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At least 847 records · Page 47Linked to original sources
PubMed1997

Characterization of immune response to Eimeria tenella antigens in a natural immunity model with hosts which differ serologically at the B locus of the major histocompatibility complex.

A model to simulate natural immunity to Eimeria tenella was developed in three chicken lines which differ at the B locus of the major histocompatibility complex. Homozygous, 1-day-old chicks of the B19B19, B24B24, or B30B30 genotype were trickle immunized by being orally fed a small infectious dose of E. tenella oocysts for 5 consecutive days. These naturally exposed birds were then challenged at different times between 5 and 24 days after the final dose, and the level of protection was assessed 6 days after challenge, using body weight gain and intestinal lesion scores. The duration of immunity in naturally exposed birds differed among the major histocompatibility complex lines. Trickle immunization of the B19B19 haplotype afforded the longest and strongest level of protection compared to the other two haplotypes tested. In addition, in vitro splenic and peripheral blood lymphocyte proliferative responses in trickle-immunized birds were measured against sporozoite, merozoite, and tissue culture-derived E. tenella parasite antigens isolated from the recently described SB-CEV-1/F7 established cell line. The lymphocytes obtained from B19B19 birds trickle immunized responded in vitro to the E. tenella-infected SB-CEV-1/F7 tissue culture-derived parasite antigen. Furthermore, antigen-specific immune responses appeared earlier in immune, challenged B19B19 birds than in their naive, challenged counterparts. The development of a model simulating natural immunization will serve as a foundation to further characterize both humoral and cell-mediated responses to E. tenella tissue culture-derived parasite antigens and to better understand host protective immune responses to avian coccidiosis.

Animals↗
PubMed2002

The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells.

Schwannoma tumors, which occur sporadically and in patients with neurofibromatosis, account for 8% of intracranial tumors and can only be treated by surgical removal. Most schwannomas have biallelic mutations in the NF2 tumor suppressor gene. We previously showed that schwannoma-derived Schwann cells exhibit membrane ruffling and aberrant cell spreading when plated onto laminin, indicative of fundamental F-actin cytoskeletal defects. Here we expand these observations to a large group of sporadic and NF2-related tumors and extend them to schwannomatosis-derived tumors. Mutation at NF2 correlated with F-actin abnormalities, but the extent of morphological change did not correlate with the type of NF2 mutation. We used a recently described molecular strategy, TAT-mediated protein transfer, to acutely introduce the NF2 protein, merlin, into primary human schwannoma cells in an attempt to reverse the cytoskeletal phenotype. Abnormal ruffling and cell spreading by cells with identified NF2 mutations were rapidly reversed by introduction of TAT-merlin. The effect is specific to TAT-merlin isoform 1, the growth-suppressive isoform of merlin. TAT-merlin isoform 2, a TAT-merlin mutant (L64P), and merlin lacking TAT were ineffective in reversing the cytoskeletal phenotype. Results show that merlin isoform 1 is sufficient to restore normal actin organization in NF2-deficient human tumor cells, demonstrating a key role for merlin in the NF2 phenotype. These results lay the foundation for epigenetic complementation studies in NF2 mouse models and possibly for experiments to evaluate the utility of merlin transduction into patients as protein therapy.

Actins↗
PubMed2000

Evolution of a comprehensive tobacco control programme: building system capacity and strategic partnerships--lessons from Massachusetts.

BACKGROUND: Since the passage of a voter approved state referendum in 1992 to establish a 25 cent increase on the excise tax on cigarettes and smokeless tobacco, Massachusetts has received an average of $40 million annually for its tobacco control programme. This funding allowed Massachusetts to expand and develop its tobacco control programme to become one of the most comprehensive in the world. OBJECTIVES: The development of the Massachusetts Tobacco Control Program is outlined, focusing on three stages of development: formation, strategic partnership building, and shared leadership. METHODS: The development of management structures, programmatic infrastructure, communication and partnership networks, and advisory structures are tracked throughout the three phases. RESULTS: The use of pre-existing public health resources, implementation of a strong training component, a geographical management structure, the creation of public and private partnerships, and the development of a shared leadership model contributed to building consensus and provided the foundation for coordinated approaches to tobacco control. CONCLUSION: Other states and countries can use lessons learned from Massachusetts about the organisational development of a comprehensive tobacco control programme as they embark upon similar efforts.

Humans↗
PubMedDate not supplied

On being a grantmaker.

Explore the source record for details and available documents.

Administrative Personnel↗
PubMedDate not supplied

Translating social ecological theory into guidelines for community health promotion.

Health promotion programs often lack a clearly specified theoretical foundation or are based on narrowly conceived conceptual models. For example, lifestyle modification programs typically emphasize individually focused behavior change strategies, while neglecting the environmental underpinnings of health and illness. This article compares three distinct, yet complementary, theoretical perspectives on health promotion: behavioral change, environmental enhancement, and social ecological models. Key strengths and limitations of each perspective are examined, and core principles of social ecological theory are used to derive practical guidelines for designing and evaluating community health promotion programs. Directions for future health promotion research are discussed, including studies examining the role of intermediaries (e.g., corporate decision-makers, legislators) in promoting the well-being of others, and those evaluating the duration and scope of intervention outcomes.

