Studies on the induction and expression of T cell-mediated immunity. I. Blocking of cell-mediated cytolysis by membrane antigens.
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Animals↗
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Use of an in vitro microcytotoxicity test to assess human tumor-specific cell-mediated immunity and its serum-mediated abrogation.
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Antigens, Neoplasm↗
Observations of IgG1 anti-DNP hybridoma-mediated ADCC and the failure of three IgM anti-DNP hybridomas to mediate ADCC.
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Animals↗
Studies on the induction and expression of T cell-mediated immunity. II. Antiserum blocking of cell-mediated cytolysis.
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Animals↗
The mediational deficiency of mentally retarded children. I. The establishment of retardates' mediational deficiency.
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Association↗
Influences of antilymphocyte serum on cell-mediated and antibody-mediated responses.
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Animals↗
Verbal mediation in moderately retarded children: effects of successive mediational experiences.
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Adolescent↗
[Complement and other mediators for immunologically mediated tissue damage].
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Antigen-Antibody Reactions↗
The mediational deficiency of mentally retarded children. II. Learning set's effect on mediational deficiency.
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Association↗
Chemical mediators of vascular responses in inflammation: a two mediator hypothesis [proceedings].
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Animals↗
Apparent direct cellular cytotoxicity mediated via cytophilic antibody. Multiple Fc receptor bearing effector cell populations mediating cytophilic antibody induced cytotoxicity.
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Animals↗
[Comparison of suppressive effects of inhibitor of IgE mediated chemical mediator release and H1-blocker on exercise induced asthma (author's transl)].
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Adult↗
Studies on the induction and expression of T cell-mediated immunity. X. Inhibition by Lyt 2,3 antisera of cytotoxic T lymphocyte-mediated antigen-specific and -nonspecific cytotoxicity: evidence for the blocking of the binding between T lymphocytes and target cells and not the post-binding cytolytic steps.
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Animals↗
Studies on the induction and expression of T cell-mediated immunity. XI. Inhibition of the "lethal hit" in T cell-mediated cytotoxicity by heterologous rat antiserum made against alloimmune cytotoxic T lymphocytes.
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Absorption↗
Mechanism of cell-mediated cytotoxicity at the single cell level. V. The importance of target cell structure in cytotoxic T lymphocyte-mediated antigen nonspecific lectin-dependent cellular cytotoxicity.
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Animals↗
Natural cell-mediated cytotoxicity and suppressor activity for natural cell-mediated cytotoxicity in long-term renal transplant patients.
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Chromium Radioisotopes↗
Impaired cell-mediated immunity in idiopathic membranous nephropathy mediated by suppressor cells.
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Humans↗
A new mediator (suppressor cell induction factor) activating T cell-mediated suppression: characterization of suppressor cells, kinetics of their generation, and mechanism of their action.
Human T cells precultured in MLC supernatant (SIF) could suppress responder cells in MLC. SIF-activated cells expressed suppressor effects equally on both autologous and allogeneic responder cells in MLC. The suppression observed was not due to cell crowding, cell death, depletion of nutrients, absorption of IL 2, alternation in the kinetics of MLC response, production of soluble inhibitory factor, or generation of cytotoxic cells. In this system, suppressor cells were generated after 5 days of culture, and Ia-positive cells were required in the induction of suppressor cells. Suppressor cells themselves, however, were characterized as Ia-negative subsets of T cells; they could be derived from both Fc-IgG receptor-positive and -negative subsets of T cells. Suppressor activity of SIF-treated cells on the MLC response was sensitive to mitomycin C treatment. They apparently exerted their suppressor effect on some early phase of the MLC response. This early event was almost complete within 48 hr after the initiation of MLC. The possibility that SIF may be involved in T-T interactions required in the generation of effective suppression is discussed.
Animals↗