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PubMed2001

Measurement accuracy in congenital scoliosis.

BACKGROUND: The accuracy of measurement of curves in idiopathic scoliosis has been extensively studied; however, we know of only one article in the literature concerning the accuracy of measurement of curves in congenital scoliosis. That article stated that intraobserver variability was +/- 9.6 degrees and interobserver variability was +/- 11.8 degrees. METHODS: Sixty-nine curves in fifty patients with congenital scoliosis were measured on two separate occasions by seven different observers with varying experience in curve measurement. RESULTS: Mean intraobserver variance ranged from 1.9 degrees to 5.0 degrees, with an average of 2.8 degrees (95% confidence limit, +/- 3 degrees) for the seven observers. The interobserver variance was 3.35 degrees (95% confidence limit, 7.86 degrees). CONCLUSIONS: It is possible to measure curves in congenital scoliosis with much greater accuracy than previously reported. In the clinical situation in which a skilled observer can measure two radiographs at the same time, an accuracy of +/- 3 degrees can be expected 95% of the time.

History, Modern 1601-↗
PubMed2003

Growth of the thoracic spine in congenital scoliosis after expansion thoracoplasty.

BACKGROUND: Children with congenital thoracic scoliosis associated with fused ribs with a unilateral unsegmented bar adjacent to convex hemivertebrae will invariably have curve progression without treatment. Surgery has been thought to have a negligible growth-inhibition effect on the thoracic spine in such patients because it has been assumed that the concave side of the curve and the unilateral unsegmented bar do not grow, but we are unaware of any conclusive studies regarding this assumption. METHODS: The changes in the length of the concave and convex sides, anterior and posterior vertebral edges, posterior arch, and unilateral unsegmented bars of the thoracic spine were measured in the twenty-one children with congenital scoliosis and fused ribs after expansion thoracoplasty had been carried out with use of a vertical, expandable titanium prosthetic rib. Three of these children had undergone posterior spinal fusion previously. Measurements were made with use of a three-dimensional software program that analyzed baseline and follow-up computed tomography scans. The technique was validated through measurement of the thorax of a small female adult cadaver. RESULTS: The patients without spine fusion had an average age of 3.3 years at the time of the baseline computed tomography scan, and the average duration of follow-up was 4.2 years. On the average, these patients showed significant growth (p < 0.0001) of the concave side of the thoracic spine (an increase in length of 7.9 mm/yr, or 7.1%/yr) and the convex side (8.3 mm/yr, or 6.4%/yr) compared with the baseline lengths. There was no significant difference in the increases in length (p = 0.38) between the concave and convex sides. Eleven patients with an unsegmented bar had an average 7.3% increase in the length of the bar (p < 0.0001). In the three children with prior spinal fusion, the increase in length averaged only 4.6 mm/yr (3%/yr) on the concave side of the thoracic spine and 3.7 mm/yr (2.2%/yr) on the convex side; both increases were significant (p < 0.0001). CONCLUSIONS: Longitudinal growth of the thoracic spine in a normal child has been estimated to be 0.6 cm/yr between the ages of five and nine years. After expansion thoracoplasty, growth of the thoracic spine was approximately 8 mm/yr in our series of children with congenital scoliosis and fused ribs. After expansion thoracoplasty, both the concave and the convex side of the thoracic spine and unilateral unsegmented bars appeared to grow in these patients. When a thorax is already foreshortened by congenital scoliosis, control of spine deformity with expansion thoracoplasty allows growth of the thoracic spine, and it is likely that the longer thorax provides additional volume for growth of the underlying lungs with probable clinical benefit. LEVEL OF EVIDENCE: Therapeutic study, Level IV (case series [no, or historical, control group]). See Instructions to Authors for a complete description of levels of evidence.

Child↗
PubMed2004

Long-term follow-up of female patients with idiopathic scoliosis treated with the Wilmington orthosis.