Ecology↗
PubMedDate not supplied

Virtuous capital: what foundations can learn from venture capitalists.

U.S. foundations and nonprofits work diligently on behalf of society's most needy and yet report that progress is slow and social problems persist. How can they learn to be more effective with their limited resources? Foundations should consider expanding their mission from investing only in program innovation to investing in the organizational needs of nonprofit organizations as well. Their overemphasis on program design has meant deteriorating organizational capacity at many nonprofits. If foundations are to help nonprofits be assured of making payroll, paying the rent, or buying a much-needed computer, they must develop hands-on partnering skills. Venture capital firms offer a helpful benchmark. In addition to putting up capital, they closely monitor the companies in which they have invested, provide management support and stay involved long enough to see the company become strong. If foundation officers familiarize themselves with such practices, they can begin to build organizational capacity in the nonprofit sector. Foundations can hire organizational experts to assist grantees; they can lengthen grant terms to allow nonprofits to build up organization strengths; and they can create new classes of grants that allow for organizational effectiveness. Nonprofits in turn should articulate their organizational needs when applying for grants; they should apply to foundations known for longer-term grants; and they should create plans that justify long-term support from foundations.

Capital Financing↗
PubMed1998

Theoretical foundations of TQM and CQI: or, does quality really have its own theory?

Total quality management and continuous quality improvement have been advocated as management salvation and anecdotally have been linked to improvements in operational effectiveness. The Joint Commission on Accreditation of Healthcare Organizations has adopted quality management as the organization improvement measure of the future and has mandated its application. The article explores the theoretical foundations of quality management and presents an integrated model dealing with this industry standard. An operational framework for managers is provided in an attempt to demystify the quality jargon that is so prevalent. The article also provides a prescriptive management overview incorporating quality management techniques into everyday operations.

Feedback↗
PubMed1999

Comparative patterns of follicle development and selection in ruminants.

Expanding technological capabilities, particularly in ultrasonography and molecular endocrinology, have bridged the gap between form and function of the ovary, and have been a catalyst for intense research activity in this area during the last decade. However, the study of follicular dynamics is still in its infancy in ruminant species other than cattle, and controversy persists regarding the pattern of follicular growth and the existence of follicular dominance. The bovine model of ovarian function is presented as a foundation for concepts surrounding the control of follicular development in ruminants, and to place in context the results of recent studies in sheep, goats, muskoxen, cervids and camelids. This comparative approach is used to determine important generalities that appear to be applicable, as fundamental physiological phenomena, to all ruminant species. Although clear differences in follicular dynamics are evident, differences appear to be specific rather than general, and the following conclusions are consistent with results reported in ruminant species to date: (1) follicles grow in a wave-like fashion; (2) periodic surges in circulating FSH are associated with follicular wave emergence; (3) selection of a dominant follicle involves a decline in FSH and acquisition of LH responsiveness; (4) periodic anovulatory follicular waves continue to emerge until occurrence of an LH surge (that is, at the time of luteolysis during the ovulatory season or during transition from the anovulatory season); (5) within species, there is a positive relationship between the duration of the oestrous cycle and the number of follicular waves; (6) progesterone suppresses LH secretion and growth of the dominant follicle; (7) the duration of the interwave interval is a function of follicular dominance, and is negatively correlated with circulating FSH; (8) follicular dominance in all species is more pronounced during the first and last follicular waves of the oestrous cycle; and (9) pregnancy, the prepubertal period and seasonal anoestrus are characterized by regular, periodic surges in FSH and emergence of anovulatory follicular waves.

Animals↗
PubMed2001

Understanding the evolution of restriction-modification systems: clues from sequence and structure comparisons.

Restriction-modification (RM) systems comprise two opposing enzymatic activities: a restriction endonuclease, that targets specific DNA sequences and performs endonucleolytic cleavage, and a modification methyltransferase that renders these sequences resistant to cleavage. Studies on molecular genetics and biochemistry of RM systems have been carried out over the past four decades, laying foundations for modern molecular biology and providing important models for mechanisms of highly specific protein-DNA interactions. Although the number of known, relevant sequences 3D structures of RM proteins is growing steadily, we do not fully understand their functional diversities from an evolutionary perspective and we are not yet able to engineer new sequence specificities based on rational approaches. Recent findings on the evolution of RM systems and on their structures and mechanisms of action have led to a picture in which conserved modules with defined function are shared between different RM proteins and other enzymes involved in nucleic acid biochemistry. On the other hand, it has been realized that some of the modules have been replaced in the evolution by unrelated domains exerting similar function. The aim of this review is to give a survey on the recent progress in the field of structural phylogeny of RM enzymes with special emphasis on studies of sequence-structure-function relationships and emerging potential applications in biotechnology.

