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At least 865 records · Page 48Linked to original sources
PubMed1976

[Time factors in human skin desquamations (author's transl)].

A clinical study of human skin desquamation has provided the variation of the isoeffect curve as a function of the fraction number and overall time. These results have been compared to ELLIS formula (N.S.D.). These results have been compared to relationships related to intestinal mucosa and lung. Differential effects are put in evidence between these tissues as a function of fractionation and overall time. Such differential effects are likely to exist between tumors and normal tissues; however the basic data are still missing for optimizing the time factors of the therapeutic irradiations.

Humans↗
PubMed1976

[Applications of the normal standard dose in clinical practice].

On the basis of experience in the François-Baclesse Centre, the practical consequences of the application of the N.S.D. of Ellis are reviewed and in particular : -- the effects of overdose and subdosage in the volume irradiated; -- interpretation of dose at the site of complications; -- the definition of doses of tolerance in critical organs; -- the establishment of optimal dosimetry in the treatment of skin cancers. Despite the approximate character of the exponents used by Ellis and the theoretical discussions which his formula may provoke, it is concluded that it provides the radiotherapist at the present time which a good practical guide and that, within the limitations of the study presented, the clinical results fall within expectations.

Humans↗
PubMedDate not supplied

[Radiation protective efficacy of alpha-adrenomimetics during local gamma irradiation of the skin].

In experiment with mice and rats radioprotective properties of direct alpha-adrenomimetic drugs: indraline, mesaton (phenylephrine) and naphthyzine (naphazoline) have been investigated by local early and late radiation injuries. The drugs were S. C. and C. administrated at the site of the thigh of the hind of the animal at intervals of 5-8 min locally was irradiated with gamma-60Co-rays in the doses of 26.3-53.7 Gy at a rate of the dose of 1.31-1.54 Gy/min. When S. C. injected the topical effect of the adrenomimetics was higher than the systemic one. In experiment with mice radioprotective efficiency of topical indraline (S. C. 50 and 100 mg/kg) in term of DRF was equal to 1.34 and 1.67 for radiation burn of the skin, 1.56 and 1.91 for 3rd month radiation contracture of the hind and 1.10 and 1.50 for partial amputation of the one. In the same condition the effect of topical mesaton (S. C. 1, 2.5, 5 mg/kg) in term of DRF was accordingly equal to 1.29, 1.49 and 1.62 for early radiation injury, 1.08, 1.20 and 1.46 for 3th month radiation contracture of the hind and 1.0, 1.14, 1.33 for partial amputation of the one; the effect of topical naphthyzine (5 mg/kg) in the term of DRF was 1.36 for early radiation injury. In experiment with rats radioprotective property of systemic indraline (I. M. 100 mg/kg) in the term of DRF was equal to 1.39 for radiation burn of the skin, 1.39 for 6th month radiation contracture of the hind, 1.41 for partial amputation of the one. When C. administrated the effect of topical indraline (5% solution in 50% DMSO or ethyl alcohol solution) in term of DRF was accordingly equal to 1.17 and 1.18 for radiation burn ot the skin, 1.50 and 1.35 for radiation contracture of the hind, 1.41 and 1.28 for amputation of the one. When S. C. administrated the effect of topical and systemic mesaton (2.5 mg/kg) in term of DRF was accordingly equal to 1.30 and 1.04 for radiation burn ot the skin. 1.25 and 1.0 for radiation contracture of the hind, 1.30 and 1.0 for amputation of the one.

Administration, Cutaneous↗
PubMed1998

A multimedia database for dermatology.

The World Health Organisation (WHO) Radiation Emergency Medical Preparedness (REMPAN) centres have built up the International Computer Database for Radiation Accident Case Histories (ICDREC) to document the treatment of acute radiation syndrome (ARS) patients. Radiation induced skin lesions may cause severe late effects in radiation accident patients. Dermatological multimedia documentation is included into the ICDREC. In particular, retrieval and display of digitised skin photographs and medical reports serves to improve patient care, medical education, and scientific analysis concerning the cutaneous radiation syndrome (CRS). The database has been built up as a client/server system. A particular focus has been set on using commercial off-the-shelf software components. The medical data including the multimedia data are stored in a relational database system. The database can be accessed by inexpensive personal computers in the dermatologist's workplace. Authorised institutions can access the database via the Internet. Retrieval of one skin photograph via local area network (LAN) requires approximately 3 seconds. The current state of the application is illustrated with the skin lesion treatment of a Chernobyl patient. An example is given on how to access the ICDREC from a dermatologist's desktop personal computer. The discussion focuses on the advantages of storing the textual and pictorial data in one central database to be accessed from different care centres and how the results can be generalised for medical multimedia information systems.

