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Nonspecific inflammatory pseudotumour of the caecum unrelated to the vermiform appendix.

A case of nonspecific inflammatory pseudotumour of the caecum unrelated to the appendix is reported. Symptomatology, radiological findings, and intraoperative findings suggested a caecal carcinoma. A right hemicolectomy was carried out. Histologic examination revealed an inflammatory mass with abundant fibroblastproliferation and collagen formation infiltrating the muscularis and adjacent pericolic adipose tissue. The caecal mucosa was entirely intact and normal. Histology suggested sclerosing mesenteritis. A correct preoperative diagnosis of nonspecific inflammatory pseudotumours of the caecum is difficult, but awareness of its existence might prevent too radical surgical resections. The differential diagnosis is discussed.

Aged↗

[A scanning electron microscopy study of the normal rabbit appendix].

The surface relief of the mucous membrane of the normal rabbit appendix was studied under scanning electron microscopy. Two different types of surface relief were identified. One consisted of relatively regular crests and grooves of the mucosa, the other one exhibited scattered crater-like openings into which "heads of lymphatic nodes" were inserted to varying extent and which were separated from the surface mucosa by broad alveolar cavities. Since adequate terminology has not yet been coined for the description of the observed structures, the authors use the terminology of classical histology and from analogous descriptions of other reliefs.

Animals↗

[Histological changes in the appendix in the prodromal stage of measles].

Morphological changes of adenoid tissue associated with morbilli are known. However, it is less known that the disease may start with symptoms of acute appendicitis and on the basis of histological picture morbilli can be raised or rendered probable, respectively, before appearance of typical clinical symptoms. Among morbilli cases of recently increased number the later developed morbilli was diagnosed from appendix in an appendectomy performed on a patient being in prodormal stage.

Adult↗

[Carcinoid tumor of the appendix].

The Authors report a case of tumour carcinoid of the appendix incidentally found at operation for appendicitis in a young patient. Diagnosis was confirmed at histologic analysis of the operating piece. Appendiceal carcinoid is the most frequent carcinoid tumor of the gastrointestinal tract and rarely becomes malignant. The Authors emphasize the importance of the knowledge of this not rare neoplasm.

Adult↗

[Myxoglobulosis of the cecal appendix].

We report a case of mucinous cystadenoma of the appendix with myxoglobulosis associated to cecal adenocarcinoma. Appendiceal myxoglobulosis present typical gross and microscopical findings. The clinical diagnosis of myxoglobulosis should be followed by a careful evaluation of the patient in order to detect an appendicular neoplasm and/or an assoiciated occult intestinal carcinoma.

Adenocarcinoma↗

[Experimental ultrasound analysis of the appendix. Contribution to improving the diagnosis of acute inflammation in routine clinical practice].

Sonographic investigations of fresh operative specimens - 50 non-infected, 50 chronic and 50 acute inflammatory appendices - and also of 335 pertinent operated patients with "typical" appendiceal disorders were performed. All other entities, mimicking acute or perforated appendicitis were excluded from this study. Under experimental conditions, negative, chronic and acute or phlegmonous appendices appeared as "cockade" or "pseudokidney sign" with reflecting wall and echoless lumen. The application of a 5 Mz linear transducer made the differentiation of three wall layers feasible, in negative appendices as well as in dilated acute appendicitis, whereas in chronic inflammation and in obliterating acute appendicitis a wall layer stratification was not possible. In clinical application of 335 operated patients we only could demonstrate cases of acute or perforated appendicitis (n = 182/220), but no cases of non-infected appendix. In 57% of pertinent cases the objectivation of lumen dilatation, in 35% a wall layer stratification was feasible. Acute, phlegmonous or perforated appendicitis was proven by demonstrating an immobile "pseudotumor mass" with dominating constant hypodense reflex property. The pertinent diameters as measured in clinical acute appendicitis exceeded significantly the diameters observed in experimental sonography of negative appendices with a differential intact mobility. Intraluminary coproliths and hyperdense reflecting attached omental segments facilitated a sonographic diagnosis. In 101/115 patients correct negative diagnosis was established. On the basis of these criteria, a sensitivity of 83%, a specificity of 88% and a diagnostic accuracy of 85% related to the diagnosis of acute or perforated appendicitis was obtained in this study.

Acute Disease↗

[The effect of histamine and histamine H1 and H2 receptor blockers on the tone of the longitudinal muscles in the human appendix].

The aims of this study were to determine whether the effect of histamine on a smooth musculature of the human appendix is mediated by histamine H1-receptors only or whether histamine H2-receptors are involved, as well. The obtained results indicate histamine increases tonus in musculature; however, histamine H1-receptor antagonist (promethazine) decreases tonus. Histamine H2-receptor antagonist (cimetidine) has caused a mild increase in tonus of musculature what indicates that it has a certain intrinsic activity. By blocking histamine receptors with H1 and H2 antagonists which were used either separately or together before cumulative histamine concentrations, it has been concluded that histamine actions are exerted not exclusively by H1-receptors but also histamine H2-receptor antagonists can significantly decrease the tonicizing effect of histamine.

