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Results for “Splenic Neoplasms”

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PubMedDate not supplied

[Insignificant carcinogenicity of chrysotile asbestos of the Ak-Dovurak deposits in Russia and its possible links].

Thrice intrapleural injection of 20 mg of dust of the chrysotile from the Ak-Dovurak deposit caused pleural mesothelioma in 10.7% of the rats, which was significantly less than that upon exposure to the chrysotiles from other deposits and amphiboles. The reason for the less carcinogenicity of this chrysotile is the structural features of the surface of its fibrils, namely, its high homogeneity and hence the lack of sites at which the electrically charged centers may be located.

Animals↗
PubMed1992

[Experimental model of liver metastases of the mouse].

3 syngeneic tumor-mouse systems were used to establish experimental model of liver metastasis. Only one system, SC42-DS, was suitable for the purpose. When 2 x 10(5) SC42 tumor cells was injected into the spleen of DS mouse and splenectomy was done after 24 hours preventing of spleen tumor due to implantation, multiple nodular liver metastasis were observed in all mice after 14 days. The numbers of nodulus were well correlated with the liver weight.

Animals↗
PubMed1992

[Solitary metastasis in the spleen originating from pulmonary adenocarcinoma, verified by ultrasonically guided fine needle biopsy].

Metastasis of various neoplasms to the spleen is very rare and most frequently recognized at autopsy as part of a disseminated cancer. The case of a woman aged 55 years who had been treated operatively for an adenocarcinoma of the lung is presented here. The sole detectable distant metastasis was located in the spleen and diagnosed by fine-needle aspiration under ultrasonic guidance.

Adenocarcinoma↗
PubMed1992

Friend murine leukaemia virus is integrated at a common site in most primary spleen tumours of erythroleukaemic animals.

A common proviral integration site was identified and characterized in erythroleukaemias induced by Friend murine leukaemia virus (F-MuLV). Using inverse polymerase chain reaction, we found a proviral integration site common to at least 90% of 20 primary tumours tested. This site was identical to Fli-1, a locus recently reported by others to be rearranged in 75% (9/12) of cell lines established from spleens of erythroleukaemic mice and to code for a member of the ets gene family. Our data suggest that about half of the F-MuLV-induced erythroleukaemias contained more than one cell clone with a proviral integration in Fli-1, with different individual integration sites within Fli-1 in each cell clone. All proviruses were found to be integrated in the same transcriptional orientation with respect to flanking cellular DNA. We discuss these findings in relation to multistage models of neoplasm.

Animals↗
PubMedDate not supplied

[Microcellular lung carcinoma in patient with hepatosplenic T-cell lymphoma: a case report].

Hepatosplenic T-cell lymphoma (HSTCL) is a rare form of extranodal non-Hodgkin lymphoma derived from cytotoxic T-cells, usually manifesting by sinusoidal infiltration of spleen, liver and bone marrow. In 1997 World Health Organization classified malignant lymphomas and placed HSTCL among peripheral T-cell neoplasms. The course of the diseases is usually very agressive with a median survival time of 8 to 16 moths despite multiagent chemotherapy. We present a case of a 48-year-old male patient whose initial symptoms were fatigue, weight loss and night sweats, which were followed by splenomegaly and pancytopenia. After clinical examination we suspected him to have HSTCL which was proved pathohistologically upon splenectomy and it is the first case of this lymphoma diagnosed in "Merkur" Clinical Hospital. As a first line of lymphoma therapy we decided to apply FED course (fludarabine, cyclophosphamide, prednisone), being aware of the published poor results the standard CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisolone) yields. As far as we know, the results of this chemotherapy course in the therapy of this tumor have never been published. The patient underwent 6 courses of FED therapy, which he tolerated well and was in good clinical condition. Upon the completion of the 6th course of therapy he was diagnosed with lung anaplastic microcellular carcinoma and was treated with 3 course of PE therapy (cisplatin, etoposide).

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1991

[2 cases of malignant insulinoma of the pancreas].