Dermatology↗
PubMed1999

Fluoroscopic-induced radiation dermatitis.

A case of radiation dermatitis following fluoroscopy is described. Radiation dermatitis occurs rarely after fluoroscopic procedures and may pose a diagnostic challenge. Many patients do not consider fluoroscopy to be a source of radiation exposure, and clinicians may be confused by its unusual presentation.

Coronary Disease↗
PubMedDate not supplied

[Sevoflurane in airway management using fibrobronchoscopy: apropos of 2 difficult orotracheal intubation cases].

We report two cases of difficult orotracheal intubation in which intubation with a fiberoptic bronchoscope was performed after induction with an inhalational anesthetic. Mild inhalational anesthesia with sevoflurane was started fairly rapidly, with no respiratory incidences. The tubes were then inserted through a fiberoptic bronchoscope, with no airway management problems.

Anesthetics, Inhalation↗
PubMed1999

Skin care for patients receiving radiotherapy.

Radiotherapy can cause significant skin reactions. Research suggests that skin care practices are diverse for patients receiving radiotherapy. Standardised practice enables nurses to evaluate interventions.

Bandages↗
PubMed1999

Results and side effects of dermatologic radiotherapy: a retrospective study of irradiated cutaneous epithelial neoplasms.

BACKGROUND: Ionizing radiation therapy has a well-defined role among several therapeutic options available for the management of cutaneous neoplasms. However, many dermatologists today are not aware of its potential. OBJECTIVE: Our purpose was to evaluate the effectiveness and safety of radiotherapy in a large series of patients with primary malignant epithelial neoplasms (PMENs), who had been subjected to radiotherapy between 1982 and 1995. METHODS: A retrospective study was performed on 1188 patients with a total of 2002 PMENs that had been treated by contact, superficial, and intermediate x-ray therapy. RESULTS: Complete remission was obtained in 98.7% of the irradiated lesions. The 5-year cure rate was 90.73%. Cosmetic results were evaluated as "good" or "acceptable" in 84.01% of the treated lesions. Acute complications occurred in 1.94% and chronic complications in 0.34%. To date, neither radio-induced skin neoplasms nor late stochastic effects have been observed. CONCLUSION: This study confirms that dermatologic radiotherapy is an effective and reliable form of treatment of PMENs and has a favorable cure rate/toxicity ratio.

Adult↗
PubMed1999

[Breast-saving therapy and primary reconstruction with latissimus dorsi flap combined with radiotherapy].

OBJECTIVE: The use of latissimus-dorsi-flap with postoperative radiotherapy is method of choice in primary reconstruction of breast cancer. The efforts of radiotherapy on flap healing, cosmetic results and formation of edema in the arm were studied in 30 patients. MATERIALS AND METHODS: 30 patients were followed in three to six months intervals clinically and sonographically (ATL-Ultramark 9, HDI). RESULTS: The most frequent symptom was a moderate edema. No healing problems or interference with cosmetic results were observed. Blood flow in the thoraco-dorsal vessels showed unchanged pre- and postoperatively. CONCLUSIONS: The complains might be the consequence of the combination of surgical dissection of the axilla, radiotherapy and possible additional factors such as trauma and overstress for example. Cosmetic result and healing seems to be impaired by 50 to 60 gy.

Adult↗
PubMed1999

Supportive use of amifostine in patients with head and neck tumors undergoing radio-chemotherapy. Is it possible to limit the duration of the application of amifostine?

BACKGROUND: Amifostine is a new cancer-supporting agent to protect normal tissue in patients receiving radio-chemotherapy. The main question of our study is whether the application of amifostine can be limited on the duration of chemotherapy in patients with advanced head and neck tumors undergoing radio-chemotherapy. PATIENTS AND METHODS: In a randomized study 14 patients were treated with amifostine (500 mg, day 1 to 5 and 29 to 33) during concurrent radio-chemotherapy with carboplatin (70 mg/m2, day 1 to 5 and 29 to 33), 14 patients were treated without amifostine. The analyzed parameters were dermatitis, mucositis, skin temperature, white blood and platelet count, creatinine and scintigram of salivary glands. Median survival of the amifostine group was 19 months, of the control group 10 months. RESULTS: There were no relevant differences in all analyzed parameters between both arms of the study. CONCLUSION: Our form of amifostine application is probably not able to obtain a relevant reduction of the toxicity of radio-chemotherapy.

