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At least 865 records · Page 48Linked to original sources
PubMedDate not supplied

Progressive disseminated histoplasmosis 10 years after return out of Africa in an immunocompetent host.

We report on a patient without immunologic dysfunction who developed a reactivation of a latent histoplasma infection, acquired during a previous stay in Africa more than 10 years before. The current reactivation resulted in a subacute progressive disseminated histoplasmosis. He developed progressive weight loss, prostration and different oropharyngeal lesions together with bilateral adrenal masses on CT scan. The diagnosis was made on histology of biopsies of the oropharyngeal lesions. All systemic symptoms normalised, the oropharyngeal lesions disappeared and the adrenal masses regressed under amphotericin B therapy followed by itraconazole consolidation therapy.

Amphotericin B↗
PubMed2006

African histoplasmosis - masquerading as a malignant bone tumour.

A 23-year-old immunocompetent woman presented with a two-month history of fungating left shoulder and left elbow swellings associated with fever, weight loss and anaemia. X-rays showed lytic destruction of the lateral third of the left clavicle and distal half of the left humerus. Histology of biopsy specimen confirmed African histoplasmosis. The lesion resolved following treatment with ketoconazole.

Adult↗
PubMed1998

Histoplasmosis in the skin and gingiva in a dog.

An 8-year-old, female mongrel dog had granulomatous lesions in the skull skin and gingiva of the left mandible. The lesions were macroscopically seen as grayish white papular granulomas, and microscopically consisted to numerous swollen macrophages and a few neutrophils without fibrocaseous necrosis. Macrophages contained many small oval or round-shaped yeast-like cells and a few rod-shaped organisms indicating a narrow based budding in their cytoplasm. The yeast-like cells were 2-5 microns (average 3.5 microns) in diameter, and appeared as a central, spherical, lightly basophilic body surrounded by a clear zone or "halo". The cell wall and central body were stained by the periodic acid-Shiff, Grocott's methenamine silver impregnation, or Gridley fungus method. Immunohistochemically, yeast-like cells were positive to anti-histoplasma yeast antibody, and rod-shaped organisms were positive to anti-histoplasma mycelial antibody. The present paper describes the first case of canine histoplasmosis in Japan.

Animals↗
PubMed2001

Histoplasmosis in the lung of a race horse with yersiniosis.

A 4-year-old female thoroughbred race horse died of acute peritonitis caused by necrotizing granulomatous duodenitis. Yersinia enterocolitica was immunohistochemically demonstrated in macrophages in granulomas developed in the duodenum, lung, liver and abdominal lymph nodes. The yeast-like fungi were found in the cytoplasmic vacuoles of macrophages in the lung that infiltrated into the granulomas and surrounding alveoli with congestive edema. The yeast-like fungi were positively stained by Gomori-Grocott chromic acid methenamine silver stain and immuno-histochemically stained with anti-histoplasma antibody. In this case, it was considered that granulomas formed in the duodenum, lung, liver and abdominal lymph nodes were primarily caused by Yersinia enterocolitica due to idiopathic weakening of the immune system. Yeast-like fungi immunohistochemically identified as histoplasmas secondarily infected the lung. This is the first case regarded as equine histoplasmosis capsulati in Japan.

Animals↗
PubMed1975

Mediastinal histoplasmosis with abscess.

A mediastinal mass of clinically undetermined nature was found at autopsy to be an enormous abcess due to secondary infection in granulamatous caseating mediastinal nodes caused by Hitosplasma capsulatum. Other complications of mediastinal histoplasmosis are briefly reviewed.

Abscess↗
PubMed1975

A cutaneous manifestation of untreated disseminated histoplasmosis.

We present a case of histoplasmosis with skin manifestations occurring 17 years after initial diagnosis. The clinical manifestations of disseminated disease are discussed. Amphotericin B administered through an A-V shunt resulted in prompt resolution of the skin lesions.

Aged↗
PubMed1977

Disseminated histoplasmosis followed by disseminated coccidioidomycosis.