Two cases are reported of malignant insuloma: in one of the patients the tumor was hormonally active in the other inactive. Treatment was operative. The great difficulties in establishing the diagnosis preoperatively and the complications accompanying this grave disease are pointed out. The clinical and laboratory examinations which may help to reach at the correct diagnosis are discussed.

Adult↗
PubMed1990

[Immune function of cancer patients with spleen-deficiency syndrome].

According to this study, the immunological function was aberrant in cancer patients with Spleen-deficiency syndrome. The TII cell in normal persons (n = 26) was 30, 86 +/- 9.70% (means +/- S) and in these cases (n = 43) was 22.62 +/- 9.92%, P less than 0.002. The cytotoxicity of NK cell in patients (n = 59) was 17.65 +/- 10.58%, in normal controls (n = 43) was 25.51 +/- 14.10%. The combining ability of NK cell in patients (n = 48) was 39.11 +/- 19.43%, the normal persons (n = 41) was 55.88 +/- 17.94%. It showed that the immune function of the cancer patients with Spleen-deficiency syndrome were markedly lower than that of normal persons. The serum IgA in saliva of patients (n = 37) was 0.44 +/- 0.17 microgram/ml. It was much higher than that of normals' (n = 24, 0.30 +/- 0.06 microgram/ml), P less than 0.001. Some patients' NK cell function and the level of level of SIgA in saliva were recovered to normal after treatment of Shengxue Tang which could strengthen the Spleen and replenish the Kidney. These studies proved that the TCM played an important role for modulating immune function in treating cancer patients.

Adult↗
PubMedDate not supplied

Angiosarcoma of the spleen. Case report and review of literature.

Angiosarcomatous tumours of the spleen are rather rare. We report such a tumor in a 46 year old male. The pathology is described as well as a review of the literature. The pathogenesis is unknown, the symptomatology indistinct but spontaneous rupture is a rare event. Definite diagnosis is only possible with exploratory laparotomy and splenectomy. The prognosis is poor.

Adult↗
PubMed1986

Intravascular death of disseminated cancer cells mediated by superoxide anion.

The release of radiolabelled Lewis lung carcinoma cells arrested in the vasculature of the major organs of mice after intravenous injection was significantly inhibited in animals treated with the oxygen radical scavenger, superoxide dismutase. There was a parallel increase in the numbers of tumor nodules which developed after injection of non-radiolabelled cells into superoxide dismutase-treated mice. The results indicate that superoxide anion plays an important role in the lethal release of arrested cancer cells, either directly since the radical is cytotoxic or possibly indirectly since its metabolites are also highly toxic. It is suggested that a major source of toxic oxygen species is the polymorphonuclear leukocyte.

Animals↗
PubMed1988

Surgical therapy of localized abdominal non-Hodgkin's lymphomas.

Non-Hodgkin's lymphomas may involve a variety of abdominal organs, including the liver, spleen, gastrointestinal tract, and retroperitoneum. The number of organs potentially involved and the noncontiguous mode of spread make non-Hodgkin's lymphoma a difficult tumor to evaluate at the time of laparotomy. To clarify the surgical management of patients with this tumor, we retrospectively reviewed the medical records of 202 patients with histologically proven abdominal lymphomas. Within this group, 36 patients underwent laparotomy before they had chemotherapy or radiation therapy. Ten patients were explored to establish a histologic diagnosis of lymphoma. The remaining 26 patients underwent laparotomy because of presumed benign disease. Twenty patients were found to have localized disease at laparotomy. Patients with localized disease demonstrated significantly better survival than patients with extranodal and nodal involvement (p less than 0.05). Four patients with local resection received no adjuvant therapy and were free of disease a median of 50 months after surgery.

Abdominal Neoplasms↗
PubMed1986

[Splenosis].

Explore the source record for details and available documents.

Choristoma↗
PubMed1979

[Primary tumors of the spleen].

Four cases of so-called primary tumour of the spleen are discussed, stress being laid on their rarity and clinical course. The importance of splenectomy for precise histological diagnosis and assessment of the stage of the disease, factors which are indispensable for the oncologist when planning therapy, is also emphasized.

Adult↗