BACKGROUND: A spinal orthosis is commonly utilized in the nonoperative treatment of idiopathic scoliosis. The purpose of this study was to evaluate the long-term radiographic and functional outcomes of female patients with idiopathic scoliosis who had completed a program of treatment with the Wilmington thoracic-lumbar spinal orthosis. METHODS: We retrospectively reviewed the clinical records and radiographs of all female patients who had successfully completed a course of treatment with the orthosis between 1973 and 1983. Ninety-one patients met the criteria for inclusion, and fifty-five women returned for a follow-up evaluation. Their mean age was thirty-one years at the time of follow-up, which was carried out at a mean of 14.6 years after the completion of treatment. The patients were evaluated clinically and radiographically, and they each completed a comprehensive questionnaire assessing their ability to perform twenty-six activities of daily living, their overall physical appearance, the cosmetic appearance of the back, their self-image, and the severity of any back pain. The questionnaire was also administered to a control group of fifty-five women without scoliosis matched for age, number of children, and occupation. RESULTS: Seven patients (13%) demonstrated >or=5 degrees of progression of the curve, compared with the curve at the start of treatment, after discontinuing use of the orthosis. No curve progressed >17 degrees compared with the deformity at the time of the initial treatment. There was no significant overall difference between the orthotic treatment group and the control group in terms of back pain, physical activities, functional activities (with the exception of shopping) or self-care activities. As a group, the patients reported significantly greater difficulty with selected positional activities (p = 0.007). Fifty-one (93%) of the fifty-five treated women reported no subjective deterioration in their physical appearance, the cosmetic appearance of the back, or their self-image in the period since they discontinued using the brace. CONCLUSIONS: The majority of patients who successfully complete treatment with a Wilmington thoracic-lumbar spinal orthosis for idiopathic scoliosis with an initial magnitude of between 20 degrees and 45 degrees can anticipate that the curve will remain stable into middle adulthood. Any apparent correction of the curve that occurs during treatment can be expected to be lost over time, resulting in a deformity that is equal or nearly equal in magnitude to that measured at the initiation of the orthotic management. Because some patients did demonstrate some progression of the curve by the third or fourth decade of life, it is reasonable to recommend a spinal radiograph during that time to monitor the status of the curve.

Adolescent↗
PubMed2004

Indications for magnetic resonance imaging in presumed adolescent idiopathic scoliosis.

BACKGROUND: The use of magnetic resonance imaging has led to the diagnosis of abnormalities of the central nervous system associated with apparent idiopathic scoliosis. The indications for magnetic resonance imaging for presumed adolescent idiopathic scoliosis have not been established. METHODS: One thousand, two hundred and eighty children with presumed adolescent idiopathic scoliosis were evaluated over a ten-year period. Magnetic resonance imaging of the central nervous system (brainstem and spinal cord) was performed for specific patients, on the basis of the presence of selected indicators determined from the clinical history, physical examination, and plain radiographic examination of the spine. The medical records were reviewed to determine the specific indicators, the results of the imaging studies, and the subsequent treatment. RESULTS: Magnetic resonance imaging was ordered for 274 (21%) of the 1280 children who were evaluated. Abnormal findings were seen in twenty-seven (10%) of the 274 patients who underwent imaging, or 2% of the entire cohort. The most valuable single indicator of an abnormal finding on magnetic resonance imaging was absence of thoracic apical segment lordosis: eight of thirty-nine patients with that indicator had an abnormal finding on magnetic resonance imaging. The optimal diagnostic yield for a single category of indicators occurred when an atypical curve pattern was the only indicator: six of fifty-eight patients in whom this was the case had an abnormal finding on magnetic resonance imaging. None of the twenty children in whom pain was the only indicator category had an abnormal imaging study. The optimal diagnostic yield occurred when both an atypical curve pattern and neurological indicators were present: thirteen (25%) of fifty-three patients in whom this was the case had an abnormal finding on magnetic resonance imaging. Thirteen of the twenty-seven patients received surgical treatment for the abnormality of the central nervous system revealed by the imaging. CONCLUSIONS: The correct use of diagnostic tests is an important component of effective medical practice. An abnormality of the central nervous system is present in approximately 10% of patients with presumed adolescent idiopathic scoliosis in whom only subtle abnormalities are identified on the basis of the clinical history, physical examination, or radiographic examination. Knowledge of the diagnostic value of the specific clinical indicators, considered individually and in combination, can help the clinician to determine more effectively when advanced imaging of the central nervous system should be performed.