A case of disseminated histoplasmosis followed later by disseminated coccidioidomycosis is described. The clinical illness and immunologic studies suggest subtle defects that may have existed antecedent to infection and, thus, provided an opportunity for widespread dissemination by these normally nonopportunistic organisms. Poor correlation was noted between the clinical course and in vitro tests of cell-mediated immunity.

Adult↗
PubMed1983

Cavitation in acute histoplasmosis.

Cavitary lung lesions in histoplasmosis are usually associated with the chronic form of the disease. This report describes a ten-year-old boy with the clinical and serologic pattern of acute Histoplasma capsulatum infection who had multiple cavitary lesions.

Acute Disease↗
PubMed1990

Pulmonary function changes in the acute stage of histoplasmosis, with follow-up. An analysis of eight cases.

We have studied eight patients, six children and two adults, during a microepidemic of soil- and patient-proven histoplasmosis. Pulmonary function tests were performed between the 15th and 23rd days after the onset of symptoms, and repeated between the fifth and sixth, the ninth and tenth and the 15th and 22nd months afterward. Initial abnormalities were mild in seven cases and severe in one. There was a restrictive pattern in three cases and an obstructive pattern in two. The fraction of CO extraction was reduced in five cases and the diffusing capacity for CO was reduced in five of six cases so tested. Hypoxemia was present in three cases. On follow-up, the obstructive defect had disappeared by the sixth month, the restrictive pattern by the tenth month, and the diffusing defect still remained in three cases by the end of follow-up. Hypoxemia remained only in the severe case.

Adolescent↗
PubMed1981

[Myelopathy caused by histoplasmosis: report of a case].

A case of myelytic syndrome caused by histoplasmosis is reported. The patient had an acute paraparesis with impairment of all types of sensibility at T11-T12 level, with loss of sphincter control. The laminectomy revealed meningeal thickness and granulomatosis, microscopically identified as H. capsulatum. Intrathecal and parenteral therapy with amphotericin B, gave poor results.

Adult↗
PubMed1993

[Histoplasmosis of the central nervous system: study of cerebrospinal fluid in 8 patients].

One hundred and thirteen samples of CSF from eight patients with chronic meningitis were studied in a 12 years period (September, 1980-August, 1992). None of them had AIDS. In all, CNS histoplasmosis diagnosis was made by CSF examination. All cases tested positive for antibodies to Histoplasma capsulatum in CSF; in one case the yeast grew in Sabouraud culture in three different occasions. The main findings in CSF by the time of the diagnosis were: moderate hypercytosis marked by lymphocytes and monocytes, neutrophils-being present and in some cases eosinophil cells; moderate increase of total proteins content; decrease in the glucose content; and moderate increase of gamma globulins sometimes with oligoclonal reaction. Patients were followed-up from 7 to 102 months, and periodically submitted to CSF examinations according to clinics. Cell number and total protein content of CSF showed marked episodes of exacerbation in the follow-up, with a dissociated profile favoring total protein content which got higher with the chronification of the disease. Changes in the CSF pattern with treatment were: rapid decrease of hypercytosis; disappearence of neutrophil and eosinophil cells; increase in glucose content; and slow reduction of the increased contents of total proteins and gamma globulins.

Adolescent↗
PubMed1993

[Histoplasmosis of the central nervous system. Clinical aspects in 8 patients].

Clinical approach has been made in eight patients with histoplasmosis of the central nervous system. All patients had no evidence of immunodepression. Time disease at diagnosis ranged from 6 to 108 months (median 36 months). Main signs and symptoms were: intracranial hypertension in 6 patients; impairment of memory in 4; confusion in 4; seizures in 2; urinary incontinence in 2; sexual impotency in 1. Meningo-encephalitic form was present in 6 patients, while the granulomatous form was found in 2. Diagnostic confirmation was based on: biopsy, in 1 case; necropsy, in 2 cases; cerebrospinal fluid (CSF) sediment culture, in 1; detection of antibodies against Histoplasma capsulatum in the CSF, in 5 cases. There was, in all patients, an expressive difference between CSF alterations (intense, merging acute and chronic phase elements) and clinical symptomatology (patients in general oligosymptomatic).

