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At least 865 records · Page 48Linked to original sources
PubMed1992

[Strategies for antiplatelet therapy-drug-fixed method and suppression-fixed method].

The strategies for antiplatelet therapy and recent trends in the research field are reviewed. In addition to the approach to finding new drugs, basic research on the function of the platelet which should be suppressed and on how drugs should be used, is required for the improvement of the efficacy of antiplatelet therapy. Our approach to suppression-fixed antiplatelet therapy which is in contrast with the previous drug-fixed method and is based on a principle that aggregation and release are strongly suppressed by the use of aspirin plus ticlopidine close to the limit, found observations on primary platelet dysfunction is described. Preliminary results of this on the prevention of stroke indicate that recurrence was 0.88% per year in contrast with the 4.3% in a group with normal platelet function and 5-15% in groups without antithrombotic therapy in Japan.

Aspirin↗
PubMed1992

[Antiplatelet therapy in cardiac diseases].

1) Myocardial infarction (MI): Aspirin (160-300 mg/day) therapy started immediately after the onset, with or without simultaneous coronary arterial thrombolytic therapy, reduces the mortality rate in vascular diseases, including MI, and prevents reinfarction. Maintenance therapy with the same dosage is also recommended. 2) Angina pectoris: In unstable angina, aspirin in a dose of 300 mg/day for 2 years reduces the mortality and the incidence of MI. Ticlopidine decreases anginal attacks in a few cases of angina at rest. 3) Coronary artery bypass grafting (CABG): Long-term administration of 325 mg aspirin/day should be started on the day of surgery and combined with 200-400 mg dipyridamole/day administered from 2 days before to 1 week after the surgery. 4) Percutaneous transluminal coronary angioplasty (PTCA): Current antiplatelet drugs prevent post-procedural acute coronary occlusion but not late restenosis.

Angioplasty, Balloon, Coronary↗