Potentially serious interaction of warfarin with sulphinpyrazone.
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The diagnosis of gout depends on showing urate crystals in synovial effusions or, with less certainty, recognizing a characteristic clinical presentation. The management of gout has four phases: control of inflammation, diagnostic evaluation, education of the patient, and treatment for the hyperuricemia. Sound logical principles guide each aspect. Careful attention to these four phases of management should lead to highly satisfactory control of the syndrome of gout.
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Major advances are being made in our understanding of the pathophysiology of ischemic stroke. In the past 25 years anticoagulation, carotid endarterectomy, and antiplatelet aggregation agents, along with less well-accepted therapies, have been introduced for the management of this complex disorder. Also, noninvasive diagnostic methods have been developed for evaluating these patients. This article reviews the pathophysiology of cerebral ischemia and the data on the effectiveness of the various therapies advocated for its management.
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Retrospective analysis of newly diagnosed gout cases seen at the Mayo Clinic from 1949 through 1972 shows a progressive decline in tophaceous gout, from 14% to 3%. Gout diagnoses remained stable in a range of 1.5 to 2.2/1,000 patients seen.
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