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Results for “Alcoholic Intoxication”

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At least 865 records · Page 48Linked to original sources
PubMed1979

Prevention of effects of alcohol intoxication by naloxone.

In a double-blind, cross-over study of twenty male volunteers intravenous injection of 0.4 mg naloxone prevented the impairment of psychomotor performance induced by low levels of blood alcohol. The possibility that alcohol produces intoxication by stimulating the release of endogenous opioid peptides should be investigated.

Adult↗
PubMedDate not supplied

Cortical microvascular changes in chronological aging, cortical insults and chronic alcohol intoxication in rats. Effects of antihypoxic drug on these phenomena.

Chronic alcohol pulmonary exposure in rats produced a cortical hypervascularization from one to four weeks after the onset of the alcoholization procedure. This alcohol-induced cortical hypervascularization, resembling closely the enhanced cortical vascular network observed in chronologically aged rats as well as around a lesion-induced cavity performed on the cortex, was significantly reduced by a concomitant treatment with Sabeluzole, a chemically benzothiazol derivative with antihypoxic and antiischaemic properties. The blood alcohol level of rats treated with the antihypoxic agent remained stable and constant at a mean level of 1 g/l during a whole 2-week-alcoholization duration in contrast to that of untreated rats which was directly related to the increased alcohol concentration of the atmosphere insufflated in the alcoholization chamber. Finally, a free-choice paradigm achieved after the chronic intoxication also revealed that Sabeluzole-treated rats chose to drink less alcohol as compared to untreated rats suggesting Sabeluzole well modulated the alcohol-induced behavioral preference.

Aging↗
PubMed1986

Individual differences in state-dependent retrieval effects of alcohol intoxication.

Individual differences in susceptibility to the state-dependent retrieval (SDR) effects from alcohol in twelve subjects was tested on repeated occasions. There was a threefold variability in frequency of SDR among the subjects. A significant positive correlation between frequency of SDR and history of blackouts and heavy drinking was found.

Adult↗
PubMed1991

[Does the highest judicial ordinance for a new limit value for absolute driving incapacity (BGH 4 StR 297/90, Beschl. v. 28 June 1990) allow unequal treatment of alcohol intoxicated drivers?].

The jurisdiction in the BRD knows a threshold value of the blood alcohol concentration from which on the actual absolute driving unfitness without any further evidence will be assumed. This threshold value has been lowered by the highest german criminal court (BGH) from so far 1.3% to now 1.1 g%. As the determination of the alcohol content takes place in two different procedures as a mean value out of four or five single values, the highest court orders a dispersion control--the standard deviation from 0.03 g% or 0.04 g%. The authors proof that therefore a dissimilar treatment of motor traffic participants under the influence of alcohol may be possible. The reason is to be traced in the different distributions of a single values around the mean value and in the incorrect application of the standard deviation.

Accidents, Traffic↗
PubMed2005

A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injury.

This study examined the role of protein phosphatase type-1 (PP1), type-2A (PP2A), and mitogen-activated protein kinase phosphatase-1 (MKP-1) in altered mesenteric lymph node (MLN) T cell function in a two-hit model of alcohol (EtOH) intoxication and burn injury. Male rats (250 g) were gavaged with EtOH to achieve a blood EtOH level of approximately 100 mg/dL prior to burn or sham injury (25% total body surface area). MLN T cells harvested 24 h after injury show a significant decrease in p38 and extracellular signal-regulated kinase (ERK)-1/2 phosphorylation in T cells from rats receiving a combined insult of EtOH intoxication and burn injury compared with rats receiving EtOH intoxication or burn injury alone. Treatment of cells with inhibitors of PP1/PP2A [calyculin A (CA) and okadaic acid (OA)] prevented the suppression in T cells p38 and ERK-1/2 activation. In addition, the suppression in interleukin-2 and interferon-gamma production was attenuated in T cells cultured in the presence of CA and OA. MKP-1 inhibitor triptolide did not prevent the suppression in T cells p38/ERK-1/2 and cytokine production. Furthermore, there was a significant decrease in PP1alpha phosphorylation (Thr320) and an increase in PP2A (Tyr307) phosphorylation in T cells following a combined insult of EtOH intoxication and burn injury. As phosphorylation of PP1 at Thr320 and PP2A at Tyr307 led to an inhibition of their enzymatic activities, the decrease in the PP1alpha phosphorylation correlates with an increase in its enzyme activity. Thus, these results suggest that activation of PP1 is likely to play a predominant role in T cell suppression following a combined insult of EtOH intoxication and burn injury.

Alcoholic Intoxication↗