Appendix↗

[Vermiform appendix used as a segment of the ureter].

A man aged 67 with a single kidney was admitted on account of haematuria and raised serum creatinine. Investigation revealed a poorly differentiated invasive transitional cell tumour at the middle of the right ureter. After resection of the tumour, a space of 10 cm remained between the two ends of the ureter. During the operation, it had become apparent that the usual methods of reconstruction could not be employed and, therefore, the vermiform appendix was employed as an intermediate segment of the ureter. The appendicular graft functioned satisfactorily until recurrence of the cancer occurred and the patient died one year later. This method may be employed in selected cases where Boariflap, uretero-trans-ureterostomy or autotransplantation of the kidney cannot be employed.

Aged↗

[Signet ring cell carcinoid of the appendix. Morphological, histochemical and immunohistochemical study of a case].

A case of carcinoid tumor of the appendix with "signet ring" cells pattern and asymptomatic clinical course is presented. The tumor was detected during a Bilroth I gastrectomy procedure. Mucin-secreting cells with cytoplasms often containing argentaffin and argyrophil granules was the predominant histologic pattern. Lack of neuron-specific enolase activity and their positivity for lysozyme and EMA marker indicate an origin from crypt cell and not a neural crest source. After simple appendectomy, the patient was healthy 3 years following surgery.

Adenocarcinoma, Mucinous↗

Crohn's disease of the appendix.

This study reports eight patients who underwent appendicectomy between 1978 and 1986 for apparently isolated, previously undiagnosed Crohn's disease of the appendix. All patients have since remained well with no sign of disease recurrence. This may represent a less aggressive form of Crohn's disease or be a different entity, namely granulomatous appendicitis.

Adolescent↗

Immunoglobulin- and J chain-producing cells associated with lymphoid follicles in the human appendix, colon and ileum, including Peyer's patches.

Immunohistochemistry of B cells associated with normal human Peyer's patches and solitary lymphoid follicles of the ileum, colon and appendix mucosa showed that local accumulation of IgG-producing cells is a common feature of gut-associated lymphoid tissue (GALT). These immunocytes have strikingly down-regulated J-chain expression, indicating that they belong to mature memory clones. They are located mainly in the dome areas, alongside the follicles, and to a lesser extent in the germinal centres, and are accompanied by a much smaller number of J-chain negative IgA- and IgM-producing cells. It is concluded that B cells of mature memory clones are retained in GALT, whereas relatively early counterparts with a high J chain-expressing potential probably emigrate rapidly after stimulation and seed distant secretory sites where they undergo terminal differentiation to produce mainly J chain-containing dimeric IgA.

Adolescent↗

[Role of mechanical suture instruments in surgery of the appendix].

Mechanical sutures can be used in some appendicectomies for closure of the caecum or of the caeco-appendicular junction. This technique is indicated in cases of necrosis of the appendix extending to the lower end of the caecum and in patients with very wide caeco-appendicular junction. In such cases, it provides a simple and safe solution, with reduced risk of sepsis, to the problem of appendicular ligature.

Acute Disease↗

[Primary cancer of the appendix].

Case report about a carcinoma of the appendix, recognized by obduction of an 58-years old man. Discussion of rarity, difficult clinical diagnostic, histological classification, metastasis and problems of differential diagnosis and therapy.

Appendiceal Neoplasms↗

[Primary carcinoma of the vermiform appendix].

A 54-year-old Japanese woman with primary adenocarcinoma of the appendix was treated. The diagnosis was established before surgery by means of barium studies and ultrasound examination. Histologically, the tumor was a mucinous cystadenocarcinoma. The patient was treated by ileocecal resection, and a 10-month follow-up has revealed neither evidence of recurrence nor of metastases. The preoperative investigations, pathologic features and surgical management in this case are briefly discussed.

Appendiceal Neoplasms↗

Retained lead shot in the appendix.

Sixty-two patients with retained lead shot in their appendices, discovered during routine radiographic studies, were followed for periods ranging from two months to 13 years. The number of lead shot in the appendices varied from one to over 200. Twenty patients who had barium studies showed no evidence of luminal obstruction of their appendices. Eight patients who had appendectomies showed no evidence of appendicitis on tissue examination. None of the other patients developed any clinical evidence of appendicitis or lead poisoning. It is concluded that no causal relationship exists between retention of lead shot, their number, the duration of their presence in the appendix, and appendicitis.

Adult↗

Contribution to the question of relationships between Enterobius vermicularis (L.) and inflammatory processes in the appendix.

We evaluated a bioptic material of appendices from the hospital in Ceské Budĕjovice, obtained from 1977-1981. Of these, 2173 appendices were removed as cases of a clinical appendicitis, 788 for preventive reasons. In the cases of a clinical appendicitis with the incidence of pin worms in the appendix, the histological picture displayed significantly more chronical, inflammatory changes than in acute cases (test chi 2), while in cases of a clinical appendicitis without the presence of pin worms, we found more acute than chronical forms of inflammations. Our results are supported also by an analysis of preventively removed appendices, where again more chronical, inflammatory changes were found in appendices with pin worms.

Acute Disease↗