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At least 865 records · Page 48Linked to original sources
PubMed1980

[Pathogenetic therapy of cobalt-induced cardiomyopathies].

The pathogenesis of damage to the heart muscle caused by exposure to the effect of cobalt compounds is demonstrated. Agents with various mechanisms of action were tested in the experiment. The most effective pharmacological agents (beta-adrenergic blocking agents, anabolic steroids) are recommended for testing in the clinic. A positive effect was registered in the treatment of cobalt cardiomyopathy in the clinic. The mechanisms of the favourable effect of beta-adrenergic blocking agents and anabolic steroids are discussed.

Adrenergic beta-Antagonists↗
PubMed1980

[Morphophysiologic changes in the thyroid gland following exposure to retabolyl].

Morphofunctional rearrangement of the thyroid gland resulted from retabolile effect has been studied in 25 tortoises (Testudo horsfieldi) and in 30 white rats. The changes observed evidence in favour of activation of all secretory phases in thyroid hormones. At an overstrained hormonal stress in the thyroid gland, hypofunction of the organ is the initial state in the tortoise, while in the white rat an increased physiological wearing out in thyroid cells and their destruction are noted. Therefore, the relation between proliferation and destruction of thyrocytes is shifted towards the latter.

Anabolic Agents↗
PubMedDate not supplied

[Effect of sodium selenite, vitamin E, retabolil and their combination on the ATP, creatine phosphate and inorganic phosphorus content of organs of rats of different ages in the "aurantin" model of hypotrophy].

The effect of sodium selenite, vitamin E, retabolil and their combinations on the content of ATP, creatine phosphate (CP) and inorganic phosphorus in the liver and skeletal muscle was studied in 3 groups of white rats (one- and two-month old and adults). Sodium selenite (30 micrograms/kg), vitamin E (50 mg/kg), retabolil (4 mg/kg) and their combination administered in a single subcutaneous dose for 14 days increased the content of ATP, CP and inorganic phosphorus in the liver and skeletal muscle after these parameters had decreased because of aurantine administration (50 micrograms/kg). Combined use of sodium selenite, vitamin E and retabolil appeared to be most efficacious.

Adenosine Triphosphate↗
PubMed1983

[Anemia of chronic renal insufficiency. II. Effect of androgen therapy in 17 subjects treated with periodic hemodialysis].

Seventeen patients with severe anaemia due to renal insufficiency treated by periodical haemodialysis received high parenteral doses (7 mg/kg/week) of androgens for a period of 10 months. Kinetic studies of erythroid stemcells (plasma clot method), erythropoiesis (radio-iron kinetics, bone marrow scintigraphy) and haemolysis (autologous and homologous red cell life span) were performed before and after treatment. Complete failure was observed in 6 patients, slight improvement in 4 and distinctly satisfactory results in 7. In three cases relapse was noted after treatment was discontinued. Clinical effectiveness was due to correction of the erythropoietic defect, without changes in the degree of haemolysis. Virilization was the only side-effect recorded. All subjects whose anaemia improved, even to a slight degree, felt much better. The following parameters were found to be predictive of androgen effectiveness: absence of bilateral nephrectomy, young age, and relatively slight erythropoietic deficiency. The clinical results were unrelated to the initial number of erythroid stem cells and to their increase under androgen therapy.

Adolescent↗
PubMed1984

Studies on the pathophysiology and therapy of osteoporosis.

Etiologic and pathologic factors in clinical osteoporosis are reviewed. Techniques were developed to determine total skeletal calcium content with in vivo neutron activation analysis and to induce osteoporosis (in about three months) with low calcium diet, corticosteroid or heparin treatment in experimental animals. Genetic influence was demonstrated: C3H/St (Ha) mice were more susceptible to osteoporosis by all three modalities than C57B1/6 (J) mice. Fluoride was ineffective in preventing osteoporosis induced by either of these three modalities. Heparin induced osteoporosis was prevented by conjugated estrogens, progestins or their combinations. Progestins were shown in other studies to inhibit estrogen induced metaplasia and neoplasia. Combining estrogens with progestin may result in an increased therapeutic index for the prevention of postmenopausal osteoporosis. Human and salmon calcitonin, Deca - Durabolin, an anabolic steroid, Mopidamole, a pyrimidopyrimidine derivative, Trental, a methylxanthine derivative, certain 2-thiophene carboxylic acid derivatives and imidazoquinazolines exhibited anti-osteoporotic effects.

Animals↗
PubMed1984

[Effect of retabolyl on the dynamics of urinary catecholamine and DOPA excretion and electroneuromyographic indices in patients with Duchenne's myodystrophy].

The monitoring of the use of anabolic hormones in patients with progressive Duchenne's muscular dystrophy was shown to be possible with the help of the clinical analysis of the patients' motor possibilities, electroneuromyographic examination and determination of the time-course of the urinary excretion of catecholamines and DOPA.

Catecholamines↗
PubMed1984

[Possible ways of correcting disorders of the amino acid content of the blood serum and gastric mucosa during treatment of peptic ulcer].

Investigations made by the authors permit the conclusion that in order to correct the disturbed amino acid content of the gastric mucosa and blood serum, mirroring the trends in the catabolic processes occurring in the body and disorder of liver amino acid-forming function, it is necessary to include the drugs eliminating the causes of the disorders (e. g. neurogenic dystrophy), stimulants of protein synthesis and amino acid preparations as structural material for proteins into the complex of treatment measures.

Amino Acids↗
PubMed1984

[Correction of protein metabolism in myocardial infarction according to the results of radionuclide studies with 131-albumin during during treatment with a number of drugs (retabolyl, methyluracil, panangin, strophanthin) and combinations of them].

The effect of a series of drugs (retabolil, strophanthin, retabolil with strophanthin, retabolil with panangin , methyluracil with panangin ) on protein metabolism was investigated in 246 patients with acute myocardial infarction. Retabolil both alone and combined with panangin , and a methyluracil-- panangin combination were found to have anticatabolic and protein synthesizing effects. Strophanthin, when used in the acute period of myocardial infarction, contributes to an increase in the protein decay rate and a decrease in protein synthesis. When it is employed in combination with metabolism corrective agents (retabolil), the adverse effects of strophanthin mentioned above are eliminated.

Adult↗
PubMed1984

[Clinical efficacy of using amino acids in combination with anabolic steroids for the purpose of limiting the size of a myocardial infarct].

The authors report on the experience with amino acid drugs ( alvesin -new, aminon ) used in combination with anabolic steroids (retabolil) in patients with acute myocardial infarctions. Specific protein reparative therapy was associated with a favourable course of the disease, earlier (as against the control group) normalization of the electrotopocartographic (precordial mapping) and enzymic (CPK, LDH and LDH1) parameters. The patients' faster readaptation toward exercise and a significant elevation in the hemodynamic parameters justify the advisability of including protein reparative agents into the multiple modality treatment of myocardial infarction.

Alanine Transaminase↗