Adolescent↗
PubMed2005

Decreased orthotic effectiveness in overweight patients with adolescent idiopathic scoliosis.

BACKGROUND: Many studies have demonstrated that orthotic treatment is effective for the prevention of curve progression in patients with adolescent idiopathic scoliosis. However, the effect of being overweight on the outcome of orthotic treatment has not been reported. The purpose of the present study was to determine whether orthotic treatment of adolescent idiopathic scoliosis is less successful for patients who are overweight than it is for those who are not overweight. METHODS: A ten-year multicenter retrospective review of patients in whom adolescent idiopathic scoliosis had been treated with a Boston or a custom-molded thoracolumbosacral orthosis was performed. The inclusion criteria were no previous treatment, skeletal immaturity (a Risser sign of 0, 1, or 2), a curve of 25 degrees to 40 degrees at the time of orthotic initiation, and follow-up to skeletal maturity. Patients were divided into two groups according to body habitus, with overweight patients defined as those with a body mass index in the eighty-fifth percentile or greater. Curve progression was compared between the two groups. Successful orthotic treatment was defined as no more than a 5 degrees increase in the primary curve from the start of orthotic wear to skeletal maturity. Absolute curve progression to 45 degrees or greater also was considered to be an adverse outcome. RESULTS: Two hundred and seventy-six consecutive patients from two institutions were analyzed, and thirty-one patients were considered to be overweight. The mean curve progression was 9.6 degrees +/- 7.3 degrees for the patients who were overweight, compared with 3.6 degrees +/- 9.4 degrees for those who were not overweight (p < 0.01). Overweight patients were 3.1 times more likely to have an unsuccessful result than those who were not overweight. Curve progression to 45 degrees or greater occurred in fourteen (45%) of the thirty-one patients who were overweight, compared with sixty-nine (28%) of the 245 patients who were not overweight. CONCLUSIONS: The results of the present study suggest that overweight patients with adolescent idiopathic scoliosis will have greater curve progression and less successful results following orthotic treatment than those who are not overweight. The ability of an orthosis to transmit corrective forces to the spine through the ribs and soft tissue may be compromised in overweight patients. This factor should be taken into consideration when making treatment decisions. Additional study is warranted to determine a threshold effect.

Body Mass Index↗
PubMed2005

Results of preoperative pulmonary function testing of adolescents with idiopathic scoliosis. A study of six hundred and thirty-one patients.

BACKGROUND: Previous research has suggested a correlation between pulmonary impairment and thoracic spinal deformity. The curve magnitude, number of involved vertebrae, curve location, and decrease in thoracic kyphosis independently contribute to pulmonary impairment, but the strength of these associations has been variable. The objectives of this study were to test the hypothesis that increased thoracic deformity is associated with decreased pulmonary function and to determine which, if any, radiographic measurements of deformity predict pulmonary impairment. METHODS: Preoperative pulmonary function testing and radiographic examination were performed on 631 patients with adolescent idiopathic scoliosis. Correlation analysis and subsequent stepwise multiple regression analysis were carried out to assess the associations between radiographic measurements of deformity and the results of pulmonary function testing. RESULTS: The magnitude of the thoracic curve, the number of vertebrae involved in the thoracic curve, the thoracic hypokyphosis, and coronal imbalance had a minimal but significant effect on pulmonary function. While these four factors were associated with an increased risk of moderate or severe pulmonary impairment, they explained only 19.7%, 18.0%, and 8.8% of the observed variability in forced vital capacity, forced expiratory volume in one second, and total lung capacity, respectively. The degrees of scoliosis that were associated with clinically relevant decreases in pulmonary function were much smaller than previously described, but the majority of the observed variability in pulmonary function was not explained by the radiographic characteristics of the deformity. CONCLUSIONS: Some patients with adolescent idiopathic scoliosis may have clinically relevant pulmonary impairment that is out of proportion with the severity of the scoliosis, and this may alter the decision-making process regarding which fusion technique will produce an acceptable clinical result with the least additional effect on pulmonary function.

Adolescent↗
PubMed1979

Moiré topography for the diagnosis and documentation of scoliosis.

