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At least 865 records · Page 48Linked to original sources
PubMed1986

Thorotrast-induced hepatosplenic neoplasia: CT identification.

Despite discontinuation of its use in the 1950s, the consequences of Thorotrast usage continue to be recognized. In a review of plain film and CT findings of 20 cases of Thorotrast exposure, 15 of 17 patients demonstrated Thorotrast accumulation in the liver and spleen on plain films. Typically, this appeared as regions of trabeculated increased density within the liver. The spleen was of normal or decreased size and often demonstrated a finely punctate pattern of opacification. Only two malignancies could be suggested on plain film alone: one hepatic and one splenic. Five patients with hepatic malignancies underwent CT examinations: three with cholangiocarcinoma, one with angiosarcoma, and one with hepatocellular carcinoma. No specific criteria could be established to distinguish among these lesions, as each neoplasm appeared as relatively low-density mass(es). Two cases of splenic angiosarcoma appeared as low-density filling defect(s) in the otherwise opaque spleen, one case primary and the other metastatic from the liver. CT was superior to plain radiography in detecting and characterizing Thorotrast distribution and any superimposed malignancy. In addition to periodic liver function tests, screening CT of patients exposed to Thorotrast might detect hepatic neoplasms at an operable stage.

Adenoma, Bile Duct↗
PubMed1979

Carcinoma of the parotid gland following sialography with thorotrast. Report of two cases.

Two cases are presented of malignant tumour of the parotid gland following sialography with Thorotrast, 28 and 45 years previously. Both cases were histologically established as squamous cell carcinoma and the presence of Thorotrast in the tumours was confirmed by autohistoradiography. It is suggested that the tumours may have developed from metaplastic ductal epithelium after many years of exposure to the alpha radiation from Thorotrast deposits in the gland.

Autoradiography↗
PubMed1977

Thorotrast-induced bilateral carcinoma of the kidney.

A case of transitional cell carcinoma in the left kidney 25 years after urinary tract investigations, and squamous cell carcinoma in the right kidney 6 years later is described. Thorotrast was identified in the kidneys and in the reticulo-endothelial system post mortem and was presumably the contrast material used for the original retrograde pyelogram. When retained in the kidneys after retrograde pyelography Thorotrast produces a characteristic radiological and histological appearance and can be identified by the spectrum of radiation which it emits. The authors believe that this report of bilateral renal carcinomas related to Thorotrast is unique.

Carcinoma, Squamous Cell↗
PubMed1981

Regional renal function measured by videodensitometry.

The videodensitometric method was applied for the determination of regional renal blood flow and filtration fraction using 2 contrast agents, where Thorotrast represented an intravascular indicator and Angiografin will be distributed in the intravascular and interstitial space and, in addition being freely filtrable in the glomeruli. The contrast density was continuously monitored from the light intensity on a TV-screen, where the region to be analyzed could be outlined by a light pen. The passage time of Angiografin analyzed from the videodensitometric curve was compared to that of 125I-labelled Angiografin as analyzed in the venous effluent. The two methods yielded almost identical values. Knowing the volume of distribution of the agents, the regional blood flow could be calculated and was found to be the same for the two contrast agents used. The curves for Thorotrast showed a rapid passage with a rapid declination towards the base-line. For Angiografin the curves ended in an almost horizontal plateau reflecting the fraction of the Angiografin filtered and remaining into the tubular system. The height of the plateau was then used for the determination of the filtration fraction. The figure obtained was compared to that obtained by conventional clearance techniques, and was found to yield similar values. It is concluded that the videodensitometric method allows for evaluation of the functional characteristics of the kidney in addition to the anatomical information given by the conventional angiography performed in parallel to the videodensitometric measurements.

Animals↗
PubMed1983

Latency of thorotrast-induced renal tumours. Survey of the literature and a case report.

A case of thorotrast-induced renal tumour is reported. The relevant literature is briefly surveyed. The latency periods to tumour detection in the published cases were analyzed. Latency was longer in transitional cell carcinoma than in the other histological tumour types. The difference was statistically significant. It is concluded that discovery of more cases of thorotrast-induced renal tumour is to be expected. The importance of bearing this possibility in mind when confronted with roentgenograms showing 'calcifications' in or near the kidney is pointed out.

Aged↗