Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “THIOPENTAL”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 847 records · Page 47Linked to original sources
PubMed1983

[Comparison of the hemodynamic effects of midazolam-fentanyl and thiopental-fentanyl combinations in the induction of general anesthesia].

The hemodynamic changes during anesthetic induction for elective abdominal aortic surgery were studied in two groups of patients. Group M (9 patients) received midazolam 0.3 mg . kg-1 and fentanyl 6 micrograms . kg-1. Group T (10 patients) received thiopentone 6 mg . kg-1 and fentanyl 5 micrograms . kg-1. The radial and pulmonary arteries were catheterized under local anesthesia. An intravenous infusion was administered in order to normalize pulmonary wedge pressure. Systemic and pulmonary arterial pressures, pulmonary wedge pressure, cardiac output and heart rate were measured after the infusion and 5 min after intubation. Mean arterial pressure showed a statistically significant reduction in both groups. Cardiac index remained unchanged in group M, but was significantly diminished in group T. There was no significant reduction in the systemic vascular resistance index for group M, but group T showed a statistically significant increase. This study confirmed the good hemodynamic tolerance of the midazolam induction technique, even with a high dose of 0.3 mg . kg-1.

Adult↗
PubMed1986

[Pharmacokinetics of thiopental in women and newborn infants].

Plasma thiopentone concentrations after a single intravenous dose were determined by high pressure liquid chromatography in female surgical patients (n = 13), in pregnant women at term (n = 13) and in neonates (n = 13). In pregnant women, the apparent volume of distribution (Vd = 10.02 +/- 3.26 l X kg-1), plasma clearance (Cl = 22.03 +/- 7.55 l X h-1) and elimination half-life (t 1/2 (3) = 21.71 +/- 11.12 h) were significantly greater than in the surgical patients (Vd = 4.22 +/- 1.16 l X kg-1; Cl = 12.49 +/- 3.50 l X h-1; t 1/2 (3) = 13.79 +/- 3.09 h). Elimination half-life in neonates (t 1/2(e) = 17.9 +/- 9.7 h) was not different from half-life in mothers or in the surgical group. At delivery, the simultaneous concentrations were 5.3 +/- 1.3 mg X l-1 in venous blood and 3.8 +/- 1.6 mg X l-1 in cord venous blood. Apgar score was 10 in eleven neonates. For two babies, an Apgar score at 6 was explained by a uterine incision-to-delivery time interval greater than 2 min.

Adult↗