Adolescent↗
PubMed1999

Amifostine--a radioprotector in locally advanced head and neck tumors.

PURPOSE: There are some preliminary informations about the beneficial use of amifostine in avoiding side effects in patients with head and neck tumors who underwent radiotherapy. PATIENTS AND METHOD: Amifostine was given as daily intravenous application (500 mg) 10 to 15 minutes prior to radiotherapy in 20 patients. The results were compared with another collective of patients which was similar. RESULTS: According to the WHO score mucositis became manifest in 10 patients (Grade I) and 4 patients (Grade II) in the amifostine group vs 9 patients (Grade II), 6 patients (Grade III) and 1 patient (Grade IV) in the control group. Xerostomia has been seen in 15 patients (Grade I) and 5 patients (Grade II) after administration of amifostine. Without the drug 2 patients suffered from xerostomia (Grade I), 8 patients (Grade II) and 8 patients (Grade III), respectively. Administering amifostine had been feasible and non problematic. Only a small rate of toxic side effects like nausea (11%) or emesis (4%) was documented. CONCLUSIONS: Amifostine is an effective radioprotector decreasing acute and late side effects in patients with head and neck tumors.

Adult↗
PubMedDate not supplied

[Mouth opening limitations due to soft tissue lesions].

Mouth opening limitations following on soft tissue lesions are subdivided according to aetiology into collagen disease connectival lesions, cutaneous and mucosa lesions consequent on the action of physical agents and, finally, cicatricial lesions of the cheeks and lips as a result of surgery for cancer or trauma. The commonest forms of plastic surgery used to correct such lesions are reviewed.

Burns↗
PubMed2000

[Skin and mucous membrane reactions during and after radiotherapy].

The temporary acute reactions during radiotherapy are a burden for the patient. These reactions are due to a depletion of stem cells and depend on the single dose, the total dose and the irradiated volume. The WHO describes the acute changes in a graded scale from 0 to IV. A knowledge of the course of these events helps the otolaryngologist to inform patients competently, calm their fears and give support during treatment. Efficacious measures to alleviate symptoms are presented.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Accidental radiation exposure and azoospermia.

Seven Georgian male soldiers (19-25 years old) had accidentally been exposed to radiation by Cs-137 between April 1996 and May 1997. No information about the exact time and duration of exposure was available. All patients presented with the subacute stage of Cutaneous Radiation Syndrome with deep painful ulcers on different body sites, predominantly on the legs. Semen analyses showed complete azoospermia in 4 patients, with elevated follicle-stimulating hormone (FSH) in 3 and elevated luteinizing hormone (LH) in 2 of them. One patient had severe oligozoospermia of 7 million sperm per mL, with normal sperm motility and morphology; his FSH and LH levels were elevated. One patient had complete normozoospermia, and the seventh patient had polyzoospermia of 340 million per mL; both of these patients had normal serum hormone levels. Only the patient with oligozoospermia reported a history of delayed testicular descent; his physical examination showed relatively soft and small testicles and a varicocele with considerable reflux. The physical andrological examinations were normal in the other 6 patients. It is very likely that the azoospermia in the 4 patients can be attributed to the radiation accident. In conclusion, it is essential to perform andrological examinations in patients who have been exposed to radiation even if there are only cutaneous injuries detectable, as a high percentage of them can show azoospermia.

Adult↗
PubMed2000

Papular elastosis.

I report two typical cases of a cutaneous disorder caused by sunlight, which is common in Phoenix, Arizona, "The Valley of the Sun." It currently masquerades under the misnomer, adult colloid milium. It generally presents clinically as asymptomatic, shiny, smooth, firm papules, 1 to 10 mm in diameter, involving chronically sun-damaged skin of adults. The papules are generally multiple, but may be solitary, with various colorations. Microscopically, the papules all show severe elastosis involving most of the papillary cutis. It is most important to biopsy these lesions because clinically they may mimic a variety of skin lesions, some of which would require further investigations and therapy. This is a distinct clinical form of severe solar elastosis, which I propose to term papular elastosis.

Adult↗