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PubMed1993

Lumbar and cervical spondylosis and spondylotic myelopathy.

The problem of chronic spondylitic spinal disease is markedly underrepresented in the literature. The principal focus is on procedures and diagnostic techniques. It has been suggested that the classic clinical syndromes are rare and that interventional protocols based on them are likely to be inadequate. New diagnostic techniques have revolutionized the evaluation of patients: magnetic resonance imaging is now the standard whereas myelography use is being steadily reduced. It is clear that the outcome of spinal surgery for herniated disk, in expert hands, is excellent. Nevertheless, there is an emphasis on minimally invasive and percutaneous techniques to try to avoid major surgery, which has been the standard. The natural history of these problems is still understood incompletely. Long-term follow-ups are generally not available and the value of nearly every form of conservative care remains unproven.

Cervical Vertebrae↗
PubMed1996

Vulnerability of vertebral artery in anterolateral decompression for cervical spondylosis.

This study aimed to provide anatomic data for the location of the vertebral artery and offer an optimal approach for lateral cervical decompression that minimizes the risk of injury to the vertebral artery. Anatomically, there has been little study documenting the safe zone to prevent vertebral artery injury during the resection of the uncinate process or uncovertebral joint during the lateral decompression of the nerve root. The transverse foramen and its related parameters were measured on dry cervical spines from C3 to C7. The cadaveric cervical spines were dissected to determine a method for resection of the uncovertebral joint with decreased risk of vertebral artery laceration. The anteroposterior diameters of the transverse foramina gradually decreased from C6 to C3. The transverse diameters of the transverse foramina were smaller at C5. The interforaminal distance, width of the vertebrae, interuncinate distance, and the distance from the lateral tip of the uncinate process to the medial border of the transverse foramen became smaller in more cephalad vertebrae. After subtotal vertebrectomy and opening of the anterior walls of the transverse foramina, the resection of the uncovertebral joint and lateral decompression became easier and safer. Anatomic measurements obtained in this study indicate the vertebral artery to be at risk during decompression of the more cephalad vertebrae. The lateral decompression can be completed under direct vision with smaller rongeurs and curettes, rather than with high speed burr after deroofing the anterior walls of transverse foramina and retracting the vertebral artery laterally.

Adult↗
PubMedDate not supplied

Cervical spondylosis: diagnosis, symptomatology, and treatment.

This article reviews in detail cervical anatomy and pathophysiology. It then details appropriate workup including x-rays and other diagnostic studies. It concludes with a brief description on nonoperative and operative management.

Cervical Vertebrae↗
PubMed1997

Anatomic considerations for uncovertebral involvement in cervical spondylosis.

Morphometric analysis of 54 dry cervical spines from C3 to C7 (a total of 270 cervical vertebrae) and bilateral dissection of 10 anatomic specimen cervical spines were performed. The uncinate processes were significantly higher at C4 to C6 (5.8 +/- 1.1 mm to 6.1 +/- 1.3 mm) levels than at C3 or C7 levels. The anteroposterior diameter of the intervertebral foramina was smaller at the C4, C5, and C6 levels compared with that at the C3 or C7 levels. The length of nerve root between the lateral border of dural tube and medial border of vertebral artery gradually increased from C3 (3.3 +/- 1.1 mm) to C7 (8.1 +/- 2.1 mm). A combination of higher uncinate process, smaller anteroposterior diameter of intervertebral foramina, and longer course of nerve roots in close proximity of the uncovertebral joints at the C4 to C6 levels may explain the predilection of nerve root compression by uncovertebral osteophytes at these levels. The distance from apex of the uncinate process to medial border of the transverse foramen gradually increased from C3 (1.7 +/- 0.8 mm) to C7 (3.3 +/- 1.0 mm), which may predispose the midcervical level to compression of the vertebral artery by laterally projecting uncovertebral osteophytes.

Adult↗
PubMed2001

The relationship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc.

STUDY DESIGN: Apoptosis in cervical intervertebral disc cells and cartilaginous endplate cells was examined by the nick end labeling (TUNEL) technique during the process of natural aging and in a mouse experimental spondylosis model. OBJECTIVES: To determine the role of apoptosis in aging and degeneration of intervertebral discs by monitoring chronologic changes in the quantity and localization of apoptotic cells. SUMMARY OF BACKGROUND DATA: Apoptosis occurs within human intervertebral discs, but little is known about the pathologic significance of this process. On the other hand, the cartilaginous endplate is known to decrease in thickness and to disappear with aging and degeneration. The cause of this age-related change remains unclear. METHODS: A mouse spondylosis model was prepared via surgical resection of the posterior spinal element in 12 mice to examine the experimentally induced spondylosis process. Eighteen naturally aged mice were also used to examine the influence of aging. Paraffin-embedded midsagittal sections of the cervical spine were obtained 2, 3, 6, and 12 months after surgery in the spondylosis model and in the age-matched naturally aged mice, as well as in 4-week-old and 18-month-old naturally aged mice. Sections were stained with hematoxylin and eosin, safranin-O, and the TUNEL procedure. The number of apoptotic cells and vital cells were counted in the cartilaginous endplate of the intervertebral disc excluding the growth cartilage, and the degree of disappearance of the cartilaginous endplate was evaluated. RESULTS: Apoptosis, particularly noticeable in the cartilaginous endplate, increased with age and resulted in a marked decrease in cell density. Subsequently, the structure of the cartilaginous endplate began to disappear. Apoptosis was more evident and the structure of the cartilaginous endplate began to disappear more rapidly in the surgically treated group than in the naturally aged group. CONCLUSIONS: TUNEL-positive cells in the cartilaginous endplate increased with age, with destruction of the cartilaginous endplate after apoptosis (TUNEL-positive cell death). The application of the spondylosis model increased the incidence of apoptosis preceding the development of spondylosis. This suggests that apoptosis plays a role in the age-related changes seen in the cartilaginous endplate of the intervertebral disc and in the experimentally induced spondylosis process.

Aging↗
PubMed1991

Clinical long-term results of anterior discectomy without interbody fusion for cervical disc disease.

There were 55 patients (soft disc, 21 and spondylosis, 34) who underwent anterior cervical discectomy without fusion (ACD) using an operating microscope. Discectomy of a single level was performed on 48 cases and two levels on 7. There were 37 patients with radiculopathy, and 18 patients with myelopathy or myeloradiculopathy who were followed clinically for 2-13 years postoperatively. Overall 81% of patients were improved in soft disc herniation, and no significant differences were noted between the group of radiculopathy and myelopathy. In spondylosis all but one patient reported initial relief of their preoperative symptoms; however, overall improvement was noted in only 16 patients (47%). The causes of symptomatic deterioration after ACD for spondylosis were later symptomatic recurrence in 5 patients, severe neck pain in 4, and development of new symptoms due to adjacent spur formation in 2. The authors eventually added interbody fusion in 4 cases. Cervical spine roentgenograms almost always showed a loss of height of the interspace and an anterior angulation immediately after ACD, but the alignment of the spine tended to improve with time, so that, at last follow-up, 82% had a good alignment. A spontaneous osseous fusion occurred in 74% of cases. An adjacent spur formation was observed in 3 patients with spondylosis. The most troublesome complication was neck and/or scapular pain. This pain usually subsided spontaneously, but this continued for more than 4 years postoperatively in 4 patients with spondylosis. Using an operating microscope ACD is a safe and effective procedure for patients with soft disc herniation, but the authors still prefer anterior cervical discectomy with interbody fusion for the patients with advanced spondylosis.

Cervical Vertebrae↗