanner operates only in 3-dimensional (3D) mode because there are no interplane septa. Performance measurements on the G-PET scanner were made following National Electrical Manufacturers Association NU 2-2001 procedures for most measurements, although NU 2-1994 procedures were used when these were considered more appropriate for a brain scanner (e.g., scatter fraction and counting-rate performance measurements). RESULTS: The transverse and axial resolutions near the center are 4.0 and 5.0 mm, respectively. At a radial offset of 10 cm, these numbers deteriorate by approximately 0.5 mm. The absolute sensitivity of this scanner measured with a 70-cm long line source is 4.79 counts per second (cps)/kBq. The scatter fraction measured with a line source in a 20-cm-diameter x 19-cm-long cylinder is 39% (for a lower energy threshold of 410 keV). For the same cylinder, the peak noise equivalent counting rate is 60 kcps at an activity concentration of 7.4 kBq/mL (0.20 micro Ci/mL), whereas the peak true coincidence rate is 132 kcps at an activity concentration of 14 kBq/mL (0.38 micro Ci/mL). Images from the Hoffman brain phantom as well as (18)F-FDG patient scans illustrate the high quality of images acquired on the G-PET scanner. CONCLUSION: The G-PET scanner attains the goal of high performance for brain imaging through the use of an Anger-logic GSO detector design with continuous optical coupling. This detector design leads to good energy resolution, which is needed in 3D imaging to minimize scatter and random coincidences.

Brain↗

Peer and family influences on adolescent anger expression and the acceptance of cross-gender aggression.

Past research has examined the relative impact of family and peers on adolescent behavior, but very little research has examined it in relation to youth dating violence. Eight hundred and sixty-five adolescents, primarily urban Latino youth, completed self-administered surveys at school. Multivariate analyses indicated that exposure to prior family violence was not significantly associated with adolescents' aggressive expression of anger or their acceptance of cross-gender aggression. However, current conflict--either family or peer--was associated with adolescent behavior and attitudes, with the exception that current peer conflict was not significantly associated with adolescents' acceptance of male on female aggression. Parental monitoring and attachment were not found to be moderators of these relationships. Implications for dating violence interventions and future directions for research are explored.

Adolescent↗

The Ketterer Stress Symptom Frequency checklist: anger and the severity of coronary artery disease.

Recent research suggests that the most potent feature of the Type A behavior pattern for prospectively predicting cardiac disease is aggravation, irritation, anger, and impatience (AIAI). The present study examines psychometric properties of a new AIAI measure and its relationship to the severity of coronary artery disease (CAD). Subjects included 61 males undergoing coronary angiography. Comparisons were made of mean psychometric scores across groupings, defined by number of vessels occluded. These comparisons showed that the normal or subclinically occluded coronary angiographic group had high levels of depression and anxiety. Higher levels of AIAI were observed in patients with multivessel CAD compared to those with single vessel disease. Because of their psychological abnormality, the normal and subclinically occluded angiographic patients are an inappropriate control group for AIAI studies intended to address the etiology of CAD. Nonetheless, evaluation of these patients for the presence of depressive and anxiety disorders frequently has clinical importance.

Anxiety Disorders↗

[Role of the hospital pharmacy in the preparation of an emergency plan. Experience of the central pharmacy of Angers Regional University Hospital Center].

In case of disasters, an emergency plan has been set up in Angers hospital, to conform to the law. This plan concerns many partners including the hospital Pharmacist. The two principal roles of the Pharmacist are the elaboration of a checklist of drugs, medical and hospital supplies necessary for the care of the victims and the sep up of emergency containers. The computerization of this plan will facilitate its management. Thus the Hospital Pharmacist contributes to the rationalization of a health care necessity in a constrained economic context.

Drug Packaging↗

Performance changes of an Anger camera in magnetic fields up to 10 G.

Magnetic fields much larger than the earth's magnetic field can exist many feet away from NMR units. Gamma camera manufacturers already shield photomultiplier tubes from the earth's magnetic field (approximately 0.5 G). The effects of larger magnetic fields on an Anger camera, were made in fields up to 10 G. Sensitivity and positional stability were studied as a function of gantry angle in a magnetic field. Scans of uniform and hot rod sections of and ECT phantom were also performed. No visible artifacts were found in reconstructions of the phantom measured in a 5-G magnetic field, although some small sensitivity and linearity effects did exist. In 10-G fields, planar and reconstructed images were grossly distorted. Magnetic shielding placed across the collimator reduced the influence of the magnetic field but at a cost in sensitivity that varies with photon energy.

Evaluation Studies as Topic↗

Scintigraphic imaging with tantalum-178 and the Anger scintillation camera: concise communication.

Tantalum-178 is a short-liver radionuclide (T 1/2 = 9.3 min.) and emits primarily 56- to 64-keV characteristic x-rays. We have determined the imaging characteristics with this radionuclide and a large-field-of-view Anger camera. With a pinhole collimator, good spatial resolution is possible with Ta-178, although the image quality is superior with Tc-99m under comparable conditions. Spatial resolution with parallel-hole or converging collimators was much less satisfactory with Ta-178 because of septal penetration by high-energy photons. Pulmonary perfusion and liver-spleen images of excellent quality were obtained in the rabbit using the pinhole collimator and Ta-178-labeled agents.

Animals↗

[Value of MS associated factors for test procedures in multiple sclerosis: 2. Angers' MS-induced substance in the LAI test].