Adolescent↗
PubMed2003

[Central nervous system involvement by histoplasmosis as the unique manifestation of this disease in immunocompetent patients: presentation of two cases].

We present two patients with central nervous system involvement as the unique clinical manifestation of histoplasmosis. A clinical review confirmed the infrequency of this form of the disease, overall in childhood, being one of these cases the youngest in Brazilian reports. Comments about the diversity of clinical presentation and main differential diagnosis are presented. We analyze the serologic and cerebrospinal fluid results and, finally, discuss the drugs and duration of treatment.

Adult↗
PubMedDate not supplied

[The sources of histoplasmosis infection on the Isla de la Juventud, Cuba].

The purpose of this work is to report the isolation of Histoplasma capsulatum, etiologic agent of histoplasmosis, from soil in sites inhabited by bats and chicken in the Island of Youth, Cuba. The fungus was cultured from four species of cave dwelling bats too. The identification of H. capsulatum was done by mycelial to yeast conversion and exoantigen test. It is pointed out the epidemiological value of some of these isolations in caves of great importance from the archaeological, speleological or tourist point of view, and the potential risk that they represent to human health. The authors conclude with some recommendation to prevent the infection with H. capsulatum in people who have to keep in contact with those environments.

Animals↗
PubMedDate not supplied

African histoplasmosis. Report of the first case in Brazil and treatment with itraconazole.

We report the first case of African histoplasmosis diagnosed in Brazil. The patient was an immigrant from Angola who had come to Brazil six months after the appearance of the skin lesion. The skin of the right retroauricular area was the only site of involvement. The diagnosis was established by direct mycologic examination, culture and by histopathologic examination of the lesion. The patient was successfully treated with Itraconazole 100mg a day for 52 days. No recurrent skin lesions were observed during the ten month follow-up period.

Adult↗
PubMedDate not supplied

Histoplasmosis in the Muñiz Hospital of Buenos Aires.

Some epidemiological and immunological characteristics and the methodology of diagnosis of 44 cases of histoplasmosis (HP); 36 (27 males and 9 women) associated with AIDS (HP+AIDS) and 8 (7 males and 1 female) with other predisposing factors (HP+non AIDS), diagnosed in the Muñiz Hospital (MH) during 1994, were retrospectively studied. The median age (MA) of HP+AIDS patients was 28 years; 25.5 (22-40) in the women and 28.5 (20-42) in the men and 50 (22-58) years in the HP+non AIDS patients. The more frequent risk factors for HIV infection were intravenous drug addiction (55%) and homo/bisexuality (19%). The MA of these groups were 28 (20-39) and 41 (26-42) years, respectively. Tobaccoism was a predisposing factor in 83% of HP+non AIDS patients. The muco-cutaneous lesions scraping and blood-cultures established the initial diagnosis in 53% and 36% of HP+AIDS patients, respectively and the muco-cutaneous lesions biopsies in 75% of HP+non AIDS cases. At time of diagnosis, all HP+AIDS patients had < 200 while HP+non AIDS patients had > 200 CD4 + lymphocytes/microliters. Seventy two per cent of HP+AIDS patients were born in Buenos Aires (Bs As) city and 62% of HP+non AIDS patients were born in provinces of Argentina other than Bs As. At moment of diagnosis, 87.5% of HP+AIDS and 62.5% of HP+non AIDS patients lived in Bs As city and Bs As outskirts.

AIDS Serodiagnosis↗
PubMedDate not supplied

[Skin lesions in progressive disseminated histoplasmosis associated with AIDS].

The protean manifestations of progressive disseminated histoplasmosis in AIDS patients (PDH/AIDS) specially the cutaneous lesions, may confuse the clinician or the pathologist. A case of PDH/AIDS diagnosed by direct and histologic examination and cultures of subcutaneous nodule aspirate and skin biopsy is reported. The requirement of special histologic and cultures procedures is emphasized. Clinical manifestations of the disease are discussed.

AIDS-Related Opportunistic Infections↗