Catalytic Domain↗
PubMed2006

Applying Roberts' Triple ABCD Model in the aftermath of crisis-inducing and trauma-inducing community disasters.

Natural and man-made community disasters, such as hurricanes, earthquakes, school shootings, and mass terrorist attacks, heavily impact the safety, mental health, and well-being of large numbers of individuals, families and groups. Millions of individuals who experience acute crisis episodes or psychological trauma are not consistently provided with the early psychological interventions they urgently need. There is a critical need for tools and a framework to quickly and effectively promote interventions. This article presents one such effort, the Roberts' Triple ABCD Model. This model is an up-to-date and integrated conceptual framework that helps to provide the foundation for developing a unified standard of care for crisis and disaster mental health interventions. This model can be useful in determining which early intervention methods and techniques are most likely to reduce traumatic stress, treat acute crisis and psychosocial symptoms, and promote recovery.

Clinical Competence↗
PubMed1983

Primate research resources in the Soviet Union.

The authors visited Soviet medical institutions as part of a USA-USSR Professional Exchange Program sponsored by the Fogarty International Center. The primary purpose of this visit was to obtain a general view of the Soviet use and care of laboratory animals in biomedical research and to lay a foundation for a continuing exchange of information and models.

Academies and Institutes↗
PubMed1978

[Voice and vibration sensations in the speech forming organs: clinical and theoretical aspects of rare symptoms specific for schizophrenia].

When studying 750 psychiatric in-patients with psychoses of various diagnostic groups, the symptoms of voice sensations and vibration feelings could only be found among patients with paranoid schizophrenia. In addition, these symptoms were located exclusively in body areas that are involved in the peripheral motor production of voice and speech (areas of head, throat, thorax). In 11 of 15 such cases that could be identified, the sensations of voices and vibrations occurred simultaneously and in identical body parts; in the remaining 4 cases only voices without vibration sensations were reported. Therefore these symptoms can be considered as highly specific for schizophrenia. According to the terminology of Bleuler these two symptoms are because of their rareness to be taken as accessoric symptoms; according to the terminology of Kurt Schneider they have the value of first rank symptoms because of their highly diagnostic specifity for schizophrenia. The pathogenesis of these symptoms is on the one hand discussed under the perspective of language development and the changing function of language for behaviour control; on the other hand, the pathogenesis of these symptoms is discussed from the viewpoint of cybernetic, or neurophysiological-neuroanatomical foundation of speech production and speech control. Both models of explanation have in common that the ideational component of speech is noticed as acustic halluzinations and the motor proprioceptive part of speech is noticed as sensation of vibrations, both in a typically schiphrenic manner, i.e. dissociated and ego-alienated.

Adult↗
PubMed1975

[Study of the role of colicins in the formation of microbial association in experiments in chick embryos].

Experiments were conducted on chick embryos; conditions of formation of bacterial cenosis of Shigella sonnei and E. coli were reproduced. The role of colicinogenia in the formation of bacterial cenosis was demonstrated. An accumulation of colicines in high titres (1: 5120- 1:2560) in the chick embryonic cavity was noted in combined or separate cultivation of colicinogenic shigellae and E. coli. An intergenera transmission of the col-factor was traced in experiments on chick embryos. The data obtained served as foundation for recommendation of the accessible and economic model (chick embryos) for the in vivo study of colicinogenia of the enteric bacteria representatives.

Animals↗
PubMed1997

DNA vaccines for malaria: the past, the present, & the future.

The first clinical trial of a DNA vaccine designed to protect against malaria has just commenced. This vaccine has been designed to induce protective CD8+ T cell responses against Plasmodium falciparum infected hepatocytes. Herein, we review the rationale behind the development of vaccines that induce protective CD8+ T cells, the strategy for the development of a DNA vaccine designed to protect against falciparum malaria, and the experimental data in rodent models and nonhuman primates which has provided the foundation for trials of DNA vaccines against P. falciparum malaria in humans.

Animals↗
PubMed1998

Compositional concept representation using SNOMED: towards further convergence of clinical terminologies.

This paper describes several approaches to the expression and coding of clinical concepts as composites of elementary entities, and describes an approach based on SNOMED RT that may permit further convergence of clinical terminology efforts. We explain the shortcomings of previous approaches to compositional concept representation, as well as the reasons for SNOMED's current approach, which adopts a foundation based in description logics (DLs). The DL model has many advantages: it establishes a formal semantics for SNOMED assertions and suggests a syntax; it provides a basis for understanding expressiveness and computational complexity, through correspondence with known results from DLs; and it helps to clarify the relationships among existing concept representation methods in SNOMED, NHS Clinical Terms (formerly the Read Codes), and GALEN, making a path to convergence more clear.

Models, Theoretical↗