Attempts to find test systems specific for multiple sclerosis are directed to the investigation of MS-associated factors in serum. Basing on the methods of the adherence of antigen-reactive leukocytes, the MSRM (MS-related material) a substance conditioned by the disease was derived from blood of MS-patients and applied in the leukocyte adherence-inhibition (LAI)-test. The mean values in the LAI-test showed a significant difference between MS, the other neurological diseases (OND) and the normals. For the limiting value mean NK +/- 2 s a positive LAI-effect resulted in 58% of the intermittent and in 43% of the chronic-progredient cases of MS, yet also in 11% of the OND. The fact that the rate of detection is lower than that reported by Angers, could depend on factors caused by the method used or by anomalies of immune regulation in MS (including the so-called blocking factors in serum). The results received with LAI-test applying the MSRM don't allow any definite diagnostical assessment specific for MS.

Antigens, Viral↗

A new method of multiplanar emission tomography using a seven pinhole collimator and an Anger scintillation camera.

A new method of multiplanar emission tomography is described; it uses a wide-field Anger scintillation camera (37.5 cm crystal diameter) and a seven-pinhole collimator. The pinholes (5.5 mm) acquire data simultaneously from the emissing source and project the data onto seven independent regions of the camera crystal. Multiple planes are reconstructed from the initial seven-view data acquisition through the use of a computerized addition-multiplication algorithm and variation of the superposition relationships among the projected views. These planes are then altered iteratively by a least-error criterion following ray-sum comparison with the original views. Planar resolution (full-width-half-maximum) is 1.0 cm and depth resolution is 1.5 cm. In 42 patients with angiographically demonstrated coronary-artery disease, studies of myocardial Tl-201 perfusion, under exercise, have shown improved detection sensitivity in comparison with scintigraphy using parallel-hole collimation.

Coronary Disease↗

Adrenal scintigraphy: comparison of the Anger tomoigraphic scanner and the large-field gamma camera: concise communication.

To evaluate observer performance in adrenal scintigraphy with two different imaging instruments and to assess the requirement for computer processing in routine adrenal imaging, gamma-camera images (analog and computer processed) and Anger tomoscanner studies were independently interpreted by three observers. Thirty-eight pairs of images were used for the analysis of the receiver operating characteristic (ROC) curve in comparing the tomoscanner with the large-field gamma camera, and 44 pairs of images were used for the comparison of the gamma camera analog images with computer-processed images. ROC analysis demonstrated a higher detection rate for the tomographic images. The computer-processed images did not improve adrenal detection. When each case was considered individually, the tomoiscanner was preferred in 37% of cases, and in 50% of cases, both instruments were considered to be equaly valuable.

Adolescent↗

A dual collimator design for beat-to-beat measurement of cardiac performance with an Anger camera.

A dual collimator was designed for an Anger camera to permit measurement of cardiac performance on a beat-to-beat basis. Special all-purpose (SAP) and special high-sensitivity (SHS) collimator sections can be interchanged without movement of the patient. Thus, left-ventricular regions of interest delineated on SAP multigated images can be transferred to SHS dynamic images to generate beat-to-beat volume curves. Preliminary balloon studies demonstrated an excellent correlation between ejection fractions calculated with the two collimators: r greater than 0.99, n = 17, p less than 0.001. Varying the volume of an adjacent "right ventricle" balloon failed to alter significantly the count rate from the "left ventricle" balloon's region of interest. Preliminary results on 12 patients, comparing standard-camera ejection fractions with average beat-to-beat ejection fractions, showed that is is possible to measure cardiac function on a beat-to-beat basis with a single-crystal gamma camera. There was minimal difference between the ejection fractions calculated by the dual-collimator method and a standard gated technique (r = 0.98, n = 12, p less than 0.001).

Erythrocytes↗

A measure of Anger-camera linearity: results with and without a corrector.

A method for measuring the X and Y linearity of an Anger camera coupled to a computer is presented. It has similarities to, and differences from, the method recommended by the National Electrical Manufactures Association (NEMA). Test images are taken through a lead plate with parallel and equally spaced slots, and the locations of the lines in the images are fitted by least-squares with an equation that allows for slight misalignment. Discrepancies from the fit are calculated and displayed as a distribution over the camera field. The maximum and average discrepancies are tabulated. The field of view that is of interest is selectable within the analysis program. Among four large-field-of-view uncorrected cameras, three 37-tube types (two measured using Tc-99m and one with Au-195) show a similar degree of nonlinearity. However, the maximum and average discrepancies from linearity for a 61-tube prototype camera, measured using Tc-99m over a 15-in. field of view, are 40% of those for the other three. For the four cameras, an event-shifting on-line corrector with best-case sampling improves linearity by an average factor of 5.5, including both 15-and 11.25-in. fields of view.

Computers↗

Comparison of Ga-67 citrate images obtained with rectilinear scanner and large-field Anger camera.

Two methods for Ga-67 citrate imaging were compared on 20 patients. Scans were performed using approximately equal procedure time with two instruments: (A) a dual 5-in. rectilinear scanner with medium-energy collimator, with a single window spanning both the 93-keV and the 185-keV spectral peaks; and (B) a large-field (15-in. diam) Anger camera equipped with moving table, medium-energy collimator, and three windows covering the 93-keV, 185-keV, and 300-keV peaks separately. Sixteen abnormal sites and 24 normal sites were selected for comparison. Each site was evaluated by four physicians experienced in interpreting Ga-67 citrate images. The observers performed significantly better using the images obtained with the large-field camera (three windows) than with the dual 5-in. scanner (single window).

Citrates↗