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At least 865 records · Page 48Linked to original sources
PubMed2003

Effects of a propofol--ketamine admixture in human volunteers.

As the ideal sedative does not exist for all situations, particularly in settings with limited resources, the effect of a propofol-ketamine combination in human volunteers was examined. Eleven American Society of Anesthesiologists (ASA) physical status I volunteers were administered propofol at a loading dose of 1 mg/kg and two minutes later by 0.7 mg/kg of ketamine. This was followed by a propofol-ketamine combination of 5 mg/kg of propofol admixed with 0.7 mg/kg of ketamine that was infused over one hour via a 60 gtts/ml intravenous. Infusion set. Cardiorespiratory parameters were recorded and blood samples taken to measure plasma catecholamine levels prior to, during and for thirty minutes following the termination of the infusion. Rate of respiration and oxygen saturation levels did not alter significantly from baseline levels. When there was a cardiovascular decrease from base line levels it was on average 11% for systolic, 15% diastolic blood pressure and 14% for heart rate. Only plasma adrenaline and noradrenaline increased by 28 and 20%, 10 minutes following the bolus injectons. No dysphoria was experienced. This combined sedoanalgesic technique in nonstimulated human volunteers maintains spontaneous ventilation and may be considered as abalanced alternative to traditional conscious sedation or general anesthesia.

Adrenergic Agonists↗
PubMed1991

Antineoplastic admixtures.

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Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

[The sensitizing properties of the ballast admixtures in human leukocyte interferon].

Due to the features of its production technology, human leukocyte interferon (HLI) for intranasal administration is likely to contain ovalbumin (OA). Commercial batches of HLI were tested for the presence of OA responsible for the sensitizing effect of HLI given intranasally. The content of OA in commercial batches of HLI was shown to vary widely and to exceed by far the concentrations having the sensitizing effect. As a result of these studies, the upper limit of OA content was established and the technology of HLI production was modified. These measures permitted production of commercial batches of HLI with OA content not exceeding 0.05 micrograms/ml.

Anaphylaxis↗