Moiré topography is a biosteriometric method, which produces a three-dimensional image of the shape of the trunk. In structural scoliosis an asymmetry of the two halves of the back is seen. This method has been studied and the range of the asymmetry of the moire pattern has been compared with clinical observations and X-ray findings in 216 cases with structural scoliosis. A statistically significant correlation between these three ways of describing a structural scoliosis was found. Because of the sensitivity of the moire method an asymmetry of at least one fringe interval could be regarded as a positive result. All the observed asymmetries less than one fringe interval had a lateral deviation of the spine of less than 10 degrees according to Cobb when X-rayed examined. The moire method seems to be very suitable for the screening of structural scoliosis, owing to its ability to detect and document even small deformities by photography and the simplicity of the technique which can be carried out even by staff without medical training.

Adolescent↗
PubMed1979

A late neurologic complication of scoliosis surgery in connection with syringomyelia.

A case of scoliosis in connection with syringomyelia is described. Theories are proposed to explain the progression of the neurological symptoms after surgical correction and fusion of the deformity. Special points are emphasized that will aid in the recognition of syringomyelia in scoliosis patients. i) Abnormal neurology, in particular a dissociated disturbance of pain and temperature in the upper extremity. ii) Abnormal localization of a scoliosis curve. iii) Rapid progression of the scoliosis. iv) Bony anomalies of the upper cervical spine. v) Increased diameter of the cervical spinal canal.

Adolescent↗
PubMed1980

Collagen-induced platelet aggregation and bleeding time in adolescent idiopathic scoliosis.

Collagen is the main supportive protein of connective tissue. Another of its functions is the initiation of haemostasis by activation of the platelets. It has been suggested that collagen is abnormal in idiopathic scoliosis. The present study lends further support to this view: collagen of fascia specimens from patients with adolescent idiopathic scoliosis was found to aggregate platelets less readily than collagen from non-scoliotic controls and suspensions of fascia patients with adolescent idiopathic scoliosis contained more collagen than those from the controls. The collagen abnormality is probably also reflected in a prolonged bleeding time. The changes in the collagen in patients with scoliosis persist at least for some years after the cessation of growth.

Adolescent↗
PubMed1988

Growth and ethnicity in scoliosis.

We analyzed height, weight, and body-mass index of 54,030 male and 38,102 female army recruits who underwent a complete routine health assessment at the age of 17 years. Totally, 6,711 males and 4,864 females were diagnosed as having idiopathic scoliosis and were categorized according to 3 grades of severity. There was a difference in prevalence in both sexes with parental origin from Iraq and western Europe. Females as compared with the males were at increased risk of developing the more severe grades of scoliosis. Young scoliotic adults were taller, lighter, and thinner than the nonscoliotic controls. These differences in height, weight, and body-mass index correlated with the severity of the scoliosis. We suggest that genetic factors and growth pattern are of major importance for the prevalence of scoliosis.

Adolescent↗
PubMed1991

Spinal cord and brain stem anomalies in scoliosis. MR screening of 26 cases.

The spinal cord and brain were examined with magnetic resonance (MR) in 26 patients with idiopathic scoliosis to study the prevalence of spinal cord and brainstem anomalies. Two patients had small centrally located spinal cord syrinxes, one at C6-C8 and the other at T6-T8, without association with any brainstem or cerebellar deformity. The lowest position of the cerebellar tonsils was 0.5 cm below the foramen magnum, which was also seen in 2 other patients. Scoliosis associated with syringomyelia may be more common than previously thought, and may be wrongly classified as idiopathic. A neurogenic cause of scoliosis should always be considered, and at least in atypical cases be excluded by MR imaging of the spinal cord. MR should be mandatory before bracing or operative correction of scoliosis.

Adolescent↗
PubMed1991

Familial back shape in adolescent scoliosis. A photogrammetric population study.

A stereophotogrammetric technique (ISIS scanning) was used to assess the back shape of children with adolescent idiopathic scoliosis (index cases), their unaffected relatives, normal adults and children, and children with small idiopathic scoliotic curves (Cobb's angle less than 30 degrees) to detect any familial trends that may predispose to scoliosis. The analysis revealed a characteristic three-dimensional scoliotic back shape; no differences in unaffected relatives as regards sex or a positive family history of scoliosis; similar back shapes in unaffected parents and normal adults, both of whom differ from index cases and children with small curves. Unaffected siblings had a sagittal profile between those of normal children and children with small curves. This may represent an inherited tendency to scoliosis.

