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At least 865 records · Page 48Linked to original sources
PubMed2004

Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose.

BACKGROUND: Treatment with pegylated interferon (peginterferon) and ribavirin for 48 weeks is more effective than conventional interferon and ribavirin in patients with chronic hepatitis C. OBJECTIVE: To assess the efficacy and safety of 24 or 48 weeks of treatment with peginterferon-alpha2a plus a low or standard dose of ribavirin. DESIGN: Randomized, double-blind trial. SETTING: 99 international centers. PATIENTS: 1311 patients with chronic hepatitis C. INTERVENTION: Peginterferon-alpha2a, 180 microg/wk, for 24 or 48 weeks plus a low-dose (800 mg/d) or standard weight-based dose (1000 or 1200 mg/d) of ribavirin. MEASUREMENT: Sustained virologic response: undetectable HCV RNA concentration at the end of treatment and during 12 to 24 weeks of follow-up. RESULTS: Overall and in patients infected with HCV genotype 1, 48 weeks of treatment was statistically superior to 24 weeks and standard-dose ribavirin was statistically superior to low-dose ribavirin. In patients with HCV genotype 1, absolute differences in sustained virologic response rates between 48 and 24 weeks of treatment were 11.2% (95% CI, 3.6% to 18.9%) and 11.9% (CI, 4.7% to 18.9%), respectively, between standard- and low-dose ribavirin. Sustained virologic response rates for peginterferon-alpha2a and standard-dose ribavirin for 48 weeks were 63% (CI, 59% to 68%) overall and 52% (CI, 46% to 58%) in patients with HCV genotype 1. In patients with HCV genotypes 2 or 3, the sustained virologic response rates in the 4 treatment groups were not statistically significantly different. CONCLUSION: Treatment with peginterferon-alpha2a and ribavirin may be individualized by genotype. Patients with HCV genotype 1 require treatment for 48 weeks and a standard dose of ribavirin; those with HCV genotypes 2 or 3 seem to be adequately treated with a low dose of ribavirin for 24 weeks.

Adult↗
PubMed2002

Virologic investigations of free-living European bison (Bison bonasus) from the Bialowieza Primeval Forest, Poland.

We conducted virologic investigations on postmortem specimens from 261 free-living European bison (Bison bonasus) from the Bialowieza Primeval Forest, Poland collected between 1990 and 2000. Fifty-four of 94 males had balanoposthitis; none of the 167 female bison examined had reproductive tract lesions. Peripheral blood, swabs, and various tissues were analyzed for bovine viruses as well as for viral DNA by bovine herpesvirus 1 (BoHV-1) and bovine herpesvirus 4 (BoHV-4) specific polymerase chain reaction (PCR) technique. An infectious bovine rhinotracheitis like BoHV-1 strain was isolated from the spleen of a female bison calf and additionally was detected by nested PCR from splenic tissue. None of the bison had significant antibody titers against BoHV-1, bovine herpesvirus 2, BoHV-4, caprine herpesvirus 1, cervid herpesvirus 1, or bovine viral diarrhea (BVD) virus-1. However, low antibody titers in two animals indicate that this European bison population has been exposed to BVD virus or BVD-like viruses and BoHV-2.

Animals↗
PubMed2002

Antibodies against Mycoplasma bovigenitalium in free-living European bison (Bison bonasus) with balanoposthitis.

Since 1980 severe chronic balanoposthitis has been observed in free-living European bison (Bison bonasus) in the Białowieza Primeval Forest (Poland). Sera of 50 bison with balanoposthitis and 48 clinically healthy male and 49 female bison were investigated for antibodies against Mycoplasma bovis and M. bovigenitalium by western blot analysis. Prevalence of antibodies against M. bovigenitalium was significantly higher in bison with balanoposthitis than in unaffected male bison. Mycoplasma bovigenitalium may play a role in the pathogenesis of balanoposthitis in European bison.

Animals↗
PubMed1998

Detection of plum pox virus by enzyme-linked immunosorbent assay in some apricot and peach varieties and hybrids in Romania.

Plum pox virus (PPV) is a potyvirus widely spread in many species of the Prunus genus such as plum, apricot, peach, sweet cherry and others. This potyvirus causes great damage to stone fruit trees in Romania and other European countries as Hungary, Italy, Czech Republic, France, Spain, Greece, Turkey, and Slovak Republic. The Research Station for Fruit Tree Growing Baneasa in Bucharest has realized many studies on the epidemiology and spread of PPV and also on the disease symptomatology and detection possibilities. The control of sharka disease by sanitary selection measures requires corresponding detection techniques. The aim of this study was to determine the presence or absence of PPV in some apricot and peach varieties and hybrids in 1995-1997 by the enzyme-linked immunosorbent assay (ELISA) and to verify if some of our biological materials evaluated as symptom-free under field conditions for many years are also virus-free and can be considered healthy.

Enzyme-Linked Immunosorbent Assay↗
PubMedDate not supplied

[Zoon's balanoposthitis. A preliminary note].

OBJECTIVE: To review the different aspects of inflammatory disease of the glans penis and prepuce with special reference to Zoon's balanoposthitis. METHODS: The clinical history of patients that had been diagnosed and treated for Zoon's balanoposthitis are reviewed and discussed. RESULTS/CONCLUSIONS: Zoon's balanoposthitis is not a malignant lesion. Circumcision will suffice for the management and treatment of this condition.

Adult↗