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Alpha 1-antitrypsin in amniotic fluid.

Amniotic fluid a1-antitrypsin values were determined by radial immunodiffusion of 317 samples obtained between the 10th and 43rd weeks of gestation in normal pregnant patients and those with complications. Serial determinations of a1-antitrypsin values revealed that in normal patients values decreased as pregnancy advanced while values increased as pregnancy advanced in cases in which there was severe Rh-alloimmunization and hydramnios. A wide range of values was observed for each week of gestation. Although there was a definite tendency for values to decrease as pregnancy advanced (60.8 mg/100 ml before 30 weeks and 17.9/100 ml after 40 weeks); the method must be regarded as unreliable for determining fetal maturity in clinical practice. In the case of newborn infants with hyaline membrane disease, no decrease in amniotic fluid a1-antitrypsin values has been found.

Amniotic Fluid↗

[The occurrence of eclampsia in the last six decades in the University Gynecological Hospital, Greifswald )author's transl)].

Epricrisis evaluation of 308 eclampsias which were observed from 1910-1974 in a total of 62,910 birth (0,5%) showed a reduction of incidence from 3.1% to 0%. The etiology of eclampsia is still unknown even today. Primiparae are most frequently affected. Preexisting renal diseases and the pathological complications of a gestosis play a role. During the 64 years, therapy has alternated between the conservative and active. Accouchement force, if at all possible within the first hour after the first attack and simultaneous drug therapy (hypotensives, sedatives, diuretics) gave the best results. The regression of the frequency of eclampsia is due to the intensive antenatal consultation.

Age Factors↗

[Investigations of changes in the phenolsulphonphthalein plasma levels in pregnant women with EPH syndrome (author's transl)].

In 53 patients, 24 healthy pregnant women and 29 patients with EPH (edema, proteinuria, hypertension) syndrome, the intravenous phenolsulphonphthalein test was performed between the 32nd and 42 weeks of pregnancy. At the same time, the serum creatinine and estrogen excretion in the 24 hour urine were determined. According to this, normal pregnancy and also pregnancies with one or more symptoms of the EPH syndrome without raised blood pressure do not cause changes of the PSP plasma level. A statistically significant rise in the PSP plasma level is only found with a blood pressure of 140/90 mm Hg, and simultaneously a close correlation to the estrogen excretion in the urine (r = -0.4) and the blood pressure (r = 0.6). Estrogen excretion is reduced with increasing blood pressure (r = -0.75). No correlation could be established between the PSP serum level and the creatinine in the serum.

Adolescent↗

[Changes in indication for caesarean section analysis of 1241 caesarean sections (author's transl)].

On the basis of a large schema of indications (tab. 1, 2) 1241 Caesarean sections during 1966-1973 are analysed. The following points can be summarized: 1) The percentage rose from 6.4% (1966) to 10.75% (1973) (Fig. 1). 2) The percentage of Caesarean sections decided on for the sake of the child rose from 54% (1966/67) to 63.9 (1972/73) (tab. 3). 3) Vital indications fell due to increasingly preventive obstetrics from 71.7% (1966) to between 30% and 41.3% (1973) (tab. 4). 4) Perinatal mortality of 1258 children delivered by Caesarean section was 4.05% (tab. 5). Of Children delivered surgically for vital indications 6.1% died, of those delivered surgically for preventive indications only 0.9% died in the perinatal period (tab. 6). 5) This shift from the vital towards preventive indication is particularly pronounced for repeated Caesarean section (tab. 7) and for breech presentation (tab. 8). 6) Maternal mortality after Caesarean section reached 3.2%, after spontaneous delivery only 0.16%. This great difference in the maternal risk between those treated with Caesarean section and those with spontaneous delivery emphasizes the need for indications for Caesarean section which are critical, conscious of the responsibility and not too generous.

Age Factors↗

[Relationship between premature labor and maternal age, as well as between premature labor and parity].

Various publications of the last years and own studies, too demonstrate that birth rank and maternal age, as well, in each case independently influence the risk of prematurity. The rate of prematurity for primiparous and multiparous women is above the average; it is just the same for very young and comparatively old women. Basing on a review of literature eventual causes are briefly discussed.

Female↗

[Perinatal fate of children delivered by cesarean section with a birth weight less than or equal to 2000g].

The fate from children with a brithweight less than or equal to 2000 g in attendence of caesarean section is doubtful. From 35 children, born by caesarean section because of maternal and/or fetal indications died 17 (approximately 50 per cent). Maternal indication entitled always to perform sectio parva during the III. trimester of pregnancy--or to a earlier period. Clear fetal indication for caesarean section from the 34. week of gestation justified one-self. This is relative seldom. Caesarean section--performed before the 34. week of gestation--is changed with a high perinatal mortality and morbidity.

Apgar Score↗

[The significance of radioimmunological HPL determination in obstetrics (author's transl)].

The serum HPL level was studied in normal and high-risk pregnancies. 30 patients with premature labour showed significantly decreased levels. In 24 patients with monosymptomatic toxaemia, HPL patterns showed a statistically significant deviation from the normal standard curve; a highly significant decrease was observed in 23 cases of polysymptomatic gestoses. As opposed to the results of other authors, no significant difference from the normal distribution of HPL was found in cases of Rh sensitisation (13 patients) and diabetes mellitus (16 patients). A noteworthy results was seen in 19 cases of cervix insufficiency: after purse-string suturing of the cervix (original method of Shirodkar), the previously low plasma HPL level rapidly rose to normal levels. Because of the small number of cases without an adequate control group this phenomenon cannot be attributed with certainly, as yet, to the cerclage procedure.

Blood Group Incompatibility↗