Adolescent↗
PubMed2003

Correction of adult scoliosis via a posterior-only approach.

OBJECT: Adult scoliosis is a pathologically different entity from adolescent idiopathic scoliosis. The curves are more rigid, and rotational deformity and multilevel sagittal vertebral slippages compound the coronal malalignment. To correct these deformities, a surgical anterior release procedure is usually required, as well as posterior instrumentation-assisted fusion. This exposes the patient to the risks of a second procedure and of a thoracotomy or laparotomy. To decrease these risks, the authors have performed an anterior release, posterior release, and reduction via a posterior-only approach. The purpose of this study was to analyze quantitatively the degree of pre- and postoperative coronal deformity, the extent of correction, and related complications. METHODS: Data obtained in 20 patients with adult scoliosis were retrospectively studied. Patients presented with persistent back or lower-extremity pain, progressive deformity, or progressive neurological deficit. Sixteen patients underwent Gill-type laminectomy, radical discectomy (including fracture of any anterior and lateral osteophytes), and posterior lumbar interbody fusion (PLIF) of all apical and adjacent segments. One to four anterior release procedures were performed in each patient. Posterior instrumentation was placed over three to 15 levels. Autograft was obtained from the laminectomy sites and posterior iliac crest for fusion. There were no deaths; all patients were followed for a minimum of 1 year. The mean coronal Cobb angle improved from 36 degrees to 14.7 degrees. All spondylolisthetic lesions were reduced to at least Grade I. At the most recent follow-up examination, evidence of fusion was demonstrated in all patients. Reoperation for adjacent-segment failure, cephalad to the highest level of fusion, was required in two cases. CONCLUSIONS: In many cases of adult scoliosis, a satisfactory multiplanar correction may be obtained via a single posterior approach and by using extended PLIF techniques. Cephalad adjacent-segment failure remains a significant problem in patients with osteoporosis, and routine extension of posterior instrumentation to the upper thoracic spine should be considered in these cases.

Adult↗
PubMed1979

Scoliosis and hydrocephalus in myelocele patients. The effects of ventricular shunting.

Developmental scoliosis is a common cause of increasing disability and deformity in long-term myelocele survivors, and is believed to result from a paralytic collapsing spine. The possible etiological role of compensated hydrocephalus and hydromyelia was assessed by determining the effect of ventricular shunting on 11 myelocele patients with developmental scoliosis. After successful shunting, one patient with a 47 degrees curve continued to deteriorate. Three cases with curves greater than 60 degrees were stabilized for short periods, but eventually required spinal fusion. Seven cases with curves less than 55 degrees were improved from a mean scoliosis of 29 degrees to 13 degrees during a 20-month follow-up period. Several patients had pre-existing shunts that were found to be non-functional on shuntogram. These findings suggest that the spinal complications of hydrocephalus may be more common than previously recognized in myelocele patients and that advanced developmental scoliosis may be avoided by early recognition and ventricular shunting.

Adolescent↗
PubMed2005

Superior mesenteric artery syndrome following scoliosis surgery: its risk indicators and treatment strategy.

