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PubMed1978

[Fatal outcome of emphysema without increased bronchial resistance and 6 cases of chronic dyspneic hypoxemic bronchial disease with normal spirometry].

The cases of seven patients with dyspnea, hypoxemia and normal ventilatory tests are presented. Closing volume was measured in 6 and was increased. Two were heavy smokers, 2 were obese, and 2 were exposed to inhalation of industrial irritants. The last patient had severe dyspnea and pronounced hypoxemia which eventually resulted in pulmonary hypertension and right ventricular failure. Lung scan was normal. Plethysmography showed normal bronchial resistance. Autopsy revealed chronic bronchitis, bronchiolectasis and emphysema. This case was interpreted as an example of fatal outcome of small airway disease.

Adult↗
PubMed1984

Spirometry.

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Female↗
PubMed1984

[Normal values of spirometry for the 15- to 20-year-old age group].

In 130 healthy young men and women aged 15 to 20 years, all non-smokers, volume flow curves were recorded during forced expiratory vital capacity measurements. The forced vital capacity (FVC), the forced expiratory volume of 1 sec (FEV1) and the mid-expiratory flow rate (MEF50) were evaluated in order to establish new standard values for normal people in this particular age group. FVC is strongly height and sex dependent. Our new normal values are in good agreement with those of the literature. Our FVC values, however, are in general slightly higher than those of previous authors. MEF50 turns out to be sex independent but height dependent, but not as much as FVC. Our new normal values for MEF50 are in good agreement with those of Knudson et al., though slightly lower. The FEV1/FVC quotient was found to decrease significantly with height from 0.9 to 0.8. This decrease may be due to the increase in lung volume with growth. It could also be due to lung damage caused by atmospheric air pollution in young adults who are still growing.

Adolescent↗
PubMed1984

The single-breath N2-test and spirometry in healthy non-smoking males.

Healthy males (aged 30-70), who had never smoked, were studied. The 178 subjects were selected by systematic sampling from an urban population. Using the single-breath N2-washout test we measured the closing volume (CV) and the slope of the alveolar plateau (delta N2). A prediction equation for CV was produced by simple regression on age. delta N2 showed an accelerated increase with age above the age of 50. A curvilinear equation was established: delta N2 (%/1) = 0.85 + e0.0929 x A( yrs ) -6.302. Reference equations were also established for vital capacity (VC), forced expiratory volume in one second (FEV1) and FEV1 in per cent VC (FEV%) by means of linear multiple regression on age and height. The distribution of delta N2 was not homogenous throughout the age-range. As an upper limit of the reference range, we suggest 180% of the predicted value.

Adult↗
PubMed1983

Impact of spirometry on the management of chronic obstructive airway disease.

A simple spirometer was tested in an outpatient family practice to determine whether its use increased detection of chronic obstructive airway disease (COAD) in patients at risk, more accurately identified patients with reversible bronchospasm, and helped to make the most of their bronchodilator therapy. Three (17 percent) of 18 patients at risk, previously unlabeled, were found to have COAD. Of 28 patients with a previous COAD diagnosis, 5 (18 percent) had the diagnosis deleted, and 5 who had previously been classified as "reversible" were reclassified as having "irreversible" bronchospasm (P less than .025). Of 46 patients studied, bronchodilator therapy was changed in 18 (39 percent); 12 of these improved symptomatically according to a subjective score (P less than .02). A few patients demonstrated a significant improvement in 1-second forced expiratory volume.

Adult↗