AIM: To investigate the risk indicators, pattern of clinical presentation and treatment strategy of superior mesenteric artery syndrome (SMAS) after scoliosis surgery. METHODS: From July 1997 to October 2003, 640 patients with adolescent scoliosis who had undergone surgical treatment were evaluated prospectively, and among them seven patients suffered from SMAS after operation. Each patient was assigned a percentile for weight and a percentile for height. Values of the 5th, 10th, 25th, 50th, 75th, and 95th percentiles were selected to divide the observations. The sagittal Cobb angle was used to quantify thoracic or thoracolumbar kyphosis. All the seven patients presented with nausea and intermittent vomiting about 5 d after operation. An upper gastrointestinal barium contrast study showed a straight-line cutoff at the third portion of the duodenum representing extrinsic compression by the superior mesenteric artery (SMA). RESULTS: The value of height in the seven patients with SMAS was above the mean of sex- and age-matched normal population, and the height percentile ranged from 5% to 50%. On the contrary, the value of weight was below the mean of normal population with the weight percentile ranging from 5% to 25%. Among the seven patients, four had a thoracic hyperkyphosis ranging from 55 degrees to 88 degrees (average 72 degrees), two had a thoracolumbar kyphosis of 25 degrees and 32 degrees respectively. The seven patients were treated with fasting, antiemetic medication, and intravenous fluids infusion. Reduction or suspense of traction was adopted in three patients with SMAS during halo-femoral traction after anterior release of scoliosis. All the patients recovered completely with no sequelae. No one required operative intervention with a laparotomy. CONCLUSION: Height percentile < 50%, weight percentile < 25%, sagittal kyphosis, heavy and quick halo-femoral traction after spinal anterior release are the potential risk indicators for SMAS in patients undergoing correction surgery for adolescent scoliosis.

Adolescent↗
PubMed1999

Synteny-defined candidate genes for congenital and idiopathic scoliosis.

Idiopathic scoliosis (IS) is a common but poorly understood syndrome. Congenital scoliosis (CS) is less common but comparably unexplored. Previous studies suggest that each has a significant genetic component. However, the occurrence of scoliosis in the presence of other hereditary connective tissue syndromes raises the possibility that IS and CS are in fact a heterogeneous group of disorders with varied pathogenetic mechanisms. Mouse mutations have proven informative in identifying genes that are important in the development of the musculoskeletal system and provided important mechanistic insights regarding their roles in human disease. We sought to identify candidate genes for human IS and CS by reviewing mouse mutations with phenotypes affecting the axial skeleton. We performed a systematic review using the Mouse Genome Database (MGD), the Genome Database (GDB), and the Online Mendelian Inheritance in Man (OMIM) world-wide-web sites with additional searches performed based on the results of this initial search. We identified approximately 400 mouse mutations, reviewed approximately 250 of these for vertebral phenotypes, assessed 45 of these for synteny conservation between mouse and man, and identified 28 mouse mutations for which 29 credible candidates for human scoliosis could be identified based on mouse phenotypic and mapping data. For each of these, we have synthesized information about the mouse mutant phenotype, mapping data, information regarding molecular pathogenesis when a specific causative gene has been identified, and information regarding plausible candidates based on map position when the causative gene has not been identified. Among these were three loci for which the mutant gene had been identified and the human homologue was known. Some of the mouse mutants have phenotypes similar to human syndromes.

Animals↗
PubMed1976

[Bioelectric activity of paravertebral muscles in experimental scoliosis].

The paper is concerned with a study of the bioelectrical activity of the paravertebral muscles in 2 groups of rabbits with differently expressed degrees of experimental scoliosis and in a control group of intact animals. The results demonstrated an asymmetry in the tonic bioelectric activity in the paravertebral muscles in scoliosis, unlike the reactions of the control group of animals. The character of asymmetry depends upon the degree of deformation: in cases of moderately expressed scoliosis there is a prevalence of the tonic bioelectric activity on the level of the basic arc of distortion on the side of the concavity; in severely expressed scoliosis the tonic bioelectrical activity of the paravertebral muscles on the concave side appears to be less than on the convex side. An asymmetry of the tonic activity takes place on the level of compensatory arcs as well. The authors come to the conclusion on the pathogenetical role of the muscular dysbalance in the genesis of scoliotic deformation.

Animals↗
PubMed1999

[Natural history of scoliosis from childhood to old age].

Idiopathic scoliosis arises at any age in childhood. Its increasing is usually progressive, following growth, with a peak at puberty. Well codified determining factors for severity are: age at beginning, angulation and bone maturation. Functional and consequential effects remain anyway limited. Many scoliosis increase in adult life, giving way to deterioration, prevailing at the lumbar level, with osteo-arthritic changes and typical patterns such as dislocation at the junctional areas. Functional repercussion may thus arise, mainly pain and, in severe thoracic scoliosis impairment of the pulmonary function. A special form of degenerative scoliosis may appear over 45 or 50 years of age with progressive backache and/or radicular pain.

Adolescent↗